Non-invasive imaging of subsurface paint layers with optical coherence tomography

Optical coherence tomography (OCT) systems are fast scanning infrared Michelson interferometers designed for the non-invasive examination of the interiors of the eye and subsurface structures of biological tissues. OCT has recently been applied to the non-invasive examinations of the stratigraphy of paintings and museum artefacts. So far this is the only technique capable of imaging non-invasively the subsurface structure of paintings and painted objects. Unlike the traditional method of paint cross-section examination where sampling is required, the non-invasive and non-contact nature of the technique enables the examination of the paint cross-section anywhere on a painting, as there is no longer an issue with conservation ethics regarding the taking of samples from historical artefacts. A range of applications of the technique including the imaging of stratigraphy of paintings and painted artefacts, the imaging of underdrawings to the analysis of the optical properties of paint and varnish layers is presented. Future projects on the application of OCT to art conservation are discussed

Design and standalone characterisation of a capacitively coupled HV-CMOS sensor chip for the CLIC vertex detector

The concept of capacitive coupling between sensors and readout chips is under study for the vertex detector at the proposed high-energy CLIC electron positron collider. The CLICpix Capacitively Coupled Pixel Detector (C3PD) is an active High-Voltage CMOS sensor, designed to be capacitively coupled to the CLICpix2 readout chip. The chip is implemented in a commercial $180$ nm HV-CMOS process and contains a matrix of $128\times128$ square pixels with $25$ $\mu$m pitch. First prototypes have been produced with a standard resistivity of $\sim20$ $\Omega$cm for the substrate and tested in standalone mode. The results show a rise time of $\sim20$ ns, charge gain of $190$ mV/ke$^{-}$ and $\sim40$ e$^{-}$ RMS noise for a power consumption of $4.8$ $\mu$W/pixel. The main design aspects, as well as standalone measurement results, are presented.Comment: 13 pages, 13 figures, 2 tables. Work carried out in the framework of the CLICdp collaboratio

Optical coherence tomography - a tool for high resolution non-invasive 3D-imaging of the subsurface structure of paintings

Optical Coherence Tomography (OCT) is an imaging technique originally developed for high-resolution 3D imaging of the human eye. In 2004, Targowski et al. and Liang et al. first reported its application to paintings, demonstrating that it was possible to produce cross-section images noninvasively with this technique. In 2005 Liang et al. explored further applications such as imaging of underdrawing at a resolution and contrast greater than that achievable with infrared reflectography Since then the authors have been conducting a project to investigate systematically the potential of O C T as a new tool in the non-invasive examination of paintings and to design an O C T optimised for use in museums. This paper discusses recent developments in this work and presents examples of the use of O CT on paintings undergoing conservation treatment in the National Gallery, London

Hardening and non-associated flow NURBS plasticity.

In numerical analysis the failure of engineering materials is controlled through specifying yield envelopes (or surfaces) that bound the allowable stress in the material. Simple examples include the prismatic von Mises (circle) and Tresca (hexagon) yield surfaces. However, each surface is distinct and requires a specific equation describing the shape of the surface to be formulated in each case. These equations impact on the numerical implementation (specifically relating to stress integration) of the models and therefore a separate algorithm must be constructed for each model. Recently a framework was proposed that allows any isotropic yield surface to be represented by a NURBS surface and the constitutive model formulated using the name numerical algorithm. This paper presents, for the first time, an extension to this framework to allow both hardening (expansion/contraction of the surfaces) and a non-associated plastic flow rule. As with previous work on NURBS plasticity, the constitutive framework is combined with an implicit backward-Euler-type stress integration algorithm. The numerical performance of the algorithm is demonstrated using both material point investigations and boundary value simulations

Effect of Litter Treatment on the Occurrence of Foot Pad Lesions

Pododermatitis (foot pad lesions) is one of the main welfare problems in modern broiler production in countries with developed poultry farming. Factors contributing to the occurrence of these lesions are nutrition, stocking density and material used for litter. There are a number of different procedures that can be applied in order to prevent and reduce the number of lesions with the most pronounced defects. The experiment was conducted on broiler chickens grown in 10 buildings of 240 m2 each. The stocking density was 35 kg/m2. The experiment was set up in five treatments with two replicates. Treatment one (T1) - control with a straw litter, treatment two (T2) - litter treated with microbial preparation Micropan®, treatment three (T3) – litter with addition of lignin, treatment four (T4) – litter with addition of lignin and Micropan® and treatment five (T5) - chopped straw without supplements. At the end of the experiment, on day 42 the intensity of the lesions was scored on the slaughter line. The presence of lesions was scored using scale from 0 (no lesions) to 3 (plantar pads with more than 50% damage). Based on the results of the trial it can be concluded that litter has a significant impact on the presence and the degree of foot pad lesions. The lowest score of foot pad lesions was observed in the treatment T5 (chopped straw). Different treatments of litters may also contribute to the solution of the problem of pododermatitis since the results in all treated groups (T2, T3, T4 and T5) were better when compared to the control

Optical coherence tomography for art conservation and archaeology

Optical coherence tomography (OCT) is a fast scanning Michelson interferometer originally designed for in vivo imaging of the eye. In 2004, our group along with two other groups first reported the application of OCT to art conservation and archaeology. Since that time we have been conducting a project to investigate systematically the potential of OCT as a new tool for non-invasive examinations of a wide range of museum objects and to design an OCT optimised for in situ use in museums. Here we present the latest results from this ongoing project, which include the determination of the optimum spectral windows for OCT imaging of paintings and painted objects executed using traditional techniques, and non-invasive imaging of the subsurface stratigraphy of painted layers at multiple wavelengths. OCT imaging in assisting spectral pigment identification and in measuring refractive indices of paint will also be presented to illustrate the potential of the technique

Prototyping of an HV-CMOS demonstrator for the High Luminosity-LHC upgrade

HV-CMOS sensors can offer important advantages in terms of material budget, granularity and cost for large area tracking systems in high energy physics experiments. This article presents the design and simulated results of an HV-CMOS pixel demonstrator for the High Luminosity-LHC. The pixel demonstrator has been designed in the 0.35 μm HV-CMOS process from ams AG and submitted for fabrication through an engineering run. To improve the response of the sensor, different wafers with moderate to high substrate resistivities are used to fabricate the design. The prototype consists of four large analog and standalone matrices with several pixel flavours, which are all compatible for readout with the FE-I4 ASIC. Details about the matrices and the pixel flavours are provided in this article

Determination of fatty acids profile in original brown cows dairy products and relationship with alpine pasture farming system

This study aimed to evaluate the relationships between fatty acids and the pattern that most contributes to discriminate between two farming systems, in which the main difference was the practice, or not, of alpine summer-grazing. Milk and cheese were sampled every month in two farms of Original Brown cows identical under geographical location and management during no grazing season point of view in the 2018 season. Fatty acids concentrations were determined by gas chromatography. The principal component analysis extracted three components (PCs). Mammary gland de novo synthetized fatty acids (C14:0, C14:1 n9, and C16:0) and saturated and monosaturated C18 fatty acids (C18:0, C18:1 n9c) were inversely associated in the PC1; PC2 included polyunsaturated C18 fatty acids (C18:2 n6c, C18:3 n3) and C15:0 while conjugated linoleic acid (CLA n9c, n11t) and fatty acids containing 20 or more carbon atoms (C21:0, C20:5 n3) were associated in the PC3. The processes of rumen fermentation and de novo synthesis in mammary gland that are, in turn, influenced by diet, could explain the relationships between fatty acids within each PC. The discriminant analyses showed that the PC2 included the fatty acids profile that best discriminated between the two farming systems, followed by PC3 and, lastly, PC1. This model, if validated, could be an important tool to the dairy industry

Comparison of diuretic strategies in diuretic-resistant acute heart failure: A systematic review and network meta-analysis

OBJECTIVE: Up to 50% of patients hospitalized for acute heart failure (AHF) show resistance to diuretics. This condition contributes to a prolonged hospital length of stay and a higher risk of death. This review aimed to investigate whether a diuretic therapeutic approach more effective than furosemide alone exists for patients with diuretic-resistant AHF. MATERIALS AND METHODS: We identified all randomized controlled trials (RCTs) evaluating diuretic therapy in patients with diuretic-resistant AHF. We searched Pubmed, BioMed Central, and Cochrane CENTRAL databases. RESULTS: Six RCTs were identified, involving a total of 845 patients. The P-score ranges from 0.6663 for furosemide to 0.2294 for the tolvaptan-furosemide. We found no significant differences in efficacy for any drug comparison. CONCLUSIONS: None of the diuretics considered in RCTs performed to date (tolvaptan, metolazone, hydrochlorothiazide, indapamide) appear to be more effective than furosemide therapy alone for the treatment of patients with diuretic-resistant AHF