Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

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Improving working conditions in an Iranian hospital: a participatory ergonomics approach

Objectives. The future workshop (FW), as a participatory ergonomics approach, is used to change the actual situation of a system into a preferable one. This study was conducted at a major hospital to identify ergonomic problems and provide appropriate solutions for improving working conditions using the FW technique. Methods. Twenty-five mid-level managers of the hospital participated in a 2-day FW. In the critique phase, the ergonomic problems were thoroughly discussed. After brainstorming followed by structuring and grouping of ideas, 75 ergonomic problems were identified and classified into four groups. Solutions and action plans were proposed to improve working conditions. Results. There were nine problems in the personnel-managerial group. Eighteen action plans were proposed to fix them. Stressful occupational factors were the worst problem in this group. Five problems were characterized in the physical space group and 10 action plans were presented. Seven problems were detected in the equipment group, for which 13 action plans were presented. In the welfare group, six problems and 12 action plans were presented. Conclusion. The results revealed that the FW was an appropriate method to find ergonomic bottlenecks in the hospital and a good basis for devising ergonomic interventions

Efficacy of intravenous Dexamethasone in treatment of acute migraine headache: A randomized clinical trial running title

Abstract Introduction: Migraine is characterized by unilateral and pulsatile headache with or without aura. There are various treatments of migraine attack. One of them is intravenous (IV) Corticosteroids which is used in status migrainous. The aim of this study is comparison of the efficacy of I.V Dexamethasone with intramuscular (I.M) Methadone in improvement of migraine attacks. Materials and Methods: This study was a controlled double-blind randomized clinical trial on all patients whom referred to emergency room with diagnosis of migraine attack. The patients were randomized in four groups. Groups I and II received intravenous 8 mg Dexamethasone, while groups III and IV received intramuscular 10 mg Methadone. Thereafter all of them were evaluated after 2, 4 and 6 hours. Results: One-hundred and eighty one patients were evaluated; 107 patients were treated with IV Dexamethasone and 74 patients with IM Methadone. One-hundred and three of 107 patients (96.2%) had complete or significant improvement whereas 63 of 74 patients (85%) whom received IM Methadone had similar improvement (P= 0.01). Conclusion: Our study showed that treatment of acute migraine headache by using intravenous Dexamethasone is more effective than Methadone

HLA-DRA is associated with Parkinson's disease in Iranian population

The rs3129882, a noncoding variant in HLA-DR, was found to be associated with Parkinson's disease (PD) using several genome-wide association studies. The aim of this replication study was to explore the relationship between this variant and PD in Iranian population. Genomic DNA was extracted from peripheral blood samples, and the rs3129882 SNP was genotyped using a PCR-RFLP method in 520 PD patients and 520 healthy Iranian controls. Significant differences were found in allele frequencies between patients and controls (χ2 = 4.64, P = 0.031). Under additive and dominant models, the association of the SNP with PD risk is significant, where the A allele was observed to be protective. The results suggest that rs3129882 polymorphism may be a risk factor for PD in Iranian. This is the first study reporting such an association in this population. More replication studies are needed to confirm this data. © 2014 John Wiley & Sons Ltd

RIT2 Polymorphisms: Is There a Differential Association?

Neurological disorders include a wide variety of mostly multifactorial diseases related to the development, survival, and function of the neuron cells. Single-nucleotide polymorphisms (SNPs) have been extensively studied in neurological disorders, and in a number of instances have been reproducibly linked to disease as risk factors. The RIT2 gene has been recently shown to be associated with a number of neurological disorders, such as Parkinson’s disease (PD) and autism. In the study reported here, we investigated the association of the rs12456492 and rs16976358 SNPs of the RIT2 gene with PD, essential tremor (ET), autism, schizophrenia (SCZ), and bipolar disorder (BPD; total of 2290 patients), and 1000 controls, by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Significant association was observed between rs12456492 and two disorders, PD and ET, whereas rs16976358 was found to be associated with autism, SCZ, and BPD. Our findings are indicative of differential association between the RIT2 SNPs and different neurological disorders. © 2016, Springer Science+Business Media New York