Improved Dynamic Modeling of the Cascade Distillation Subsystem and Analysis of Factors Affecting Its Performance

The Cascade Distillation Subsystem (CDS) is a rotary multistage distiller being developed to serve as the primary processor for wastewater recovery during long-duration space missions. The CDS could be integrated with a system similar to the International Space Station Water Processor Assembly to form a complete water recovery system for future missions. A preliminary chemical process simulation was previously developed using Aspen Custom Modeler (ACM), but it could not simulate thermal startup and lacked detailed analysis of several key internal processes, including heat transfer between stages. This paper describes modifications to the ACM simulation of the CDS that improve its capabilities and the accuracy of its predictions. Notably, the modified version can be used to model thermal startup and predicts the total energy consumption of the CDS. The simulation has been validated for both NaC1 solution and pretreated urine feeds and no longer requires retuning when operating parameters change. The simulation was also used to predict how internal processes and operating conditions of the CDS affect its performance. In particular, it is shown that the coefficient of performance of the thermoelectric heat pump used to provide heating and cooling for the CDS is the largest factor in determining CDS efficiency. Intrastage heat transfer affects CDS performance indirectly through effects on the coefficient of performance

Grand narratives then and now: can we still conceptualise history?

Reading the Communist Manifesto today, it is impossible not to be struck by the confidence with which it conceptualises history. The positive energy of this bold grand narrative stands in such stark contrast to the negative and jaded mentality of our times, which conceives of grand narratives only to tell us that there can be none. Such talk as there is of history today is more likely to be of "the end of history". There are three senses in which references to the end of history feature in contemporary debates: apocalyptic prediction, postmodernist pronouncement and capitalist triumphalism. This paper addresses the crisis of historicity in our time in relation to these positions and asks what is it about our age that produces them. It explores the widespread rejection of grand narratives, as well as grand narratives, which nevertheless persist, implicit and explicit, right and left. It looks at the position of marxism in the 1990s, counterposing it to postmarxism and postmodernism in particular on the question of grand narratives. It calls for resistance to the detotalising pressures of the age and revival of a totalising (as opposed to totalised) philosophy of history

Block Diagonalization using SRG Flow Equations

By choosing appropriate generators for the Similarity Renormalization Group (SRG) flow equations, different patterns of decoupling in a Hamiltonian can be achieved. Sharp and smooth block-diagonal forms of phase-shift equivalent nucleon-nucleon potentials in momentum space are generated as examples and compared to analogous low-momentum interactions ("v_lowk").Comment: 4 pages, 9 figures (pdfLaTeX

Architectural mismatch tolerance

The integrity of complex software systems built from existing components is becoming more dependent on the integrity of the mechanisms used to interconnect these components and, in particular, on the ability of these mechanisms to cope with architectural mismatches that might exist between components. There is a need to detect and handle (i.e. to tolerate) architectural mismatches during runtime because in the majority of practical situations it is impossible to localize and correct all such mismatches during development time. When developing complex software systems, the problem is not only to identify the appropriate components, but also to make sure that these components are interconnected in a way that allows mismatches to be tolerated. The resulting architectural solution should be a system based on the existing components, which are independent in their nature, but are able to interact in well-understood ways. To find such a solution we apply general principles of fault tolerance to dealing with arch itectural mismatche

Quantum phase space picture of Bose-Einstein Condensates in a double well: Proposals for creating macroscopic quantum superposition states and a study of quantum chaos

We present a quantum phase space model of Bose-Einstein condensate (BEC) in a double well potential. In a two-mode Fock-state analysis we examine the eigenvectors and eigenvalues and find that the energy correlation diagram indicates a transition from a delocalized to a fragmented regime. Phase space information is extracted from the stationary quantum states using the Husimi distribution function. It is shown that the quantum states are localized on the known classical phase space orbits of a nonrigid physical pendulum, and thus the novel phase space characteristics of a nonrigid physical pendulum such as the $\pi$ motions are seen to be a property of the exact quantum states. Low lying states are harmonic oscillator like libration states while the higher lying states are Schr\"odinger cat-like superpositions of two pendulum rotor states. To study the dynamics in phase space, a comparison is made between a displaced quantum wavepacket and the trajectories of a swarm of points in classical phase space. For a driven double well, it is shown that the classical chaotic dynamics is manifest in the dynamics of the quantum states pictured using the Husimi distribution. Phase space analogy also suggests that a $\pi$ phase displaced wavepacket put on the unstable fixed point on a separatrix will bifurcate to create a superposition of two pendulum rotor states - a Schr\"odinger cat state (number entangled state) for BEC. It is shown that the choice of initial barrier height and ramping, following a $\pi$ phase imprinting on the condensate, can be used to generate controlled entangled number states with tunable extremity and sharpness.Comment: revised version, 13 pages, 13 figure

Multi-filament structures in relativistic self-focusing

A simple model is derived to prove the multi-filament structure of relativistic self-focusing with ultra-intense lasers. Exact analytical solutions describing the transverse structure of waveguide channels with electron cavitation, for which both the relativistic and ponderomotive nonlinearities are taken into account, are presented.Comment: 21 pages, 12 figures, submitted to Physical Review

Doubling of the bands in overdoped Bi2Sr2CaCu2O8-probable evidence for c-axis bilayer coupling

We present high resolution ARPES data of the bilayer superconductor Bi2Sr2CaCu2O8 (Bi2212) showing a clear doubling of the near EF bands. This splitting approaches zero along the (0,0)-(pi,pi) nodal line and is not observed in single layer Bi2Sr2CuO6 (Bi2201), suggesting that the splitting is due to the long sought after bilayer splitting effect. The splitting has a magnitude of approximately 75 meV near the middle of the zone, extrapolating to about 100 meV near the (pi,0) poin

Site investigation for the effects of vegetation on ground stability

The procedure for geotechnical site investigation is well established but little attention is currently given to investigating the potential of vegetation to assist with ground stability. This paper describes how routine investigation procedures may be adapted to consider the effects of the vegetation. It is recommended that the major part of the vegetation investigation is carried out, at relatively low cost, during the preliminary (desk) study phase of the investigation when there is maximum flexibility to take account of findings in the proposed design and construction. The techniques available for investigation of the effects of vegetation are reviewed and references provided for further consideration. As for general geotechnical investigation work, it is important that a balance of effort is maintained in the vegetation investigation between (a) site characterisation (defining and identifying the existing and proposed vegetation to suit the site and ground conditions), (b) testing (in-situ and laboratory testing of the vegetation and root systems to provide design parameters) and (c) modelling (to analyse the vegetation effects)

Antenatal atazanavir: a retrospective analysis of pregnancies exposed to atazanavir.

INTRODUCTION: There are few data regarding the tolerability, safety, or efficacy of antenatal atazanavir. We report our clinical experience of atazanavir use in pregnancy. METHODS: A retrospective medical records review of atazanavir-exposed pregnancies in 12 London centres between 2004 and 2010. RESULTS: There were 145 pregnancies in 135 women: 89 conceived whilst taking atazanavir-based combination antiretroviral therapy (cART), "preconception" atazanavir exposure; 27 started atazanavir-based cART as "first-line" during the pregnancy; and 29 "switched" to an atazanavir-based regimen from another cART regimen during pregnancy. Gastrointestinal intolerance requiring atazanavir cessation occurred in five pregnancies. Self-limiting, new-onset transaminitis was most common in first-line use, occurring in 11.0%. Atazanavir was commenced in five switch pregnancies in the presence of transaminitis, two of which discontinued atazanavir with persistent transaminitis. HIV-VL < 50 copies/mL was achieved in 89.3% preconception, 56.5% first-line, and 72.0% switch exposures. Singleton preterm delivery (<37 weeks) occurred in 11.7% preconception, 9.1% first-line, and 7.7% switch exposures. Four infants required phototherapy. There was one mother-to-child transmission in a poorly adherent woman. CONCLUSIONS: These data suggest that atazanavir is well tolerated and can be safely prescribed as a component of combination antiretroviral therapy in pregnancy

Disease-specific, neurosphere-derived cells as models for brain disorders

There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses. We describe here a new cell model based on patient-derived cells from the human olfactory mucosa, the organ of smell, which regenerates throughout life from neural stem cells. Olfactory mucosa biopsies were obtained from healthy controls and patients with either schizophrenia, a neurodevelopmental psychiatric disorder, or Parkinson's disease, a neurodegenerative disease. Biopsies were dissociated and grown as neurospheres in defined medium. Neurosphere-derived cell lines were grown in serum-containing medium as adherent monolayers and stored frozen. By comparing 42 patient and control cell lines we demonstrated significant disease-specific alterations in gene expression, protein expression and cell function, including dysregulated neurodevelopmental pathways in schizophrenia and dysregulated mitochondrial function, oxidative stress and xenobiotic metabolism in Parkinson's disease. The study has identified new candidate genes and cell pathways for future investigation. Fibroblasts from schizophrenia patients did not show these differences. Olfactory neurosphere-derived cells have many advantages over embryonic stem cells and induced pluripotent stem cells as models for brain diseases. They do not require genetic reprogramming and they can be obtained from adults with complex genetic diseases. They will be useful for understanding disease aetiology, for diagnostics and for drug discovery