Artists Residencies, Challenges and Opportunities for Communities’ Empowerment and Heritage Regeneration

The paper debates the results of a research carried out by the Department of Architecture of the University of Naples “Federico II” (DiARC), as part of the Creative Europe 2018 Artists in Architecture, Re-activating modern European houses program (entitled EACEA 32/2017 and EACEA 35/2017; scientific coordinator: Maria Rita Pinto; project manager: Serena Viola). The research investigates the relationships between creativity and sharing as tools of a new form of social sustainability. These elements can induce positive effects on the settlement qualities of the places, acting as engines of the custody of the settlement values and the collaborative regeneration of the built environment. The methodology is based on participatory approaches able to restore the levels of cohesion, care, and creativity that the experimentation typology of the Artists Residencies is able to trigger on the territory and on the communities who inhabit it. The results return in the form of the complex process of the artist exhibition reception a significant strategy of sustainable development, capable of influencing the community by entrusting it with the role of custodian of the existing heritage and of renewing local entrepreneurship with innovative productions

Satisfação dos acompanhantes das crianças com a qualidade de atendimento do banco de urgência pediátrico do Hospital Agostinho Neto

Mestrado em Gestão e Avaliação de Tecnologias em SaúdeA qualidade dos cuidados e serviços prestados tem vindo a afirmar-se como uma preocupação central para os gestores e profissionais de saúde, sendo evidente que a satisfação dos utentes constitui um legítimo indicador do nível de desempenho. Conhecer a opinião do utente é indispensável para a monitorização da qualidade e reorganização dos serviços de saúde. O presente estudo teve como objetivo avaliar a satisfação dos acompanhantes das crianças face à qualidade do atendimento no banco de urgência pediátrico do Hospital Agostinho Neto na Cidade da Praia. Método: Para atingir o objetivo preconizado, foi realizado um estudo não experimental, quantitativo do tipo descritivo-correlacional e transversal, numa amostra de 103 acompanhantes de crianças que recorreram ao Banco de Urgência Pediátrico do HAN no período de 1 a 30 de abril. Resultados: Os itens com os maiores níveis de satisfação estão relacionados com o desempenho dos profissionais de saúde, sendo que 34% dos acompanhantes estavam bastante satisfeitos e 45% totalmente satisfeitos com o desempenho da equipa médica. Os resultados obtidos em relação ao desempenho da equipa de enfermagem também revelaram bons níveis de satisfação, pois 27% da amostra manifestou-se bastante satisfeita e 37% totalmente satisfeita. Todavia, no que respeita às instalações, não podemos falar de níveis positivos de satisfação, dado que, e de acordo com os resultados da pesquisa, 61% dos acompanhantes informaram estar “nada satisfeito” em relação à inexistência de fraldário na casa de banho. Conclusão: A pesquisa efetuada permite concluir que existem níveis de satisfação positivos em relação ao desempenho dos recursos humanos no banco de urgência do Hospital Agostinho Neto, não obstante a insatisfação em relação à estrutura física do serviço, principalmente em relação a inexistência de fraldários nas casas de banho, limpeza e higiene das casas de banho e conforto do ambiente. No que diz respeito à satisfação dos acompanhantes das crianças em função do sexo, nível de escolaridade e grau de parentesco, verificou-se não existir relação estatisticamente significativa.ABSTRACT - Quality of care and services has been asserting itself as a central concern for managers and health professionals, and it is evident that the user's satisfaction is a legitimate indicator of performance level. Knowing the patient’s opinion is indispensable for health services quality monitoring and reorganization. Methods: The present study aims at evaluating the children’s companions’ satisfaction with the care quality provided by the pediatric emergency department at Agostinho Neto Hospital in Praia. To achieve this goal, a non-experimental, quanti-qualitative, descriptive-correlational, and cross-sectional study was conducted on a sample of 103 children’s companions who used the HAN Pediatric Emergency Room from April 1 to 30. Results: The items with the highest levels of satisfaction are related to the health professional’s performance, with 34% of the companions being very satisfied and 45% totally satisfied with the medical team’s performance. The results obtained regarding the nursing team performance also revealed good levels of satisfaction, as 27% of the sample was very satisfied and 37% fully satisfied. However, regarding the facilities, there’s a lack of positive levels of satisfaction, since, according to the survey results, 61% of the companions reported being “not satisfied” with the nonexistence of changing rooms in the toilets. Conclusion: This research shows that the satisfaction levels concerning Hospital Agostinho Neto ’s Emergency Room’s, human resources performance are positive, despite the dissatisfaction with the service physical structure, especially regarding the lack of diaper changing facilities in the rooms and bathrooms, bathrooms hygiene, and the environment’s comfort. There was no significant statistical relationship between the satisfaction of children’s companions and their respective gender, educational level, and degree of kinship.N/

Genetic diversity and recent ancestry based on whole-genome sequencing of endangered Swedish cattle breeds

Several indigenous cattle breeds in Sweden are endangered. Conservation of their genetic diversity and genomic characterization is a priority.Whole-genome sequences (WGS) with a mean coverage of 25X, ranging from 14 to 41X were obtained for 30 individuals of the breeds Fjallko, Fjallnara, Bohuskulla, Rodkulla, Ringamala, and Vaneko. WGS-based genotyping revealed 22,548,028 variants in total, comprising 18,876,115 single nucleotide polymorphisms (SNPs) and 3,671,913 indels. Out of these, 1,154,779 SNPs and 304,467 indels were novel. Population stratification based on roughly 19 million SNPs showed two major groups of the breeds that correspond to northern and southern breeds. Overall, a higher genetic diversity was observed in the southern breeds compared to the northern breeds. While the population stratification was consistent with previous genome-wide SNP array-based analyses, the genealogy of the individuals inferred from WGS based estimates turned out to be more complex than expected from previous SNP-array based estimates. Polymorphisms and their predicted phenotypic consequences were associated with differences in the coat color phenotypes between the northern and southern breeds. Notably, these high-consequence polymorphisms were not represented in SNP arrays, which are used routinely for genotyping of cattle breeds.This study is the first WGS-based population genetic analysis of Swedish native cattle breeds. The genetic diversity of native breeds was found to be high. High-consequence polymorphisms were linked with desirable phenotypes using whole-genome genotyping, which highlights the pressing need for intensifying WGS-based characterization of the native breeds

Propuesta de un algoritmo genético para la programación diaria de los pedidos de una empresa del sector de la construcción

El objetivo del presente trabajo es proponer un algoritmo genético para determinar la programación integrada de la producción y de la distribución de un producto de carácter perecedero y no almacenable, el hormigón. La empresa en cuestión cuenta con diferentes plantas productivas desde las cuales distribuye los pedidos hasta cada obra, con la ayuda de una flota de vehículos. La programación de los pedidos se efectúa el día anterior a su distribución, siendo el objetivo cumplir con el nivel de servicio acordado con el cliente y minimizar su coste asociado. El problema es NP-hard. Los resultados obtenidos muestran que el algoritmo genético propuesto realiza la programación minimizando costes y respetando las condiciones de entrega pactadas con el cliente.Postprint (published version

Fertility preservation in gynaecologic cancers

Due to substantial improvement in the diagnosis and treatment of gynaecologic cancers, a better understanding of patient care needs to be revised. We reviewed the literature related to fertility preservation strategies in gynaecological cancer and discussed current general management approaches. New technical modalities and patients’ own desire for motherhood should be integral and paramount in the clinical evaluation to significantly contribute to preserving fertility in those women diagnosed with gynaecologic cancers during the reproductive years

La confisca di prevenzione nella tutela costituzionale multilivello: tra istanze di tassatività e ragionevolezza, se ne afferma la natura ripristinatoria (C. cost. 24/2019)

info:eu-repo/semantics/publishedVersio

Retinoblastoma (hereditary predisposition)

Review on Retinoblastoma, with data on clinics, and the gene involved

ESQUISSE D’UN VOLUME EN COURS DE REALISATION : INTERFERENCES LINGUISTIQUES ET CULTURELLES FRANÇAISES EN AFRIQUE

Le livre "Interférences linguistiques et culturelles françaises en Afrique" édité par Anna Maria Di Tolla, Flavia Aiello, Maria Centrella et Sarah N. Pinto, traite des interactions du français avec les langues et cultures africaines. Il aborde les formes actuelles d'interférences culturelles et linguistiques françaises en Afrique, en mettant l'accent sur le monde berbère et tout le continent. Les contributions explorent des sujets tels que le rôle du français dans l'éducation, les représentations sociales de la culture française, les emprunts lexicaux et les interactions linguistiques. Le livre encourage une approche interdisciplinaire et vise à susciter davantage de recherches dans le domaine des études africaines

Mutations in the Schmallenberg virus Gc glycoprotein facilitate cellular protein synthesis shutoff and restore pathogenicity of NSs deletion mutants in mice

Serial passage of viruses in cell culture has been traditionally used to attenuate virulence and identify determinants of viral pathogenesis. In a previous study, we found that a strain of Schmallenberg virus (SBV) serially passaged in tissue culture (termed SBVp32) unexpectedly displayed increased pathogenicity in suckling mice compared to wild type SBV. In this study, we mapped the determinants of SBVp32 virulence to the viral genome M segment. SBVp32 virulence is associated with the capacity of this virus to reach higher titers in the brains of experimentally infected suckling mice. We also found that the Gc glycoprotein, encoded by the M segment of SBVp32, facilitates host cell protein shutoff in vitro. Interestingly, while the M segment of SBVp32 is a virulence factor, we found that the S segment of the same virus confers by itself an attenuated phenotype to wild type SBV as has lost the ability to block the innate immune system of the host. Single mutations present in the Gc glycoprotein of SBVp32 are sufficient to compensate both the attenuated phenotype of the SBVp32 S segment and the attenuated phenotype of NSs deletion mutants. Our data also indicate that the SBVp32 M segment does not act as an IFN antagonist. Therefore SBV mutants can retain pathogenicity even when they are unable to fully control the production of IFN by the infected cells. Overall, this study suggests that the viral glycoprotein of orthobunyaviruses can compensate, at least in part, the function of NSs. In addition, we also provide evidence that the induction of total cellular protein shutoff by SBV is determined by multiple viral proteins while the ability to control the production of IFN maps to the NSs protein. Importance The identification of viral determinants of pathogenesis is key to the development of prophylactic and interventions measures. In this study we found that the bunyavirus Gc glycoprotein is a virulence factor. Importantly, we show that mutations in the Gc glycoprotein can restore pathogenicity of attenuated mutants resulting from deletions or mutations in the non-structural protein NSs. Our findings highlight the fact that careful consideration should be taken when designing live attenuated vaccines based on deletions of non-structural proteins since single mutations in the viral glycoproteins appear to revert attenuated mutants to virulent phenotypes