Self-induced structure in the current-voltage characteristics of RSQUIDs

Resistive two-junction SQUIDs (RSQUIDs) made from high-temperature superconductors are being developed as narrow-linewidth tunable oscillators in the GHz frequency range. We present here the results of numerical simulation of RSQUIDs of this type. These studies have identified conditions where sub-harmonic steps and other features are apparent in the current-voltage characteristics, driven by the internally-generated heterodyne frequency. The behavior is sensitive to the frequency (set by the voltage across the resistive element in the RSQUID), the temperature and also the loop inductance. We have studied the effects of thermal noise on these features. We also assess how these effects might be observed, and consider how they might affect practical applications of high frequency heterodyne RSQUID oscillators

Simulation of HTS Josephson Mixers

© 2016 IEEE. The Commonwealth Scientific and Industrial Research Organization has developed superconducting microwave monolithic integrated circuit (MMIC) mixers using step-edge Josephson junctions and on-chip filters, made from YBaCuO on MgO substrates. Integration into an MMIC results in a compact and efficiently coupled structure. These have been shown to have outstanding conversion efficiency, dynamic range, and linearity. We report here a range of simulations of this type of mixer. We have mainly used Josephson simulators and analyze the data in both the time and frequency domains. More recently, we have also used microwave simulators incorporating a novel Verilog-A Josephson junction model that we have developed. We have looked at the interactions of junction bias current, local oscillator power, and radio-frequency input power with conversion efficiency, dynamic range, and linearity. Good agreement is found overall with measurements

A 36 GHz HTS MMIC Josephson mixer - Simulation and measurement

© 2002-2011 IEEE. Modeling, simulation, and measurement of a compact 36 GHz high-temperature superconducting (HTS) monolithic Josephson junction mixer are presented in this paper. A full HTS microwave monolithic integrated circuit (MMIC) simulation was carried out for the circuit combining HTS passive devices and the Josephson junction. Optimal impedance matching and bias conditions were investigated, and the circuit layout was designed accordingly. The HTS circuit has a compact dimension of 5 × 4 × 0.3 mm3, including filters, resonators, and impedance matching circuits. The HTS MMIC mixer was fabricated and packaged with an LNA to realize a receiver front end with a total dimension of 28 × 25 × 15 mm3. Measurement result showed an overall conversion gain around 35 dB, with local oscillator driving power around -45 dBm at operating temperature of 40 K

Immune Mechanisms of Resistance to Cediranib in Ovarian Cancer

This paper investigates mechanisms of resistance to the VEGF receptor inhibitor cediranib in high-grade serous ovarian cancer, HGSOC, and defines rational combination therapies. We used three different syngeneic orthotopic mouse HGSOC models that replicated the human tumor microenvironment, TME. After 4-5 weeks treatment of established tumors, cediranib had anti-tumor activity with increased tumor T cell infiltrates and alterations in myeloid cells. However, continued cediranib treatment did not change overall survival or the immune microenvironment in two of the three models. Moreover, treated mice developed additional peritoneal metastases not seen in controls. Cediranib-resistant tumors had intrinsically high levels of IL-6 and JAK/STAT signaling and treatment increased endothelial STAT3 activation. Combination of cediranib with a murine anti-IL-6 antibody was superior to monotherapy, increasing mouse survival, reducing blood vessel density and pSTAT3, with increased T cell infiltrates in both models. In a third HGSOC model, that had lower inherent IL-6 JAK/STAT3 signaling in the TME but high PD1 signaling, long-term cediranib treatment significantly increased overall survival. When the mice eventually relapsed, pSTAT3 was still reduced in the tumors but there were high levels of immune cell PD1 and PDL1. Combining cediranib with an anti-PD1 antibody was superior to monotherapy in this model, increasing T cells and decreasing blood vessel densities. Bioinformatics analysis of two human HGSOC transcriptional datasets revealed distinct clusters of tumors with IL-6 and PD-1 pathway expression patterns that replicated the mouse tumors. Combination of anti-IL-6 or anti-PD1 in these patients may increase activity of VEGFR inhibitors and prolong disease-free survival

The effects of neo-adjuvant chemotherapy on myeloid cells in high-grade serous ovarian cancer metastases

PhD Thesi

Applied physics : can a fraction of a quantum be better than a whole one?

An editorial on applied physic

Studies of chaos and thermal noise in a driven Josephson Junction using an electronic analog

Using an electronic analog of a resistively shunted driven Josephson junction, the authors have demonstrated a number of effects, including the appearance of a devil's staircase in the current-voltage characteristic, the onset of chaos, and the effect of noise on these phenomena. It is stressed that the analog is simple, but models the junction behavior with a high degree of accuracy and detai