A data acquisition and consolidation system based on openEHR applied to physical medicine and rehabilitation

Shoulder pathologies are prevalent and reduce the quality of life. Due to the shoulder joint's complexity, healthcare professionals face challenges to evaluate, diagnose, and treat these pathologies. On the other hand, the acquisition, presentation, and analysis of patient data in healthcare is complex and hindered by the absence of standardization and interoperability in Database Management Systems. Hence, in this study, we propose a web platform based on openEHR structures that incorporates user interface forms for registering patient physical examinations. The benefits of implementing this approach include structured and standardized data collection, and better communication and information exchange between different systems.This work has been supported by FCT (Fundação para a Ciência e Tecnologia) within the R&D Units Project Scope: UIDB/00319/2020. Diana Ferreira thanks FCT Portugal for the grant 2021.06308.BD

Predictive data mining in nutrition therapy

The assessment and measurement of health status in communities throughput the world is a massive information technology challenge. Data mining, plays a vital role in health care industry since it really has the potential to generate a knowledge-rich environment that reduces medical errors, decreases costs by increasing efficiency, improves the quality of clinical decisions and significantly enhances patient's outcomes and quality of life. This study falls within the context of nutrition evaluation and its main goal is to apply classification algorithms in order to predict if a patient needs to be followed by a nutrition specialist. One of the tools resorted in this study was the Waikato Environment for Knowledge Analysis (Weka in advance) Workbench since it allows to quickly try out and compare different machine learning solutions. The tasks involved in the development of this project included data preparation, data preprocessing, data transformation and cleaning, application of several classifiers and its respective evaluation through performance measures that include the confusion matrix, accuracy, error rate, and others. The accomplished results showed to be quite optimistic presenting promising values of performance measures. specifically an accuracy around 91 %.This work has been supported by Compete: POCI-01-0145-FEDER-007043 and FCT within the Project Scope UID/CEC/00319/2013

Experiência Profissionalizante na vertente de Farmácia Comunitária e Investigação

O presente relatório foi realizado no âmbito da cadeira “Estágio” integrante no Mestrado Integrado em Ciências Farmacêuticas da Universidade da Beira Interior possuindo dois capítulos. No capítulo um apresenta-se o trabalho de investigação, desenvolvido no Centro de Investigação de Ciências da Saúde na Universidade da Beira Interior intitulado “Otimização da Fase Oleosa de nanoemulsões de fenitoína”. Neste projeto foi aplicado o planeamento estatístico de experiências para estabelecer qual a melhor formulação anidra para dissolução do fármaco fenitoína e posterior obtenção da emulsão correspondente. Foram testadas diversas emulsões sendo avaliadas quanto às suas características de formação, tamanho hidrodinâmico, osmolalidade, transmitância e viscosidade, avaliando-se qual a emulsão que apresentava, no seu conjunto, as melhores características. No capítulo dois apresenta-se descrito o período de estágio em farmácia comunitária, realizado na Farmácia Ferreira Leite em Fafe (Braga, Portugal) por um período de 800 horas. Onde se apresentam as atividades realizadas, bem como todo o circuito do medicamento dentro de uma farmácia comunitária.This report was written as part of the subject “Estágio” of the Pharmaceutical Sciences Masters Degree of University of Beira Interior having two chapters. Chapter one presents the research work, developed at the Health Sciences Research Centre of University of Beira Interior entitled “Optimization of the oily phase in Phenytoin Nanoemulsions”. In this project was used the design of experiments to establish the best anhydrous formulation to promote the phenytoin dissolution and posteriorly elaboration of the correspondent emulsion. Several emulsions were tested in relation to their formation characteristics, hydrodynamic size, osmolality, transmittance and viscosity, evaluating which emulsion presented, as a whole, the best characteristics. The chapter two describes the period of internship in community pharmacy, held at the Farmácia Ferreira Leite in Fafe (Braga, Portugal) for a period of 800 hours. Where the activities performed within community pharmacy, as well as the whole circuit of the drug, are presented

A influência dos estagiários profissionais e voluntários na inserção nos mercado de trabalho dos fisioterapeutas

Dissertação de mestrado em Economia e Política da SaúdeEm Portugal tem-se feito muitos esforços no sentido de aproximação, em termos de escolaridade, à média Europeia. Na área da Fisioterapia, o número de escolas e vagas tem sido uma crescente. Este fenómeno, associado à era da globalização e da crise económico/financeira, desencadeou o aumento do desemprego, com especial relevo na camada jovem. Neste sentido, os estágios surgem como uma tentativa de inserção no mercado de trabalho. O presente trabalho pretende verificar empiricamente se a realização de estágio facilita a inserção no mercado de trabalho dos Fisioterapeutas e se esta varia em função das características sócio-demográficas dos estagiários. Adicionalmente, pretende verificar se a influência da realização de estágio sobre a empregabilidade difere entre os designados estágios profissionais e voluntários. Para a concretização destes objetivos, foi elaborado um questionário numa aplicação do site “Gmail”, denominada “Google docs”, sendo emitido um link desse questionário que foi enviado e publicado em páginas relacionadas com a Fisioterapia. Foram respondidos 338 questionários num período entre 27.11.2011 e 20.02.2012. Da análise dos dados obtidos, conclui-se que a realização de estágio não é fator estatisticamente determinante para a inserção no mercado de trabalho. Contudo, os Fisioterapeutas que realizaram estágio profissional têm uma maior probabilidade de ficar a trabalhar no local de estágio do que os Fisioterapeutas que fizeram estágio voluntário.Portugal has made many efforts to approximate schooling levels to the European average. In the area of Physiotherapy, the number of schools has been increasing. This phenomenon, associated with the economic/financial crisis, triggered an increase in unemployment, particularly among the youth. In this context, internships appear as an attempt to facilitate youth integration in the labor market. The present work aims to verify empirically whether the implementation of internships facilitates integration into the labor market for physiotherapists, and if this varies depending on the sociodemographic characteristics of trainees. Additionally, it aims to verify whether such integration differs between the types of internships that can be made: the so-called professional or volunteer internships. To achieve these objectives, a questionnaire was designed in an application site "Gmail", called "Google docs", which was sent and published on pages related to Physiotherapy. A total of 338 questionnaires were answered in the period between 27.11.2011 and 20.02.2012. From the statistical analysis of the data obtained, it is concluded that internships are not statistically determining factors for integration in the labor market. It is also concluded that physiotherapists who underwent professional internships are more likely to be working on the local of the internships than those who did volunteer internships

Nanoemulsions and thermosensitive nanoemulgels of phenytoin and fosphenytoin for intranasal administration: Formulation development and in vitro characterization

Phenytoin is a low solubility anticonvulsant drug. It has, nonetheless, other possible therapeutic indications, such as neuropathic pain, including trigeminal neuralgia, or wound healing. Its use has decreased due to side effects, but nasal/intranasal administration could significantly increase drug safety and efficacy. The aim of this work was to develop and study nanoemulsions and thermosensitive nanoemulgels of phenytoin and fosphenytoin, in combination, for intranasal administration, with immediate and sustained release profiles. Nanoemulsions were prepared by adding the aqueous phase, containing gelling polymers in the case of nanoemulgels, to emulsion preconcentrates, followed, in the optimized procedure, by premix membrane emulsification. Formulation design and optimization was guided by drug strength, rheological behavior, osmolality, mean droplet size and polydispersity. Fosphenytoin interfered significantly with Carbopol but not with Pluronic's gelation, and allowed to achieve drug strengths equivalent to 22 or 27 mg/g of phenytoin in lead nanoemulsions, and 16.7 mg/g of phenytoin in the lead nanoemulgel. The final selected low viscosity nanoemulsions had an immediate or prolonged fosphenytoin release profile, depending of anhydrous phase proportion (10% or 40%, respectively). The thermosensitive nanoemulgel, with 10% anhydrous phase, showed prolonged drug release. Future studies will establish whether they are more suited for topical effects or therapeutic brain delivery.info:eu-repo/semantics/publishedVersio

Impact of storage temperature abuse on the microbial quality and safety of fresh-cut vegetables and fruits

info:eu-repo/semantics/publishedVersio

OpenEHR based bariatric surgery follow-up

According to the World Health Organization (WHO), more than one billion people in the world are obese, and this number is still increasing. When this disease becomes a high risk to the individual's health and the non-invasive approach does not result in weight loss, it is usual to resort to an invasive intervention, bariatric surgery. Due to all the specifications, as well as the multidisciplinary treatment inherent to this procedure, the need for a specialized environment emerges. In this context, the main objective of this topic focuses on the development of a platform for registration and monitoring of bariatric surgery. For this purpose, a web platform was created, which integrates openEHR forms for the registration of appointments regarding this intervention, and uses openEHR modeling to build the interoperable template. The development of this project aims to provide greater ease and speed in patient care, assisting health professionals in their daily lives.This work has been supported by “FCT–Fundac¸ao para a Ciência e Tecnologia” within the R&D Units Project ˆ Scope: UIDB/00319/2020. D.F. thanks FCT Portugal for the grant 2021.06308.B

Achillea millefolium L. hydroethanolic extract inhibits growth of human tumor cell lines by interfering with cell cycle and inducing apoptosis

info:eu-repo/semantics/publishedVersio

Tectonic evolution of the Juvenile Tonian Serra da Prata magmatic arc in the Ribeira belt, SE Brazil: Implications for early west Gondwana amalgamation

The evolution of the Ribeira belt resulted from the progressive amalgamation of several terranes against the eastern margin of the São Francisco Craton between ca. 620 and 580 Ma. This work brings new field, U-Pb geochronology, geochemistry and isotopic (Sm-Nd and Sr) data on the evolution primitive rocks from the Serra da Prata magmatic arc and their relationships with the previously described Rio Negro arc. The new U-Pb data allow the distinction of two episodes of arc generation: the Serra da Prata Arc (856–838 Ma) and the Rio Negro Arc (790–620 Ma). Rocks from the oldest stage are composed of metaluminous calc-alkaline diorites, tonalites and granodiorites, and geochemical signatures compatible with magmatic arc scenarios. Their rocks are associated to a metamorphosed volcano-sedimentary of intra or back-arc basin setting platform carbonates, amphibolites (basaltic lavas) and psammitic rocks of the Italva group. Whole-rock Nd and Sr isotope data indicate more primitive contribution than earliest stage: initial εNd = −3.7 to +5.2, TDM = 1.68–0.92 Ga and ⁸⁷Sr/⁸⁶Sr initial ratios between 0.7061 and 0.7113. The second stage – Rio Negro arc – yielded more mature arc signatures: initial εNd = −8.4 to −2.5, TDM = 1.93–1.33 Ga and ⁸⁷Sr/⁸⁶Sr initial ratios between 0.7098 and 0.7211. The new data have been interpreted as an evolution of a Tonian primitive intra-oceanic stage of the magmatic arc generation, followed by more continental or transitional arcs during the Rio Negro stage. The data from both arc stages contrast with the younger Serra da Bolívia and Rio Doce continental arcs (570–590 Ma) developed in a proximal location. The data are similar to other Tonian-Ediacaran magmatic arcs: the Goiás arc in the Brasília Belt (ca. 862–630 Ma) and the São Gabriel arc (ca. 840–690 Ma), located respectively along the western margin of the São Francisco and Rio de La Plata cratons. In a Western Gondwana scenario, the juvenile signature indicates intra-oceanic tectonic settings. The combination of the older Tonian arcs with the more evolved Cryogenian to Ediacaran arcs within the Neoproterozoic belts, suggests more than 200 m.y. of subduction around the older cratonic blocks that made up Western Gondwana

Evaluation of the Extraction Temperature Influence on Polyphenolic Profiles of Vine-Canes (Vitis vinifera) Subcritical Water Extracts

This work focused on evaluating the possibility of using vineyard pruning wastes from two Portuguese Vitis vinifera varieties; Touriga Nacional (TN) and Tinta Roriz (TR), as new potential ingredients for the nutraceutical industry. An environmentally friendly extraction technique; namely subcritical-water extraction (SWE), was employed. The overall results indicate that phenolic acids were the major class of compounds quantified; being gallic acid the principal one. The highest value for total phenolic content (TPC) was obtained for the TR extract at 250 °C (181 ± 12 mg GAE/g dw). In terms of antioxidant activity; the DPPH values for the extracts obtained at 250 °C were approximately 4-fold higher than the ones obtained at 125 °C; with TR extract presenting the highest value (203 ± 22 mg TE/g dw). Thus, the TR extract obtained through SWE at 250 °C was selected to evaluate the scavenging activity and the in vitro effects on cells due to the best results achieved in the previous assays. This extract presented the ability to scavenge reactive oxygen species (O2●-, HOCl and ROO●). No adverse effects were observed in HFF-1 viability after exposure to extract concentrations below 100 μg/mL. This work demonstrated that vine-canes extracts could be a potential ingredient to nutraceutical industryO.D. is thankful for the research grant from project PTDC/BII-BIO/30884/2017—POCI-01-0145-FEDER-030884. D.P. is thankful for the PhD grant (SFRH/BD/144534/2019) financed by POPH-QREN and subsidized by the European Science Foundation and Ministério da Ciência, Tecnologia e Ensino Superior. M.M.M. (project CEECIND/02702/2017) and A.F.P. (DL57/2016–Norma transitória) are grateful for the financial support financed by national funds through FCT—Fundação para a Ciência e a Tecnologia, I.P. and to REQUIMTE/LAQV. The supply of the vineyard pruning is acknowledged to Sogrape, S.A. The authors are grateful to João Vasconcellos Porto for the provided identification of the studied plant material.info:eu-repo/semantics/publishedVersio