16 research outputs found
Biobanking, consent, and commercialization in international genetics research: the Type 1 Diabetes Genetics Consortium
Background and Purpose This article describes several ethical, legal, and social issues typical of
international genetics biobanking, as encountered in the Type 1 Diabetes Genetics Consortium
(T1DGC)
Measurement of islet cell antibodies in the Type 1 Diabetes Genetics Consortium: efforts to harmonize procedures among the laboratories
Background and Purpose Three network laboratories measured antibodies to islet autoantigens.
Antibodies to glutamic acid decarboxylase (GAD65 [GADA]) and the intracellular
portion of protein tyrosine phosphatase (IA-2ic [IA-2A]) were
measured by similar, but not identical, methods in samples from participants in
the Type 1 Diabetes Genetics Consortium (T1DGC)
Innovative Self-Regulation Strategies to Reduce Weight Gain in Young Adults: The Study of Novel Approaches to Weight Gain Prevention (SNAP) Randomized Clinical Trial
Weight gain occurs commonly in young adults and has adverse effects on health. Reducing weight gain in young adults would have significant public health impact
Quality control of phenotypic forms data in the Type 1 Diabetes Genetics Consortium
Background When collecting phenotypic data in clinics across the globe, the Type 1 Diabetes
Genetics Consortium (T1DGC) used several techniques that ensured consistency, completeness, and
accuracy of the data
HLA genotyping in the international Type 1 Diabetes Genetics Consortium
Background Although human leukocyte antigen (HLA) DQ and
DR loci appear to confer the strongest genetic risk for
type 1 diabetes, more detailed information is required for other loci within the
HLA region to understand causality and stratify additional risk factors. The
Type 1 Diabetes Genetics Consortium (T1DGC) study design included
high-resolution genotyping of HLA-A, B,
C, DRB1, DQ, and
DP loci in all affected sibling pair and trio families, and
cases and controls, recruited from four networks worldwide, for analysis with
clinical phenotypes and immunological markers
Dietary outcomes within the study of novel approaches to weight gain prevention (SNAP) randomized controlled trial
Abstract
Background
Young adults (YA) are at high-risk for unhealthy dietary behaviors and weight gain. The Study of Novel Approaches to Weight Gain Prevention (SNAP) Trial demonstrated that two self-regulation approaches were effective in reducing weight gain over 2 years compared with control. The goal of this analysis was to examine effects of intervention on dietary outcomes and the association of diet changes with weight change.
Methods
Participants were 599 YA, age 18–35 years, BMI 21.0–30.0 kg/m2 (27.4 ± 4.4 years; 25.4 ± 2.6 kg/m2; 22% men; 73% non-Hispanic White), who were recruited in Providence, RI and Chapel Hill, NC and randomized to self-regulation with Small Changes (SC), self-regulation with Large Changes (LC) or Control (C). SC and LC emphasized frequent self-weighing to cue behavior changes (small daily changes vs. periodic large changes) and targeted high-risk dietary behaviors. Diet and weight were assessed at baseline, 4 months and 2 years.
Results
LC and SC had greater decreases in energy intake than C at 4 months but not 2 years. LC had the greatest changes in percent calories from fat at 4 months, but differences were attenuated at 2 years. No differences in diet quality were observed. Across conditions, increased total energy consumption, fast food, meals away from home, and binge drinking, and decreased dietary quality and breakfast consumption were all associated with weight gain at 2 years.
Conclusions
This study suggests the need to strengthen interventions to produce longer term changes in dietary intake and helps to identify specific behaviors associated with weight gain over time in young adults.
Trial registration
Clinicaltrials.gov #
NCT01183689
, registered August 18, 2010
Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium
Background and Purpose The Type 1 Diabetes Genetics Consortium (T1DGC) is an
international project whose primary aims are to: (a) discover genes that modify type
1 diabetes risk; and (b) expand upon the existing genetic resources for type 1
diabetes research. The initial goal was to collect 2500 affected sibling pair (ASP)
families worldwide.
Methods T1DGC was organized into four regional networks (Asia-Pacific, Europe,
North America, and the United Kingdom) and a Coordinating Center. A Steering
Committee, with representatives from each network, the Coordinating Center, and
the funding organizations, was responsible for T1DGC operations. The Coordinating
Center, with regional network representatives, developed study documents and data
systems. Each network established laboratories for: DNA extraction and cell line
production; human leukocyte antigen genotyping; and autoantibody measurement.
Samples were tracked from the point of collection, processed at network laboratories
and stored for deposit at National Institute for Diabetes and Digestive and Kidney
Diseases (NIDDK) Central Repositories. Phenotypic data were collected and entered
into the study database maintained by the Coordinating Center.
Results T1DGC achieved its original ASP recruitment goal. In response to research
design changes, the T1DGC infrastructure also recruited trios, cases, and controls.
Results of genetic analyses have identified many novel regions that affect
susceptibility to type 1 diabetes. T1DGC created a resource of data and samples
that is accessible to the research community.
Limitations Participation in T1DGC was declined by some countries due to study
requirements for the processing of samples at network laboratories and/or final
deposition of samples in NIDDK Central Repositories. Re-contact of participants was
not included in informed consent templates, preventing collection of additional
samples for functional studies.
Conclusions T1DGC implemented a distributed, regional network structure to
reach ASP recruitment targets. The infrastructure proved robust and flexible enough
to accommodate additional recruitment. T1DGC has established significant resources that provide a basis for future discovery in the study of type 1 diabetes genetics.Joan E Hilner, Letitia H Perdue, Elizabeth G Sides, June J Pierce, Ana M Wägner, Alan Aldrich, Amanda Loth, Lotte Albret, Lynne E Wagenknecht, Concepcion Nierras, Beena Akolkar and the T1DG