Ene Reaction of β-Pinene with 4-Phenyl-3H-1,2,4-triazole-3,5(4H)-dione: Effects of Temperature, High Pressure, and Solvent Nature

© 2018, Pleiades Publishing, Ltd. The effects of temperature, solvent nature, and high hydrostatic pressure on the rate of the ene reaction of 4-phenyl-3H-1,2,4-triazole-3,5(4H)-dione with β-pinene have been studied. The reaction gives only one product and is accompanied by a large heat effect. Comparison of the activation and reaction volumes indicates cyclic structure of the transition state. The reaction rate changes by a factor of 200 in the series of nine examined solvents, but this variation is not determined by solvent polarity

Synthesis of benzothiazine sulfonamides via heteroatomic Diels-Alder reaction of para-fluoro-N-sulfinylaniline with bicyclo[2.2.1]heptenes

© 2016 Pleiades Publishing, Ltd.Reaction of 4-fluoro-N-sulfinylaniline with norbornene and norbornadiene has afforded the Diels-Alder adducts of benzothiazine structure that have been oxidized into the corresponding benzothiazine sulfonamides. Structure of the obtained compounds and stereochemistry of the diene addition and epoxidation of norbornene olefin bonds have established by means of X-ray diffraction method

Synthesis of new decasubstituted pillar[5]arenes containing glycine fragments and their interactions with Bismarck brown y

© 2015 Mendeleev Communications. Published by ELSEVIER B.V. on behalf of the N. D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences. New water-soluble decasubstituted pillar[5]arenes containing glycine and glycylglycine fragments were synthesized and characterized. The UV, DLS and TEM study showed that interaction of self-associates of the glycylglycine derivatives with Bismarck brown Y produced particles of about 59 nm in size

Synthesis of cyclic sulfonamides by reaction of N-Sulfinyl-3-(trifluoromethyl)aniline with Norbornenes

© Pleiades Publishing, Ltd., 2016.N-Sulfinyl-3-(trifluoromethyl)aniline reacted with bicyclo[2.2.1]hept-2-ene and bicyclo[2.2.1]hepta-2,5-diene to give the corresponding Diels‒Alder adducts which were oxidized to 8-trifluoromethyl2,3,4,4a,6,10b-hexahydro-5λ6-1,4-methanodibenzo[c,e][1,2]thiazine-5,5(1H)-diones. The cycloaddition occurred predominantly with participation of the S=N–C1=C6 fragment of N-sulfinyl-3-(trifluoromethyl)aniline and exclusively at the endo side of bicyclo[2.2.1]heptenes

Synthesis of S-containing derivatives of the sesquiterpene lactone Britanin

The optimal method for isolating the sesquiterpene lactone britanin from the aerial part of Inula britannica L. (Asteraceae) was developed. Britanin was functionalized by reacting it with methyl mercaptoacetate. ©2005 Springer Science+Business Media, Inc

Synthesis and structure of novel substituted N-sulfinylanilines

© 2017, Pleiades Publishing, Ltd. N-Sulfinylanilines derived from 4-bromoaniline, 3-nitroaniline, and 4,4′-di(ethane-1,2-diyl)dianiline were synthesized. X-ray diffraction analysis of 4-bromo-N-sulfinylaniline, 3-nitro-N-sulfinylaniline, and 4,4′-(ethane-1,2-diyl)di-N-sulfinylaniline was performed. The sulfinyl function in the planar conformation of the Ar-NSO fragment was found to have Z configuration. The nature of intra- and intermolecular structure-forming interactions was established

Synthesis of Hybrid Pharmacophores Based on Adducts of N-Sulfinylaniline and Norbornadiene

© 2018, Pleiades Publishing, Ltd. Acylation of benzothiazinesulfonamides obtained by the oxidation of N-sulfinylaniline and norbornadiene adducts with acid chlorides and carboxylic anhydrides led to the formation of N-acylated sulfonamide hybrid pharmacophores. Molecular and crystal structure of the acylated products was established by X-ray diffraction method

Acylated benzothiazinesulfoneamides: Synthesis and molecular structure

© 2016, Pleiades Publishing, Ltd.1,2,3,4,4a,10b-Hexahydro-1,4-methano-6H-dibenzo[c,e]-5,6-thiazine-5,5-dioxide has been converted into the corresponding N-acyl derivatives via the reaction with acid chlorides and anhydrides. X-Ray diffraction data have revealed the presence of an intramolecular С–H···O=S hydrogen bond in the molecules of the obtained compounds

Water-soluble pillar[5]arenes: Synthesis and characterization of the inclusion complexes with p-toluenesulfonic acid

© ISUCT Publishing. Novel symmetric cationic water-soluble pillar[5]arenes bearing trimethylammonium/methyldiethylammonium groups at both of two rims were synthesized by step-by-step functionalization of the perhydroxylated pillar[5]arene. The recognition ability of water-soluble pillar[5]arenes toward p-toluenesulfoacid was studied. The information on binding mode of the guest inclusion was studied by 1H and 2D NMR spectroscopy. The interaction of synthesized pillar[5]arenas with the substrate and the formation of the 1:1 complexes was shown by UV spectroscopy

Amphiphilic adducts of myrcene and N-substituted maleimides as potential drug delivery agents

The title drug delivery compounds with pharmacophoric moieties were synthesized, and their interaction with model biomembranes (dipalmitoylphosphatidylcholine vesicles) was examined. © 2014 Mendeleev Communications. All rights reserved