11 research outputs found

    GaAs MESFET Logic

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    Two 2” Gallium Arsenide wafers underwent MBE deposition processing to create two differing epitaxial layer schemes for processing of MESFET devices. ~ four level process was used to fabricate isolated MESFET structures, diodes, resistors, other test structures, and simple logic gates using Buffered FET Logic (BFL). Two ohmic contact schemes were utilized; Aluminum for an as-deposited contact to InGaAs and AuGe as an alloyed contact to Gags. Results were working MESFETs with pinchoff voltages ranging from -lv to -4V, source to drain saturation currents ranging from 7 to 28 mP~, and transconductances up to 22.4 milliSiemens. Schottky C-V and interdigitated diodes had threshold voltages of 0.4 to 0.6 volts. Logic reliability, however, was very low, with few gates functional

    A Roadmap for HEP Software and Computing R&D for the 2020s

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    Particle physics has an ambitious and broad experimental programme for the coming decades. This programme requires large investments in detector hardware, either to build new facilities and experiments, or to upgrade existing ones. Similarly, it requires commensurate investment in the R&D of software to acquire, manage, process, and analyse the shear amounts of data to be recorded. In planning for the HL-LHC in particular, it is critical that all of the collaborating stakeholders agree on the software goals and priorities, and that the efforts complement each other. In this spirit, this white paper describes the R&D activities required to prepare for this software upgrade.Peer reviewe

    ICAROHS - Inter-Comparison of Aerosol Retrievals and Observational Requirements for Multi-wavelength HSRL Systems

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    The ESA-STSE study ICAROHS exploits the potential improvements and benefits of novel multi-wavelength High Spectral Resolution Lidar (HSRL) technology combined with innovative retrieval methods for future satellite missions. Single-wavelength HSRL data from several field studies form the data base for developing improved scientific algorithms for retrievals of aerosol optical properties and of tools for future multi-wavelength spaceborne HSRL instrument assessments. These quality-controlled observational data feed into the existing EarthCARE simulator (ECSIM), which serves as the platform for algorithm development and verification. Light scattering by non-spherical particles is implemented into ECSIM as scattering libraries based on T-matrix calculations. Recommendations for future multi-wavelength HSRL missions are formulated on the basis of a combined retrieval of aerosol properties from the entire available lidar and in-situ data. This retrieval study forms the benchmark for aerosol properties accessible by respective HSRL missions and defines the technical limits for required accuracy and resolution of the lidar input data to the novel algorithms

    Neuroinflammation in Alzheimer's disease

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    Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction. External factors, including systemic inflammation and obesity, are likely to interfere with immunological processes of the brain and further promote disease progression. Modulation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or preventive strategies for Alzheimer's diseas

    Atmospheric radiation: 1975–1983

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    A Roadmap for HEP Software and Computing R&D for the 2020s

    No full text
    Particle physics has an ambitious and broad experimental programme for the coming decades. This programme requires large investments in detector hardware, either to build new facilities and experiments, or to upgrade existing ones. Similarly, it requires commensurate investment in the R&D of software to acquire, manage, process, and analyse the shear amounts of data to be recorded. In planning for the HL-LHC in particular, it is critical that all of the collaborating stakeholders agree on the software goals and priorities, and that the efforts complement each other. In this spirit, this white paper describes the R&D activities required to prepare for this software upgrade
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