Scalable production of graphene inks via wet-jet milling exfoliation for screen-printed micro-supercapacitors

The miniaturization of energy storage units is pivotal for the development of next-generation portable electronic devices. Micro-supercapacitors (MSCs) hold a great potential to work as on-chip micro-power sources and energy storage units complementing batteries and energy harvester systems. The scalable production of supercapacitor materials with cost-effective and high-throughput processing methods is crucial for the widespread application of MSCs. Here, we report wet-jet milling exfoliation of graphite to scale-up the production of graphene as supercapacitor material. The formulation of aqueous/alcohol-based graphene inks allows metal-free, flexible MSCs to be screen-printed. These MSCs exhibit areal capacitance (Careal) values up to 1.324 mF cm-2 (5.296 mF cm-2 for a single electrode), corresponding to an outstanding volumetric capacitance (Cvol) of 0.490 F cm-3 (1.961 F cm-3 for a single electrode). The screen-printed MSCs can operate up to power density above 20 mW cm-2 at energy density of 0.064 uWh cm-2. The devices exhibit excellent cycling stability over charge-discharge cycling (10000 cycles), bending cycling (100 cycles at bending radius of 1 cm) and folding (up to angles of 180{\deg}). Moreover, ethylene vinyl acetate-encapsulated MSCs retain their electrochemical properties after a home-laundry cycle, providing waterproof and washable properties for prospective application in wearable electronics

Proton-driven patterning of bulk transition metal dichalcogenides

At the few-atom-thick limit, transition metal dichalcogenides (TMDs) exhibit a host of attractive electronic optical, and structural properties. The possibility to pattern these properties has a great impact on applied and fundamental research. Here, we demonstrate spatial control over the light emission, lattice deformation, and hydrogen storage in bulk TMDs. By low-energy proton irradiation, we create uniquely favorable conditions for the production and accumulation of molecular hydrogen just one or few monolayers beneath the crystal basal plane of bulk WS2, WSe2, WTe2, MoSe2, and MoS2 samples. H2 therein produced coalesces to form bubbles, which lead to the localized swelling of one X-M-X plane prevalently. This results eventually in the creation of atomically thin domes filled with molecular hydrogen at 10 atm. The domes emit light strongly well above room temperature and can store H2 indefinitely. They can be produced with the desired density, well-ordered positions, and size tunable from the nanometer to the micrometer scale, thus providing a template for the manageable and durable mechanical and electronic structuring of two-dimensional materials

Treatment with 8-OH-modified adenine (TLR7 ligand)-allergen conjugates decreases T helper type 2-oriented murine airway inflammation

A strategy to improve allergen-specific immunotherapy is to employ new adjuvants stably linked to allergens. The study is addressed to evaluate the in vivo and in vitro effects of allergens [natural Dermatophagoides pteronyssinus 2 (nDer p 2) and ovalbumin (OVA)] chemically bound to an 8-OH-modified adenine. Humoral and cellular responses were analysed in allergen-sensitized and challenged mice by using conjugates (Conj) in a therapeutic setting. The in vitro activity of the conjugates on cytokine production induced by bone marrow dendritic cells and the co-culture system was also investigated. The nDer p 2-Conj treatment in nDer p 2-primed and challenged BALB/c mice reduced the numbers of eosinophils in bronchoalveolar lavage fluid and lung, airway allergen-driven interleukin-13 (IL-13) production in lung mononuclear cells and IgE, in comparison with nDer p 2-treated mice. The increase of IgG2a paralleled that of interferon-γ (IFN-γ) and IL-10 in allergen-stimulated spleen cells. Similar effects were elicited by treatment with OVA-Conj in an OVA-driven BALB/c model. The nDer p 2-Conj or OVA-Conj redirected memory T helper type 2 cells towards the production of IL-10 and IFN-γ also in C57BL/6 mice and when subcutaneously administered. Interleukin-10, IL-12 and IL-27 were produced in vitro by Conj-stimulated bone marrow dendritic cells, whereas IL-10 and IFN-γ were up-regulated in co-cultures of CD11c(+) and CD4(+) T cells from Conj-treated mice stimulated with allergen. Cytofluorometric analysis indicated that the Conj expanded IFN-γ- and IL-10- producing memory T cells. The Conj effects on IL-10(−/−) and IL-12(−/−) mice confirmed the role of IL-10 and IFN-γ in inducing a protective and balanced redirection the T helper type 2-mediated airway inflammation

Liquid Phase Exfoliated Indium Selenide Based Highly Sensitive Photodetectors

Layered semiconductors of the IIIA-VIA group have attracted considerable attention in (opto)electronic applications thanks to their atomically thin structures and their thickness-dependent optical and electronic properties, which promise ultrafast response and high sensitivity. In particular, 2D indium selenide (InSe) has emerged as a promising candidate for the realization of thin-film field effect transistors and phototransistors due to its high intrinsic mobility (>10(2) cm(2) V-1 s(-1)) and the direct optical transitions in an energy range suitable for visible and near-infrared light detection. A key requirement for the exploitation of large-scale (opto)electronic applications relies on the development of low-cost and industrially relevant 2D material production processes, such as liquid phase exfoliation, combined with the availability of high-throughput device fabrication methods. Here, a beta polymorph of indium selenide (beta-InSe) is exfoliated in isopropanol and spray-coated InSe-based photodetectors are demonstrated, exhibiting high responsivity to visible light (maximum value of 274 A W-1 under blue excitation 455 nm) and fast response time (15 ms). The devices show a gate-dependent conduction with an n-channel transistor behavior. Overall, this study establishes that liquid phase exfoliated beta-InSe is a valid candidate for printed high-performance photodetectors, which is critical for the development of industrial-scale 2D material-based optoelectronic devices

A sub-analysis of the SAGE study in Italy indicates good glycemic control in type 1 diabetes

use pumps/continuous glucose monitoring and HbA1