Capturing multi-stakeholder needs in Customer-Centric Cloud Service Design

Cloud computing applications and services go hand in hand, yet there is no clear mechanism for ensuring that the cloud applications are designed from a customer’s perspective. Likewise services can require adaptation for multiple customers of stakeholders, which require differing user experience outcomes. This paper describes the initial design and development of a predictive analytics cloud service application, which uses historic customer data to predict the existing customers that are most likely to churn. Service blueprinting, a service innovation method, was used as the underlying design model for developing an initial shared understanding of the required service. Personas were used in the requirements analysis to develop insights into multi-stakeholder needs. Using the design science paradigm an extended cloud service design theory is proposed, as an outcome of the ongoing development of this analytics platform

Assessing fishery and ecological consequences of alternate management options for multispecies fisheries

Demands for management advice on mixed and multispecies fisheries pose many challenges, further complicated by corresponding requests for advice on the environmental impacts of alternate management options. Here, we develop, and apply to North Sea fisheries, a method for collectively assessing the effects of, and interplay between, technical interactions, multispecies interactions, and the environmental effects of fishing. Ecological interactions involving 21 species are characterized with an ensemble of 188 plausible parameterizations of size-based multispecies models, and four fleets (beam trawl, otter trawl, industrial, and pelagic) characterized with catch composition data. We use the method to evaluate biomass and economic yields, alongside the risk of stock depletion and changes in the value of community indicators, for 10 000 alternate fishing scenarios (combinations of rates of fishing mortality F and fleet configuration) and present the risk vs. reward trade-offs. Technical and multispecies interactions linked to the beam and otter trawl fleets were predicted to have the strongest effects on fisheries yield and value, risk of stock collapse and fish community indicators. Increasing beam trawl effort led to greater increases in beam trawl yield when otter trawl effort was low. If otter trawl effort was high, increases in beam trawl effort led to reduced overall yield. Given the high value of demersal species, permutations of fleet effort leading to high total yield (generated primarily by pelagic species) were not the same as permutations leading to high catch values. A transition from F for 1990 to 2010 to FMSY, but without changes in fleet configuration, reduced risk of stock collapse without affecting long-term weight or value of yield. Our approach directly addresses the need for assessment methods that treat mixed and multispecies issues collectively, address uncertainty, and take account of trade-offs between weight and value of yield, state of stocks and state of the environment

Correction: An exploration of homo- and heterometallic UO22+ hybrid materials containing chelidamic acid: synthesis, structure, and luminescence studies

Correction for ‘An exploration of homo- and heterometallic UO22+ hybrid materials containing chelidamic acid: synthesis, structure, and luminescence studies’ by Paula M. Cantos et al., CrystEngComm, 2013, 15, 9039–9051, DOI: 10.1039/C3CE41655K

Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neurons.

The neuronal ceroid lipofuscinoses (NCLs or Batten disease) are a group of inherited, fatal neurodegenerative disorders of childhood. In these disorders, glial (microglial and astrocyte) activation typically occurs early in disease progression and predicts where neuron loss subsequently occurs. We have found that in the most common juvenile form of NCL (CLN3 disease or JNCL) this glial response is less pronounced in both mouse models and human autopsy material, with the morphological transformation of both astrocytes and microglia severely attenuated or delayed. To investigate their properties, we isolated glia and neurons from Cln3-deficient mice and studied their basic biology in culture. Upon stimulation, both Cln3-deficient astrocytes and microglia also showed an attenuated ability to transform morphologically, and an altered protein secretion profile. These defects were more pronounced in astrocytes, including the reduced secretion of a range of neuroprotective factors, mitogens, chemokines and cytokines, in addition to impaired calcium signalling and glutamate clearance. Cln3-deficient neurons also displayed an abnormal organization of their neurites. Most importantly, using a co-culture system, Cln3-deficient astrocytes and microglia had a negative impact on the survival and morphology of both Cln3-deficient and wildtype neurons, but these effects were largely reversed by growing mutant neurons with healthy glia. These data provide evidence that CLN3 disease astrocytes are functionally compromised. Together with microglia, they may play an active role in neuron loss in this disorder and can be considered as potential targets for therapeutic interventions

Chromophore-labelled, luminescent platinum complexes: syntheses, structures, and spectroscopic properties

Ligands based upon 4-carboxamide-2-phenylquinoline derivatives have been synthesised with solubilising octyl hydrocarbon chains and tethered aromatic chromophores to give naphthyl (HL2), anthracenyl (HL3) and pyrenyl (HL4) ligand variants, together with a non-chromophoric analogue (HL1) for comparison. 1H NMR spectroscopic studies of the ligands showed that two non-interchangeable isomers exist for HL2 and HL4 while only one isomer exists for HL1 and HL3. Supporting DFT calculations on HL4 suggest that the two isomers may be closely isoenergetic with a relatively high barrier to exchange of ca. 100 kJ mol−1. These new ligands were cyclometalated with Pt(II) to give complexes [Pt(L1–4)(acac)] (acac = acetylacetonate). The spectroscopically characterised complexes were studied using multinuclear NMR spectroscopy including 195Pt{1H} NMR studies which revealed δPt ca. −2785 ppm for [Pt(L1–4)(acac)]. X-ray crystallographic studies were undertaken on [Pt(L3)(acac)] and [Pt(L4)(acac)], each showing the weakly distorted square planar geometry at Pt(II); the structure of [Pt(L3)(acac)] showed evidence for intermolecular Pt–Pt interactions. The UV-vis. absorption studies show that the spectral profiles for [Pt(L2–4)(acac)] are a composite of the organic chromophore centred bands and a broad 1MLCT (5d → π*) band (ca. 440 nm) associated with the complex. Luminescence studies showed that complexes [Pt(L2–4)(acac)] are dual emissive with fluorescence characteristic of the tethered fluorophore and long-lived phosphorescence attributed to 3MLCT emission. In the case of the pyrenyl derivative, [Pt(L4)(acac)], the close energetic matching of the 3MLCT and 3LCpyr excited states led to an elongation of the 3MLCT emission lifetime (τ = 42 μs) under degassed solvent conditions, suggestive of energy transfer processes between the two states

The Impact of Packet Fragmentation and Reassembly in Resource Constrained Wireless Networks

Low-power and lossy (LLN) networks, including Wireless Sensor Networks, provide an important building block for Internet of Things (IoT) technology. The resource constraints associated with LLN devices necessitate the redesign of a number of basic Internet protocols. This paper evaluates the effect of packet fragmentation on the performance of protocols redesigned for LLN systems. We focus on the important class of tree-based LLNs that exhibit both one-to-many and many-to-one communication patterns. In particular, we measure the impact of fragmentation on these communication protocols. Our results demonstrate that excessive packet fragmentation has a tremendously negative impact on communication within a tree-based LLN system. This work provides a guideline for IoT engineers in techniques for avoiding these damaging effects

AUTOMATIC MOTORIZED ADJUSTMENT OF LENS-HOLDING ASSEMBLY TO ALIGN A USER’S PUPIL AND AN OPTICAL LENS, AND SYSTEMS AND METHODS OF USE THEREOF

A method, apparatus, and system with an artificial-reality headset including a lens-holding assembly configured to hold a lens system for the artificial-reality headset is provided. The headset includes at least one sensor configured to determine a location of a user’s pupil relative to the lens system, an actuator coupled to the lens-holding assembly and configured to move the lens-holding assembly about an axis, and one or more processors. The one or more processors are configured to automatically, without human intervention, detect a triggering event, and, in response to only detecting the triggering event, determine whether the lens system is not aligned with the location of the user’s pupil. In response to the determination, the headset may move, via the actuator, the lens-holding assembly about the axis until the lens system is determined to be in alignment with the location of the user’s pupil

Adolescents\u27 Attitudes and Intentions to Use a Smartphone App to Promote Safe Driving

Purpose Designing effective driving safety interventions is imperative as traffic crashes are the leading cause of injury and death for adolescents. Using concepts from the Integrated Behavioral Model, we investigated adolescents\u27 attitudes and intentions towards engaging in safe driving practices and using smartphone-based driving safety technology. Methods Two-hundred and seven adolescents aged 14–18 (M = 16.1, SD = 0.8) completed a safe driving survey. A path model testing the associations between individual scores of attitudes, perceived norms, and perceived behavioral control with intentions controlling for demographic covariates was conducted. Results Greater intentions to drive safely was associated with greater perceived norms from family and peers (β = 0.75, p \u3c .001) and perceived capability (β = 0.19, p \u3c .001) to drive safely. Greater intentions to adopt a driving safety app was associated with greater perceived norms from family and peers (β = 0.29, p = .007). Females reported greater intentions to adopt a driving safety app than males (β = −0.15, p = .044). Conclusions Assessing attitudes and perceptions provides further understanding of what behavioral constructs are important for the development of adolescent driver safety interventions. Experimental research targeting and modifying behavior constructs is warranted