Topical Formulation with Cordia verbenacea Essential Oil and Glycolic Acid

This study evaluated the effect of Cordia verbenacea essential oil (CV) and glycolic acid 70 % (GA), isolated and associated, on Wistar rats back skin. A base gel was added to 2 % of CV and/or 10 % of GA, thus forming 4 formulations: 1) GA + CV, 2) CV, 3) GA, and 4) gel base. All formulation had their final pH adjusted to 3,5 and were applied once daily, for 15 consecutive days, on 4 areas with 1 cm(2), while another area without application (control). Statistical analysis of biopsies showed no difference in epidermis thickness and stratum corneum. Among fibroblast counts there was a statistical significance for groups exposed to the GA and to the association. Only in the group exposed to GAT there was significant difference in leukocytes number. The association of GA with CV proved favorable because it increased fibroblast counts without increasing leukocyte numbers, meaning inflammatory reaction may be reduced.2961004100

Effects of Formulations Containing Dimethylaminoethanol (DMAE) Acetoamidobenzoate and Pidolate on the Skin

The aim of this study was to analyze the effects of formulations containing DMAE pidolate and DMAE acetoamidobenzoate on the skin. Four areas of five swines were submitted to following treatments during 15 days: C (Control), S (Silicone = 80 % DC*LC Blend (R)), F1 (DMAE acetoamidobenzoate), F2 (DMAE pidolate). Measures of the thickness of epidermis and stratum corneum, and the density population of fibroblasts and leukocytes in papillary dermis were obtained. We also assessed possible variations in birefringence of dermis collagen bundles. Means of the data was compared using ANOVA followed by the Tukey test. The F1 and F2 groups showed a thicker epidermis than the control group (p < 0.01), but did not demonstrate a significant difference in the number of fibroblasts and leukocytes, as well as in the birefringent areas of collagen bundles, in comparison with the control groups. The DMAE-supplemented formulations enhanced viable epidermis thickness, but did not modify structures related with mechanical properties of the skin.30464164