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In the spring after his 45th birthday, Joseph E. Skip fell in love with the channel six weather lady. Her name was Cathy Robertson and Joe fell in love with her during a delayed broadcast of the ten p.m. news that came on after the late movie. Joe was an avid watcher of late movies, and on the night he fell in love, he had fallen asleep while watching It\u27s a Wonderful Life (it was Jimmy Stewart week)

Detection of a Novel Alphaherpesvirus and Avihepadnavirus in a Plantar Papilloma from a Rainbow Lorikeet (Trichoglosis moluccanus)

Cutaneous plantar papillomas are a relatively common lesion of wild psittacine birds in Australia. Next-generation sequencing technology was used to investigate the potential aetiologic agent(s) for a plantar cutaneous papilloma in a wild rainbow lorikeet (Trichoglosis moluccanus). In the DNA from this lesion, two novel viral sequences were detected. The first was the partial sequence of a herpesvirus with the proposed name, psittacid alphaherpesvirus 6, from the Mardivirus genus of the family alphaherpesviruses. This represents the first mardivirus to be detected in a psittacine bird, the first mardivirus to be detected in a wild bird in Australia, and the second mardivirus to be found in a biopsy of an avian cutaneous papilloma. The second virus sequence was a complete sequence of a hepadnavirus, proposed as parrot hepatitis B genotype H (PHBV-H). PHBV-H is the first hepadnavirus to be detected in a wild psittacine bird in Australia. Whether other similar viruses are circulating in wild birds in Australia and whether either of these viruses play a role in the development of the plantar papilloma will require testing of biopsies from similar lesions and normal skin from other wild psittacine birds

Color-octet scalars at the LHC

Color-octet scalars, if present at the TeV scale, will be produced in abundance at the LHC. We discuss in some detail the phenomenology of scalars in the (8,2)_{1/2} representation, recently identified by Manohar and Wise as an addition to the standard-model Higgs sector consistent with the principle of minimal flavor violation. Couplings of this multiplet to the Higgs lift the mass degeneracy among its states, possibly allowing for two-body decays of a heavier colored scalar to a lighter one and a gauge boson. We perform a renormalization group analysis of these couplings and find that limits from Tevatron searches leave little room for these decays. This fact, and the assumption of minimal flavor violation, lead us to study the case where the octets decay to the heaviest kinematically accessible fermion pairs. Focusing on pair-production events leading to (t t-bar t t-bar), (b b-bar b b-bar), and (b b-bar t t-bar) final states, we find that discovery at the LHC should be possible up to masses exceeding 1 TeV.Comment: 15 pages, 6 figues; corrected typos and added discussion of decays to b b-ba

Genome Sequence of a Beak and Feather Disease Virus from an Unusual Novel Host, Australian Boobook Owl (Ninox boobook)

The beak and feather disease virus (BFDV) is a pathogen of psittacine birds. BFDVs infecting nonpsittacine birds remain largely uncharacterized. We report the genome of a BFDV from a boobook owl (Ninox boobook), a nonpsittacine bird. The genome consisted of 1,993 bp containing two major bidirectionally transcribed open reading frames

Museum material reveals a frog parasite emergence after the invasion of the cane toad in Australia

<p>Abstract</p> <p>Background</p> <p>A parasite morphologically indistinguishable from <it>Myxidium immersum </it>(Myxozoa: Myxosporea) found in gallbladders of the invasive cane toad (<it>Bufo marinus</it>) was identified in Australian frogs. Because no written record exists for such a parasite in Australian endemic frogs in 19^thand early 20^thcentury, it was assumed that the cane toad introduced this parasite. While we cannot go back in time ourselves, we investigated whether material at the museum of natural history could be used to retrieve parasites, and whether they were infected at the time of their collection (specifically prior to and after the cane toad translocation to Australia in 1935).</p> <p>Results</p> <p>Using the herpetological collection at the Australian Museum we showed that no myxospores were found in any animals (<it>n </it>= 115) prior to the cane toad invasion (1879-1935). The green and golden bell frog (<it>Litoria aurea</it>), the Peron's tree frog (<it>Litoria peronii</it>), the green tree frog (<it>Litoria caerulea</it>) and the striped marsh frog (<it>Limnodynastes peronii</it>) were all negative for the presence of the parasite using microscopy of the gallbladder content and its histology. These results were sufficient to conclude that the population was free from this disease (at the expected minimum prevalence of 5%) at 99.7% confidence level using the 115 voucher specimens in the Australian Museum. Similarly, museum specimens (<it>n </it>= 29) of the green and golden bell frog from New Caledonia, where it was introduced in 19^thcentury, did not show the presence of myxospores. The earliest specimen positive for myxospores in a gallbladder was a green tree frog from 1966. Myxospores were found in eight (7.1%, <it>n </it>= 112) frogs in the post cane toad introduction period.</p> <p>Conclusion</p> <p>Australian wildlife is increasingly under threat, and amphibian decline is one of the most dramatic examples. The museum material proved essential to directly support the evidence of parasite emergence in Australian native frogs. This parasite can be considered one of the luckiest parasites, because it has found an empty niche in Australia. It now flourishes in > 20 endemic and exotic frog species, but its consequences are yet to be fully understood.</p

Characterization of a Near-Complete Genome Sequence of a Chaphamaparvovirus from an Australian Boobook Owl (Ninox boobook)

This study reports a complete genome sequence of a variant of psittacine chaphamaparvovirus 2 detected in kidney tissue from an Australian boobook (Ninox boobook), compiled using next-generation sequencing. The genome was 4,312 bp long, encoding four open reading frames. The detection of this variant in boobook represents a significant host-switching event

Aligning Forces for Quality: Engaging Healthcare Consumers Through Social Media: Maine Alliance Case Study

Reviews the planning, activities, outcomes, lessons, and future plans of the social media campaign conducted as part of Maine AF4Q's consumer outreach efforts. Outlines the need for stakeholder buy-in, detailed planning, and dedicated staff and resources

Molecular Characterisation of a Novel and Highly Divergent Passerine Adenovirus 1

Wild birds harbour a large number of adenoviruses that remain uncharacterised with respect to their genomic organisation, diversity, and evolution within complex ecosystems. Here, we present the first complete genome sequence of an atadenovirus from a passerine bird that is tentatively named Passerine adenovirus 1 (PaAdV-1). The PaAdV-1 genome is 39,664 bp in length, which was the longest atadenovirus to be sequenced, to the best of our knowledge, and contained 42 putative genes. Its genome organisation was characteristic of the members of genus Atadenovirus; however, the novel PaAdV-1 genome was highly divergent and showed the highest sequence similarity with psittacine adenovirus-3 (55.58%). Importantly, PaAdV-1 complete genome was deemed to contain 17 predicted novel genes that were not present in any other adenoviruses sequenced to date, with several of these predicted novel genes encoding proteins that harbour transmembrane helices. Subsequent analysis of the novel PaAdV-1 genome positioned phylogenetically to a distinct sub-clade with all others sequenced atadenoviruses and did not show any obvious close evolutionary relationship. This study concluded that the PaAdV-1 complete genome described here is not closely related to any other adenovirus isolated from avian or other natural host species and that it should be considered a separate species

Characterisation of a novel aviadenovirus associated with disease in tawny frogmouths (Podargus strigoides)

Aviadenoviruses are widespread in wild birds but rarely cause disease in nature. However, when naïve species are exposed to poultry or aviaries, aviadenoviruses can lead to disease outbreaks. This study characterised a novel aviadenovirus infection in a native Australian bird, the tawny frogmouth (Podargus strigoides) during an outbreak investigation. The identified complete genome of aviadenovirus, named tawny frogmouth aviadenovirus A (TwAviAdV-A) was 41,175 bp in length containing 52 putative genes. TwAviAdV-A exhibits the common aviadenovirus genomic organisation but with a notable monophyletic subclade in the phylogeny. The TwAviAdV-A virus was hepatotrophic and the six frogmouths presented to the wildlife hospitals in South Eastern Queensland most commonly exhibited regurgitation (in four frogmouths). Three were died or euthanized, two recovered, and one showed no signs. The detection of TwAviAdV-A in frogmouths coming into care re-emphasizes the need for strict biosecurity protocols in wildlife hospitals and care facilities

Pharmacokinetic profile of enrofloxacin and its metabolite ciprofloxacin in Asian house geckos (Hemidactylus frenatus) after single-dose oral administration of enrofloxacin

The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were determined following oral administration in 21 Asian house geckos (Hemidactylus frenatus) at a dose of 10 mg/kg. Changes in enrofloxacin and ciprofloxacin plasma concentrations were quantified at regular intervals over 72 h (1, 2, 6, 12, 24, 48, and 72 h). Samples were analysed by high-pressure liquid chromatography (HPLC) and the enrofloxacin pharmacokinetic data underwent a two-compartment analysis. Due to the limited ciprofloxacin plasma concentrations above the lower limit of quantification (LLOQ), the ciprofloxacin data underwent non-compartment analysis and the half-life was determined by the Lineweaver-Burke plot and analysis. The enrofloxacin and ciprofloxacin mean half-lives (t½) were 0.95 h (α) / 24.36 h (β), and 11.06 h respectively, area under the curve (AUC0-24h) were 60.56 and 3.14 µg/mL*h, respectively, maximum concentrations (Cmax) were 12.31 and 0.24 µg/mL, respectively, and time required to reach the Cmax (Tmax) were 1 and 2 h respectively. Enrofloxacin was minimally converted to the active metabolite ciprofloxacin, with ciprofloxacin concentrations contributing only 4.91% of the total fluoroquinolone concentrations (AUC0-24h). Based on the pharmacokinetic indices when using susceptibility breakpoints when determined at mammalian body temperature it is predicted that single oral administration of enrofloxacin (10 mg/kg) would result in plasma concentrations effective against susceptible bacterial species inhibited by an enrofloxacin MIC ≤ 0.5 µg/mL in vitro, but additional studies will be required to determine its efficacy in vivo