3,242 research outputs found
Single cell analysis shows decreasing FoxP3 and TGFβ1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes
Natural CD4+CD25+ regulatory T (CD4+CD25+ T reg) cells play a key role in the immunoregulation of autoimmunity. However, little is known about the interactions between CD4+CD25+ T reg cells and autoreactive T cells. This is due, in part, to the difficulty of using cell surface markers to identify CD4+CD25+ T reg cells accurately. Using a novel real-time PCR assay, mRNA copy number of FoxP3, TGFβ1, and interleukin (IL)-10 was measured in single cells to characterize and quantify CD4+CD25+ T reg cells in the nonobese diabetic (NOD) mouse, a murine model for type 1 diabetes (T1D). The suppressor function of CD4+CD25+CD62Lhi T cells, mediated by TGFβ, declined in an age-dependent manner. This loss of function coincided with a temporal decrease in the percentage of FoxP3 and TGFβ1 coexpressing T cells within pancreatic lymph node and islet infiltrating CD4+CD25+CD62Lhi T cells, and was detected in female NOD mice but not in NOD male mice, or NOR or C57BL/6 female mice. These results demonstrate that the majority of FoxP3-positive CD4+CD25+ T reg cells in NOD mice express TGFβ1 but not IL-10, and that a defect in the maintenance and/or expansion of this pool of immunoregulatory effectors is associated with the progression of T1D
Baryon Junction Loops in HIJING/B\=Bv2.0 and the Baryon/Meson Anomaly at RHIC
A new version, v2.0, of the HIJING/B\=B Monte Carlo nuclear collision event
generator is introduced in order to explore further the possible role of baryon
junctions loops in the baryon/meson anomaly (2 5 GeV/c) observed in
200A GeV Au+Au reactions at RHIC. We show that junction loops with an enhanced
intrinsic GeV/c transverse momentum kick may provide a partial
explanation of the anomaly as well as other important baryon stopping
observables.Comment: 27 pages, Latex(revtex), 8 figure
Predictions for Pb Collisions at TeV: Comparison with Data
Predictions made in Albacete {\it et al} prior to the LHC Pb run at
TeV are compared to currently available data. Some
predictions shown here have been updated by including the same experimental
cuts as the data. Some additional predictions are also presented, especially
for quarkonia, that were provided to the experiments before the data were made
public but were too late for the original publication are also shown here.Comment: 55 pages 35 figure
Are we close to the QGP? - Hadrochemical vs. microscopic analysis of particle production in ultrarelativistic heavy ion collisions
Ratios of hadronic abundances are analyzed for pp and nucleus-nucleus
collisions at sqrt(s)=20 GeV using the microscopic transport model UrQMD.
Secondary interactions significantly change the primordial hadronic cocktail of
the system. A comparison to data shows a strong dependence on rapidity. Without
assuming thermal and chemical equilibrium, predicted hadron yields and ratios
agree with many of the data, the few observed discrepancies are discussed.Comment: 12 pages, 4 figure
Examine the species and beam-energy dependence of particle spectra using Tsallis Statistics
Tsallis Statistics was used to investigate the non-Boltzmann distribution of
particle spectra and their dependence on particle species and beam energy in
the relativistic heavy-ion collisions at SPS and RHIC. Produced particles are
assumed to acquire radial flow and be of non-extensive statistics at
freeze-out. J/psi and the particles containing strangeness were examined
separately to study their radial flow and freeze-out. We found that the strange
hadrons approach equilibrium quickly from peripheral to central A+A collisions
and they tend to decouple earlier from the system than the light hadrons but
with the same final radial flow. These results provide an alternative picture
of freeze-outs: a thermalized system is produced at partonic phase; the
hadronic scattering at later stage is not enough to maintain the system in
equilibrium and does not increase the radial flow of the copiously produced
light hadrons. The J/psi in Pb+Pb collisions at SPS is consistent with early
decoupling and obtains little radial flow. The J/psi spectra at RHIC are also
inconsistent with the bulk flow profile.Comment: 12 pages, 4 figures, added several references and some clarifications
et
Do Search for Dibaryonic De - Excitations in Relativistic Nuclear Reactions
Some odd characteristics are observed in the single particle distributions
obtained from interactions at momenta which are
explained as the manifestation of a new mechanism of strangeness production via
dibaryonic de-excitations. A signature of the formation of hadronic and
baryonic clusters is also reported. The di-pionic signals of the dibaryonic
orbital de-excitations are analyzed in the frame of the MIT - bag Model and a
Monte Carlo simulation.The role played by the dibaryonic resonances in
relativistic nuclear collisions could be a significant one.
Key words: Relativistic nuclear interactions negative pions, negative kaons,
di-pions , streamer chamber, dibaryons, MIT - bag model
PACS codes: 25.75.+r,14.40.Aq,14.20.Pt,12.40.AsComment: 17 pages,LATEX, preprint ICTP -243 1993,figures available by reques
Thermal Conductivity and Thermal Rectification in Graphene Nanoribbons: a Molecular Dynamics Study
We have used molecular dynamics to calculate the thermal conductivity of
symmetric and asymmetric graphene nanoribbons (GNRs) of several nanometers in
size (up to ~4 nm wide and ~10 nm long). For symmetric nanoribbons, the
calculated thermal conductivity (e.g. ~2000 W/m-K @400K for a 1.5 nm {\times}
5.7 nm zigzag GNR) is on the similar order of magnitude of the experimentally
measured value for graphene. We have investigated the effects of edge chirality
and found that nanoribbons with zigzag edges have appreciably larger thermal
conductivity than nanoribbons with armchair edges. For asymmetric nanoribbons,
we have found significant thermal rectification. Among various
triangularly-shaped GNRs we investigated, the GNR with armchair bottom edge and
a vertex angle of 30{\deg} gives the maximal thermal rectification. We also
studied the effect of defects and found that vacancies and edge roughness in
the nanoribbons can significantly decrease the thermal conductivity. However,
substantial thermal rectification is observed even in the presence of edge
roughness.Comment: 13 pages, 5 figures, slightly expanded from the published version on
Nano Lett. with some additional note
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