4,329 research outputs found
The role of feedback in shaping the structure of the interstellar medium
We present an analysis of the role of feedback in shaping the neutral hydrogen (H I) content of simulated disc galaxies. For our analysis, we have used two realizations of two separate Milky Way-like (similar to L star) discs - one employing a conservative feedback scheme (McMaster Unbiased Galaxy Survey), the other significantly more energetic [Making Galaxies In a Cosmological Context (MaGICC)]. To quantify the impact of these schemes, we generate zeroth moment (surface density) maps of the inferred H I distribution; construct power spectra associated with the underlying structure of the simulated cold interstellar medium, in addition to their radial surface density and velocity dispersion profiles. Our results are compared with a parallel, self-consistent, analysis of empirical data from The H I Nearby Galaxy Survey (THINGS). Single power-law fits (P proportional to k(gamma)) to the power spectra of the stronger feedback (MaGICC) runs (over spatial scales corresponding to similar to 0.5 to similar to 20 kpc) result in slopes consistent with those seen in the THINGS sample (gamma similar to -2.5). The weaker feedback (MUGS) runs exhibit shallower power-law slopes (gamma similar to -1.2). The power spectra of the MaGICC simulations are more consistent though with a two-component fit, with a flatter distribution of power on larger scales (i.e. gamma similar to -1.4 for scales in excess of similar to 2 kpc) and a steeper slope on scales below similar to 1 kpc (gamma similar to -5), qualitatively consistent with empirical claims, as well as our earlier work on dwarf discs. The radial H I surface density profiles of the MaGICC discs show a clear exponential behaviour, while those of the MUGS suite are essentially flat; both behaviours are encountered in nature, although the THINGS sample is more consistent with our stronger (MaGICC) feedback runs
The HI Content of Local Late-Type Galaxies
We present a solid relationship between the neutral hydrogen (HI) disk mass
and the stellar disk mass of late-type galaxies in the local universe. This
relationship is derived by comparing the stellar disk mass function from the
Sloan Digital Sky Survey and the HI mass function from the HI Parkes All Sky
Survey (HIPASS). We find that the HI mass in late-type galaxies tightly
correlates with the stellar mass over three orders of magnitude in stellar disk
mass. We cross-check our result with that obtained from a sample of HIPASS
objects for which the stellar mass has been obtained by inner kinematics. In
addition, we derive the HI versus halo mass relationship and the dependence of
all the baryonic components in spirals on the host halo mass. These
relationships bear the imprint of the processes ruling galaxy formation, and
highlight the inefficiency of galaxies both in forming stars and in retaining
their pristine HI gas.Comment: 6 pages, 5 figures. Match to the published version. References
update
Tuneable interfacial surfactant aggregates mimic lyotropic phases and facilitate large scale nanopatterning.
It is shown that the air-liquid interface can be made to display the same rich curvature phenomena as common lyotropic liquid crystal systems. Through mixing an insoluble, naturally occurring, branched fatty acid, with an unbranched fatty acid of the same length, systematic variation in the packing constraints at the air-water interface could be obtained. The combination of atomic force microscopy and neutron reflectometry is used to demonstrate that the water surface exhibits significant tuneable topography. By systematic variation of the two fatty acid proportions, ordered arrays of monodisperse spherical caps, cylindrical sections, and a mesh phase are all observed, as well as the expected lamellar structure. The tuneable deformability of the air-water interface permits this hitherto unexplored topological diversity, which is analogous to the phase elaboration displayed by amphiphiles in solution. It offers a wealth of novel possibilities for the tailoring of nanostructure
Evaluating the perceptions of the transgender and non-binary communities of pelvic radiotherapy side effect information booklets
The stellar metallicity distribution of disc galaxies and bulges in cosmological simulations
By means of high-resolution cosmological hydrodynamical simulations of Milky
Way-like disc galaxies, we conduct an analysis of the associated stellar
metallicity distribution functions (MDFs). After undertaking a kinematic
decomposition of each simulation into spheroid and disc sub-components, we
compare the predicted MDFs to those observed in the solar neighbourhood and the
Galactic bulge. The effects of the star formation density threshold are visible
in the star formation histories, which show a modulation in their behaviour
driven by the threshold. The derived MDFs show median metallicities lower by
0.2-0.3 dex than the MDF observed locally in the disc and in the Galactic
bulge. Possible reasons for this apparent discrepancy include the use of low
stellar yields and/or centrally-concentrated star formation. The dispersions
are larger than the one of the observed MDF; this could be due to simulated
discs being kinematically hotter relative to the Milky Way. The fraction of low
metallicity stars is largely overestimated, visible from the more negatively
skewed MDF with respect to the observational sample. For our fiducial Milky Way
analog, we study the metallicity distribution of the stars born "in situ"
relative to those formed via accretion (from disrupted satellites), and
demonstrate that this low-metallicity tail to the MDF is populated primarily by
accreted stars. Enhanced supernova and stellar radiation energy feedback to the
surrounding interstellar media of these pre-disrupted satellites is suggested
as an important regulator of the MDF skewness.Comment: 20 pages, 14 figures, MNRAS, accepte
Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells
© The Author(s) 2016. Acquired resistance to conventional and targeted therapies is becoming a major hindrance in cancer management. It is increasingly clear that cancer cells are able to evolve and rewire canonical signalling pathways to their advantage, thus evading cell death and promoting cell invasion. The Axl receptor tyrosine kinase (RTK) has been shown to modulate acquired resistance to EGFR-targeted therapies in both breast and lung cancers. Glioblastoma multiforme (GBM) is a highly infiltrative and invasive form of brain tumour with little response to therapy. Both Axl and EGFR have been identified as major players in gliomagenesis and invasiveness. However, the mechanisms underlying a potential signalling crosstalk between EGFR and Axl RTKs are unknown. The purpose of this study was to investigate this novel and unconventional interaction among RTKs of different families in human GBM cells. With the use of western blotting, in vitro kinase activity, co-immunoprecipitation and bimolecular fluorescence complementation assays, we show that EGF stimulates activation of Axl kinase and that there is a hetero-interaction between the two RTKs. Through small interfering RNA knockdown and quantitative PCR screening, we identified distinct gene expression patterns in GBM cells that were specifically regulated by signalling from EGFR-EGFR, Axl-Axl and EGFR-Axl RTK parings. These included genes that promote invasion, which were activated only via the EGFR-Axl axis (MMP9), while EGFR-EGFR distinctly regulated the cell cycle and Axl-Axl regulated invasion. Our findings provide critical insights into the role of EGFR-Axl hetero-dimerisation in cancer cells and reveal regulation of cell invasion via Axl as a novel function of EGFR signalling
Transport behavior of holes in boron delta-doped diamond structures
Boron delta-doped diamond structures have been synthesized using microwave plasma chemical vapor deposition and fabricated into FET and gated Hall bar devices for assessment of the electrical characteristics. A detailed study of variable temperature Hall, conductivity, and field-effect mobility measurements was completed. This was supported by SchrâŹdinger-Poisson and relaxation time o calculations based upon application of Fermiâs golden rule. A two carrier-type model was developed with an activation energy of 1 cm2/Vs and the bulk valence band with high mobility. This new understanding of the transport of holes in such boron delta-doped structures has shown that although Hall mobility as high as 900 cm2/Vs was measured at room temperature, this dramatically overstates the actual useful performance of the device
interview in EDICT magazine
An interview with Annie Whiles about her work with Cathie Pilkington, consisting of ten A3 pages of photography and text. The magazine is the work of Photographer Perou and this edition of the magazine includes the work of Will Alsop, Miron Zownir and Jamie Oliver
The politics of in/visibility: carving out queer space in Ul'yanovsk
<p>In spite of a growing interest within sexualities studies in the concept of queer space (Oswin 2008), existing literature focuses almost exclusively on its most visible and territorialised forms, such as the gay scene, thus privileging Western metropolitan areas as hubs of queer consumer culture (Binnie 2004). While the literature has emphasised the political significance of queer space as a site of resistance to hegemonic gender and sexual norms, it has again predominantly focused on overt claims to public space embodied in Pride events, neglecting other less open forms of resistance.</p><p>
This article contributes new insights to current debates about the construction and meaning of queer space by considering how city space is appropriated by an informal queer network in Ulâianovsk. The group routinely occupied very public locations meeting and socialising on the street or in mainstream cafĂ©s in central Ulâianovsk, although claims to these spaces as queer were mostly contingent, precarious or invisible to outsiders. The article considers how provincial location affects tactics used to carve out communal space, foregrounding the importance of local context and collective agency in shaping specific forms of resistance, and questioning ethnocentric assumptions about the empowering potential of visibility.</p>
Internally driven large-scale changes in the size of Saturn's magnetosphere
Saturnâs magnetic field acts as an obstacle to solar wind flow, deflecting plasma around the
planet and forming a cavity known as the magnetosphere. The magnetopause defines the boundary
between the planetary and solar dominated regimes, and so is strongly influenced by the variable nature
of pressure sources both outside and within. Following from Pilkington et al. (2014), crossings of the
magnetopause are identified using 7 years of magnetic field and particle data from the Cassini spacecraft
and providing unprecedented spatial coverage of the magnetopause boundary. These observations reveal
a dynamical interaction where, in addition to the external influence of the solar wind dynamic pressure,
internal drivers, and hot plasma dynamics in particular can take almost complete control of the systemâs
dayside shape and size, essentially defying the solar wind conditions. The magnetopause can move by up to
10â15 planetary radii at constant solar wind dynamic pressure, corresponding to relatively âplasma-loadedâ
or âplasma-depletedâ states, defined in terms of the internal suprathermal plasma pressure
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