14 research outputs found
The challenge of remanufactured products: the role of returns policy and channel structure to reduce consumers' perceived risk
While remanufactured products represent an increasingly researched phenomenon in the literature, not much is known about consumers' understanding and acceptance of such products. This study explores this issue in the context of the theory of perceived risk (TPR), investigating return policy leniency and distribution channel choice as potential factors to foster remanufactured products' sales
Electrical integration and persistence of transplanted induced pluripotent stem cell-derived cardiomyocytes from different developmental stages
Investigation of action potential properties of native atrial and ventricular cardiomyocytes from the early embryonic to the adult stage allows the determination of the developmental stage of iPSCM
Susceptibility to induced ventricular tachycardias increases with time after transplantation of induced pluripotent stem cell-derived cardiomyocytes into infarcted mouse hearts
Arrhythmic risk after transplantation of induced pluripotent stem cell derived cardiomyocytes into infarcted mouse hearts
“Some of the things I understand but not all of it”. A group of deaf adolescents’ sources of knowledge and concerns regarding the adequacy of their level of knowledge about human immunodeficiency virus/acquired immune deficiency syndrome
Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis
Nitro-fatty acids are electrophilic anti-inflammatory mediators which are generated during myocardial ischemic injury. Whether these species exert anti-arrhythmic effects in the acute phase of myocardial ischemia has not been investigated so far. Herein, we demonstrate that pretreatment of mice with 9- and 10-nitro-octadec-9-enoic acid (nitro-oleic acid, NO2-OA) significantly reduced the susceptibility to develop acute ventricular tachycardia (VT). Accordingly, epicardial mapping revealed a markedly enhanced homogeneity in ventricular conduction. NO2-OA treatment of isolated cardiomyocytes lowered the number of spontaneous contractions upon adrenergic isoproterenol stimulation and nearly abolished ryanodine receptor type 2 (RyR2)-dependent sarcoplasmic Ca2+ leak. NO2-OA also significantly reduced RyR2-phosphorylation by inhibition of increased CaMKII activity. Thus, NO2-OA might be a novel pharmacological option for the prevention of VT development