Ciprofloxacin/amikacin combination therapy: evaluation in biofilms of Pseudomonas aeruginosa overproducting efflux pumps

International audienc

Caractérisation du système de sécrétion Ess/Type VII (SST7) chez Staphylococcus lugdunensis

International audienc

Impact de la méthodologie CA-SFM/EUCAST 2015 sur l'évaluation de l'activité de l'amoxicilline-acide clavulanique vis-à-vis de souches de Escherichia coli

International audienc

Daptomycine : AMM ou réalité ?

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fbl-typing of Staphylococcus lugdunensis: a frontline tool for epidemiological studies

International audienc

Changes of pulse wave transit time after haemodynamic manoeuvres in healthy adults : a prospective randomised observational trial (PWTT volunteer study)

Background: Pulse wave transit time (PWTT) shows promise for monitoring intravascular fluid status intraoperatively. Presently, it is unknown how PWTT mirrors haemodynamic variables representing preload, inotropy, or afterload. Methods: PWTT was measured continuously in 24 adult volunteers. Stroke volume was assessed by transthoracic echocardiography. Volunteers underwent four randomly assigned manoeuvres: ‘Stand-up’ (decrease in preload), passive leg raise (increase in preload), a ‘step-test’ (adrenergic stimulation), and a ‘Valsalva manoeuvre’ (increase in intrathoracic pressure). Haemodynamic measurements were performed before and 1 and 5 min after completion of each manoeuvre. Correlations between PWTT and stroke volume were analysed using the Pearson correlation coefficient. Results: ‘Stand-up’ caused an immediate increase in PWTT (mean change +55.9 ms, P-value <0.0001, 95% confidence interval 46.0–65.7) along with an increase in mean arterial pressure and heart rate and a drop in stroke volume (P-values <0.0001). Passive leg raise caused an immediate drop in PWTT (mean change −15.4 ms, P-value=0.0024, 95% confidence interval −25.2 to −5.5) along with a decrease in mean arterial pressure (P-value=0.0052) and an increase in stroke volume (P-value=0.001). After 1 min, a ‘step-test’ caused no significant change in PWTT measurements (P-value=0.5716) but an increase in mean arterial pressure and heart rate (P-values <0.0001), without changes in stroke volume (P-value=0.1770). After 5 min, however, PWTT had increased significantly (P-value <0.0001). Measurements after the Valsalva manoeuvre caused heterogeneous results. Conclusion: Noninvasive assessment of PWTT shows promise to register immediate preload changes in healthy adults. The clinical usefulness of PWTT may be hampered by late changes because of reasons different from fluid shifts

Escherichia coli : caractérisation moléculaire de souches de cystites récidivantes

International audienc

Activité de traitements par ciprofloxacine et/ou amikacine, en condition planctonique et en biofilm, vis-à-vis de souches de Pseudomonas aeruginosa surexprimant un efflux.

International audienc