11 research outputs found
Prevalence of left ventricular dysfunction in female carriers of Duchenne and Becker muscular dystrophy
Effects of recombinant human granulocyte colony鈥恠timulating factor on leucopenia in zidovudine鈥恡reated patients with AIDS and AIDS related complex, a phase I/II study
Summary. Twelve male patients, eight with the acquired immunodeficiency syndrome (AIDS) and four with AIDS related complex (ARC), who had zidovudine associated neutropenia (<1 x 109 neutrophils/l) were treated with recombinant human granulocyte colony鈥恠timulating factor (G鈥怌SF) in a phase I/II study. Treatment consisted of daily subcutaneous injections with G鈥怌SF in a weekly increasing dose of 0路4, 2, 5 or 10 渭g/kg body weight until a neutrophil count of more than 3 x 109 neutrophils/l was observed. This effective dose was continued for up to 4 weeks, followed by 4 weeks observation period without G鈥怌SF treatment. Two patients (both with ARC) reached target neutrophil counts at the lowest G鈥怌SF dose, whereas nine patients needed 2 渭g/kg. One patient discontinued treatment before he reached target neutrophil counts. Mean(卤SD) neutrophil counts before and after 1 and 4 weeks of effective dose treatment were 0路65(卤0路188) 脳 109, 6路016(卤2路595) x 109 and 5路54(卤4路237) x 109/l respectively (P<0路01). The number of monocytes increased from 0路171(卤0路113) to 0路501(卤0路274) and 0路474(卤0路374) x 109/l after 1 and 4 weeks of treatment (P<0路01). Other haematologic parameters did not change significantly. Two weeks post鈥恡reatment the numbers of neutrophils and monocytes had returned to pre鈥恡reatment values. Mild side effects consisting of bone, joint or muscle pain were observed in three patients. Two patients (both with AIDS) did not complete the study. One patient stopped treatment because of fever and malaise, attributable to a generalized cytomegalovirus (CMV) infection and one patient had to stop zidovudine treatment because of severe thrombocytopenia. We conclude that G鈥怌SF increases the number of circulating neutrophilic granulocytes in zidovudine鈥恡reated patients at relatively low doses and with few side鈥恊ffects
Pharmacokinetics and Pharmacodynamics of Saruplase, an Unglycosylated Single-chain Urokinase-type Plasminogen Activator, in Patients with Acute Myocardial Infarction
Prevalence of left ventricular dysfunction in female carriers of Duchenne and Becker muscular dystrophy
Diagnostic Accuracy of Transesophageal Echocardiography During Cardiopulmonary Resuscitation
Myocardial contrast echocardiography for the detection of coronary artery stenosis : a prospective multicenter study in comparison with single-photon emission computed tomography.
The purpose of this study was to compare myocardial contrast echocardiography (MCE) with single-photon emission computed tomography (SPECT) for the detection of significant coronary artery disease (CAD) in patients with symptoms suggestive of CAD
Cardiac sympathetic neuronal activity and function in the early phase of left ventricular volume and pressure overload
Cardiac disease in young adult patients with end-stage renal disease since childhood: A Dutch cohort study
Background. Cardiovascular disease is the most important cause of death in patients with pediatric end-stage renal disease (ESRD). Yet, few data exist on cardiac function in these patients. We assessed the extent of cardiac abnormality and analyzed its association with potential determinants in young adult patients with pediatric ESRD in a long-term follow-up study. Methods. All Dutch living adult patients with ESRD onset at age of 0 to 14 years between 1972 and 1992 were invited for echocardiography and blood pressure assessment. Special attention was paid to evidence of left ventricular hypertrophy (LVH), diastolic dysfunction, and aortic valve calcification. We collected data on determinants by review of all medical charts. Results. Of all the 187 living patients, 140 participated in the study. Of those, 110 patients had received a transplant and 30 patients were on dialysis. Mean age was 29.2 (20.7 to 41.8) years. Left ventricular mass index (LVMI) exceeded 150 g/m(2) in 47% of all male patients and 120 g/m(2) in 39% of all female patients, both consistent with LVH. Diastolic dysfunction, defined as an early over atrial transmitral blood flow velocity (E/A ratio) <1, was found in 18 (13%) patients; 27 (19%) had aortic valve calcification. Multiple regression analysis revealed the following: a high LVMI was associated with a current high blood pressure (尾 = 0.46, P <0.001) and male gender (beta = 0.21, P = 0.009), a low E/A ratio with aging (beta = -0.28, P <0.001) and a glomerular filtration rate (GFR) <25 mL/min/1.73 m(2) (beta = -0.29, P <0.001), and aortic valve calcification with prolonged peritoneal dialysis (尾 = 0.36, P <0.001). Conclusion. Young adult patients with pediatric ESRD are at risk for LVH caused by hypertension and for aortic valve calcification. Diastolic function decreases with age and is enhanced by a current low GFR. Prolonged peritoneal dialysis may enhance aortic valve calcificatio