International Multicenter Evaluation of Autoantibodies to Ribosomal P Proteins

Autoantibodies to the ribosomal phosphoproteins (Rib-P) are a serological feature of patients with systemic lupus erythematosus (SLE). The reported prevalence of anti-Rib-P antibodies in SLE ranges from 10 to 40%, being higher in Asian patients. The variation in the observed frequency may be related to a number of factors but is dependent in large part on the test system used to detect the autoantibodies. An association of anti-Rib-P with central nervous system involvement and neuropsychiatric manifestations of SLE has been controversial. In the present international multicenter study, we evaluated the clinical accuracy of a new sensitive Rib-P-specific enzyme-linked immunosorbent assay based on recombinant Rib-P polypeptides. The results showed that 21.3% of 947 SLE patients, but only 0.7% of 1,113 control patients, had a positive test result (P < 0.0001). The sensitivity, specificity, positive and negative predictive values, and diagnostic efficiency were determined to be 21.3%, 99.3%, 95.6%, 62.2%, and 65.3%, respectively. When evaluated in the context of participating centers, the prevalence of anti-Rib-P antibodies was found in descending frequency, as follows: China (35%) > Poland (34%) > Japan (28%) > United States (26%) > Germany (Freiburg; 23.3%) > Denmark (20.5%) > Germany (Berlin; 19%) > Mexico (15.7%) > Israel (11.7%) > Brazil (10%) > Canada (8%). The substantial data from this study indicate that the prevalence of anti-Rib-P antibodies may not be restricted to the genetic background of the patients or to the detection system but may depend on regional practice differences and patient selection. We confirm previously reported associations of antiribosomal antibodies with clinical symptoms and serological findings. Remarkably, we found a lower occurrence of serositis in Rib-P-positive lupus patients

The Council of Trent and the Augsburg \u3cem\u3eInterim\u3c/em\u3e

The Augsburg Interim (“Declaration of His Roman Imperial Majesty on the Observance of Religion within the Holy Empire Until the Decision of the General Council”) was adopted at the 1548 Diet of Augsburg, marking the victory of Emperor Charles V (r. 1516–1556) in the Schmalkaldic War (1546–1547) by attempting to impose a religious reconciliation between followers of Martin Luther and the Catholic Church. Charles, also king of Spain, was beset by problems throughout his European possessions, stemming largely from the Reformation. The Interim was one effort to control these problems. The purpose of the document was to create a temporary compromise, to promote religious and political stability while waiting for a more definitive statement from the Council of Trent (which was in session at the time). The provisional nature did nothing to lessen Protestant fears of attempting to suppress dissent or to dampen concerns on the part of some Catholics that heresy was going unpunished; instead, it hardened divisions. Its failures contributed to a breakdown in Habsburg authority in central Europe

Calvin’s Friends: Farel, Viret, and Beza

John Calvin did not create the French Reformed movement alone. At every step of the way, he was assisted by close friends and allies. Guillaume Farel preceded Calvin and established many of the key doctrines and practices that would come to define Calvinism. Pierre Viret was perhaps Calvin’s closest friend and worked steadily to implement Calvin’s vision of reform first in Lausanne and later in France, while also popularizing Calvinist theology in his many vernacular dialogues. And Theodore Beza emerged as an important theologian in his own right before taking over as Calvin’s successor as head of the Geneva Company of Pastors, from which position he helped to guide the French Reformed churches during the Wars of Religion and to unify the Swiss Reformed churches behind a common theology