Consumption of dried fruit of Crataegus pinnatifida (hawthorn) suppresses high-cholesterol diet-induced hypercholesterolemia in rats

Author name used in this publication: Mabel Yin-Chun YauAuthor name used in this publication: Peter Hoi-Fu Yu2009-2010 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Evaluation of anti-oxidant capacity of root of Scutellaria baicalensis Georgi, in comparison with roots of polygonum multiflorum thunb and Panax ginseng CA Meyer

Author name used in this publication: Jian-Hong WuAuthor name used in this publication: Alice Lai-Shan AuAuthor name used in this publication: Peter Hoi-Fu Yu2009-2010 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways

Author name used in this publication: Jian-Hong WuAuthor name used in this publication: Min-Yi WuAuthor name used in this publication: De-Jian GuoAuthor name used in this publication: Shi-Lin ChenAuthor name used in this publication: Alice L. S. AuAuthor name used in this publication: Christina C. W. Poon2010-2011 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Icariin, but not genistein, exerts osteogenic and anti-apoptotic effects in osteoblastic cells by selective activation of non-genomic ER alpha signaling

201810 bcrcVersion of RecordRGC15103614Publishe

Icariin, a phytoestrogen, exerts rapid estrogenic actions through crosstalk of estrogen receptors in osteoblasts

202406 bcchRGCPublished12 monthsGreen (AAM

Vitamin D supplementation improves handgrip strength in postmenopausal women : a systematic review and meta-analysis of randomized controlled trials

202307 bcwwVersion of RecordOthersNational Natural Science Foundation of China; Science and Technology Commission of Shanghai Municipality; P rogram of Shanghai Academic Research LeaderPublishe

Icariin ameliorates estrogen-deficiency induced bone loss by enhancing IGF-I signaling via its crosstalk with non-genomic ERα signaling

202104 bcvcNot applicableRGC15103614Early release12 month

Amelioration of hyperglycemia-induced mitochondrial ROS generation of single pancreatic islet β-cells of obese/diabetic mice by chronic N-Acetyl-L-Cysteine

This journal issue contain abstracts of the 13th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine 2009Abstracts for Posters: no. P12BACKGROUND: Mitochondria are the principal source of reactive oxygen species (ROS) in pancreatic islets β-cells and impairment of mitochondrial functions is intrinsically related with diabetes mellitus. Hyperglycemiainduced ROS production by mitochondria is an important aspect in β-cell glucose toxicity. However, most previous studies were performed in either normal islets/single β-cells or insulinoma cells which were bathed in high glucose medium which could not mimic the pathophysiological conditions. OBJECTIVES: To compare and measure hyperglycemia-induced mitochondria ROS generation of primary pancreatic islet β-cells of obese/diabetic (+db/+db) and lean/control (+db/+m) mice, and the effects (acute and chronic) of N-acetyl-L-cysteine (NAC) on ROS generation. METHODS: Collagenase-dissociated single pancreatic islet β-cells of C57BL/KsJ obese/diabetic (+db/+db) mice which exhibit phenotypes of the human T2DM were harvested, and the effects (acute, 10 min; chronic, 24 h) of NAC (20 mM) on high glucose-induced mitochondrial ROS generation were evaluated. Mitochondrial ROS levels were estimated by MitoTracker Red (reduced form) (a selective fluorescence probe for mitochondrial ROS measurement) using con-focal microscope. RESULTS: A trend of, but a non-significant, higher resting/basal ROS level was observed in single pancreatic β-cells of +db/+db mice compared to +db/+m mice. High glucose (15 mM) application gradually caused an increase in ROS levels in single pancreatic β-cells of +db/+db mice whereas no apparent change was observed in +db/+m mice. Chronic (24 h), but not acute (10 min), treatments with NAC (20 mM) ameliorated high-glucose induced ROS generation in single pancreatic β-cells of +db/+db mice. CONCLUSIONS: Hyperglycemia elicited mitochondrial ROS generation only in single pancreatic β-cells of +db/+db mice. Chronic NAC (a well known anti-oxidant) pre-treatment eradicated high glucose-induced ROS generation. Current study is underway to elucidate the underlying mechanism(s) involved in the differential effects of high glucose on ROS generation as well as the identification of the particular mitochondrial ROS generating system.link_to_OA_fulltex

N-Acetyl-L-Cysteine reduces high glucose-induced mitochondrial ROS generation and cortical F-Actin cytoskeleton levels in pancreatic islets β-Cells of obese/diabetic mice

This journal issue is proceedings of ICSM 2010Abstracts for PostersBACKGROUND: Failure of insulin secretion associated with β-cell dysfunction caused by glucotoxicity is a key factor in the development and progression of type 2 diabetes mellitus (T2DM). The beneficial effects of ...link_to_OA_fulltextThe 14th Annual Scientific Meetingof the Institute of Cardiovascular Science and Medicine, Hong Kong, China, 18 December 2010. In Journal of the Hong Kong College of Cardiology, 2010, v. 18 n. 2, p. 77, abstract no. P2

Distinct effects of simvastatin on cytosolic Ca2+ changes and Ca2+: sensing receptor expression of isolated pancreatic islets ß cells of obese/diabetic mice

Abstracts for Posters: no. P30link_to_OA_fulltex