Tools for the implementation of a SCADA system in a desalination process

In this work a system is designed and implemented in SCADA MOVICON 11.5, in which the operation of five seawater desalination lines by reverse osmosis which work in parallel, with four coastal wells and two end-of-line pumps of the permeated water obtainedare integrated, synchronized and supervised as a single plant. Each desalination line has its own control system and can operate independently. As a product, synchronization algorithms were obtained that were added to the system through script codes, which guarantee continuous productivity in the desalination process, achieving synchronization between the mentioned sub-processes. Simultaneous operations of starting, washing and stopping that affected the performance of the osmosis lines are avoided. Alarmsare generated, reports are created, historical records and trends for the decision making on failures prediction, predictive maintenance and troubleshooting

Screening and identification of metacaspase inhibitors: Evaluation of inhibition mechanism and trypanocidal activity

A common strategy to identify new antiparasitic agents is the targeting of proteases, due to their essential contributions to parasite growth and development. Metacaspases (MCAs) are cysteine proteases present in fungi, protozoa, and plants. These enzymes, which are associated with crucial cellular events in trypanosomes, are absent in the human host, thus arising as attractive drug targets. To find new MCA inhibitors with trypanocidal activity, we adapted a continuous fluorescence enzymatic assay to a medium-throughput format and carried out screening of different compound collections, followed by the construction of dose-response curves for the most promising hits. We used MCA5 from Trypanosoma brucei (TbMCA5) as a model for the identification of inhibitors from the GlaxoSmithKline HAT and CHAGAS chemical boxes. We also assessed a third collection of nine compounds from the Maybridge database that had been identified by virtual screening as potential inhibitors of the cysteine peptidase falcipain-2 (clan CA) from Plasmodium falciparum. Compound HTS01959 (from the Maybridge collection) was the most potent inhibitor, with a 50% inhibitory concentration (IC50) of 14.39mM; it also inhibited other MCAs from T. brucei and Trypanosoma cruzi (TbMCA2, 4.14mM; TbMCA3, 5.04mM; TcMCA5, 151mM). HTS01959 behaved as a reversible, slow-binding, and noncompetitive inhibitor of TbMCA2, with a mechanism of action that included redox components. Importantly, HTS01959 displayed trypanocidal activity against bloodstream forms of T. brucei and trypomastigote forms of T. cruzi, without cytotoxic effects on Vero cells. Thus, HTS01959 is a promising starting point to develop more specific and potent chemical structures to target MCAs.Fil: Perez, Brian Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Bouvier, León Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Cazzulo, Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Agüero, Fernan Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Salas Sarduy, Emir. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Alvarez, Vanina Eder. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentin

PLANEACIÓN DIDÁCTICA GENERAL DE LA ASIGNATURA DE PROGRAMACIÓN Y CÓMPUTO

GUÍA DIDÁCTICA / PLANEACIÓN DIDÁCTICA (NMS

Epidemiological investigation of bovine tuberculosis herd breakdowns in Spain 2009/2011

We analyzed the most likely cause of 687 bovine tuberculosis (bTB) breakdowns detected in Spain between 2009 and 2011 (i.e., 22% of the total number of breakdowns detected during this period). Seven possible causes were considered: i) residual infection; ii) introduction of infected cattle from other herds; iii) sharing of pastures with infected herds; iv) contiguous spread from infected neighbor herds; v) presence of infected goats in the farm; vi) interaction with wildlife reservoirs and vii) contact with an infected human. For each possible cause a decision tree was developed and key questions were included in each of them. Answers to these key questions lead to different events within each decision tree. In order to assess the likelihood of occurrence of the different events a qualitative risk assessment approach was used. For this purpose, an expert opinion workshop was organized and ordinal values, ranging from 0 to 9 (i.e., null to very high likelihood of occurrence) were assigned. The analysis identified residual infection as the most frequent cause of bTB breakdowns (22.3%; 95%CI: 19.4-25.6), followed by interaction with wildlife reservoirs (13.1%; 95%CI: 10.8-15.8). The introduction of infected cattle, sharing of pastures and contiguous spread from infected neighbour herds were also identified as relevant causes. In 41.6% (95%CI: 38.0-45.4) of the breakdowns the origin of infection remained unknown. Veterinary officers conducting bTB breakdown investigations have to state their opinion about the possible cause of each breakdown. Comparison between the results of our analysis and the opinion from veterinary officers revealed a slight concordance. This slight agreement might reflect a lack of harmonized criteria to assess the most likely cause of bTB breakdowns as well as different perceptions about the importance of the possible causes. This is especially relevant in the case of the role of wildlife reservoirs

Effect of Preventive Chlamydia abortus Vaccination in Offspring Development in Sheep Challenged Experimentally

Ovine enzootic abortion, caused by Chlamydia abortus, leads to important economic losses worldwide. In addition to reproductive failures, infection may impact lamb growth during the first weeks after birth, yet this effect has not been well characterized. Vaccination can help to control the disease but variable efficacy values have been described, possibly related with factors associated with the host, the vaccine, the parameter used for efficacy determination and the challenge conditions. In this context, we evaluated the efficacy of an inactivated standard commercial vaccine and a 1/2 diluted dose in pregnant sheep challenged with C. abortus by examining multiple indicators ofvaccine effect (including incidence of reproductive failures, bacterial excretion, and evolution of weight gain of viable lambs during the first month of life). Three groups of ewes [control non-vaccinated, C (n = 18); vaccinated with standard dose, SV (n = 16) and vaccinated with 1/2 dose, DV (n = 17)], were challenged approximately 90 days post-mating and tested using direct PCR (tissue samples and vaginal swabs) and ELISA (serum) until 31 days post-reproductive outcome. There were not significant differences in the proportions of reproductive failures or bacterial shedding after birth/abortion regardless the vaccination protocol. However, a beneficial effect of vaccination on offspring growth was detected in both vaccinated groups compared with the controls, with a mean increase in weight measured at 30 days of life of 1.5 and 2.5 Kg (p = 0.056) and an increase in the geometric mean of the daily gain of 8.4 and 9.7% in lambs born from DV and SV ewes compared to controls, respectively. Our results demonstrate the effect of an inactivated vaccine in the development of the offspring of C. abortus-infected ewes at a standard and a diluted dose, an interesting finding given the difficulty in achieving sufficient antigen concentration in the production of EAE-commercial vaccines

Televisión digital en 2010: El reto de la interoperabilidad

En este artículo se plantea la situación actual de despliegue de la televisión digital en España desde el punto de vista de la necesaria interoperabilidad que debe haber entre los eslabones de la cadena de valor en un mercado horizontal, con especial atención, por una parte, a la navegación y la presentación de la información de programación y, por otra, a la accesibilidad de las personas con discapacidad. Los patentes problemas de interoperabilidad existentes se han producido a pesar de la existencia de un completo conjunto de disposiciones legales y normas técnicas, lo que sugiere la necesidad además de laboratorios de interoperabilidad que supongan un punto de encuentro entre los actores del sector, con el apoyo de las administraciones públicas (Utray 2009: 211‐225

Uso de las tecnologías de la información y las comunicaciones en la carrera de Enfermería

Introduction: new technologies favor the scientific and technical development of society, which is why these must be assimilated into the teaching-learning process by nursing care students.Objective: to characterize the use of information and communication technologies by students of the Degree in Nursing at Pinar del Río University of Medical Sciences between January and March 2018.Methods: observational, descriptive, and cross-sectional study of second-academic year students of bachelor degree in nursing care. Theoretical and empirical methods were used. Statistical measures were applied as absolute frequency and relative percentage.Results: it was found that 23.5 % did not have access to any personal computers. Half of the target group said they own a mobile phone with Android or iOS operating system; 59.3 % of the students did not use the institutional Internet network, 23.5 % used it for teaching purposes; 76.5 % reported using lectures and complementary computerized materials for the individual study; 46. 9% used both computers and conventional aids; 12 % of the students expressed they do not find computer-aided learning useful.Conclusions: it was found the application of Information and Communication Technologies in the teaching-learning process is very useful, having a high access; where Smartphone is the most used; there is a poor use of Internet network for the teaching-learning and research processes. Computer-aided learning is widely used to the individual study.Introducción: las nuevas tecnologías favorecen el desarrollo científico técnico de la sociedad, por lo cual se deben asimilar en el proceso enseñanza aprendizaje por los estudiantes de la carrera.Objetivo: caracterizar el uso de las tecnologías de la información y las comunicaciones por los estudiantes de la carrera Licenciatura en Enfermería de la Universidad de Ciencias Médicas de Pinar del Río entre enero y marzo de 2018.Métodos: estudio observacional, descriptivo, y transversal en los estudiantes de segundo año de licenciatura en Enfermería. Se emplearon métodos teóricos y empíricos. Se aplicaron medidas estadísticas como frecuencia absoluta y relativa porcentual.Resultados: se encontró que el 23,5 % no poseía acceso a ningún medio informático. La mitad del universo de estudio expresó poseer un teléfono móvil con sistema operativo Android o iOS. El 59,3 % de los estudiantes no empleaban la conexión institucional a Internet, el 23,5 % la emplea para fines docentes. El 76,5 % refirió utilizar las conferencias y materiales complementarios digitalizados para el estudio; el 46,9 % empleó tanto los medios digitales, como los convencionales. El 12 % de los estudiantes expresó que no encuentran útiles los medios informáticos para el aprendizaje.Conclusiones: Se encontró utilidad en el uso de las Tecnologías de la Información y la Comunicación en el proceso docente, los cuales poseen con elevado acceso; donde los teléfonos inteligentes, son las más empleadas, existiendo una pobre utilización del Internet para el proceso docente e investigativo. Los materiales en soporte digital son ampliamente empleados para el estudio.

Application of information and communication technologies in nursing care studies

Introduction: new technologies favor the scientific and technical development of society, which is why these must be assimilated into the teaching-learning process by nursing care students. Objective: to characterize the use of information and communication technologies by students of the Degree in Nursing at Pinar del Río University of Medical Sciences between January and March 2018. Methods: observational, descriptive, and cross-sectional study of second-academic year students of bachelor degree in nursing care. Theoretical and empirical methods were used. Statistical measures were applied as absolute frequency and relative percentage. Results: it was found that 23.5 % did not have access to any personal computers. Half of the target group said they own a mobile phone with Android or iOS operating system; 59.3 % of the students did not use the institutional Internet network, 23.5 % used it for teaching purposes; 76.5 % reported using lectures and complementary computerized materials for the individual study; 46. 9% used both computers and conventional aids; 12 % of the students expressed they do not find computer-aided learning useful. Conclusions: it was found the application of Information and Communication Technologies in the teaching-learning process is very useful, having a high access; where Smartphone is the most used; there is a poor use of Internet network for the teaching-learning and research processes. Computer-aided learning is widely used to the individual study

HERMES-TDT: Herramientas de monitorización y control de servicios de accesibilidad para la TDT

Los servicios de accesibilidad a la televisión digital constituyen un medio para acceder al audio o vídeo de los programas de TV y son necesarios para un número creciente de personas