Detection of KRAS mutation using plasma samples in non-small-cell lung cancer: a systematic review and meta-analysis

BackgroundThe aim of this study was to investigate the diagnostic accuracy of KRAS mutation detection using plasma sample of patients with non-small cell lung cancer (NSCLC).MethodsDatabases of Pubmed, Embase, Cochrane Library, and Web of Science were searched for studies detecting KRAS mutation in paired tissue and plasma samples of patients with NSCLC. Data were extracted from each eligible study and analyzed using MetaDiSc and STATA.ResultsAfter database searching and screening of the studies with pre-defined criteria, 43 eligible studies were identified and relevant data were extracted. After pooling the accuracy data from 3341 patients, the pooled sensitivity, specificity and diagnostic odds ratio were 71%, 94%, and 59.28, respectively. Area under curve of summary receiver operating characteristic curve was 0.8883. Subgroup analysis revealed that next-generation sequencing outperformed PCR-based techniques in detecting KRAS mutation using plasma sample of patients with NSCLC, with sensitivity, specificity, and diagnostic odds ratio of 73%, 94%, and 82.60, respectively.ConclusionCompared to paired tumor tissue sample, plasma sample showed overall good performance in detecting KRAS mutation in patients with NSCLC, which could serve as good surrogate when tissue samples are not available

Phase evolution and superconductivity enhancement in Se-substituted MoTe2_2 thin films

The strong spin$-$orbit coupling (SOC) and numerous crystal phases in few$-$layer transition metal dichalcogenides (TMDCs) MX$_2$ (M$=$W, Mo, and X$=$Te, Se, S) has led to a variety of novel physics, such as Ising superconductivity and quantum spin Hall effect realized in monolayer 2H$-$ and Td$-$MX$_2$, respectively. Consecutive tailoring of the MX$_2$ structure from 2H to Td phase may realize the long$-$sought topological superconductivity in one material system by incorporating superconductivity and quantum spin Hall effect together. In this work, by combing Raman spectrum, X-ray photoelectron spectrum (XPS), scanning transmission electron microscopy imaging (STEM) as well as electrical transport measurements, we demonstrate that a consecutively structural phase transitions from Td to 1T$'$ to 2H polytype can be realized as the Se-substitution concentration increases. More importantly, the Se$-$substitution has been found to notably enhance the superconductivity of the MoTe$_2$ thin film, which is interpreted as the introduction of the two$-$band superconductivity. The chemical constituent induced phase transition offers a new strategy to study the s$_{+-}$ superconductivity and the possible topological superconductivity as well as to develop phase$-$sensitive devices based on MX$_2$ materials.Comment: 27 pages, 5 figure

Impact of lockdown on the growth of children in China aged 3-6 years during the COVID-19 pandemic

BackgroundLockdowns in COVID-19 pandemic led to less physical activity and more intake of unhealthy food in children. The aim of this study was to investigate the negative impact of major lockdowns on the growth of children aged 3-6 years during COVID-19 pandemic period.MethodsPhysical examination results in 2019 to 2022 from 5834 eligible children (2972 males and 2862 females) from Southwestern China who were 3 years old in 2019 were retrospectively collected. Height and weight data points were extracted from the results, and percentiles of height (height%), weight (weight%), and BMI (BMI%), and rates of overweight and obesity were calculated and compared between different years during the pandemic.ResultsAfter analyzing the 15404 growth data points from 5834 children, a slowly increasing trend of height% from 2019 to 2022 was observed. Weight%, BMI%, overweight rate, obesity rate, and combined overweight and obesity rate had two peaks in 2020 and 2022 when major lockdowns were adopted and a drop in between (year 2021), except for obesity rate which did not drop in 2021. Similar results were shown after stratification by gender.ConclusionThe lockdowns in COVID-19 pandemic promoted obesity of kindergarten children, but did not show any negative impact on their height growth possibly due to over-nutrition of children during lockdowns. More efforts need to be made to limit the increase of obesity rate in kindergarten children during possible future lockdowns

Reconstructing Writer Identities, Student Identities, Teacher Identities, and Gender Identities: Chinese Graduate Students in America

The increasing presence of Chinese international graduate students in American higher education has mandated a closer examination of their multifaceted lives against stereotypes that hinder their efforts to find, transform, or assert their identities in the dominant discourses of American academia and culture. Cross cultural studies of Chinese international students tend to reinforce stereotypes of their writer identities, learner identities, and teacher identities. Examining these various identities discloses dichotomies that read Chinese students’ traits and behaviors as handicaps and thus characterize them as “abnormal” in relation to the “normal” traits and behaviors of Chinese students’ Western counterparts. Whereas Western student writers are described as direct and logical, Chinese student writers are characterized as indirect and illogical. In comparison to the assertive and critical way of thinking that is regarded as the norm among American students, Chinese students are seen as submissive “rote learners.” Conversely, the liberatory, student-centered approach to teaching that is promoted in the American educational system is thought to be antithetical to what is considered to be an authoritarian, teacher-centered approach of Chinese education. Underlying these binaries is an unchallenged gender binary. Deeply entrenched Western notions about masculinity and femininity ultimately lead to a feminization of Chinese identities. Despite the constant critique from various disciplines, dichotomous views of gender persist and consequently lead to misconceptions about Chinese subjectivity in U.S. This project argues that these misconceptions have produced consistently devastating effects on Chinese students and further demobilize them from acculturating themselves into the dominant discourse in the United States. To deconstruct these socially, culturally, and ideologically constructed binaries, this work uses scholarship on subjectivity and identity by Michel Foucault and Homi Bhabha to examine critically how identity is formed and transformed; it also draws heavily on scholarship in rhetoric and composition and in feminist studies to delineate how Chinese students’ various identities are formed and transformed. The goal of this work is to advance a complementary thinking to advocate new conceptions about Chinese students’ various identities and ultimately to allow Chinese students to assume more active agency in their identity transformation process in the U.S

Influences of Different Interlayers on Mechanical and Tribological Properties of DLC Films

Adhesion between the film and the substrate is a key factor to determine the performance of the films.Due to the low adhesion of diamond-like carbon(DLC)film on cemented carbide,the DLC films with different W interlayer(single W layer,single WC layer,W bilayer,and W trilayer)were deposited on cemented carbide YG8substrate by a novel linear ion beam source composited with a DC magnetron sputtering process.The mechanical and tribological properties of DLC films were evaluated.The results show that the DLC films with different W interlayers are dense,and the interfacial columnar structure with the increased layers is interrupted,which is conducive to improve the toughness of DLC films.For the DLC film with W trilayer,its the biggest toughness is 6.44MPa·m~(1/2). The hardness decreases, howerver,the residual stress can be reduced by 55%compared to the film with single W layer and the adhesion strength reaches to 85N.Additionally,this film has lower friction coefficient and wear rate,which exhibits excellent anti-wear and anti-friction properties

Comparative efficacy and safety of sodium–glucose cotransporter 2 inhibitors for renal outcomes in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis

AbstractIn this study, the summarized WMDs and RRs were calculated using a pairwise analysis and a network meta-analysis with a random effects model, to compare and rank the efficacy and safety of SGLT-2i for renal outcomes in patients with T2DM. Among 1894 identified articles, 30 trials including 50,244 patients with T2DM were evaluated. Network analysis revealed that the administration of canagliflozin was associated with a reduced risk of renal impairment (surface under the cumulative ranking: 90.8%). Further, although the administration of SGLT-2i was not associated with the risk of renal impairment (RR = 0.88, 95%CI = 0.68–1.15, p = 0.354), the administration of empagliflozin was associated with a reduced risk of renal impairment compared to that with the administration of placebo (RR = 0.74, 95%CI = 0.62–0.90, p = 0.002). Moreover, compared with the administration of a placebo, the administration of 50, 100, and 200 mg of canagliflozin was associated with lower serum creatinine levels. Furthermore, compared with the administration of a placebo, the administration of 100 mg canagliflozin, 2.5 mg dapagliflozin, and 25 mg empagliflozin was associated with a lower reduction in the estimated glomerular filtration rate. Except for 300 mg canagliflozin, all SGLT-2i were associated with greater increases in blood urea nitrogen levels (WMD = 1.39, 95%CI = 1.20–1.59, p < 0.001). Finally, the administration of all SGLT-2i significantly increased the ratio of urinary glucose to creatinine compared with the ratio upon administration of placebo (WMD = 36.21, 95%CI = 31.50–40.92, p < 0.001). Briefly, canagliflozin exerts the greatest therapeutic effect in terms of reducing the risk of renal impairment. Empagliflozin and canagliflozin may be more effective than other SGLT-2i in preventing renal impairment

Bactericidal abilities and in vitro properties of diamond-like carbon films deposited onto MAO-treated titanium

Bactericidal abilities and in vitro properties of diamond-like carbon films deposited onto MAO-treated titaniu

Integration of Micro-Nano-Engineered Hydroxyapatite/Biochars with Optimized Sorption for Heavy Metals and Pharmaceuticals

From the perspective of treating wastes with wastes, bamboo sawdust was integrated with a hydroxyapatite (HAP) precursor to create engineered nano-HAP/micro-biochar composites (HBCs) by optimizing the co-precipitated precursor contents and co-pyrolysis temperature (300, 450, 600 &deg;C). The physicochemical properties of HBCs, including morphologies, porosities, component ratios, crystalline structures, surface elemental chemical states, surface functional groups, and zeta potentials as a function of carbonization temperatures and components of precursors, were studied. Biochar matrix as an efficient carrier with enhanced specific surface area to prevent HAP from aggregation was desired. The sorption behavior of heavy metal (Cu(II), Cd(II), and Pb(II)) and pharmaceuticals (carbamazepine and tetracycline) on HBCs were analyzed given various geochemical conditions, including contact time, pH value, ionic strength, inferencing cations and anions, coexisting humic acid, and ambient temperature. HBCs could capture these pollutants efficiently from both simulated wastewaters and real waters. Combined with spectroscopic techniques, proper multiple dominant sorption mechanisms for each sorbate were elucidated separately. HBCs presented excellent reusability for the removal of these pollutants through six recycles, except for tetracycline. The results of this study provide meaningful insight into the proper integration of biochar&ndash;mineral composites for the management of aquatic heavy metals and pharmaceuticals

Comparative efficacy and safety of paricalcitol versus vitamin D receptor activators for dialysis patients with secondary hyperparathyroidism: a meta-analysis of randomized controlled trials

Abstract Background Secondary hyperparathyroidism (SHPT) is a severe complication for dialysis patients. Vitamin D receptor activators (VDRAs) are used to treat SHPT, but the comparative efficacy and safety between paricalcitol and other vitamin D receptor activators for management of SHPT in dialysis patients has been unproven. Methods We searched PubMed, Embase, and the Cochrane Library for the time period through June 2017 to identify randomized controlled trials that evaluated paricalcitol compared with other VDRAs for treatment of SHPT. The primary outcome was the percentage of patients with target reduction of intact parathyroid hormone (iPTH) from baseline. Secondary outcomes included incidences of hypercalcemia and hyperphosphatemia. The random-effects model was used to estimate relative risks (RRs) with 95% confidence intervals (CIs). Results Eight studies (N = 759) were eligible for final inclusion. Compared with other VDRAs, no significant differences were found in the percentage of patients with target reduction of intact parathyroid hormone (iPTH) from baseline for paricalcitol treatment of SHPT in dialysis patients (RR, 1.01; 95% CI, 0. 87–1.18; p = 0.85). There were no differences in the incidence of hypercalcemia (RR, 0.95; 95% CI, 0.74–1.21; p = 0. 65) and hyperphosphatemia (RR, 0.94; 95% CI, 0.77–1.16; p = 0.58). Conclusions The presently available evidence is insufficient to draw a conclusion regarding whether paricalcitol therapy has a comparative efficacy and safety over other VDRAs for treating dialysis patients with SHPT. Large-sample, well-conducted, high-quality RCTs with patient-level outcomes (i.e., mortality) are urgently needed