OBLIQUE RADIATIVE CORRECTIONS IN THE VECTOR CONDENSATE MODEL OF ELECTROWEAK INTERACTIONS

Oblique radiative corrections are calculated to the parameter $S$ in a version of the standard model where the Higgs doublet is replaced by a doublet of vector bosons and the gauge symmetry is broken dynamically. We show that to each momentum scale there exists a domain of the masses of charged and neutral vector bosons where $S$ is compatible with the experiments. At a scale of 1 TeV this requires vector boson masses of at least $m_0 \approx$ 400--550 GeV, $m_+ \approx$ 200--350 GeV.Comment: 6 pages LATEX, 1 Latex figure include

Contributions to modeling and computer efficient estimation for Gaussian space -time processes

This thesis research provides several contributions to computer efficient methodology for estimation with space-time data. First we propose a parsimonious class of computer-efficient Gaussian spatial interaction models that includes as special cases CAR and SAR-like models. This extended class is capable of modeling smooth spatial random fields. We show that, for rectangular lattices, this class is equivalent to higher-order Markov random fields. Thus we capture the computational advantage of iterative updating of Markov random fields, while at the same time provide the possibility of simple interpretation of smooth spatial structure. This class of spatial models is defined via a spatial structure removing orthogonal transformation, which we propose for any spatial interaction model as a means to improve computation time. Such a transformation is a one-time preprocessing step in iterative estimation, such as in MCMC. For very large data on a rectangular lattice we can achieve further computational savings by circulant embedding which enables use of FFT for calculations. We examine how the model as well as the embedding can be incorporated in hierarchical models for space time data with spatially varying temporal trend components. We describe an application in arctic hydrology where gridded runoff fields are investigated for local trends

Note on Unitarity Constraints in a Model for a Singlet Scalar Dark Matter Candidate

We investigate perturbative unitarity constraints in a model for a singlet scalar dark matter candidate. Considering elastic two particle scattering processes of the Higgs particle and the dark matter candidate, a real Klein-Gordon scalar field, perturbative unitarity constrains the self-couplings of the scalar fields.Comment: 6 pages, 4 eps figure

Lymphotoxin is an autocrine growth factor for Epstein-Barr virus-infected B cell lines.

Because human lymphotoxin (LT) was originally isolated from a lymphoblastoid cell line, we investigated the role of this molecule in three newly established Epstein-Barr virus (EBV)-infected human B cell lines. These lines were derived from acute lymphoblastic leukemia (Z-6), myelodysplastic syndrome (Z-43), and acute myelogenous leukemia (Z-55) patients who had a prior EBV infection. Each lymphoblastoid cell line had a karyotype that was different from that of the original parent leukemic cells, and all expressed B cell, but not T cell or myeloid surface markers. In all three lines, rearranged immunoglobulin heavy chain joining region (JH) bands were found, and the presence of EBV DNA was confirmed by Southern blotting. Z-6, Z-43, and Z-55 cell lines constitutively produced 192, 48, and 78 U/ml LT, respectively, as assessed by a cytotoxicity assay and antibody neutralization. Levels of tumor necrosis factor (TNF) were undetectable. Scatchard analysis revealed that all the cell lines expressed high-affinity TNF/LT receptors with receptor densities of 4197, 1258, and 1209 sites/cell on Z-6, Z-43, and Z-55, respectively. Furthermore, labeled TNF binding could be reversed by both unlabeled TNF, as well as by LT. Studies with p60 and p80 receptor-specific antibodies revealed that the three lines expressed primarily the p80 form of the TNF receptor. When studied in a clonogenic assay, exogenous LT stimulated proliferation of all three cell lines in a dose-dependent fashion at concentrations ranging from 25 to 500 U/ml. Similar results were obtained with [3H]TdR incorporation. Monoclonal anti-LT neutralizing antibodies at concentrations of 25-500 U/ml inhibited cellular multiplication in a dose-dependent manner. It is interesting that in spite of a common receptor, TNF (1,000 U/ml) had no direct effect on Z-55 cell growth, whereas it partially reversed the stimulatory effect of exogenous LT. In addition, TNF inhibited Z-6 and Z-43 cell proliferation, and its suppressive effect was reversed by exogenous LT. Both p80 and p60 forms of soluble TNF receptors suppressed the lymphoblastoid cell line proliferation and their inhibitory effect was partially reversed by LT. Our data suggest that (a) LT is an autocrine growth factor for EBV-transformed lymphoblastoid B cell lines; and (b) anti-LT antibodies, soluble TNF/LT receptors, and TNF itself can suppress the growth of lymphoblastoid cells, probably by modulating or competing with LT.(ABSTRACT TRUNCATED AT 400 WORDS

A Unified Conformal Model for Fundamental Interactions without Dynamical Higgs Field

A Higgsless model for strong, electro-weak and gravitational interactions is proposed. This model is based on the local symmetry group SU(3)xSU(2)xU(1)xC where C is the local conformal symmetry group. The natural minimal conformally invariant form of total lagrangian is postulated. It contains all Standard Model fields and gravitational interaction. Using the unitary gauge and the conformal scale fixing conditions we can eliminate all four real components of the Higgs doublet in this model. However the masses of vector mesons, leptons and quarks are automatically generated and are given by the same formulas as in the conventional Standard Model. The gravitational sector is analyzed and it is shown that the model admits in the classical limit the Einsteinian form of gravitational interactions. No figures.Comment: 25 pages, preprin