Fault Detection and Isolation of Nonlinear Systems with Generalized Hamiltonian Representation

The problem of fault diagnosis in a class of nonlinear system is considered. Systems that can be written in the so‐called Generalized Hamiltonian Representation (which is equivalent to an Euler‐Lagrange representation) are studied, and a model‐based observer approach for this class of systems is developed. The main advantage of the proposed approach is the facility to design the required observers, which take advantage of the system structure given by the Hamitonian representation. In order to show the proposed schema, a model of a permanent magnet synchronous machine is revised and the fault diagnosis schema presented. Simulation results confirm the effectivity of the proposed schema

Dietary fat and carbohydrate modulate the effect of the ATP-binding cassette A1 (ABCA1) R230C variant on metabolic risk parameters in premenopausal women from the Genetics of Atherosclerotic Disease (GEA) Study

Table S1. Demographic characteristics of the population. Table S2. Comparison of biochemical parameters stratified by gender and menopausal status. Table 3. Correlation between metabolic parameters and dietary macronutrients according to ABCA1/R230C genotypes in premenopausal women. Table S4. Comparison of biochemical parameters stratified by ABCA1/R230C genotypes in the study population and premenopausal women. Table 5. Comparison of biochemical parameters stratified by ABCA1/R230C genotypes and carbohydrate percentage tertiles in premenopausal women. Table 6. Comparison of biochemical parameters stratified by ABCA1/R230C genotypes and fat percentage tertiles in premenopausal women. (DOCX 162 kb

The Respiratory Exchange Ratio is Associated with Fitness Indicators Both in Trained and Untrained Men: A Possible Application for People with Reduced Exercise Tolerance

Background The respiratory exchange ratio (RER) indirectly shows the muscle's oxidative capacity to get energy. Sedentarism, exercise and physically active lifestyles modify it. For that reason, this study evaluates the associations between RER during sub-maximum exercise and other well established fitness indicators (body fat, maximum heart rate, maximum O 2 uptake, workload, and lactate threshold), in physically active trained and untrained men. Methods The RER, O 2 uptake and blood lactate were measured in eight endurance trained and eight untrained men (age, 22.9 ± 4.5 vs. 21.9 ± 2.8 years; body mass, 67.1 ± 5.4 vs. 72.2 ± 7.7 kg; body fat, 10.6 ± 2.4% vs. 16.6 ± 3.8% and maximum O2 uptake, 68.9 ± 6.3 vs. 51.6 ± 5.8 ml · kg −1 · min −1 ), during maximum exercise test and during three different sub-maximum exercises at fixed workload: below, within or above the lactate threshold. Results Endurance trained men presented higher O 2 uptake, lower blood lactate concentrations and lower RER values than those in untrained men at the three similar relative workloads. Even though with these differences in RER, a strong association (p < 0.05) of RER during sub-maximum exercise with the other well established fitness indicators was observed, and both maximum O 2 uptake and lactate threshold determined more than 57% of its variance (p < 0.05). Conclusions These data demonstrate that RER measurement under sub-maximum exercise conditions was well correlated with other established physical fitness indicators, despite training condition. Furthermore, the results suggest that RER could help obtain an easy approach of fitness status under low exercise intensity and could be utilized in subjects with reduced exercise tolerance

Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo

Inflammation is part of the physiological response of the organism to infectious diseases caused by organisms such as bacteria, viruses, fungi, or parasites. Innate immunity, mediated by mono nuclear phagocytes, including monocytes and macrophages, is a first line of defense against infectious diseases and plays a key role triggering the delayed adaptive response that ensures an efficient defense against pathogens. Monocytes and macrophages stimu lation by pathogen antigens results in activation of different signaling pathways leading to the release of proinflammatory cyto kines. However, inflammation can also participate in the pathogenesis of several diseases, the autoimmune diseases that represent a relevant burden for human health. Dendrimers are branched, multivalent nanoparticles with a well-defined structure that have a high potential for biomedical applications. To explore new approaches to fight against the negative aspects of inflammation, we have used neutral high-generation phosphorus dendrimers bearing 48 (G3) or 96 (G4) bisphosphonate groups on their surface. These dendrimers show no toxicity and have good solubility and chemical stability in aqueous solutions. Here, we present data indicating that neutral phosphorus dendrimers show impressive antiinflammatory activities both in vitro and in vivo. In vitro, these dendrimers reduced the secretion of proinflammatory cytokines from mice and human monocyte derived macrophages. In addition, these molecules present efficient antiinflammatory activity in vivo in a mouse model of subchronic inflammation. Taken together, these data suggest that neutral G3- G4 phosphorus dendrimers have strong potential applications in the therapy of inflammation and, likely, of autoimmune diseases.info:eu-repo/semantics/publishedVersio

Impact of N2 plasma power discharge on AlGaN/GaN HEMT performance

The effects of power and time conditions of in situ N2 plasma treatment, prior to silicon nitride (SiN) passivation, were investigated on an AlGaN/GaN high-electron mobility transistor (HEMT). These studies reveal that N2 plasma power is a critical parameter to control the SiN/AlGaN interface quality, which directly affects the 2-D electron gas density. Significant enhancement in the HEMT characteristics was observed by using a low power N2 plasma pretreatment. In contrast, a marked gradual reduction in the maximum drain-source current density (IDS max) and maximum transconductance (gm max), as well as in fT and fmax, was observed as the N2 plasma power increases (up to 40% decrease for 210 W). Different mechanisms were proposed to be dominant as a function of the discharge power range. A good correlation was observed between the device electrical characteristics and the surface assessment by atomic force microscopy and Kelvin force microscopy techniques

Continuity of Nursing Care in Patients with Coronary Artery Disease: A Systematic Review

Coronary artery disease is the leading cause of death worldwide and patient continuity of care is essential. Health professionals can help in the transition stage by providing resources to achieve pharmacological treatment adherence, as well as social and emotional support. The objective was to analyse the effects of nursing interventions based on continuity of care in patients with coronary artery disease after hospital discharge. A systematic review of randomised controlled trials and quasi-experimental studies was carried out. Cochrane, CINAHL, Health & medical collection, Medline, and Scopus databases were consulted in January 2022. PRISMA guidelines were followed with no time limits. In total, 16 articles were included with a total of 2950 patients. Nurse-led continuity of care programs improved the monitoring and control of the disease. Positive effects were found in the quality of life of patients, and in mental health, self-efficacy, and self-care capacity dimensions. Clinical parameters such as blood pressure and lipid levels decreased. The continuity of care provided by nurses had a positive influence on the quality of life of patients with coronary artery disease. Nurse-led care focused on the needs and resources, including continuity of care, plays a key role

MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project

DNA damage and subsequent repair pathways have been involved in the initiation and progression of atherosclerosis. Meiotic recombination 11 homolog A (MRE11A) gene polymorphisms have been associated with the presence of myocardial infarction. We analyzed five MRE11A gene polymorphisms in 386 individuals with subclinical atherosclerosis and 1093 healthy controls. Under different models, the rs13447720 (Odds ratio = 0.646, Padditive = 0.009; Odds ratio = 0.636, Pdominant = 0.012; Odds ratio = 0.664, Pover–dominant = 0.025; Odds ratio = 0.655, Pcodominant1 = 0.021) and rs499952 (Odds ratio = 0.807, Padditive = 0.032; Odds ratio = 0.643, Pcodominant2 = 0.034) polymorphisms were associated with a lower risk of subclinical atherosclerosis. On the other hand, the rs2155209 polymorphism was associated with a reduced risk of having a coronary artery calcification score ≥ 100 Agatston units. The rs13447720, rs499952, and rs2155209 polymorphisms, as well as the haplotypes that included the five studied polymorphisms were associated with some clinical and metabolic parameters in both subclinical atherosclerosis and healthy individuals. Our results suggest that the rs13447720 and rs499952 polymorphisms are associated with a decreased risk of developing subclinical atherosclerosis, whereas the rs2155209 is associated with a lower subclinical atherosclerosis severity (coronary artery calcification &lt; 100 Agatston units). MRE11A polymorphisms and haplotypes were associated with clinical and metabolic parameters

Evaluación del modelo educativo constructivista de orientación educativa e intervención psicopedagógica desde el enfoque socioformativo

El propósito de esta investigación es identificar y valorar el modelo de intervención que aplican equipos psicopedagógicos concretos en algunos centros de educación básica pública. Metodológicamente, se realizó un estudio descriptivo valorativo mediante la aplicación de cuestionarios con preguntas cerradas a los miembros de dichos equipos psicopedagógicos. Los resultados más importantes fueron que un alto porcentaje de profesionales aplica el denominado enfoque clínico, modelo criticado por toda la literatura científica a causa del bajo impacto que ha ejercido y de los malos resultados que ha obtenido. Por ello, se concluye proponiendo actualizar la normativa y la formación de estos docentes, a fin de encaminarles hacia una práctica psicopedagógica dirigida por el modelo educativo constructivista a través de un enfoque socioformativo por competencias.El propòsit d'aquesta investigació és identificar i valorar el model d'intervenció que apliquen uns equips psicopedagògics en alguns centres d'educació bàsica pública. Metodològicament, es va realitzar un estudi descriptiu valoratiu mitjançant l'aplicació de qüestionaris amb preguntes tancades als membres d'aquests equips psicopedagògics. Els resultats més importants van ser que un alt percentatge de professionals aplica el denominat enfocament clínic, model criticat per tota la literatura científica a causa del baix impacte que exerceix i dels mals resultats que obté. Per això es conclou proposant actualitzar la normativa i la formació d'aquests docents, a fi d'encaminar-los cap a una pràctica psicopedagògica dirigida pel model educatiu constructivista a través d'un enfocament socioformatiu per competències.This study aims to identify and assess a socioformative-based intervention model applied by psychopedagogical teams at public, basic education schools. An evaluative, descriptive study was carried out using a survey of closed-ended questions administered to a group of professionals who work in the field of inclusion. The results showed that a large percentage of professionals are applying the clinical approach; a model that has been criticized in the scientific literature due to its low impact, poor performance and scarce relevance in today's knowledge society. We conclude that the regulations concerning psychopedagogical practice and the training of these professionals should be revised and updated within the framework of the socioformative approach