101 research outputs found

    Non asymptotic sharp oracle inequalities for the improved model selection procedures for the adaptive nonparametric signal estimation problem

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    In this paper, we consider the robust adaptive non parametric estimation problem for the periodic function observed with the Levy noises in continuous time. An adaptive model selection procedure, based on the improved weighted least square estimates, is proposed. Sharp oracle inequalities for the robust risks have been obtained

    Improved robust model selection methods for a Lévy nonparametric regression in continuous time

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    In this paper, we develop the James–Stein improved method for the estimation problem of a nonparametric periodic function observed with Lévy noises in continuous time. An adaptive model selection procedure based on the weighted improved least squares estimates is constructed. The improvement effect for nonparametric models is studied. It turns out that in non-asymptotic setting the accuracy improvement for nonparametric models is more important than for parametric ones. Moreover, sharp oracle inequalities for the robust risks have been shown and the adaptive efficiency property for the proposed procedures has been established. The numerical simulations are given

    Critical parameters for efficient sonication and improved chromatin immunoprecipitation of high molecular weight proteins

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    Solubilization of cross-linked cells followed by chromatin shearing is essential for successful chromatin immunoprecipitation (ChIP). However, this task, typically accomplished by ultrasound treatment, may often become a pitfall of the process, due to inconsistent results obtained between different experiments under seemingly identical conditions. To address this issue we systematically studied ultrasound-mediated cell lysis and chromatin shearing, identified critical parameters of the process and formulated a generic strategy for rational optimization of ultrasound treatment. We also demonstrated that whereas ultrasound treatment required to shear chromatin to within a range of 100–400 bp typically degrades large proteins, a combination of brief sonication and benzonase digestion allows for the generation of similarly sized chromatin fragments while preserving the integrity of associated proteins. This approach should drastically improve ChIP efficiency for this class of proteins

    Renewal theory and its applications : lectures notes for the course "Stochastic modelling" taken by most Mathematics students and Economics students (directions of training 01.03.01 - Mathematics and 38.04.01 - Economics)

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    The goal of the course is to study the main tools of the renewal theory and their applications to some problems of the actuarial analysis for insurance companies in the framework of the Cremer - Lundberg models. We consider such important problems in the renewal theory as limit theorems for the renewal process and the ruin problems for the insurance companies with investments in the stochastic financial markets. The notes areintended for students of the Mathematics and Economics Faculties
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