A novel adaptation facilitates seed establishment under marine turbulent flows

Seeds of Australian species of the seagrass genus Posidonia are covered by a membranous wing that we hypothesize plays a fundamental role in seed establishment in sandy, wave swept marine environments. Dimensions of the seed and membrane were quantified under electron microscopy and micro-CT scans, and used to model rotational, drag and lift forces. Seeds maintain contact with the seabed in the presence of strong turbulence: the larger the wing, the more stable the seed. Wing surface area increases from P. sinuosa \u3c P. australis \u3c P.coriacea correlating with their ability to establish in increasingly energetic environments. This unique seed trait in a marine angiosperm corresponds to adaptive pressures imposed on seagrass species along 7,500 km of Australia’s coastline, from open, high energy coasts to calmer environments in bays and estuaries

Relative sea-level change in northeastern Florida (USA) during the last ~8.0 ka

An existing database of relative sea-level (RSL) reconstructions from the U.S. Atlantic coast lacked valid sea-level index points from Georgia and Florida. This region lies on the edge of the collapsing forebulge of the former Laurentide Ice Sheet making it an important location for understanding glacio-isostatic adjustment and the history of ice-sheet melt. To address the paucity of data, we reconstruct RSL in northeastern Florida (St. Marys) over the last ∼8.0 ka from samples of basal salt-marsh sediment that minimize the influence of compaction. The analogy between modern salt-marsh foraminifera and their fossil counterparts preserved in the sedimentary record was used to estimate paleomarsh surface elevation. Sample ages were determined by radiocarbon dating of identifiable and in-situ plant macrofossils. This approach yielded 25 new sea-level index points that constrain a ∼5.7 m rise in RSL during the last ∼8.0 ka. The record shows that no highstand in sea level occurred in this region over the period of the reconstruction. We compared the new reconstruction to Earth-ice models ICE 6G-C VM5a and ICE 6G-C VM6. There is good fit in the later part of the Holocene with VM5a and for a brief time in the earlier Holocene with VM6. However, there are discrepancies in model-reconstruction fit in the early to mid Holocene in northeastern Florida and elsewhere along the Atlantic coast at locations with early Holocene RSL reconstructions. The most pronounced feature of the new reconstruction is a slow down in the rate of RSL rise from approximately 5.0 to 3.0 ka. This trend may reflect a significant contribution from local-scale processes such as tidal-range change and/or change in base flow of the St. Marys River in response to paleoclimate changes. However, the spatial expression (local vs. regional) of this slow down is undetermined and corroborative records are needed to establish its geographical extent

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Kelp Aquaculture as a Nature-Based Solution for Coastal Protection: Wave Attenuation by Suspended Canopies

Suspended kelp canopies have the potential to provide a coastal protection service in addition to their primary function of generating a sustainable resource. In this study, the attenuation of incident waves by kelp suspended from the surface was quantified. We adapted an analytical 1D cross-shore wave attenuation model and tested the effect of (1) water depth, (2) vegetation density, and (3) longline density. The results show that as the percentage of vegetation in the water column increases, wave attenuation by the canopy also increases. However, this attenuation is affected by seasonal variations in kelp growth as well as harvesting strategies. Careful choice of the adopted harvesting strategy was found to be important to maintain optimal wave attenuation by kelp aquaculture farms throughout the year. Partial and targeted removal of the vegetation along longlines is preferred to harvesting all laterals on longlines. This study demonstrates that there is an opportunity for the emerging global kelp aquaculture industry to provide a coastal protection service in addition to resource production, which will help to affect how coastal protection is realized and scaled globally

A framework to quantify flow through coral reefs of varying coral cover and morphology

Flow velocities within coral reefs are greatly reduced relative to those at the water surface. The in-reef flow controls key processes that flush heat, cycle nutrients and transport sediment from the reef to adjacent beaches, all key considerations in assessments of reef resilience and restoration interventions. An analytical framework is proposed and tested with a suite of high-resolution numerical experiments. We demonstrate a single parameter that describes the total coral frontal area explains variation of horizontally averaged velocity within a reef canopy across morphologies, densities, and flow depths. With the integration of existing data of coral cover and geometry, this framework is a practical step towards the prediction of near-bed flows in diverse reef environments

Optimizing Infragravity Wave Attenuation to Improve Coral Reef Restoration Design for Coastal Defense

Coral reefs are effective natural flood barriers that protect adjacent coastal communities. As the need to adapt to rising sea levels, storms, and environmental changes increases, reef restoration may be one of the best tools available to mitigate coastal flooding along tropical coastlines, now and in the future. Reefs act as a barrier to incoming short-wave energy but can amplify low-frequency infragravity waves that, in turn, drive coastal flooding along low-lying tropical coastlines. Here, we investigate whether the spacing of reef restoration elements can be optimized to maximize infragravity wave energy dissipation while minimizing the number of elements—a key factor in the cost of a restoration project. With this goal, we model the hydrodynamics of infragravity wave dissipation over a coral restoration or artificial reef, represented by a canopy of idealized hemispherical roughness elements, using a three-dimensional Navier–Stokes equations solver (OpenFOAM). The results demonstrate that denser canopies of restoration elements produce greater wave dissipation under larger waves with longer periods. Wave dissipation is also frequency-dependent: dense canopies remove wave energy at the predominant wave frequency, whereas sparse canopies remove energy at higher frequencies, and hence are less efficient. We also identify an inflection point in the canopy density–energy dissipation curve that balances optimal energy losses with a minimum number of canopy elements. Through this work, we show that there are an ideal number of restoration elements per across-shore meter of coral reef flat that can be installed to dissipate infragravity wave energy for given incident heights and periods. These results have implications for designing coral reef restoration projects on reef flats that are effective both from a coastal defense and costing standpoint

The performance of the predictive model (Eq 8) in collapsing the effects of reef colony morphology, coral cover, water depth, orientation and flow velocity into a single predictor variable for in-reef flow attenuation.

The solid markers indicate the coral cover cases for the three archetypal coral forms. The open markers indicate cases where depth, orientation or velocity (as indicated in brackets in the legend) were varied systematically for one coral morphology. The equation for the line of best fit is indicated on the plot, with the shading representing the 95% prediction interval.</p