Computer-Aided Design (CAD) Tools to Support the Human Factors Design Teams

The scope of this assessment was to develop a library of basic 1-Gravity (G) human posture and motion elements used to construct complex virtual simulations of ground processing and maintenance tasks for spaceflight vehicles, including launch vehicles, crewed spacecraft, robotic spacecraft, satellites, and other payloads. The report herein describes the task, its purpose, performance, findings, NASA Engineering and Safety Center (NESC) recommendations, and conclusions in the definition and assemblage of the postures and motions database (PMD)

Evaluation of Reproduction and Blood Metabolites in Beef Heifers Fed Dried Distillers Grains Plus Solubles and Soybean Hulls During Late Gestation

Dried distillers grains plus solubles (DDGS) contain a significant amount of both undegradable intake protein and fat, which have both been shown to increase reproductive performance when supplemented to heifers during gestation. The mechanisms leading to enhanced reproduction when fat or UIP are supplemented have not been fully defined. The objective of this experiment was to evaluate DDGS or soybean hulls (SBH) fed during the last trimester of gestation on circulating concentrations of growth hormone (GH) and insulin-like growth factor-I (IGF-I) and reproductive efficiency. Ninety-five crossbred heifers were grouped by expected calving date, BW, BCS, and randomly assigned to DDGS or SBH (n = 6 pens per treatment). Diets were formulated to be isoenergetic and meet the nutrient requirements at d 240 of gestation. Diets were limit fed during the last trimester of gestation until parturition. Blood samples were collected prior to calving and once per week for 4 weeks following calving . Treatment had no effect on circulating concentrations of GH or IGF-I. Time influenced both GH and IGF-I. Circulating concentrations of GH were elevated at calving and decreased by 4 d after calving. Circulating concentrations of IGF-I rose for the first 2 d following calving and then decreased through d 6. At the start of the breeding season there was no difference between DDGS and SBH in the percent of heifers that had initiated estrous cycles (74% and 70%, respectively). There was a tendency for more DDGS treated heifers to become pregnant during a 64 d natural service breeding season compared to SBH treated heifers (92% vs 80%, respectively). There was no difference in the distribution of pregnancies throughout the breeding season between treatments. In summary, DDGS and SBH fed during the last trimester of pregnancy to heifers resulted in similar patterns of circulating concentrations of GH and IGF, but DDGS treated heifers tended to have improved pregnancy rates during a defined breeding season

Moyo Vol. I N 2

JDB. The Bradys On Sex: Any Excuse to Talk About Marsha . 1. Shaver, Anne. One View From Lesbos . 2. Harmless, Heather. In Sex Lies Inequality . 3. Anonymous. Mom and Dad, I Was Raped: The Account of One Anonymous Denison Woman . 4. Cockrell, Kim. When Ebony & Ivory Consumate: Interracial Sex . Perry, Christian. The State\u27s Permission? . 8. Benboe, Daniel. Fact or Fiction? 8. Gerding, Dale N. STDs: Are You At Risk? . 9. Smith, N. Confessions of A Nymphomaniac . 10. Dunham, Trey. “Sex and God”. 15. Fore, Kevin. Straight Talk on Homosexuality . 16. Sherman, Nancy. Sex, Booze, and the Swedish Bikini Team . 19. Wetterqvist, Christoffer. Tall, Blond, and Beautiful: Sex from a Swedish perspective . 20. Moore, Sheryn. AIDS & College . 21. Benboe, Daniel. Lover\u27s Dilema . 21. Ransdell, Lisa. Burnout and the Good Fight: Fourteen years in the Anti-Rape Movement . 22

TRH attenuates scopolamine-induced memory impairment in humans

The brain tripeptide thyrotropin-releasing hormone (TRH) has been demonstrated to facilitate cholinergic neurotransmission. To test its interaction with the cholinergic system in humans, high-dose TRH (0.5 mg/kg) or placebo was administered intravenously (IV) to normal controls pretreated with scopolamine (0.5–0.75 mg IV), a centrally active muscarinic antagonist, which has been used to model aspects of the memory impairment of normal aging and of dementia. Compared to placebo, TRH markedly attenuated scopolamine-induced impairment of some measures of memory, most notably on a selective reminding task. This cognitive study is the first in humans to suggest a neuromodulatory effect of a peptide on the cholinergic system, and suggests a facilitatory role for TRH in human memory processes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46332/1/213_2005_Article_BF02245795.pd

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29

The Cancer Cell Map Initiative: Defining the Hallmark Networks of Cancer

Progress in DNA sequencing has revealed the startling complexity of cancer genomes, which typically carry thousands of somatic mutations. However, it remains unclear which are the key driver mutations or dependencies in a given cancer and how these influence pathogenesis and response to therapy. Although tumors of similar types and clinical outcomes can have patterns of mutations that are strikingly different, it is becoming apparent that these mutations recurrently hijack the same hallmark molecular pathways and networks. For this reason, it is likely that successful interpretation of cancer genomes will require comprehensive knowledge of the molecular networks under selective pressure in oncogenesis. Here we announce the creation of a new effort, called The Cancer Cell Map Initiative (CCMI), aimed at systematically detailing these complex interactions among cancer genes and how they differ between diseased and healthy states. We discuss recent progress that enables creation of these Cancer Cell Maps across a range of tumor types and how they can be used to target networks disrupted in individual patients, significantly accelerating the development of precision medicine

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies