339 research outputs found
Running a psyching team: Providing mental support at long-distance running events
Psyching teams provide brief psychological support to participants before, during, and after long distance running events such as marathons. Developed and refined over the past 30 years, psyching teams benefit runners themselves, provide mental skills training and hands on experience to team members, and help de-mystify sport psychology. Using one particular model, this article is designed to describe both the content and process of psyching teams and 18 offer information for others’ development of similar volunteer programs
PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL).
B cells provide immunity to extracellular pathogens by secreting a diverse repertoire of antibodies with high affinity and specificity for exposed antigens. The B cell receptor (BCR) is a transmembrane antibody, which facilitates the clonal selection of B cells producing secreted antibodies of the same specificity. The diverse antibody repertoire is generated by V(D)J recombination of heavy and light chain genes, whereas affinity maturation is mediated by activation-induced cytidine deaminase (AID)-mediated mutagenesis. These processes, which are essential for the generation of adaptive humoral immunity, also render B cells susceptible to chromosomal rearrangements and point mutations that in some cases lead to cancer. In this chapter, we will review the central role of PI3K s in mediating signals from the B cell receptor that not only facilitate the development of functional B cell repertoire, but also support the growth and survival of neoplastic B cells, focusing on chronic lymphocytic leukemia (CLL) B cells. Perhaps because of the central role played by PI3K in BCR signaling, B cell leukemia and lymphomas are the first diseases for which a PI3K inhibitor has been approved for clinical use
Searches for Neutrinos from Gamma-Ray Bursts Using the IceCube Neutrino Observatory
Gamma-ray bursts (GRBs) are considered as promising sources of ultra-high-energy cosmic rays (UHECRs) due to their large power output. Observing a neutrino flux from GRBs would offer evidence that GRBs are hadronic accelerators of UHECRs. Previous IceCube analyses, which primarily focused on neutrinos arriving in temporal coincidence with the prompt gamma-rays, found no significant neutrino excess. The four analyses presented in this paper extend the region of interest to 14 days before and after the prompt phase, including generic extended time windows and targeted precursor searches. GRBs were selected between 2011 May and 2018 October to align with the data set of candidate muon-neutrino events observed by IceCube. No evidence of correlation between neutrino events and GRBs was found in these analyses. Limits are set to constrain the contribution of the cosmic GRB population to the diffuse astrophysical neutrino flux observed by IceCube. Prompt neutrino emission from GRBs is limited to ≲1% of the observed diffuse neutrino flux, and emission on timescales up to 104 s is constrained to 24% of the total diffuse flux.Peer Reviewe
Search for Extended Sources of Neutrino Emission in the Galactic Plane with IceCube
The Galactic plane, harboring a diffuse neutrino flux, is a particularly
interesting target to study potential cosmic-ray acceleration sites. Recent
gamma-ray observations by HAWC and LHAASO have presented evidence for multiple
Galactic sources that exhibit a spatially extended morphology and have energy
spectra continuing beyond 100 TeV. A fraction of such emission could be
produced by interactions of accelerated hadronic cosmic rays, resulting in an
excess of high-energy neutrinos clustered near these regions. Using 10 years of
IceCube data comprising track-like events that originate from charged-current
muon neutrino interactions, we perform a dedicated search for extended neutrino
sources in the Galaxy. We find no evidence for time-integrated neutrino
emission from the potential extended sources studied in the Galactic plane. The
most significant location, at 2.6 post-trials, is a 1.7 sized
region coincident with the unidentified TeV gamma-ray source 3HWC J1951+266. We
provide strong constraints on hadronic emission from several regions in the
Galaxy.Comment: 13 pages, 4 figures, 5 tables including an appendix. Accepted for
publication in Astrophysical Journa
Measurement of atmospheric neutrino mixing with improved IceCube DeepCore calibration and data processing
We describe a new data sample of IceCube DeepCore and report on the latest measurement of atmospheric neutrino oscillations obtained with data recorded between 2011–2019. The sample includes significant improvements in data calibration, detector simulation, and data processing, and the analysis benefits from a sophisticated treatment of systematic uncertainties, with significantly greater level of detail since our last study. By measuring the relative fluxes of neutrino flavors as a function of their reconstructed energies and arrival directions we constrain the atmospheric neutrino mixing parameters to be sin2θ23=0.51±0.05 and Δm232=2.41±0.07×10−3 eV2, assuming a normal mass ordering. The errors include both statistical and systematic uncertainties. The resulting 40% reduction in the error of both parameters with respect to our previous result makes this the most precise measurement of oscillation parameters using atmospheric neutrinos. Our results are also compatible and complementary to those obtained using neutrino beams from accelerators, which are obtained at lower neutrino energies and are subject to different sources of uncertainties
Measurement of Atmospheric Neutrino Mixing with Improved IceCube DeepCore Calibration and Data Processing
We describe a new data sample of IceCube DeepCore and report on the latest
measurement of atmospheric neutrino oscillations obtained with data recorded
between 2011-2019. The sample includes significant improvements in data
calibration, detector simulation, and data processing, and the analysis
benefits from a detailed treatment of systematic uncertainties, with
significantly higher level of detail since our last study. By measuring the
relative fluxes of neutrino flavors as a function of their reconstructed
energies and arrival directions we constrain the atmospheric neutrino mixing
parameters to be and , assuming a normal mass ordering. The
resulting 40\% reduction in the error of both parameters with respect to our
previous result makes this the most precise measurement of oscillation
parameters using atmospheric neutrinos. Our results are also compatible and
complementary to those obtained using neutrino beams from accelerators, which
are obtained at lower neutrino energies and are subject to different sources of
uncertainties
A Search for Coincident Neutrino Emission from Fast Radio Bursts with Seven Years of IceCube Cascade Events
This paper presents the results of a search for neutrinos that are spatially
and temporally coincident with 22 unique, non-repeating Fast Radio Bursts
(FRBs) and one repeating FRB (FRB121102). FRBs are a rapidly growing class of
Galactic and extragalactic astrophysical objects that are considered a
potential source of high-energy neutrinos. The IceCube Neutrino Observatory's
previous FRB analyses have solely used track events. This search utilizes seven
years of IceCube's cascade events which are statistically independent of the
track events. This event selection allows probing of a longer range of extended
timescales due to the low background rate. No statistically significant
clustering of neutrinos was observed. Upper limits are set on the
time-integrated neutrino flux emitted by FRBs for a range of extended
time-windows
Search for PeV gamma-ray emission from the southern hemisphere with 5 Yr of data from the IceCube observatory
The measurement of diffuse PeV gamma-ray emission from the Galactic plane would provide information about the energy spectrum and propagation of Galactic cosmic rays, and the detection of a pointlike source of PeV gamma-rays would be strong evidence for a Galactic source capable of accelerating cosmic rays up to at least a few PeV. This paper presents several unbinned maximum-likelihood searches for PeV gamma-rays in the Southern Hemisphere using 5 yr of data from the IceTop air shower surface detector and the in-ice array of the IceCube Observatory. The combination of both detectors takes advantage of the low muon content and deep shower maximum of gamma-ray air showers and provides excellent sensitivity to gamma-rays between similar to 0.6 and 100 PeV. Our measurements of pointlike and diffuse Galactic emission of PeV gamma-rays are consistent with the background, so we constrain the angle-integrated diffuse gamma-ray flux from the Galactic plane at 2 PeV to 2.61 x 10(-19) cm(-2) s(-1) TeV-1 at 90% confidence, assuming an E-3 spectrum, and we estimate 90% upper limits on pointlike emission at 2 PeV between 10(-21) and 10(-20) cm(-2) s(-1) TeV-1 for an E-2 spectrum, depending on decl. Furthermore, we exclude unbroken power-law emission up to 2 PeV for several TeV gamma-ray sources observed by the High Energy Spectroscopic System and calculate upper limits on the energy cutoffs of these sources at 90% confidence. We also find no PeV gamma-rays correlated with neutrinos from IceCube's high-energy starting event sample. These are currently the strongest constraints on PeV gamma-ray emission
Searches for Neutrinos from LHAASO ultra-high-energy {\gamma}-ray sources using the IceCube Neutrino Observatory
Galactic PeVatrons are Galactic sources theorized to accelerate cosmic rays
up to PeV in energy. The accelerated cosmic rays are expected to interact
hadronically with nearby ambient gas or the interstellar medium, resulting in
{\gamma}-rays and neutrinos. Recently, the Large High Altitude Air Shower
Observatory (LHAASO) identified 12 {\gamma}-ray sources with emissions above
100 TeV, making them candidates for PeV cosmic-ray accelerators (PeVatrons).
While at these high energies the Klein-Nishina effect suppresses exponentially
leptonic emission from Galactic sources, evidence for neutrino emission would
unequivocally confirm hadronic acceleration. Here, we present the results of a
search for neutrinos from these {\gamma}-ray sources and stacking searches
testing for excess neutrino emission from all 12 sources as well as their
subcatalogs of supernova remnants and pulsar wind nebulae with 11 years of
track events from the IceCube Neutrino Observatory. No significant emissions
were found. Based on the resulting limits, we place constraints on the fraction
of {\gamma}-ray flux originating from the hadronic processes in the Crab Nebula
and LHAASOJ2226+6057
Limits on Neutrino Emission from GRB 221009A from MeV to PeV using the IceCube Neutrino Observatory
Gamma-ray bursts (GRBs) have long been considered a possible source of
high-energy neutrinos. While no correlations have yet been detected between
high-energy neutrinos and GRBs, the recent observation of GRB 221009A - the
brightest GRB observed by Fermi-GBM to date and the first one to be observed
above an energy of 10 TeV - provides a unique opportunity to test for hadronic
emission. In this paper, we leverage the wide energy range of the IceCube
Neutrino Observatory to search for neutrinos from GRB 221009A. We find no
significant deviation from background expectation across event samples ranging
from MeV to PeV energies, placing stringent upper limits on the neutrino
emission from this source.Comment: Version in ApJ Letters Focus on the Ultra-luminous Gamma-Ray Burst
GRB 221009
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