Botulinum toxin in bruxism treatment

Introduction: Bruxism is defined as abnormal, fixed, unconscious chewing organ function, deviating qualitatively and quantitatively from normal function. Another definition speaks of motor dysfunction in the mouth, characterized by grinding and clenching of the teeth, occurring during sleep. The etiology of this disorder has not been explained until now, but it is believed to be related to localized, mental, nervous and neurotransmitter disorders. Purpose: The aim of the study is to review literature and knowledge about the use of botulinum toxin in the treatment of bruxism.Methods of treatment: The patient reports to the physician usually after a distressing, difficult to locate pain. The basis for proper treatment is to detect parafunctions and to make the patient aware of their existence. Diagnostic symptoms include dentinal lesions, recesses, enamel cracks and abfractive cavities, as well as changes in the mucosal area of the cheeks. Treatment begins with the use of an occlusive therapy to relax muscles, reduce parafunction and relieve pain. In the form of severe pain, NSAIDs are introduced and, if necessary, anxiolytics, sedatives and antidepressants. In the absence of response to the treatment used, botulinum toxin type A injections are used. The dose of the agent depends on the initial muscle tone and the effect of decrease in its activity is maintained for 4 to 6 months. Conclusions: The use of botulinum toxin makes it possible to selectively exclude overactive muscles, which is a great advantage over other techniques. An additional benefit of this therapy is achieved good cosmetic effect, reversible effect and minimal amount of side effects

The use of platelet-rich plasma in anti-aging therapy (overview)

Introduction Aging stands for the changes in the human body, which are recognized as natural processes that concern every person and are related to the passage of time. Despite ‘normalness’ of the process, a tendency is emerging to treat aging as a pathology requiring proper diagnostics. Consequently, an ‘anti-aging’ medicine has been established - defined as study of preventing and slowing down the process of aging. Aim of the study The aim of this study is to summarize and present the current knowledge, based on the overview of writing on the properties and effectiveness of the use of PRP in anti-aging therapy.    Description of knowledge   Autologous platelet-rich plasma is a concentrate of human blood platelets suspended in a small amount of plasma, wherein concentration of thrombocytes is higher than initial concentration. For autologous plasma to have high healing properties, platelet levels should be at least 1 million in 5 ml of plasma. The basic condition for initiating repair and regenerative processes in vivo is the formation of a blood clot. Also, by degranulating, platelets release many growth factors, such as PDGF, TGF-β, EGF, FGF, VEGF and others, which are involved not only in blood coagulation, but also in immune response and tissue healing. The large variety of PRP-obtaining methods and the range of concentration levels of growth factors in PRP may lead to ambiguity in the literature, as to the extent to which formulation was actually used in a variety of preclinical and clinical studies. Some of those studies are presented in this article.   Summary   Platelet-rich treatments are part of the growing popularity of regenerative medicine, which is beginning to be recognized as the medicine of the future. However, without proper control methods or optimization of numerous variables (e.g. concentration or ratio of growth factors) during PRP preparation, it is not known which ingredients are needed and preferred, and which are harmful for tissue regeneration. However, numerous studies show PRP injection as a promising method of rejuvenating the skin, therefore platelet-rich treatments are an important part of the growing popularity of regenerative medicine