9 research outputs found
Modeling linkage disequilibrium increases accuracy of polygenic risk scores
- Author
- Adank M.
- Adolfsson R.
- Agartz I.
- Agerbo E.
- Ahsan H.
- Aittomäki K.
- Albus M.
- Alexander M.
- Amin F.
- Andreassen O.
- Bacanu S.
- Baglietto L.
- Begemann M.
- Belbin G.
- Belliveau Jr. R.
- Bene J.
- Bergen S.
- Berndt S.
- Bevilacqua E.
- Bhatia G.
- Bigdeli T.
- Black D.
- Blackwood D.
- Blomquist C.
- Bramon E.
- Bruggeman R.
- Buccola N.
- Buckner R.
- Bulik-Sullivan B.
- Buxbaum J.
- Byerley W.
- Børglum A.
- Cahn W.
- Cai G.
- Campion D.
- Cantor R.
- Canzian F.
- Carr V.
- Carrera N.
- Catts S.
- Chambert K.
- Chan R.
- Chang-Claude J.
- Chanock S.
- Chasman D.
- Chen E.
- Chen R.
- Cheng W.
- Cheung E.
- Chong S.
- Cichon S.
- Clair D.
- Cloninger C.
- Cohen D.
- Cohen N.
- Collier D.
- Cormican P.
- Corvin A.
- Craddock N.
- Crisponi L.
- Crowley J.
- Curtis D.
- Czene K.
- Dahmen N.
- Daly M.
- Daly M.
- Darvasi A.
- Davidson M.
- Davis K.
- de Haan L.
- De Jager P.
- Degenhardt F.
- DeLisi L.
- Demontis D.
- Dikeos D.
- Dinan T.
- Djurovic S.
- Do R.
- Domenici E.
- Donohoe G.
- dos Santos Silva I.
- Drapeau E.
- Duan J.
- Dudbridge F.
- Durmishi N.
- Easton D.
- Ehrenreich H.
- Eichhammer P.
- Eliassen A.
- Eriksson J.
- Escott-Price V.
- Esko T.
- Essioux L.
- Fanous A.
- Farh K.
- Farrell M.
- Favero J.
- Figueroa J.
- Finucane H.
- Fletcher O.
- Frank J.
- Franke L.
- Freedman R.
- Freimer N.
- Friedl M.
- Friedman J.
- Fromer M.
- Garcia-Closas M.
- Gaudet M.
- Gejman P.
- Genovese G.
- Genovese G.
- Georgieva L.
- Gershon E.
- Gibson L.
- Giegling I.
- Gill M.
- Giusti-Rodrguez P.
- Godard S.
- Goddard M.
- Goldstein J.
- Golimbet V.
- Gopal S.
- Gratten J.
- Grove J.
- Gurling H.
- Gusev A.
- H.M.Wong E.
- H.Witt S.
- Haiman C.
- Hall P.
- Hammer C.
- Hamshere M.
- Hansen M.
- Hansen T.
- Haroutunian V.
- Hartmann A.
- Hayeck T.
- Hazra A.
- Hein R.
- Henderson B.
- Henskens F.
- Herms S.
- Hirschhorn J.
- Hoffmann P.
- Hofman A.
- Hofman A.
- Hollegaard M.
- Holmans P.
- Hopper J.
- Hougaard D.
- Huang H.
- Hultman C.
- Hunter D.
- Ikeda M.
- Irwanto A.
- Iwata N.
- Jablensky A.
- Joa I.
- Johansson M.
- Jonsson E.
- Julia A.
- K.Wormley B.
- Kaaks R.
- Kahler A.
- Kahn R.
- Kalaydjieva L.
- Karachanak-Yankova S.
- Karjalainen J.
- Kathiresan S.
- Kavanagh D.
- Keller M.
- Kelly B.
- Kendler K.
- Kennedy J.
- Kenny E.
- Keong J.
- Khrunin A.
- Kibriya M.
- Kim Y.
- Kirov G.
- Klovins J.
- Knight J.
- Knowles J.
- Konte B.
- Kraft P.
- Kraft P.
- Kucinskas V.
- Kucinskiene Z.
- Kuzelova-Ptackova H.
- Laurent C.
- Lee P.
- Lee S.
- Legge S.
- Lencz T.
- Lerer B.
- Levinson D.
- Li M.
- Li Q.
- Li T.
- Liang K.
- Lichtner P.
- Lieberman J.
- Limborska S.
- Lindström S.
- Lindström S.
- Liu J.
- Liu J.
- Lnnqvist J.
- Loh P.
- Loughland C.
- Lubinski J.
- Lund E.
- M.Williams N.
- Macek Jr. M.
- Magnusson P.
- Maher B.
- Maier W.
- Makalic E.
- Malhotra A.
- Mallet J.
- Marsal S.
- Mattheisen M.
- Mattingsdal M.
- McCarley R.
- McCarroll S.
- McCarroll S.
- McDonald C.
- McIntosh A.
- McQuillin A.
- Meier S.
- Meijer C.
- Meijers-Heijboer H.
- Meindl A.
- Melegh B.
- Melle I.
- Mesholam-Gately R.
- Metspalu A.
- Michie P.
- Milani L.
- Milanova V.
- Mller-Myhsok B.
- Mokrab Y.
- Moran J.
- Morris D.
- Mors O.
- Mortensen P.
- Mortensen P.
- Mowry B.
- Muranen T.
- Murphy K.
- Murray R.
- Myin-Germeys I.
- Müller-Myhsok B.
- Neale B.
- Neale B.
- Nelis M.
- Nenadic I.
- Nertney D.
- Nestadt G.
- Nevanlinna H.
- Nicodemus K.
- Nikitina-Zake L.
- Nisenbaum L.
- Nordin A.
- Nthen M.
- Oh S.
- Olincy A.
- Olsen L.
- Ophoff R.
- Owen M.
- O’Callaghan E.
- O’Donovan M.
- O’Dushlaine C.
- O’Neill F.
- Palotie A.
- Pantelis C.
- Papadimitriou G.
- Papiol S.
- Parkhomenko E.
- Pasaniuc B.
- Pato C.
- Pato C.
- Pato M.
- Pato M.
- Patsopoulos N.
- Patterson N.
- Paunio T.
- Peeters P.
- Pejovic-Milovancevic M.
- Perkins D.
- Pers T.
- Peto J.
- Petryshen T.
- Pietilinen O.
- Pimm J.
- Pocklington A.
- Posthuma D.
- Powell J.
- Prentice R.
- Price A.
- Price A.
- Pulver A.
- Purcell S.
- Purcell S.
- QinWu J.
- Quested D.
- R.Wolen A.
- Rahman N.
- Rasmussen H.
- Reichenberg A.
- Reimers M.
- Richards A.
- Rietschel M.
- Riley B.
- Ripke S.
- Ripke S.
- Roffman J.
- Roussos P.
- Ruderfer D.
- Rujescu D.
- Salomaa V.
- Sanders A.
- Schall U.
- Schierup M.
- Schmidt D.
- Schmutzler R.
- Schubert C.
- Schulze T.
- Schwab S.
- Scolnick E.
- Scott R.
- Sderman E.
- Seidman L.
- Sham P.
- Shi J.
- Sigurdsson E.
- Silagadze T.
- Silverman J.
- Sim K.
- Sklar P.
- Slominsky P.
- Smoller J.
- So H.
- Southey M.
- Spencer C.
- Stahl E.
- Stahl E.
- Stefansson H.
- Stefansson K.
- Steinberg S.
- Stogmann E.
- Straub R.
- Strengman E.
- Strohmaier J.
- Stroup T.
- Subramaniam M.
- Sullivan P.
- Suvisaari J.
- Svrakic D.
- Szatkiewicz J.
- Sánchez M.
- Tamimi R.
- Tamimi R.
- Thirumalai S.
- Toncheva D.
- Tooney P.
- Tosato S.
- Travis R.
- Turnbull C.
- Uitterlinden A.
- van der Luijt R.
- Van Os J.
- Veijola J.
- Vilhjálmsson B.
- Visscher P.
- Visscher P.
- Waddington J.
- Waisfisz Q.
- Walsh D.
- Walters J.
- Wang D.
- Wang Q.
- Wang Z.
- Webb B.
- Weinberger D.
- Weiser M.
- Wendland J.
- Werge T.
- Whittemore A.
- Wildenauer D.
- Williams S.
- Won H.
- Wray N.
- Xi H.
- Yang J.
- Yang R.
- Zai C.
- Zaitlen N.
- Zheng X.
- Zheng. W.
- Zimprich F.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
- Author
- Adolfsson R.
- Agartz I.
- Agerbo E.
- Akterin S.
- Albus M.
- Alexander M.
- Amin F.
- Andreassen O.
- Bacanu S.
- Begemann M.
- Belliveau R.
- Bene J.
- Bergen S.
- Bergen S.
- Bevilacqua E.
- Bigdeli T.
- Black D.
- Blackwood D.
- Bramon E.
- Brglum A.
- Bruggeman R.
- Buccola N.
- Buckner R.
- Bulik-Sullivan B.
- Buxbaum J.
- Byerley W.
- Børglum A.
- Cahn W.
- Cai G.
- Campion D.
- Cantor R.
- Carr V.
- Carrera N.
- Catts S.
- Chambert K.
- Chambert K.
- Chan R.
- Chen E.
- Chen R.
- Cheng W.
- Cheung E.
- Chong S.
- Cichon S.
- Cloninger C.
- Cohen D.
- Cohen N.
- Collier D.
- Cormican P.
- Corvin A.
- Craddock N.
- Crowley J.
- Curtis D.
- Daly M.
- Daly M.
- Darvasi A.
- Davidson M.
- Davis K.
- de Haan L.
- Degenhardt F.
- Del Favero J.
- DeLisi L.
- Demontis D.
- Dikeos D.
- Dinan T.
- Djurovic S.
- Domenici E.
- Donohoe G.
- Drapeau E.
- Duan J.
- Dudbridge F.
- Durmishi N.
- Ehrenreich H.
- Eichhammer P.
- Eriksson J.
- Escott-Price V.
- Esko T.
- Essioux L.
- Fanous A.
- Farh K.
- Farrell M.
- Finucane H.
- Frank J.
- Franke L.
- Freedman R.
- Freimer N.
- Friedl M.
- Friedman J.
- Fromer M.
- Gejman P.
- Genovese G.
- Georgieva L.
- Gershon E.
- Giegling I.
- Gill M.
- Giusti-Rodriguez P.
- Godard S.
- Goldstein J.
- Golimbet V.
- Gopal S.
- Gratten J.
- Grove J.
- Gurling H.
- Gusev A.
- Hammer C.
- Hamshere M.
- Hansen M.
- Hansen T.
- Haroutunian V.
- Hartmann A.
- Henskens F.
- Herms S.
- Hirschhorn J.
- Hoffmann P.
- Hofman A.
- Hollegaard M.
- Holmans P.
- Hougaard D.
- Huang H.
- Hultman C.
- Ikeda M.
- Iwata N.
- Jablensky A.
- Joa I.
- Julià A.
- Jönsson E.
- Kahn R.
- Kalaydjieva L.
- Karachanak-Yankova S.
- Karjalainen J.
- Kavanagh D.
- Keller M.
- Kelly B.
- Kendler K.
- Kennedy J.
- Keong J.
- Khrunin A.
- Kim Y.
- Kirov G.
- Klovins J.
- Knight J.
- Knowles J.
- Konte B.
- Kucinskas V.
- Kucinskiene Z.
- Kuzelova-Ptackova H.
- Kähler A.
- Laurent C.
- Lee P.
- Lee S.
- Legge S.
- Lencz T.
- Lerer B.
- Levinson D.
- Li M.
- Li Q.
- Li T.
- Liang K.
- Lieberman J.
- Limborska S.
- Liu J.
- Lnnqvist J.
- Loughland C.
- Lubinski J.
- Macek M.
- Magnusson P.
- Magnusson P.
- Maher B.
- Maier W.
- Malhotra A.
- Mallet J.
- Marsal S.
- Mattheisen M.
- Mattingsdal M.
- McCarley R.
- McCarroll S.
- McCarroll S.
- McDonald C.
- McIntosh A.
- McQuillin A.
- Meier S.
- Meijer C.
- Melegh B.
- Melle I.
- Mesholam-Gately R.
- Metspalu A.
- Michie P.
- Milani L.
- Milanova V.
- Mller-Myshok B.
- Mokrab Y.
- Moran J.
- Morris D.
- Mors O.
- Mortensen P.
- Mortensen P.
- Mowry B.
- Murphy K.
- Murray R.
- Myin-Germeys I.
- Neale B.
- Neale B.
- Nelis M.
- Nenadic I.
- Nertney D.
- Nestadt G.
- Nicodemus K.
- Nikitina-Zake L.
- Nisenbaum L.
- Nordin A.
- Nthen M.
- O'Callaghan E.
- O'Donovan M.
- O'Dushlaine C.
- O'Dushlaine C.
- O'Neill F.
- Oh S.
- Olincy A.
- Olsen L.
- Ophoff R.
- Owen M.
- Palotie A.
- Pantelis C.
- Papadimitriou G.
- Papiol S.
- Parkhomenko E.
- Pasaniuc B.
- Pato C.
- Pato M.
- Paunio T.
- Pejovic-Milovancevic M.
- Perkins D.
- Pers T.
- Petryshen T.
- Pietilinen O.
- Pimm J.
- Pocklington A.
- Posthuma D.
- Powell J.
- Price A.
- Price A.
- Pulver A.
- Purcell S.
- Purcell S.
- Quested D.
- Rasmussen H.
- Raychaudhuri S.
- Reichenberg A.
- Reimers M.
- Richards A.
- Rietschel M.
- Riley B.
- Ripke S.
- Roffman J.
- Roussos P.
- Ruderfer D.
- Ruderfer D.
- Rujescu D.
- Salomaa V.
- Sanders A.
- Schall U.
- Schubert C.
- Schulze T.
- Schwab S.
- Scolnick E.
- Scolnick E.
- Scott R.
- Sderman E.
- Seidman L.
- Sham P.
- Shi J.
- Sigurdsson E.
- Silagadze T.
- Silverman J.
- Sim K.
- Sklar P.
- Slominsky P.
- Smoller J.
- So H.
- Spencer C.
- St. Clair D.
- Stahl E.
- Stahl E.
- Stefansson H.
- Stefansson K.
- Steinberg S.
- Stogmann E.
- Straub R.
- Strengman E.
- Strohmaier J.
- Stroup T.
- Subramaniam M.
- Sullivan P.
- Suvisaari J.
- Svrakic D.
- Szatkiewicz J.
- Thirumalai S.
- Toncheva D.
- Tooney P.
- Tosato S.
- Trynka G.
- van Os J.
- Veijola J.
- Vilhjálmsson B.
- Visscher P.
- Waddington J.
- Walsh D.
- Walters J.
- Wang Q.
- Webb B.
- Weinberger D.
- Weiser M.
- Wendland J.
- Werge T.
- Wildenauer D.
- Williams N.
- Williams S.
- Witt S.
- Wolen A.
- Wong E.
- Wormley B.
- Wray N.
- Wray N.
- Wu J.
- Xi H.
- Xu H.
- Zai C.
- Zang C.
- Zheng X.
- Zimprich F.
- Publication venue
- 'Elsevier BV'
- Publication date
- 06/11/2014
- Field of study
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
- Author
- Agartz I
- Agerbo E
- Albus M
- Alexander M
- Amin F
- Bacanu Sa
- Begemann M
- Belbin G
- Belliveau Ra
- Bene J
- Bergen Se
- Bevilacqua E
- Bhatia G
- Bigdeli Tb
- Black Dw
- Bruggeman R
- Buccola Ng
- Buckner Rl
- Bulik Sullivan B
- Byerley W
- Cahn W
- Cai G
- Campion D
- Cantor Rm
- Carr Vj
- Carrera N
- Catts Sv
- Chambert Kd
- Chan Rc
- Chasman D
- Chen Ey
- Chen Ry
- Cheng W
- Cheung Ef
- Chong Sa
- Cloninger Cr
- Cohen D
- Cohen N
- Collier Da
- Cormican P
- Corvin A
- Craddock N
- Crowley Jj
- Curtis D
- Daly M
- Davidson M
- Davis Kl
- De Haan
- De Jager
- Degenhardt F
- Del Favero
- Delisi Le
- Demontis D
- Dikeos D
- Dinan T
- Discovery Biology
- Djurovic S
- Do R
- Donohoe G
- Drapeau E
- Duan J
- Dudbridge F
- Durmishi N
- Eichhammer P
- Eriksson J
- Escott Price V
- Essioux L
- Fanous Ah
- Farh Kh
- Farrell Ms
- Finucane Hk
- Frank J
- Franke L
- Freedman R
- Freimer Nb
- Friedl M
- Friedman Ji
- Fromer M
- Genovese G
- Genovese G
- Georgieva L
- Gershon Es
- Giegling I
- Giusti Rodrguez P
- Godard S
- Goddard M
- Goldstein Ji
- Golimbet V
- Gopal S
- Gratten J
- Grove J
- Gusev A
- Hammer C
- Hamshere Ml
- Hansen M
- Hansen T
- Haroutunian V
- Hartmann Am
- Hayeck T
- Henskens Fa
- Herms S
- Hirschhorn Jn
- Hoffmann P
- Hofman A
- Hollegaard Mv
- Holmans Pa
- Hougaard Dm
- Huang H
- Ikeda M
- J
- Joa I
- Jr
- Jr
- Julia A
- Kahler Ak
- Kahn Rs
- Kalaydjieva L
- Karachanak Yankova S
- Karjalainen J
- Kathiresan S
- Kavanagh D
- Keller Mc
- Kelly Bj
- Kennedy Jl
- Kenny Ee
- Keong Jl
- Khrunin A
- Kim Y
- Klovins J
- Knowles Ja
- Konte B
- Kraft P
- Kucinskas V
- Kucinskiene Za
- Kuzelova Ptackova H
- L
- Laurent C
- Lee P
- Lee Sh
- Legge Se
- Lerer B
- Li M
- Li T
- Liang Ky
- Lieberman J
- Limborska S
- Lindstr\uf6m S
- Lnnqvist J
- Loh Pr
- Loughland Cm
- Lubinski J
- Macek M
- Magnusson Pk
- Maher Bs
- Maier W
- Mallet J
- Marsal S
- Mattheisen M
- Mattingsdal M
- Mccarley Rw
- Mccarroll S
- Mcdonald C
- Mcintosh Am
- Meier S
- Meijer Cj
- Melegh B
- Melle I
- Mesholam Gately Ri
- Metspalu A
- Michie Pt
- Milani L
- Milanova V
- Mller Myhsok B
- Mokrab Y
- Morris Dw
- Mors O
- Mortensen Pb
- Murphy Kc
- Murray Rm
- Myin Germeys I
- Neale B
- Neale Bm
- Nelis M
- Nenadic I
- Nertney Da
- Nestadt G
- Nicodemus Kk
- Nikitina Zake L
- Nisenbaum L
- Nordin A
- O'Callaghan E
- O'Dushlaine C
- O'Neill Fa
- Oh Sy
- Olincy A
- Olsen L
- P
- Pantelis C
- Papadimitriou Gn
- Papiol S
- Parkhomenko E
- Pasaniuc B
- Pato C
- Pato M
- Pato Mt
- Patsopoulos Na
- Patterson N
- Paunio T
- Pejovic Milovancevic M
- Perkins Do
- Pers Th
- Pietilinen O
- Pimm J
- Pocklington Aj
- Powell J
- Price A
- Price Al
- Pulver Ae
- Purcell S
- Purcell Sm
- Quested D
- Rasmussen Hb
- Reichenberg A
- Reimers Ma
- Richards Al
- Ripke S
- Ripke S
- Risk of Inherited Variants in Breast Cancer study
- Roffman Jl
- Roussos P
- Ruderfer Dm
- Salomaa V
- Sanders Ar
- Schall U
- Schierup Mh
- Schubert Cr
- Schulze Tg
- Schwab Sg
- Scolnick Em
- Scott Rj
- Sderman E
- Seidman Lj
- Shi J
- Sigurdsson E
- Silagadze T
- Silverman Jm
- Sim K
- Slominsky P
- Smoller Jw
- So Hc
- Spencer Cc
- Stahl E
- Stahl Ea
- Stefansson H
- Stefansson K
- Steinberg S
- Stogmann E
- Straub Re
- Strengman E
- Strohmaier J
- Stroup Ts
- Subramaniam M
- Suvisaari J
- Svrakic Dm
- Szatkiewicz Jp
- Tamimi R
- Thirumalai S
- Toncheva D
- Tooney Pa
- Tosato Sarah
- Van Os J
- Veijola J
- Vilhj\ue1lmsson Bj
- Visscher Pm
- Visscher PM)
- Waddington J
- Walsh D
- Walters Jt
- Wang D
- Wang Q
- Webb Bt
- Weiser M
- Wildenauer Db
- Williams Nm
- Williams S
- Witt Sh
- Wolen Ar
- Won Hh
- Wong Eh
- Wormley Bk
- Wray Nr
- Wu Jq
- Xi Hs
- Yang J
- Zai Cc
- Zaitlen N
- Zheng X
- Zimprich F
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Polygenic risk scores have shown great promise in predicting complex disease risk and will become more accurate as training sample sizes increase. The standard approach for calculating risk scores involves linkage disequilibrium (LD)-based marker pruning and applying a p\ua0value threshold to association statistics, but this discards information and can reduce predictive accuracy. We introduce LDpred, a method that infers the posterior mean effect size of each marker by using a prior on effect sizes and LD information from an external reference panel. Theory and simulations show that LDpred outperforms the approach of pruning followed by thresholding, particularly at large sample sizes. Accordingly, predicted R(2) increased from 20.1% to 25.3% in a large schizophrenia dataset and from 9.8% to 12.0% in a large multiple sclerosis dataset. A similar relative improvement in accuracy was observed for three additional large disease datasets and for non-European schizophrenia samples. The advantage of LDpred over existing methods will grow as sample sizes increase
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
- Author
- Adolfsson R
- Agartz I
- Agerbo E
- Akterin S
- Albus M
- Alexander M
- Amin F
- Andreassen Oa
- B\uf8rglum Ad
- Bacanu Sa
- Begemann M
- Belliveau Ra
- Bene J
- Bergen S
- Bergen Se
- Bevilacqua E
- Bigdeli Tb
- Black Dw
- Blackwood Dh
- Bramon E
- Brglum Ad
- Bruggeman R
- Buccola Ng
- Buckner Rl
- Bulik-Sullivan B
- Bulik-Sullivan B
- Buxbaum Jd
- Byerley W
- Cahn W
- Cai G
- Campion D
- Cantor Rm
- Carr Vj
- Carrera N
- Catts Sv
- Chambert K
- Chambert Kd
- Chan Rc
- Chen Ey
- Chen Ry
- Cheng W
- Cheung Ef
- Chong Sa
- Cichon S
- Cloninger Cr
- Cohen D
- Cohen N
- Collier Da
- Cormican P
- Corvin A
- Craddock N
- Crowley Jj
- Curtis D
- Daly M
- Daly Mj
- Darvasi A
- Davidson M
- Davis Kl
- De Haan
- Degenhardt F
- Del Favero
- Delisi Le
- Demontis D
- Dikeos D
- Dinan T
- Djurovic S
- Domenici E
- Donohoe G
- Drapeau E
- Duan J
- Dudbridge F
- Durmishi N
- Ehrenreich H
- Eichhammer P
- Eriksson J
- Escott-Price V
- Esko T
- Essioux L
- Fanous Ah
- Farh Kh
- Farrell Ms
- Finucane H
- Frank J
- Franke L
- Freedman R
- Freimer Nb
- Friedl M
- Friedman Ji
- Fromer M
- Gejman Pv
- Genovese G
- Georgieva L
- Gershon Es
- Giegling I
- Gill M
- Giusti-Rodrguez P
- Godard S
- Goldstein Ji
- Golimbet V
- Gopal S
- Gratten J
- Grove J
- Gurling H
- Gusev A
- Hammer C
- Hamshere Ml
- Hansen M
- Hansen T
- Haroutunian V
- Hartmann Am
- Henskens Fa
- Herms S
- Hirschhorn Jn
- Hoffmann P
- Hofman A
- Hollegaard Mv
- Holmans Pa
- Hougaard Dm
- Huang H
- Hultman Cm
- Hultman Cm
- Hultman Cm
- Ikeda M
- Iwata N
- J\uf6nsson Eg
- Jablensky Av
- Joa I
- Juli\ue0 A
- K\ue4hler Ak
- K\ue4hler Ak
- K\ue4hler Ak
- Kahn Rs
- Kalaydjieva L
- Karachanak-Yankova S
- Karjalainen J
- Kavanagh D
- Keller Mc
- Kelly Bj
- Kendler Ks
- Kennedy Jl
- Keong Jl
- Khrunin A
- Kim Y
- Kirov G
- Klovins J
- Knight J
- Knowles Ja
- Konte B
- Kucinskas V
- Kucinskiene Za
- Kuzelova-Ptackova H
- Laurent C
- Lee P
- Lee Sh
- Lee Sh
- Lee Sh
- Legge Se
- Lencz T
- Lerer B
- Levinson Df
- Li M
- Li Qs
- Li T
- Liang Ky
- Lieberman J
- Limborska S
- Liu J
- Lnnqvist J
- Loughland Cm
- Lubinski J
- Macek M
- Magnusson Pk
- Magnusson Pk
- Maher Bs
- Maier W
- Malhotra Ak
- Mallet J
- Marsal S
- Mattheisen M
- Mattingsdal M
- Mccarley Rw
- Mccarroll S
- Mccarroll Sa
- Mccarroll Sa
- Mcdonald C
- Mcintosh Am
- Mcquillin A
- Meier S
- Meijer Cj
- Melegh B
- Melle I
- Mesholam-Gately Ri
- Metspalu A
- Michie Pt
- Milani L
- Milanova V
- Mller-Myhsok B
- Mokrab Y
- Moran Jl
- Moran Jl
- Morris Dw
- Mors O
- Mortensen Pb
- Mortensen Pb
- Mowry Bj
- Murphy Kc
- Murray Rm
- Myin-Germeys I
- Neale Bm
- Neale Bm
- Neale Bm
- Nelis M
- Nenadic I
- Nertney Da
- Nestadt G
- Nicodemus Kk
- Nikitina-Zake L
- Nisenbaum L
- Nordin A
- Nthen Mm
- O'Callaghan E
- O'Donovan Mc
- O'Dushlaine C
- O'Dushlaine C
- O'Dushlaine Cgusev
- O'Neill Fa
- Oh Sy
- Olincy A
- Olsen L
- Ophoff Ra
- Owen Mj
- Palotie A
- Pantelis C
- Papadimitriou Gn
- Papiol S
- Parkhomenko E
- Pasaniuc B
- Pato Cn
- Pato Mt
- Paunio T
- Pejovic-Milovancevic M
- Perkins Do
- Pers Th
- Petryshen Tl
- Pietilinen O
- Pimm J
- Pocklington Aj
- Posthuma D
- Powell J
- Price A
- Price Al
- Pulver Ae
- Purcell S
- Purcell Sm
- Purcell Sm
- Quested D
- Rasmussen Hb
- Raychaudhuri S
- Reichenberg A
- Reimers Ma
- Richards Al
- Rietschel M
- Riley Bp
- Ripke S
- Roffman Jl
- Roussos P
- Ruderfer D
- Ruderfer Dm
- Rujescu D
- Salomaa V
- Sanders Ar
- Schall U
- Schizophrenia Working
- Schubert Cr
- Schulze Tg
- Schwab Sg
- Scolnick E
- Scolnick Em
- Scott Rj
- Sderman E
- Seidman Lj
- Sham Pc
- Shi J
- Sigurdsson E
- Silagadze T
- Silverman Jm
- Sim K
- Sklar P
- Sklar P
- Slominsky P
- Smoller Jw
- So Hc
- Spencer Cc
- St Clair
- Stahl E
- Stahl Ea
- Stefansson H
- Stefansson K
- Steinberg S
- Stogmann E
- Straub Re
- Strengman E
- Strohmaier J
- Stroup Ts
- Subramaniam M
- Sullivan Pf
- Sullivan Pf
- Sullivan Pf
- Suvisaari J
- Svrakic Dm
- SWE-SCZ Consortium
- SWE-SCZ Consortium
- Szatkiewicz Jp
- Thirumalai S
- Toncheva D
- Tooney Pa
- Tosato S
- Trynka G
- Van Os
- Veijola J
- Vilhj\ue1lmsson Bj
- Visscher Pm
- Waddington J
- Walsh D
- Walters Jt
- Wang D
- Wang Q
- Webb Bt
- Weinberger Dr
- Weiser M
- Wendland Jr
- Werge T
- Wildenauer Db
- Williams Nm
- Williams S
- Witt Sh
- Wolen Ar
- Wong Eh
- Wormley Bk
- Wray Nr
- Wray Nr
- Wu Jq
- Xi Hs
- Xu H
- Zai Cc
- Zang C
- Zheng X
- Zimprich F
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Regulatory and coding variants are known to be enriched with associations identified by genome-wide association studies (GWASs) of complex disease, but their contributions to trait heritability are currently unknown. We applied variance-component methods to imputed genotype data for 11 common diseases to partition the heritability explained by genotyped SNPs (hg(2)) across functional
categories (while accounting for shared variance due to linkage disequilibrium). Extensive simulations showed that in contrast to current estimates from GWAS summary statistics, the variance-component approach partitions heritability accurately under a wide range of complex-disease architectures. Across the 11 diseases DNaseI hypersensitivity sites (DHSs) from 217 cell types spanned 16% of imputed SNPs (and 24% of genotyped SNPs) but explained an average of 79% (SE = 8%) of hg(2) from imputed SNPs (5.1
7 enrichment; p = 3.7
7 10(-17)) and 38% (SE =4%) of hg(2) from genotyped SNPs (1.6
7 enrichment, p = 1.0
7 10(-4)). Further enrichment was observed at enhancer DHSs and cell-type-specific DHSs. In contrast, coding variants, which span 1% of the genome, explained <10% of hg(2) despite having the highest enrichment. We replicated these findings but found no significant contribution from rare coding variants in independent schizophrenia cohorts genotyped on GWAS and exome chips. Our results highlight the value of analyzing components of heritability to unravel the functional architecture of common disease
Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases.
- Author
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Akterin Susanne
- Albus Margot
- Alexander Madeline
- Amin Farooq
- Andreassen Ole A.
- Bacanu Silviu A.
- Begemann Martin
- Belliveau Richard A.
- Bene Judit
- Bergen Sarah
- Bergen Sarah E.
- Bevilacqua Elizabeth
- Bigdeli Tim B.
- Black Donald W.
- Blackwood Douglas H.R.
- Bramon Elvira
- Brglum Anders D.
- Bruggeman Richard
- Buccola Nancy G.
- Buckner Randy L.
- Bulik-Sullivan Brendan
- Bulik-Sullivan Brendan
- Buxbaum Joseph D.
- Byerley William
- Børglum Anders D.
- Cahn Wiepke
- Cai Guiqing
- Campion Dominique
- Cantor Rita M.
- Carr Vaughan J.
- Carrera Noa
- Catts Stanley V.
- Chambert Kimberly
- Chambert Kimberly D.
- Chan Raymond C.K.
- Chen Eric Y.H.
- Chen Ronald Y.L.
- Cheng Wei
- Cheung Eric F.C.
- Chong Siow Ann
- Cichon Sven
- Cloninger C. Robert
- Cohen David
- Cohen Nadine
- Collier David A.
- Cormican Paul
- Corvin Aiden
- Craddock Nick
- Crowley James J.
- Curtis David
- Daly Mark
- Daly Mark J.
- Darvasi Ariel
- Davidson Michael
- Davis Kenneth L.
- Degenhardt Franziska
- DeLisi Lynn E.
- Del Favero Jurgen
- Demontis Ditte
- de Haan Lieuwe
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Domenici Enrico
- Donohoe Gary
- Drapeau Elodie
- Duan Jubao
- Dudbridge Frank
- Durmishi Naser
- Ehrenreich Hannelore
- Eichhammer Peter
- Eriksson Johan
- Escott-Price Valentina
- Esko Tõnu
- Essioux Laurent
- Fanous Ayman H.
- Farh Kai-How
- Farrell Martilias S.
- Finucane Hilary
- Frank Josef
- Franke Lude
- Freedman Robert
- Freimer Nelson B.
- Friedl Marion
- Friedman Joseph I.
- Fromer Menachem
- Gejman Pablo V.
- Genovese Giulio
- Georgieva Lyudmila
- Gershon Elliot S.
- Giegling Ina
- Gill Michael
- Giusti-Rodrguez Paola
- Godard Stephanie
- Goldstein Jacqueline I.
- Golimbet Vera
- Gopal Srihari
- Gratten Jacob
- Grove Jakob
- Gurling Hugh
- Gusev Alexander
- Hammer Christian
- Hamshere Marian L.
- Hansen Mark
- Hansen Thomas
- Haroutunian Vahram
- Hartmann Annette M.
- Henskens Frans A.
- Herms Stefan
- Hirschhorn Joel N.
- Hoffmann Per
- Hofman Andrea
- Hollegaard Mads V.
- Holmans Peter A.
- Hougaard David M.
- Huang Hailiang
- Hultman Christina M.
- Hultman Christina M.
- Hultman Christina M.
- Ikeda Masashi
- Iwata Nakao
- Jablensky Assen V.
- Joa Inge
- Julià Antonio
- Jönsson Erik G.
- Kahn René S.
- Kalaydjieva Luba
- Karachanak-Yankova Sena
- Karjalainen Juha
- Kavanagh David
- Keller Matthew C.
- Kelly Brian J.
- Kendler Kenneth S.
- Kennedy James L.
- Keong Jimmy Lee Chee
- Khrunin Andrey
- Kim Yunjung
- Kirov George
- Klovins Janis
- Knight Jo
- Knowles James A.
- Konte Bettina
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kuzelova-Ptackova Hana
- Kähler Anna K.
- Kähler Anna K.
- Kähler Anna K.
- Laurent Claudine
- Lee Phil
- Lee S. Hong
- Lee S. Hong
- Legge Sophie E.
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F.
- Li Miaoxin
- Li Qingqin S.
- Li Tao
- Liang Kung-Yee
- Lieberman Jeffrey
- Limborska Svetlana
- Liu Jianjun
- Lnnqvist Jouko
- Loughland Carmel M.
- Lubinski Jan
- Macek Milan
- Magnusson Patrik K.E.
- Magnusson Patrik K.E.
- Maher Brion S.
- Maier Wolfgang
- Malhotra Anil K.
- Mallet Jacques
- Marsal Sara
- Mattheisen Manuel
- Mattingsdal Morten
- McCarley Robert W.
- McCarroll Steve
- McCarroll Steven A.
- McCarroll Steven A.
- McDonald Colm
- McIntosh Andrew M.
- McQuillin Andrew
- Meier Sandra
- Meijer Carin J.
- Melegh Bela
- Melle Ingrid
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Michie Patricia T.
- Milani Lili
- Milanova Vihra
- Mller-Myhsok Bertram
- Mokrab Younes
- Moran Jennifer L.
- Moran Jennifer L.
- Morris Derek W.
- Mors Ole
- Mortensen Preben B.
- Mortensen Preben B.
- Mowry Bryan J.
- Murphy Kieran C.
- Murray Robin M.
- Myin-Germeys Inez
- Neale Benjamin M.
- Neale Benjamin M.
- Neale Benjamin M.
- Nelis Mari
- Nenadic Igor
- Nertney Deborah A.
- Nestadt Gerald
- Nicodemus Kristin K.
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nordin Annelie
- Nthen Markus M.
- Oh Sang-Yun
- Olincy Ann
- Olsen Line
- Ophoff Roel A.
- Owen Michael J.
- O’Callaghan Eadbhard
- O’Donovan Michael C.
- O’Dushlaine Colm
- O’Dushlaine Colm
- O’Neill F. Anthony
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N.
- Papiol Sergi
- Parkhomenko Elena
- Pasaniuc Bogdan
- Pato Carlos N.
- Pato Michele T.
- Paunio Tiina
- Pejovic-Milovancevic Milica
- Perkins Diana O.
- Pers Tune H.
- Petryshen Tracey L.
- Pietilinen Olli
- Pimm Jonathan
- Pocklington Andrew J.
- Posthuma Danielle
- Powell John
- Price Alkes
- Price Alkes L.
- Pulver Ann E.
- Purcell Shaun
- Purcell Shaun M.
- Purcell Shaun M.
- Quested Digby
- Rasmussen Henrik B.
- Raychaudhuri Soumya
- Reichenberg Abraham
- Reimers Mark A.
- Richards Alexander L.
- Rietschel Marcella
- Riley Brien P.
- Ripke Stephan
- Ripke Stephan
- Ripke Stephan
- Roffman Joshua L.
- Roussos Panos
- Ruderfer Douglas
- Ruderfer Douglas M.
- Rujescu Dan
- Salomaa Veikko
- Sanders Alan R.
- Schall Ulrich
- Schubert Christian R.
- Schulze Thomas G.
- Schwab Sibylle G.
- Scolnick Edward
- Scolnick Edward M.
- Scott Rodney J.
- Sderman Erik
- Seidman Larry J.
- Sham Pak C.
- Shi Jianxin
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silverman Jeremy M.
- Sim Kang
- Sklar Pamela
- Sklar Pamela
- Slominsky Petr
- Smoller Jordan W.
- So Hon-Cheong
- Spencer Chris C.A.
- St. Clair David
- Stahl Eli
- Stahl Eli A.
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Stogmann Elisabeth
- Straub Richard E.
- Strengman Eric
- Strohmaier Jana
- Stroup T. Scott
- Subramaniam Mythily
- Sullivan Patrick F.
- Sullivan Patrick F.
- Sullivan Patrick F.
- Suvisaari Jaana
- Svrakic Dragan M.
- Szatkiewicz Jin P.
- Thirumalai Srinivas
- Toncheva Draga
- Tooney Paul A.
- Tosato Sarah
- Trynka Gosia
- Van Os Jim
- Veijola Juha
- Vilhjálmsson Bjarni J.
- Visscher Peter M.
- Waddington John
- Walsh Dermot
- Walters James T.R.
- Wang Dai
- Wang Qiang
- Webb Bradley T.
- Weinberger Daniel R.
- Weiser Mark
- Wendland Jens R.
- Werge Thomas
- Wildenauer Dieter B.
- Williams Nigel M.
- Williams Stephanie
- Witt Stephanie H.
- Wolen Aaron R.
- Wong Emily H.M.
- Wormley Brandon K.
- Wray Naomi R.
- Wray Naomi R.
- Wu Jing Qin
- Xi Hualin Simon
- Xu Han
- Zai Clement C.
- Zang Chongzhi
- Zheng Xuebin
- Zimprich Fritz
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/11/2014
- Field of study
Regulatory and coding variants are known to be enriched with associations identified by genome-wide association studies (GWASs) of complex disease, but their contributions to trait heritability are currently unknown. We applied variance-component methods to imputed genotype data for 11 common diseases to partition the heritability explained by genotyped SNPs (hg2) across functional categories (while accounting for shared variance due to linkage disequilibrium). Extensive simulations showed that in contrast to current estimates from GWAS summary statistics, the variance-component approach partitions heritability accurately under a wide range of complex-disease architectures. Across the 11 diseases DNaseI hypersensitivity sites (DHSs) from 217 cell types spanned 16% of imputed SNPs (and 24% of genotyped SNPs) but explained an average of 79% (SE = 8%) of hg2 from imputed SNPs (5.1× enrichment; p = 3.7 × 10−17) and 38% (SE = 4%) of hg2 from genotyped SNPs (1.6× enrichment, p = 1.0 × 10−4). Further enrichment was observed at enhancer DHSs and cell-type-specific DHSs. In contrast, coding variants, which span 1% of the genome, explained <10% of hg2 despite having the highest enrichment. We replicated these findings but found no significant contribution from rare coding variants in independent schizophrenia cohorts genotyped on GWAS and exome chips. Our results highlight the value of analyzing components of heritability to unravel the functional architecture of common disease
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
- Author
- Adank Muriel
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Ahsan Habibul
- Aittomaki Kristiina
- Albus Margot
- Alexander Madeline
- Amin Farooq
- Andreassen Ole A
- Bacanu Silviu A
- Baglietto Laura
- Begemann Martin
- Belbin Gillian
- Belliveau Richard A
- Bene Judit
- Bergen Sarah E
- Berndt Sonja
- Bevilacqua Elizabeth
- Bhatia Gaurav
- Bigdeli Tim B
- Black Donald W
- Blackwood Douglas H R
- Blomquist Carl
- Borglum Anders D
- Bramon Elvira
- Bruggeman Richard
- Buccola Nancy G
- Buckner Randy L
- Bulik-Sullivan Brendan
- Buxbaum Joseph D
- Byerley William
- Cahn Wiepke
- Cai Guiqing
- Campion Dominique
- Cantor Rita M
- Canzian Federico
- Carr Vaughan J
- Carrera Noa
- Catts Stanley V
- Chambert Kimberly D
- Chan Raymond C K
- Chang-Claude Jenny
- Chanock Stephen J
- Chasman Daniel
- Chen Eric Y H
- Chen Ronald Y L
- Cheng Wei
- Cheung Eric F C
- Chong Siow Ann
- Cichon Sven
- Cloninger C Robert
- Cohen David
- Cohen Nadine
- Collier David A
- Cormican Paul
- Corvin Aiden
- Craddock Nick
- Crisponi Laura
- Crowley James J
- Curtis David
- Czene Kamila
- Dahmen Norbert
- Daly Mark
- Daly Mark J
- Darvasi Ariel
- Davidson Michael
- Davis Kenneth L
- De Jager Philip
- Degenhardt Franziska
- DeLisi Lynn E
- Del Favero Jurgen
- Demontis Ditte
- de Haan Lieuwe
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Do Ron
- Domenici Enrico
- Donohoe Gary
- Drapeau Elodie
- Duan Jubao
- Dudbridge Frank
- Durmishi Naser
- Easton Douglas
- Ehrenreich Hannelore
- Eichhammer Peter
- Eliassen A Heather
- Eriksson Johan
- Escott-Price Valentina
- Esko Tonu
- Essioux Laurent
- Fanous Ayman H
- Farh Kai-How
- Farrell Martilias S
- Figueroa Jonine
- Finucane Hilary K
- Fletcher Olivia
- Frank Josef
- Franke Lude
- Freedman Robert
- Freimer Nelson B
- Friedl Marion
- Friedman Joseph I
- Fromer Menachem
- Garcia-Closas Montserrat
- Gaudet Mia M
- Gejman Pablo V
- Genovese Giulio
- Genovese Giulio
- Georgieva Lyudmila
- Gershon Elliot S
- Gibson Lorna
- Giegling Ina
- Gill Michael
- Giusti-Rodrguez Paola
- Godard Stephanie
- Goddard Michael
- Goldstein Jacqueline I
- Golimbet Vera
- Gopal Srihari
- Gratten Jacob
- Grove Jakob
- Gurling Hugh
- Gusev Alexander
- Haiman Christopher A
- Hall Per
- Hammer Christian
- Hamshere Marian L
- Hansen Mark
- Hansen Thomas
- Haroutunian Vahram
- Hartmann Annette M
- Hayeck Tristan
- Hazra Aditi
- Hein Rebecca
- Henderson Brian E
- Henskens Frans A
- Herms Stefan
- Hirschhorn Joel N
- Hoffmann Per
- Hofman Albert
- Hofman Andrea
- Hollegaard Mads V
- Holmans Peter A
- Hopper John L
- Hougaard David M
- Huang Hailiang
- Hultman Christina M
- Hunter David J
- Ikeda Masashi
- Irwanto Astrid
- Iwata Nakao
- Jablensky Assen V
- Joa Inge
- Johansson Mattias
- Jonsson Erik G
- Julia Antonio
- Kaaks Rudolf
- Kahler Anna K
- Kahn Rene S
- Kalaydjieva Luba
- Karachanak-Yankova Sena
- Karjalainen Juha
- Kathiresan Sekar
- Kavanagh David
- Keller Matthew C
- Kelly Brian J
- Kendler Kenneth S
- Kennedy James L
- Kenny Eimear E
- Keong Jimmy Lee Chee
- Khrunin Andrey
- Kibriya Muhammad G
- Kim Yunjung
- Kirov George
- Klovins Janis
- Knight Jo
- Knowles James A
- Konte Bettina
- Kraft Peter
- Kraft Peter
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kuzelova-Ptackova Hana
- Laurent Claudine
- Lee Phil
- Lee Sang Hong
- Legge Sophie E
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F
- Li Miaoxin
- Li Qingqin S
- Li Tao
- Liang Kung-Yee
- Lichtner Peter
- Lieberman Jeffrey
- Limborska Svetlana
- Lindstrom Sara
- Lindstrom Sara
- Liu Jianjun
- Liu Jianjun
- Lnnqvist Jouko
- Loh Po-Ru
- Loughland Carmel M
- Lubinski Jan
- Lund Eiliv
- Macek Milan
- Magnusson Patrik K E
- Maher Brion S
- Maier Wolfgang
- Makalic Enes
- Malhotra Anil K
- Mallet Jacques
- Marsal Sara
- Mattheisen Manuel
- Mattingsdal Morten
- McCarley Robert W
- McCarroll Steve
- McCarroll Steven A
- McDonald Colm
- McIntosh Andrew M
- McQuillin Andrew
- Meier Sandra
- Meijer Carin J
- Meijers-Heijboer Hanne
- Meindl Alfons
- Melegh Bela
- Melle Ingrid
- Mesholam-Gately Raquelle I
- Metspalu Andres
- Michie Patricia T
- Milani Lili
- Milanova Vihra
- Mller-Myhsok Bertram
- Mokrab Younes
- Moran Jennifer L
- Morris Derek W
- Mors Ole
- Mortensen Preben B
- Mortensen Preben B
- Mowry Bryan J
- Muller-Myhsok Bertram
- Muranen Taru A
- Murphy Kieran C
- Murray Robin M
- Myin-Germeys Inez
- Neale Benjamin
- Neale Benjamin M
- Nelis Mari
- Nenadic Igor
- Nertney Deborah A
- Nestadt Gerald
- Nevanlinna Heli
- Nicodemus Kristin K
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nordin Annelie
- Nthen Markus M
- O'Callaghan Eadbhard
- O'Donovan Michael C
- O'Dushlaine Colm
- O'Neill F Anthony
- Oh Sang-Yun
- Olincy Ann
- Olsen Line
- Ophoff Roel A
- Owen Michael J
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N
- Papiol Sergi
- Parkhomenko Elena
- Pasaniuc Bogdan
- Pato Carlos
- Pato Carlos N
- Pato Michele
- Pato Michele T
- Patsopoulos Nikolaos A
- Patterson Nick
- Paunio Tiina
- Peeters Petra H
- Pejovic-Milovancevic Milica
- Perkins Diana O
- Pers Tune H
- Peto Julian
- Petryshen Tracey L
- Pietilinen Olli
- Pimm Jonathan
- Pocklington Andrew J
- Posthuma Danielle
- Powell John
- Prentice Ross L
- Price Alkes
- Price Alkes L
- Pulver Ann E
- Purcell Shaun
- Purcell Shaun M
- Quested Digby
- Rahman Nazneen
- Rasmussen Henrik B
- Reichenberg Abraham
- Reimers Mark A
- Richards Alexander L
- Rietschel Marcella
- Riley Brien P
- Ripke Stephan
- Ripke Stephan
- Roffman Joshua L
- Roussos Panos
- Ruderfer Douglas M
- Rujescu Dan
- Salomaa Veikko
- Sanchez Maria Jose
- Sanders Alan R
- Schall Ulrich
- Schierup Mikkel H
- Schmidt Daniel F
- Schmutzler Rita K
- Schubert Christian R
- Schulze Thomas G
- Schwab Sibylle G
- Scolnick Edward M
- Scott Rodney J
- Sderman Erik
- Seidman Larry J
- Sham Pak C
- Shi Jianxin
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silva Isabel dos Santos
- Silverman Jeremy M
- Sim Kang
- Sklar Pamela
- Slominsky Petr
- Smoller Jordan W
- So Hon-Cheong
- Southey Melissa C
- Spencer Chris C A
- Stahl Eli
- Stahl Eli A
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Stogmann Elisabeth
- Straub Richard E
- Strengman Eric
- Strohmaier Jana
- Stroup T Scott
- St Clair David
- Subramaniam Mythily
- Sullivan Patrick F
- Suvisaari Jaana
- Svrakic Dragan M
- Szatkiewicz Jin P
- Tamimi Rulla
- Tamimi Rulla
- Thirumalai Srinivas
- Toncheva Draga
- Tooney Paul A
- Tosato Sarah
- Travis Ruth
- Turnbull Clare
- Uitterlinden Andre G
- van der Luijt Rob B
- Van Os Jim
- Veijola Juha
- Vilhjalmsson Bjarni J
- Visscher Peter M
- Visscher Peter M
- Waddington John
- Waisfisz Quinten
- Walsh Dermot
- Walters James T R
- Wang Dai
- Wang Qiang
- Wang Zhaoming
- Webb Bradley T
- Weinberger Daniel R
- Weiser Mark
- Wendland Jens R
- Werge Thomas
- Whittemore Alice S
- Wildenauer Dieter B
- Williams Nigel M
- Williams Stephanie
- Witt Stephanie H
- Wolen Aaron R
- Won Hong-Hee
- Wong Emily H M
- Wormley Brandon K
- Wray Naomi R
- Wu Jing Qin
- Xi Hualin Simon
- Yang Jian
- Yang Rose
- Zai Clement C
- Zaitlen Noah
- Zheng Wei
- Zheng Xuebin
- Zimprich Fritz
- Publication venue
- Cell Press
- Publication date
- 30/10/2017
- Field of study
Polygenic risk scores have shown great promise in predicting complex disease risk and will become more accurate as training sample sizes increase. The standard approach for calculating risk scores involves linkage disequilibrium (LD)-based marker pruning and applying a p value threshold to association statistics, but this discards information and can reduce predictive accuracy. We introduce LDpred, a method that infers the posterior mean effect size of each marker by using a prior on effect sizes and LD information from an external reference panel. Theory and simulations show that LDpred outperforms the approach of pruning followed by thresholding, particularly at large sample sizes. Accordingly, predicted R2 increased from 20.1% to 25.3% in a large schizophrenia dataset and from 9.8% to 12.0% in a large multiple sclerosis dataset. A similar relative improvement in accuracy was observed for three additional large disease datasets and for non-European schizophrenia samples. The advantage of LDpred over existing methods will grow as sample sizes increase
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
- Author
- Adank Muriel
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Ahsan Habibul
- Aittomäki Kristiina
- Albus Margot
- Alexander Madeline
- Amin Farooq
- Andreassen Ole A.
- Bacanu Silviu A.
- Baglietto Laura
- Begemann Martin
- Belbin Gillian
- Belliveau Richard A.
- Bene Judit
- Bergen Sarah E.
- Berndt Sonja
- Bevilacqua Elizabeth
- Bhatia Gaurav
- Bigdeli Tim B.
- Black Donald W.
- Blackwood Douglas H.R.
- Blomquist Carl
- Bramon Elvira
- Bruggeman Richard
- Buccola Nancy G.
- Buckner Randy L.
- Bulik-Sullivan Brendan
- Buxbaum Joseph D.
- Byerley William
- Børglum Anders D.
- Cahn Wiepke
- Cai Guiqing
- Campion Dominique
- Cantor Rita M.
- Canzian Federico
- Carr Vaughan J.
- Carrera Noa
- Catts Stanley V.
- Chambert Kimberly D.
- Chan Raymond C.K.
- Chang-Claude Jenny
- Chanock Stephen J.
- Chasman Daniel
- Chen Eric Y.H.
- Chen Ronald Y.L.
- Cheng Wei
- Cheung Eric F.C.
- Chong Siow Ann
- Cichon Sven
- Cloninger C. Robert
- Cohen David
- Cohen Nadine
- Collier David A.
- Cormican Paul
- Corvin Aiden
- Craddock Nick
- Crisponi Laura
- Crowley James J.
- Curtis David
- Czene Kamila
- Dahmen Norbert
- Daly Mark
- Daly Mark J.
- Darvasi Ariel
- David St. Clair
- Davidson Michael
- Davis Kenneth L.
- De Haan Lieuwe
- De Jager Philip
- Degenhardt Franziska
- Del Favero Jurgen
- Delisi Lynn E.
- Demontis Ditte
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Do Ron
- Domenici Enrico
- Donohoe Gary
- Dos Santos Silva Isabel
- Drapeau Elodie
- Duan Jubao
- Dudbridge Frank
- Durmishi Naser
- Easton Douglas
- Ehrenreich Hannelore
- Eichhammer Peter
- Eliassen A. Heather
- Eriksson Johan
- Escott-Price Valentina
- Esko Tonu
- Essioux Laurent
- Fanous Ayman H.
- Farh Kai-How
- Farrell Martilias S.
- Figueroa Jonine
- Finucane Hilary K.
- Fletcher Olivia
- Frank Josef
- Franke Lude
- Freedman Robert
- Freimer Nelson B.
- Friedl Marion
- Friedman Joseph I.
- Fromer Menachem
- Garcia-Closas Montserrat
- Gaudet Mia M.
- Gejman Pablo V.
- Genovese Giulio
- Genovese Giulio
- Georgieva Lyudmila
- Gershon Elliot S.
- Gibson Lorna
- Giegling Ina
- Gill Michael
- Giusti-Rodrguez Paola
- Godard Stephanie
- Goddard Michael
- Goldstein Jacqueline I.
- Golimbet Vera
- Gopal Srihari
- Gratten Jacob
- Grove Jakob
- Gurling Hugh
- Gusev Alexander
- Haiman Christopher A.
- Hall Per
- Hammer Christian
- Hamshere Marian L.
- Hansen Mark
- Hansen Thomas
- Haroutunian Vahram
- Hartmann Annette M.
- Hayeck Tristan
- Hazra Aditi
- Hein Rebecca
- Henderson Brian E.
- Henskens Frans A.
- Herms Stefan
- Hirschhorn Joel N.
- Hoffmann Per
- Hofman Albert
- Hofman Andrea
- Hollegaard Mads V.
- Holmans Peter A.
- Hopper John L.
- Hougaard David M.
- Huang Hailiang
- Hultman Christina M.
- Hunter David J.
- Ikeda Masashi
- Irwanto Astrid
- Iwata Nakao
- Jablensky Assen V.
- Joa Inge
- Johansson Mattias
- Jonsson Erik G.
- Julia Antonio
- Kaaks Rudolf
- Kahler Anna K.
- Kahn Rene S.
- Kalaydjieva Luba
- Karachanak-Yankova Sena
- Karjalainen Juha
- Kathiresan Sekar
- Kavanagh David
- Keller Matthew C.
- Kelly Brian J.
- Kendler Kenneth S.
- Kennedy James L.
- Kenny Eimear E.
- Keong Jimmy Lee Chee
- Khrunin Andrey
- Kibriya Muhammad G.
- Kim Yunjung
- Kirov George
- Klovins Janis
- Knight Jo
- Knowles James A.
- Konte Bettina
- Kraft Peter
- Kraft Peter
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kuzelova-Ptackova Hana
- Laurent Claudine
- Lee Phil
- Lee S. Hong
- Legge Sophie E.
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F.
- Li Miaoxin
- Li Qingqin S.
- Li Tao
- Liang Kung-Yee
- Lichtner Peter
- Lieberman Jeffrey
- Limborska Svetlana
- Lindström Sara
- Lindström Sara
- Liu Jianjun
- Liu Jianjun
- Lnnqvist Jouko
- Loh Po-Ru
- Loughland Carmel M.
- Lubinski Jan
- Lund Eiliv
- Macek Milan
- Magnusson Patrik K.E.
- Maher Brion S.
- Maier Wolfgang
- Makalic Enes
- Malhotra Anil K.
- Mallet Jacques
- Marsal Sara
- Mattheisen Manuel
- Mattingsdal Morten
- Mccarley Robert W.
- Mccarroll Steve
- Mccarroll Steven A.
- Mcdonald Colm
- Mcintosh Andrew M.
- Mcquillin Andrew
- Meier Sandra
- Meijer Carin J.
- Meijers-Heijboer Hanne
- Meindl Alfons
- Melegh Bela
- Melle Ingrid
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Michie Patricia T.
- Milani Lili
- Milanova Vihra
- Mller-Myhsok Bertram
- Mokrab Younes
- Moran Jennifer L.
- Morris Derek W.
- Mors Ole
- Mortensen Preben B.
- Mortensen Preben B.
- Mowry Bryan J.
- Muranen Taru A.
- Murphy Kieran C.
- Murray Robin M.
- Myin-Germeys Inez
- Müller-Myhsok Bertram
- Neale Benjamin
- Neale Benjamin M.
- Nelis Mari
- Nenadic Igor
- Nertney Deborah A.
- Nestadt Gerald
- Nevanlinna Heli
- Nicodemus Kristin K.
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nordin Annelie
- Nthen Markus M.
- O'Callaghan Eadbhard
- O'Donovan Michael C.
- O'Dushlaine Colm
- O'Neill F. Anthony
- Oh Sang-Yun
- Olincy Ann
- Olsen Line
- Ophoff Roel A.
- Owen Michael J.
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N.
- Papiol Sergi
- Parkhomenko Elena
- Pasaniuc Bogdan
- Pato Carlos
- Pato Carlos N.
- Pato Michele
- Pato Michele T.
- Patsopoulos Nikolaos A.
- Patterson Nick
- Paunio Tiina
- Peeters Petra H.
- Pejovic-Milovancevic Milica
- Perkins Diana O.
- Pers Tune H.
- Peto Julian
- Petryshen Tracey L.
- Pietilinen Olli
- Pimm Jonathan
- Pocklington Andrew J.
- Posthuma Danielle
- Powell John
- Prentice Ross L.
- Price Alkes
- Price Alkes L.
- Pulver Ann E.
- Purcell Shaun
- Purcell Shaun M.
- Quested Digby
- Rahman Nazneen
- Rasmussen Henrik B.
- Reichenberg Abraham
- Reimers Mark A.
- Richards Alexander L.
- Rietschel Marcella
- Riley Brien P.
- Ripke Stephan
- Ripke Stephan
- Roffman Joshua L.
- Roussos Panos
- Ruderfer Douglas M.
- Rujescu Dan
- Salomaa Veikko
- Sanders Alan R.
- Schall Ulrich
- Schierup Mikkel H.
- Schmidt Daniel F.
- Schmutzler Rita K.
- Schubert Christian R.
- Schulze Thomas G.
- Schwab Sibylle G.
- Scolnick Edward M.
- Scott Rodney J.
- Sderman Erik
- Seidman Larry J.
- Sham Pak C.
- Shi Jianxin
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silverman Jeremy M.
- Sim Kang
- Sklar Pamela
- Slominsky Petr
- Smoller Jordan W.
- So Hon-Cheong
- Southey Melissa C.
- Spencer Chris C.A.
- Stahl Eli
- Stahl Eli A.
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Stogmann Elisabeth
- Straub Richard E.
- Strengman Eric
- Strohmaier Jana
- Stroup T. Scott
- Subramaniam Mythily
- Sullivan Patrick F.
- Suvisaari Jaana
- Svrakic Dragan M.
- Szatkiewicz Jin P.
- Sánchez María José
- Tamimi Rulla
- Tamimi Rulla
- Thirumalai Srinivas
- Toncheva Draga
- Tooney Paul A.
- Tosato Sarah
- Travis Ruth
- Turnbull Clare
- Uitterlinden Andre G.
- Van Der Luijt Rob B.
- Van Os Jim
- Veijola Juha
- Vilhjálmsson Bjarni J.
- Visscher Peter M.
- Visscher Peter M.
- Waddington John
- Waisfisz Quinten
- Walsh Dermot
- Walters James T.R.
- Wang Dai
- Wang Qiang
- Wang Zhaoming
- Webb Bradley T.
- Weinberger Daniel R.
- Weiser Mark
- Wendland Jens R.
- Werge Thomas
- Whittemore Alice S.
- Wildenauer Dieter B.
- Williams Nigel M.
- Williams Stephanie
- Witt Stephanie H.
- Wolen Aaron R.
- Won Hong-Hee
- Wong Emily H.M.
- Wormley Brandon K.
- Wray Naomi R.
- Wu Jing Qin
- Xi Hualin Simon
- Yang Jian
- Yang Rose
- Zai Clement C.
- Zaitlen Noah
- Zheng Wei
- Zheng Xuebin
- Zimprich Fritz
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Polygenic risk scores have shown great promise in predicting complex disease risk and will become more accurate as training sample sizes increase. The standard approach for calculating risk scores involves linkage disequilibrium (LD)-based marker pruning and applying a p value threshold to association statistics, but this discards information and can reduce predictive accuracy. We introduce LDpred, a method that infers the posterior mean effect size of each marker by using a prior on effect sizes and LD information from an external reference panel. Theory and simulations show that LDpred outperforms the approach of pruning followed by thresholding, particularly at large sample sizes. Accordingly, predicted R2 increased from 20.1% to 25.3% in a large schizophrenia dataset and from 9.8% to 12.0% in a large multiple sclerosis dataset. A similar relative improvement in accuracy was observed for three additional large disease datasets and for non-European schizophrenia samples. The advantage of LDpred over existing methods will grow as sample sizes increase
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
- Author
- A. Heather Eliassen
- Aarno Palotie
- Aaron R. Wolen
- Abraham
- Abraham Reichenberg
- Aditi Hazra
- Aiden Corvin
- Alan R. Sanders
- Albert Hofman
- Alexander Gusev
- Alexander L. Richards
- Alfons Meindl
- Alice S. Whittemore
- Alkes L. Price
- Alkes Price
- Anders D. Børglum
- Andre G. Uitterlinden
- Andrea Hofman
- Andres Metspalu
- Andrew McQuillin
- Andrew J. Pocklington
- Andrew M. McIntosh
- Andrey Khrunin
- Anil K. Malhotra
- Ann Olincy
- Anna K. Kahler
- Annelie Nordin
- Annette M. Hartmann
- Ann E. Pulver
- Antonio Julia
- Ariel Darvasi
- Assen V. Jablensky
- Astrid Irwanto
- Ayman H. Fanous
- Bela Melegh
- Benjamin Neale
- Benjamin M. Neale
- Bernard Lerer
- Bertram Mller-Myhsok
- Bertram Müller-Myhsok
- Bettina Konte
- Bjarni J. Vilhjálmsson
- Bogdan Pasaniuc
- Bradley T. Webb
- Brandon K. Wormley
- Brendan Bulik-Sullivan
- Brian E. Henderson
- Brian J. Kelly
- Brien P. Riley
- Brion S. Maher
- Bryan J. Mowry
- Bulik-Sullivan
- Bush
- C. Robert Cloninger
- Carbonetto
- Carin J. Meijer
- Carl Blomquist
- Carlos Pato
- Carlos N. Pato
- Carmel M. Loughland
- Chatterjee
- Chen
- Christian Hammer
- Christian R. Schubert
- Christina M. Hultman
- Christopher A. Haiman
- Christos Pantelis
- Chris C.A. Spencer
- Clare Turnbull
- Claudine Laurent
- Clement C. Zai
- Colm McDonald
- Colm O’Dushlaine
- Daetwyler
- Dai Wang
- Dan Rujescu
- Daniel Chasman
- Daniel F. Schmidt
- Danielle Posthuma
- Daniel R. Weinberger
- David Cohen
- David Curtis
- David J. Hunter
- David Kavanagh
- David St. Clair
- David A. Collier
- David M. Hougaard
- de los Campos
- Deborah A. Nertney
- Deloukas
- Derek W. Morris
- Dermot Walsh
- Diana O. Perkins
- Dieter B. Wildenauer
- Digby Quested
- Dimitris Dikeos
- Ditte Demontis
- Dominique Campion
- Donald W. Black
- Douglas Easton
- Douglas F. Levinson
- Douglas H.R. Blackwood
- Douglas M. Ruderfer
- Draga Toncheva
- Dragan M. Svrakic
- Dudbridge
- Eadbhard O’Callaghan
- Edward M. Scolnick
- Eiliv Lund
- Eimear E. Kenny
- Elena Parkhomenko
- Eli Stahl
- Elisabeth Stogmann
- Elizabeth Bevilacqua
- Eli A. Stahl
- Elliot S. Gershon
- Elodie Drapeau
- Elvira Bramon
- Emily H.M. Wong
- Enes Makalic
- Engilbert Sigurdsson
- Enrico Domenici
- Erbe
- Eric Strengman
- Eric F.C. Cheung
- Eric Y.H. Chen
- Erik Sderman
- Erik G. Jonsson
- Esben Agerbo
- Evans
- F. Anthony O’Neill
- Farooq Amin
- Federico Canzian
- Finucane
- Fisher
- Frank Dudbridge
- Frans A. Henskens
- Franziska Degenhardt
- Fritz Zimprich
- Garcia-Closas
- Gary Donohoe
- Gaurav Bhatia
- George Kirov
- George N. Papadimitriou
- Gerald Nestadt
- Ghoussaini
- Gillian Belbin
- Giulio Genovese
- Giulio Genovese
- Goddard
- Goddard
- Golan
- Grimmett
- Guiqing Cai
- Gusev
- Habibul Ahsan
- Hageman
- Hailiang Huang
- Hana Kuzelova-Ptackova
- Hanne Meijers-Heijboer
- Hannelore Ehrenreich
- Hastie
- Heli Nevanlinna
- Henrik B. Rasmussen
- Hilary K. Finucane
- Hon-Cheong So
- Hong-Hee Won
- Hreinn Stefansson
- Hualin Simon Xi
- Hugh Gurling
- Hunter
- Igor Nenadic
- Ina Giegling
- Inez Myin-Germeys
- Inge Joa
- Ingrid Agartz
- Ingrid Melle
- Isabel dos Santos Silva
- Jaana Suvisaari
- Jacob Gratten
- Jacqueline I. Goldstein
- Jacques Mallet
- Jakob Grove
- James A. Knowles
- James J. Crowley
- James L. Kennedy
- James T.R. Walters
- Jan Lubinski
- Jana Strohmaier
- Janis Klovins
- Jeffrey Lieberman
- Jennifer L. Moran
- Jenny Chang-Claude
- Jens R. Wendland
- Jeremy M. Silverman
- Jian Yang
- Jianjun Liu
- Jianjun Liu
- Jianxin Shi
- Jim Van Os
- Jimmy Lee Chee Keong
- Jing Qin Wu
- Jin P. Szatkiewicz
- Jo Knight
- Joel N. Hirschhorn
- Johan Eriksson
- John L. Hopper
- John Powell
- John Waddington
- Jonathan Pimm
- Jonine Figueroa
- Jordan W. Smoller
- Josef Frank
- Joseph D. Buxbaum
- Joseph I. Friedman
- Joshua L. Roffman
- Jouko Lnnqvist
- Jubao Duan
- Judit Bene
- Juha Karjalainen
- Juha Veijola
- Julian Peto
- Jurgen Del Favero
- Kai-How Farh
- Kamila Czene
- Kang Sim
- Kari Stefansson
- Kenneth L. Davis
- Kenneth S. Kendler
- Kieran C. Murphy
- Kimberly D. Chambert
- Kristiina Aittomäki
- Kristin K. Nicodemus
- Kung-Yee Liang
- Lango Allen
- Larry J. Seidman
- Laura Baglietto
- Laura Crisponi
- Laura Nisenbaum
- Laurent Essioux
- Lee
- Lee
- Legarra
- Liene Nikitina-Zake
- Lieuwe de Haan
- Lili Milani
- Line Olsen
- Liu
- Logsdon
- Loh
- Lorna Gibson
- Luba Kalaydjieva
- Lude Franke
- Lynn E. DeLisi
- Lyudmila Georgieva
- Machiela
- Madeline Alexander
- Mads V. Hollegaard
- Maier
- Manuel Mattheisen
- Marcella Rietschel
- Margot Albus
- Mari Nelis
- Marian L. Hamshere
- Marion Friedl
- Mark Daly
- Mark Hansen
- Mark Weiser
- Markus M. Nthen
- Mark A. Reimers
- Mark J. Daly
- Martilias S. Farrell
- Martin Begemann
- María José Sánchez
- Masashi Ikeda
- Matthew C. Keller
- Mattias Johansson
- Melissa C. Southey
- Menachem Fromer
- Meuwissen
- Mia M. Gaudet
- Miaoxin Li
- Michael Davidson
- Michael Gill
- Michael Goddard
- Michael C. O’Donovan
- Michael J. Owen
- Michailidou
- Michele Pato
- Michele T. Pato
- Mikkel H. Schierup
- Milan Macek
- Milica Pejovic-Milovancevic
- Montserrat Garcia-Closas
- Morris
- Morten Mattingsdal
- Moser
- Muhammad G. Kibriya
- Muriel Adank
- Mythily Subramaniam
- Nadine Cohen
- Nakao Iwata
- Nancy G. Buccola
- Naomi R. Wray
- Naser Durmishi
- Nazneen Rahman
- Nelson B. Freimer
- Nick Craddock
- Nick Patterson
- Nigel M. Williams
- Nikolaos A. Patsopoulos
- Noa Carrera
- Noah Zaitlen
- Norbert Dahmen
- Ole Mors
- Ole A. Andreassen
- Olivia Fletcher
- Olli Pietilinen
- Pablo V. Gejman
- Pak C. Sham
- Pamela Sklar
- Panos Roussos
- Paola Giusti-Rodrguez
- Patricia T. Michie
- Patrick F. Sullivan
- Patrik K.E. Magnusson
- Patsopoulos
- Paul Cormican
- Paul A. Tooney
- Per Hall
- Per Hoffmann
- Peter Eichhammer
- Peter Kraft
- Peter Kraft
- Peter Lichtner
- Peter M. Visscher
- Peter A. Holmans
- Peter M. Visscher
- Petr Slominsky
- Petra H. Peeters
- Pharoah
- Phil Lee
- Philip De Jager
- Pirinen
- Plenge
- Po-Ru Loh
- Preben B. Mortensen
- Preben B. Mortensen
- Purcell
- Qiang Wang
- Qingqin S. Li
- Quinten Waisfisz
- Randy L. Buckner
- Raquelle I. Mesholam-Gately
- Raymond C.K. Chan
- Rebecca Hein
- Rene S. Kahn
- Richard Bruggeman
- Richard A. Belliveau
- Richard E. Straub
- Ridker
- Rietveld
- Ripke
- Rita K. Schmutzler
- Rita M. Cantor
- Rob B. van der Luijt
- Robert Freedman
- Robert W. McCarley
- Robin M. Murray
- Rodney J. Scott
- Roel A. Ophoff
- Rolf Adolfsson
- Ron Do
- Ronald Y.L. Chen
- Rose Yang
- Ross L. Prentice
- Ruderfer
- Rudolf Kaaks
- Rulla Tamimi
- Rulla Tamimi
- Ruth Travis
- S. Hong Lee
- Sandra Meier
- Sang-Yun Oh
- Sara Lindström
- Sara Lindström
- Sara Marsal
- Sarah Tosato
- Sarah E. Bergen
- Sawcer
- Schunkert
- Sekar Kathiresan
- Sena Karachanak-Yankova
- Sergi Papiol
- Shaun Purcell
- Shaun M. Purcell
- Sibylle G. Schwab
- Siddiq
- Silviu A. Bacanu
- Siow Ann Chong
- Solovieff
- Sonja Berndt
- Sophie E. Legge
- Speed
- Speliotes
- Srdjan Djurovic
- Srihari Gopal
- Srinivas Thirumalai
- Stacy Steinberg
- Stahl
- Stanley V. Catts
- Stefan Herms
- Stephan Ripke
- Stephan Ripke
- Stephanie Godard
- Stephanie Williams
- Stephanie H. Witt
- Stephen J. Chanock
- Steve McCarroll
- Steven A. McCarroll
- Sven Cichon
- Svetlana Limborska
- T. Scott Stroup
- Tao Li
- Taru A. Muranen
- Teimuraz Silagadze
- Thomas Hansen
- Thomas Werge
- Thomas G. Schulze
- Tibshirani
- Tiina Paunio
- Timothy Dinan
- Tim B. Bigdeli
- Todd Lencz
- Tonu Esko
- Tracey L. Petryshen
- Tristan Hayeck
- Tune H. Pers
- Ulrich Schall
- Vahram Haroutunian
- Vaidutis Kucinskas
- Valentina Escott-Price
- Vaughan J. Carr
- Veikko Salomaa
- Vera Golimbet
- Vihra Milanova
- Visscher
- Wei
- Wei Cheng
- Wei Zheng
- Wiepke Cahn
- William Byerley
- Wolfgang Maier
- Wood
- Wray
- Wray
- Xuebin Zheng
- Yang
- Yang
- Younes Mokrab
- Yunjung Kim
- Zhaoming Wang
- Zhou
- Zita Ausrele Kucinskiene
- Publication venue
- 'Elsevier BV'
- Publication date
- 04/03/2015
- Field of study
Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases
- Author
- Aarno Palotie
- Aaron R. Wolen
- Abecasis
- Abraham Reichenberg
- Adzhubei
- Aiden Corvin
- Alan R. Sanders
- Alexander Gusev
- Alexander L. Richards
- Alkes L. Price
- Alkes Price
- Anders D. Brglum
- Anders D. Børglum
- Andrea Hofman
- Andres Metspalu
- Andrew McQuillin
- Andrew J. Pocklington
- Andrew M. McIntosh
- Andrey Khrunin
- Anil K. Malhotra
- Ann Olincy
- Anna K. Kähler
- Anna K. Kähler
- Anna K. Kähler
- Annelie Nordin
- Annette M. Hartmann
- Ann E. Pulver
- Antonio Julià
- Ariel Darvasi
- Assen V. Jablensky
- Ayman H. Fanous
- Barrett
- Bela Melegh
- Benjamin M. Neale
- Benjamin M. Neale
- Benjamin M. Neale
- Bernard Lerer
- Bernstein
- Bernstein
- Bertram Mller-Myhsok
- Bettina Konte
- Bjarni J. Vilhjálmsson
- Bogdan Pasaniuc
- Bradley T. Webb
- Brandon K. Wormley
- Brendan Bulik-Sullivan
- Brendan Bulik-Sullivan
- Brian J. Kelly
- Brien P. Riley
- Brion S. Maher
- Bryan J. Mowry
- Bulik-Sullivan
- Busing
- C. Robert Cloninger
- Carbonetto
- Carin J. Meijer
- Carlos N. Pato
- Carmel M. Loughland
- Chongzhi Zang
- Christian Hammer
- Christian R. Schubert
- Christina M. Hultman
- Christina M. Hultman
- Christina M. Hultman
- Christos Pantelis
- Chris C.A. Spencer
- Claudine Laurent
- Clayton
- Clement C. Zai
- Colm McDonald
- Colm O’Dushlaine
- Colm O’Dushlaine
- Dai Wang
- Dan Rujescu
- Danielle Posthuma
- Daniel R. Weinberger
- Darnell
- David Cohen
- David Curtis
- David Kavanagh
- David St. Clair
- David A. Collier
- David M. Hougaard
- Davis
- Deborah A. Nertney
- Degner
- Derek W. Morris
- Dermot Walsh
- Diana O. Perkins
- Dieter B. Wildenauer
- Digby Quested
- Dimitris Dikeos
- Ditte Demontis
- Dominique Campion
- Donald W. Black
- Douglas Ruderfer
- Douglas F. Levinson
- Douglas H.R. Blackwood
- Douglas M. Ruderfer
- Draga Toncheva
- Dragan M. Svrakic
- Eadbhard O’Callaghan
- Edward Scolnick
- Edwards
- Edward M. Scolnick
- Elena Parkhomenko
- Eli Stahl
- Elisabeth Stogmann
- Elizabeth Bevilacqua
- Eli A. Stahl
- Elliot S. Gershon
- Elodie Drapeau
- Elvira Bramon
- Emily H.M. Wong
- Engilbert Sigurdsson
- Enrico Domenici
- Eric Strengman
- Eric F.C. Cheung
- Eric Y.H. Chen
- Erik Sderman
- Erik G. Jönsson
- Ernst
- Esben Agerbo
- Eskin
- F. Anthony O’Neill
- Falconer
- Farooq Amin
- Fischer
- Frank Dudbridge
- Frans A. Henskens
- Franziska Degenhardt
- Fritz Zimprich
- Gaffney
- Gagliano
- Gary Donohoe
- George Kirov
- George N. Papadimitriou
- Gerald Nestadt
- Gibson
- Giulio Genovese
- Gosia Trynka
- Green
- Guiqing Cai
- Gusev
- Hailiang Huang
- Han Xu
- Hana Kuzelova-Ptackova
- Hannelore Ehrenreich
- Haseman
- Hayeck
- Henrik B. Rasmussen
- Hilary Finucane
- Hindorff
- Hoffman
- Hon-Cheong So
- Howie
- Hreinn Stefansson
- Hualin Simon Xi
- Hugh Gurling
- Huyghe
- Igor Nenadic
- Ina Giegling
- Inez Myin-Germeys
- Inge Joa
- Ingrid Agartz
- Ingrid Melle
- Jaana Suvisaari
- Jacob Gratten
- Jacqueline I. Goldstein
- Jacques Mallet
- Jakob Grove
- James A. Knowles
- James J. Crowley
- James L. Kennedy
- James T.R. Walters
- Jan Lubinski
- Jana Strohmaier
- Janis Klovins
- Janss
- Jeffrey Lieberman
- Jennifer L. Moran
- Jennifer L. Moran
- Jens R. Wendland
- Jeremy M. Silverman
- Jianjun Liu
- Jianxin Shi
- Jim Van Os
- Jimmy Lee Chee Keong
- Jing Qin Wu
- Jin P. Szatkiewicz
- Jo Knight
- Joel N. Hirschhorn
- Johan Eriksson
- John Powell
- John Waddington
- Jonathan Pimm
- Jordan W. Smoller
- Josef Frank
- Joseph D. Buxbaum
- Joseph I. Friedman
- Joshua L. Roffman
- Jouko Lnnqvist
- Jubao Duan
- Judit Bene
- Juha Karjalainen
- Juha Veijola
- Jurgen Del Favero
- Kai-How Farh
- Kang Sim
- Karczewski
- Kari Stefansson
- Kellis
- Kenneth L. Davis
- Kenneth S. Kendler
- Kieran C. Murphy
- Kimberly Chambert
- Kimberly D. Chambert
- Kristin K. Nicodemus
- Kung-Yee Liang
- Langmead
- Lappalainen
- Larry J. Seidman
- Laura Nisenbaum
- Laurent Essioux
- Lee
- Lee
- Lee
- Lee
- Lee
- Lee
- Liene Nikitina-Zake
- Lieuwe de Haan
- Lili Milani
- Line Olsen
- Liu
- Liu
- Luba Kalaydjieva
- Lude Franke
- Lynch
- Lynn E. DeLisi
- Lyudmila Georgieva
- Madeline Alexander
- Mads V. Hollegaard
- Maller
- Manuel Mattheisen
- Marcella Rietschel
- Marchini
- Margot Albus
- Mari Nelis
- Marian L. Hamshere
- Marion Friedl
- Mark Daly
- Mark Hansen
- Mark Weiser
- Markus M. Nthen
- Mark A. Reimers
- Mark J. Daly
- Martilias S. Farrell
- Martin Begemann
- Masashi Ikeda
- Matthew C. Keller
- Maurano
- McVicker
- Menachem Fromer
- Miaoxin Li
- Michael Davidson
- Michael Gill
- Michael C. O’Donovan
- Michael J. Owen
- Michele T. Pato
- Milan Macek
- Milica Pejovic-Milovancevic
- Morten Mattingsdal
- Mudge
- Myers
- Mythily Subramaniam
- Nadine Cohen
- Nakao Iwata
- Nakaoka
- Nancy G. Buccola
- Naomi R. Wray
- Naomi R. Wray
- Naser Durmishi
- Nelson B. Freimer
- Neph
- Nick Craddock
- Nicolae
- Nigel M. Williams
- Noa Carrera
- Ole Mors
- Ole A. Andreassen
- Olli Pietilinen
- Pablo V. Gejman
- Pak C. Sham
- Pamela Sklar
- Pamela Sklar
- Panos Roussos
- Paola Giusti-Rodrguez
- Pasaniuc
- Patricia T. Michie
- Patrick F. Sullivan
- Patrick F. Sullivan
- Patrick F. Sullivan
- Patrik K.E. Magnusson
- Patrik K.E. Magnusson
- Paul Cormican
- Paul A. Tooney
- Per Hoffmann
- Peter Eichhammer
- Peter A. Holmans
- Peter M. Visscher
- Petr Slominsky
- Phil Lee
- Pickrell
- Pique-Regi
- Preben B. Mortensen
- Preben B. Mortensen
- Price
- Purcell
- Qiang Wang
- Qingqin S. Li
- Randy L. Buckner
- Raquelle I. Mesholam-Gately
- Raymond C.K. Chan
- René S. Kahn
- Richard Bruggeman
- Richard A. Belliveau
- Richard E. Straub
- Ripke
- Rita M. Cantor
- Robert Freedman
- Robert W. McCarley
- Robin M. Murray
- Rodney J. Scott
- Roel A. Ophoff
- Rolf Adolfsson
- Ronald Y.L. Chen
- S. Hong Lee
- S. Hong Lee
- Sandra Meier
- Sang-Yun Oh
- Sara Marsal
- Sarah Bergen
- Sarah Tosato
- Sarah E. Bergen
- Sawcer
- Schaub
- Schork
- Sena Karachanak-Yankova
- Sergi Papiol
- Shaun M. Purcell
- Shaun Purcell
- Shaun M. Purcell
- Sibylle G. Schwab
- Silviu A. Bacanu
- Siow Ann Chong
- Sophie E. Legge
- Soumya Raychaudhuri
- Speed
- Srdjan Djurovic
- Srihari Gopal
- Srinivas Thirumalai
- Stacy Steinberg
- Stanley V. Catts
- Stefan Herms
- Stephan Ripke
- Stephan Ripke
- Stephan Ripke
- Stephanie Godard
- Stephanie Williams
- Stephanie H. Witt
- Stergachis
- Steve McCarroll
- Steven A. McCarroll
- Steven A. McCarroll
- Sun
- Susanne Akterin
- Sven Cichon
- Svetlana Limborska
- T. Scott Stroup
- Tao Li
- Teimuraz Silagadze
- Thomas Hansen
- Thomas Werge
- Thomas G. Schulze
- Thurman
- Tiina Paunio
- Timothy Dinan
- Tim B. Bigdeli
- Todd Lencz
- Tracey L. Petryshen
- Trynka
- Tune H. Pers
- Tõnu Esko
- Ulrich Schall
- Vahram Haroutunian
- Vaidutis Kucinskas
- Valentina Escott-Price
- Vaughan J. Carr
- Veikko Salomaa
- Vera Golimbet
- Vihra Milanova
- Visscher
- Visscher
- Wakefield
- Ward
- Wei Cheng
- Wiepke Cahn
- William Byerley
- Williams
- Wolfgang Maier
- Wright
- Xuebin Zheng
- Yang
- Yang
- Yang
- Yang
- Younes Mokrab
- Yunjung Kim
- Zhang
- Zhou
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