Distributed storage and cloud computing: a test case

Since 2003 the computing farm hosted by the INFN Tier3 facility in Trieste supports the activities of many scientific communities. Hundreds of jobs from 45 different VOs, including those of the LHC experiments, are processed simultaneously. Given that normally the requirements of the different computational communities are not synchronized, the probability that at any given time the resources owned by one of the participants are not fully utilized is quite high. A balanced compensation should in principle allocate the free resources to other users, but there are limits to this mechanism. In fact, the Trieste site may not hold the amount of data needed to attract enough analysis jobs, and even in that case there could be a lack of bandwidth for their access. The Trieste ALICE and CMS computing groups, in collaboration with other Italian groups, aim to overcome the limitations of existing solutions using two approaches: sharing the data among all the participants taking full advantage of GARR-X wide area networks (10 GB/s) and integrating the resources dedicated to batch analysis with the ones reserved for dynamic interactive analysis, through modern solutions as cloud computing

MEL-28 Is Downstream of the Ran Cycle and Is Required for Nuclear-Envelope Function and Chromatin Maintenance

SummaryEarly embryonic development depends on the faithful execution of basic cell biological processes whose coordination remains largely unknown. With a global network analysis, we found MEL-28 to be associated with two types of complexes, one implicated in nuclear-envelope function and the other in chromatin organization [1]. Here, we show that MEL-28, a protein that shuttles between the nucleus and the kinetochore during the cell cycle, is required for the structural and functional integrity of the nuclear envelope. In addition, mel-28(RNAi) embryos exhibit defects in chromosome condensation, pronuclear migration, kinetochore assembly, and spindle assembly. This combination of mel-28(RNAi) phenotypes resemble those caused by depleting members of the Ran cycle in C. elegans[2], a conserved cellular signaling pathway that is required for mitotic spindle assembly, nuclear-envelope reformation after mitosis, and nucleocytoplasmic exchange (reviewed in [3–8]). Although MEL-28 localization to the nuclear periphery is not dependent on nuclear pore components, it is dependent on RAN-1 and other key components of the Ran cycle. Thus, MEL-28 is downstream of the Ran cycle and is required for both proper nuclear-envelope function and chromatin maintenance

Music for Piano and Electronics: Jeri-Mae G. Astolfi

Kemp Recital HallJanuary 24, 2013Thursday Evening8:00 p.m

Critical Current Oscillations in Strong Ferromagnetic Pi-Junctions

We report magnetic and electrical measurements of Nb Josephson junctions with strongly ferromagnetic barriers of Co, Ni and Ni80Fe20 (Py). All these materials show multiple oscillations of critical current with barrier thickness implying repeated 0-pi phase-transitions in the superconducting order parameter. We show in particular that the Co barrier devices can be accurately modelled using existing clean limit theories and so that, despite the high exchange energy (309 meV), the large IcRN value in the pi-state means Co barriers are ideally suited to the practical development of superconducting pi-shift devices.Comment: 4 pages 3 figures 1 table. Revised version as accepted for publication. To appear in Physical Review Letter

Graduate Joint Recital: Daniel G. Castillon III, Horn; Zhiyuan Gao, Horn; Grace Eom, Piano; Valen Pao, Piano; October 31, 2022

Kemp Recital HallOctober 31, 2022Monday Evening6:30 p.m

How Effective and Safe is Botulinum Toxin Therapy in Cervical Dystonia: The Current Stand

Cervical dystonia (CD) is the most common focal dystonia that is characterized by involuntary contraction of cervical muscles causing abnormal head movements and postures. The treatment for CD was previously limited to oral medications, however, with consequent systemic side effects. In recent years, botulinum toxin (BoNT) has demonstrated efficacy in several studies and thus has received level A recommendation from both the American Academy of Neurology and the European Federation of Neurological Sciences in the treatment of dystonia. In many countries, it is the first‐line treatment for CD. There are four types of toxin approved for the use in CD, three type A [OnabotulinumtoxinA (OnaBoNTA), AbobotulinumtoxinA (AboBoNTA), and Incobotulinumtoxin A (IncoBoNTA)] and one type B [RimabotulinumtoxinB (RimaBoNTB)]. Proper selection of affected muscles and dose of toxin are important parameters in successfully providing symptomatic treatment. Good response rate is defined as improvement of more than 25 % from baseline using the Toronto Western Torticollis Rating Scale. The most common side effect of chemodenervation with BoNT for CD is dysphagia

Senior Recital: Nathaniel J. Parson, Horn; Daniel G. Castillon III, Horn; Grace Eom, Piano; Valen Pao, Piano; November 13, 2022

Kemp Recital HallNovember 13, 2022Sunday Evening5:30 p.m