Influence of voluntary hypoventilation breathing on the functional state and physical working capacity of a person at different intensity regimes of physical load

Objective: to study the effect of voluntary hypoventilation breathing on the functional state and physical working capacity of a person under various physical load on a bicycle ergometer to failure. Materials and methods: in the survey 14 young volunteers took part in the survey performing physical work on the bicycle ergometer to the point of refusal. Surveys were conducted 4 times: 2 times before training in voluntary hypoventilation breathing and 2 times after. Voluntary hypoventilation breathing was taught for 30 days. Breathing trainings aimed at forming a subject's narrowed breathing underlied the training of voluntary hypoventilation breathing. The subjects' condition was examined sequentially during rest, 60 W warm-up, physical load and recovery after the load. The physical load was at 120 W or 160 W. During work ECG was recorded in two leads: I standard and V5 thoracic. Simultaneously, a pneumogram and EMG from the quadriceps muscle of the right thigh was recorded. The time of physical work to failure was measured. Before and after the examination, the breath-holding time by inhalation was measured. Results: voluntary hypoventilation breathing increased the hypoxic stability and physical working capacity of the subjects at 120 W and 160 W loads. The greater the load, the shorter the time of physical work to failure. Refusal to continue physical work occurred immediately after overcoming the threshold of aerobic-anaerobic metabolism. In contrast to the 120 W physical load, the 160 W load is accompanied by a higher excitability of the ECG sinus node, slower intraventricular conduction, a higher level of sympathetic influences on the heart, but a better oxygen supply of the myocardium. Conclusions: the greater intensity of physical activity, the more pronounced adaptive shifts in the body of subjects under the influence of voluntary hypoventilation breathing

Значение микроальбуминурии в стратификации риска больных неосложненной артериальной гипертонией

Microalbuminuria (MAU) and a reduction in glomerular filtration rate are independent predictors of cardiovascular morbidity and mortality. Aim was to assess the role of MAU in risk stratification of non-diabetic hypertensive patients. The subgroup of patients with MAU was much more likely to show the other signs of subclinical organ damage as compared to patients with left ventricular hypertrophy, carotid abnormalities or increased pulse wave velocity. Thus, MAU is the integral marker of subclinical organ damage.Категория сердечно-сосудистого риска определяет сроки начала медикаментозной антигипертензивной терапии и целевой уровень АД. Важнейшая роль в стратификации риска принадлежит выявлению субклинического поражения органов-мишеней. Изучали роль микроальбуминурии (МАУ) в стратификации риска больных неосложненной артериальной гипертонией. Выявлено, что МАУ значительно превосходит скорость распространения пульсовой волны между сонной и бедренной артерией > 12 м/с, гипертрофию левого желудочка, толщину комплекса интима-медиа сонных артерий > 0,9 мм по предсказывающей способности в отношении наличия других субклинических органных изменений. Результаты исследования свидетельствуют о значении МАУ как интегрального маркера субклинического поражения органов-мишеней

Hypoventilation trainings combined with physical exercises and their influences on person's functional state in physical work to failure

Objective: to study the influence of hypoventilation's trainings combined with physical exercises on the person's functional state and its physical working capacity in physical work to failure. Materials and methods: 18 young men were examined, and it were divided into 2 groups: main (12 persons) and control (6 persons). Only subjects of the main group were studied to hypoventilation breathing in combination with physical exercises. Before and after the training all subjects performed load testing on a bicycle ergometer to failure under ECG, pneumogram and EMG monitoring. Results: hypoventilation breathing combined with physical exercises was increased the work's time to failure from 165,1±25,6 to 307,3±52,0 s (

Compensatory component of PRP-technology and knee-joint osteoarthrosis of dogs

Input: Osteoarthrosis belongs to heterogenous group of diseases with similar morphological and clinical implications that leads to the cartilage and subchondral bone lesion, as well as lesion of other joint components (synovium, ligaments, capsule and periarticular muscles) (patent RU 2117997, 2240602, 2240603, 22464304, 22464305, 2271139, 2271140, 2303436, 2323694, 2323695) . Aim of research – to develop treatment technology of animals with aseptic osteoarthrosis by applying thrombocyte rich plasma. Objectives: The objects of the study were dogs with knee-joint osteoarthrosis of I-III level. Every animal was older than 6 years old, with a live weight ≥30 kg. Methods: clinical, X-ray research, endoscopy. Results: A week later after the autoplasma re-introduction, positive dynamics in all the animals was observed. In particular, lameness decreased, volume of the affected limb muscles recovered a little. At the end of therapy lameness disappeared in all animals virtually, but in some animals it was appeared after loading. Regain mobility joint crepitus disappeared. Joint mobility was recovered, crepitation disappeared. At the end of the treatment, control radiography of affected limbs showed a positive dynamics, consist in unevenness reducing of the articular surface, size of osteophytes reducing, osteosclerosis percent reduction. In the time of re-arthroscopy at the end of treatment some positive dynamics had observed; chondromalacia of I stage was marked, edema and hyperemia of synovial villi reduction, no generalized synovitis, no pulping of partial anterior cruciate ligament in particular. Discussion: Leanness, joint rigidity reduction in all animals by the end of the treatment course proves the presence of anti-inflammatory, regenerative effect of thrombocyte-rich plasma. Chondroprotective effect of platelet-derived growth factor cause reduction of edema of the synovial membrane and cartilage chondromalacia reduction, and reduction in the size of the cartilage defects observed during arthroscopic visualization. Lack of side effects and complications indicate high availability and safety of the method, in comparison with the standard treatment methods of animal osteoarthritis

Microalbuminuria in risk stratification of non-diabetic hypertesive patients

Microalbuminuria (MAU) and a reduction in glomerular filtration rate are independent predictors of cardiovascular morbidity and mortality. Aim was to assess the role of MAU in risk stratification of non-diabetic hypertensive patients. The subgroup of patients with MAU was much more likely to show the other signs of subclinical organ damage as compared to patients with left ventricular hypertrophy, carotid abnormalities or increased pulse wave velocity. Thus, MAU is the integral marker of subclinical organ damage