Towards the automation of the Local Analytic Sector subtraction

We present the state of the art of the Local Analytic Sector subtraction. The scheme is now complete at NLO in the massless case for the treatment of initial- and final-state radiations. Its flexibility has been improved by the introduction of damping factors, which can be tuned to reduce numerical instabilities, though preserving the simplicity of the algorithm. The same degree of universality has been reached at NNLO for final-state radiation, where we derived fully analytic and compact results for all integrated counterterms. This allows us to explicitly check the cancellation of the virtual infrared singularities in generic processes with massless final-state partons

May the four be with you: novel IR-subtraction methods to tackle NNLO calculations

In this manuscript, we summarise all discussions originated as a result of the WorkStop/ThinkStart 3.0: paving the way to alternative NNLO strategies that took place on 4.-6. November 2019 at the Galileo Galilei Institute for Theoretical Physics (GGI). We gratefully acknowledge the support of GGI and the COST Action CA16201 PARTICLEFACE. We wish to thank toW.M. Marroquin and M. Morandini for their help in organising the workshop. P. Banerjee acknowledges support by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 701647. A.L. Cherchiglia, B. Hiller and M.Sampaio acknowledge support from Fundacao para a Ciencia e Tecnologia (FCT) through the projects UID/FIS/04564/2020 and CERN/FIS-COM/0035/2019. The work of L. Cieri has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 754496. The work of F. Driencourt-Mangin, G. Rodrigo, G. Sborlini and W.J. Torres Bobadilla is supported by the Spanish Government (Agencia Estatal de Investigacion), ERDF funds from European Commission (Grant No. FPA2017-84445-P), Generalitat Valenciana (Grant No. PROMETEO/2017/053) and from the SpanishGovernment (FJCI-2017-32128). T. Engel acknowledges support by the Swiss National Science Foundation (SNF) under contract 200021_178967. C. Gnendiger, R. Pittau, A. Signer and D. Stockinger wish to thank B. Page for his help in establishing (2.60). The work of R. J. Hernandez-Pinto is supported by CONACyT through the Project No. A1-S-33202 (Ciencia Basica) and Sistema Nacional de Investigadores. G. Pelliccioli was supported by the Bundesministerium fur Bildung und Forschung (BMBF, German Federal Ministry for Education and Research) under contract no. 05H18WWCA1. J. Pires was supported by Fundacao para a Ciencia e Tecnologia (FCT, Portugal) through the contract UIDP/50007/2020 and project CERN/FIS-PAR/0024/2019. The work of R. Pittau has been supported by the SpanishGovernment grant PID2019-106087GB-C21 and by the Junta de Andalucia project P18-FR-4314 (fondos FEDER). M. Sampaio acknowledges a research grant from CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico 303482/2017-6). C. Signorile-Signorile was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Grant no. 396021762 - TRR 257.In this manuscript, we report the outcome of the topical workshop: paving the way to alternative NNLO strategies (https://indico.ific.uv.es/e/WorkStop-ThinkStart_3.0), by presenting a discussion about different frameworks to perform precise higher-order computations for high-energy physics. These approaches implement novel strategies to deal with infrared and ultraviolet singularities in quantum field theories. A special emphasis is devoted to the local cancellation of these singularities, which can enhance the efficiency of computations and lead to discover novel mathematical properties in quantum field theories.European Commission 701647Portuguese Foundation for Science and Technology European Commission UID/FIS/04564/2020 CERN/FIS-COM/0035/2019European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant 754496Spanish Government (Agencia Estatal de Investigacion)ERDF funds from European Commission FPA2017-84445-PGeneralitat Valenciana European Commission PROMETEO/2017/053Spanish Government European Commission FJCI-2017-32128 PID2019-106087GB-C21Swiss National Science Foundation (SNSF) 200021_178967Consejo Nacional de Ciencia y Tecnologia (CONACyT) A1-S-33202Sistema Nacional de InvestigadoresFederal Ministry of Education & Research (BMBF) 05H18WWCA1Portuguese Foundation for Science and Technology UIDP/50007/2020 CERN/FIS-PAR/0024/2019Junta de Andalucia P18-FR-4314Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) 303482/2017-6German Research Foundation (DFG) 396021762 - TRR 257GGIEuropean Cooperation in Science and Technology (COST) CA16201 PARTICLEFAC

Photoactivatable prodrugs of antimelanoma agent Vemurafenib

In this study, we report on novel photoactivatable caged prodrugs of vemurafenib. This kinase inhibitor was the first approved drug for the personalized treatment of BRAF-mutated melanoma and showed impressive results in clinical studies. However, the occurrence of severe side effects and drug resistance illustrates the urgent need for innovative therapeutic approaches. To conquer these limitations, we implemented photoremovable protecting groups into vemurafenib. In general, this caging concept provides spatial and temporal control over the activation of molecules triggered by ultraviolet light. Thus, higher inhibitor concentrations in tumor tissues might be reached with less systemic effects. Our study describes the first development of caged vemurafenib prodrugs useful as pharmacological tools. We investigated their photochemical characteristics and photoactivation. <i>In vitro</i> evaluation proved the intended loss-of-function and the light-dependent recovery of efficacy in kinase and cellular assays. The reported vemurafenib photo prodrugs represent a powerful biological tool for novel pharmacological approaches in cancer research

Vector boson scattering processes: Status and prospects

Insight into the electroweak (EW) and Higgs sectors can be achieved through measurements of vector boson scattering (VBS) processes. The scattering of EW bosons are rare processes that are precisely predicted in the Standard Model (SM) and are closely related to the Higgs mechanism. Modifications to VBS processes are also predicted in models of physics beyond the SM (BSM), for example through changes to the Higgs boson couplings to gauge bosons and the resonant production of new particles. In this review, experimental results and theoretical developments of VBS at the Large Hadron Collider, its high luminosity upgrade, and future colliders are presented

Supramolecular photochemistry of encapsulated caged ortho-nitrobenzyl triggers

ortho-Nitrobenzyl (oNB) triggers have been extensively used to release various molecules of interest. However, the toxicity and reactivity of the spent chromophore, o-nitrosobenzaldehyde, remains an unaddressed difficulty. In this study we have applied the well-established supramolecular photochemical concepts to retain the spent trigger o-nitrosobenzaldehyde within the organic capsule after release of water-soluble acids and alcohols. The sequestering power of organic capsules for spent chromophores during photorelease from ortho-nitrobenzyl esters, ethers and alcohols is demonstrated with several examples.National Science FoundationNational Science Foundation (NSF) [CHE-1807729]Kansas University Endowment AssociationFCT - Foundation for Science and TechnologyPortuguese Foundation for Science and Technology [UID/Multi/04326/2019, EMBRC.PT ALG-01-0145-FEDER-022121

Photopatterned antibodies for selective cell attachment

We present a phototriggerable system that allows for the spatiotemporal controlled attachment of selected cell types to a biomaterial using immobilized antibodies that specifically target individual cell phenotypes.o-Nitrobenzyl caged biotin was used to functionalize chitosan membranes and mediate site-specific coupling of streptavidin and biotinylated antibodies after light activation. The ability of this system to capture and immobilize specific cells on a surface was tested using endothelial-specific biotinylated antibodies and nonspecific ones as controls. Homogeneous patterned monolayers of human umbilical vein endothelial cells were obtained on CD31-functionalized surfaces. This is a simple and generic approach that is applicable to other ligands, materials, and cell types and shows the flexibility of caged ligands to trigger and control the interaction between cells and biomaterials.We thank Martina Knecht (MPIP) for help with the synthesis of caged biotin and Dr. Ron Unger and Prof. C. J. Kirkpatrick (University Clinic Mainz, RepairLab) for providing HUVECs. C.A.C. acknowledges funding support from the Portuguese Foundation for Science and Technology (FCT) (fellowship SFRH/BD/61390/2009) and from the International Max-Planck Research School in Mainz. The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. REGPOT-CT2012-316331-POLARIS

Event generators for high-energy physics experiments

We provide an overview of the status of Monte-Carlo event generators for high-energy particle physics. Guided by the experimental needs and requirements, we highlight areas of active development, and opportunities for future improvements. Particular emphasis is given to physics models and algorithms that are employed across a variety of experiments. These common themes in event generator development lead to a more comprehensive understanding of physics at the highest energies and intensities, and allow models to be tested against a wealth of data that have been accumulated over the past decades. A cohesive approach to event generator development will allow these models to be further improved and systematic uncertainties to be reduced, directly contributing to future experimental success. Event generators are part of a much larger ecosystem of computational tools. They typically involve a number of unknown model parameters that must be tuned to experimental data, while maintaining the integrity of the underlying physics models. Making both these data, and the analyses with which they have been obtained accessible to future users is an essential aspect of open science and data preservation. It ensures the consistency of physics models across a variety of experiments

Event generators for high-energy physics experiments

We provide an overview of the status of Monte-Carlo event generators for high-energy particle physics. Guided by the experimental needs and requirements, we highlight areas of active development, and opportunities for future improvements. Particular emphasis is given to physics models and algorithms that are employed across a variety of experiments. These common themes in event generator development lead to a more comprehensive understanding of physics at the highest energies and intensities, and allow models to be tested against a wealth of data that have been accumulated over the past decades. A cohesive approach to event generator development will allow these models to be further improved and systematic uncertainties to be reduced, directly contributing to future experimental success. Event generators are part of a much larger ecosystem of computational tools. They typically involve a number of unknown model parameters that must be tuned to experimental data, while maintaining the integrity of the underlying physics models. Making both these data, and the analyses with which they have been obtained accessible to future users is an essential aspect of open science and data preservation. It ensures the consistency of physics models across a variety of experiments

Retinopathy of prematurity: our experience with ret cam II

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