SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF QUINAZOLINONE DERIVATIVES

Objective: The present study aims to synthesis and evaluation of antimicrobial activity of quinazolinone derivatives. Methods: Methyl anthranilate react with acetyl chloride in ethanol gives methyl-2 acetamido benzoate (1) which on reaction with hydrazine hydrate gives 3-amino-2 methyl 4-(3H)-quinazolinone.(2) The amino group of synthesized quinazolinone with substituted acid chloride which gives 3-Chloroacetyl amino-2-methyl-4-quinazolinone (3) which on condensation with various primary amines gives 2-(2-methyl-4-oxo-4H-quinazoline-3yl-amino)-N-substituted acetamide (4a-4j). Results: The reaction sequence involves microwave-induced preparation of methyl-2 acetamido benzoate (1) from reaction of Methyl anthranilate react with acetyl chloride in ethanol. Further reaction with hydrazine hydrate gives 3-amino-2 methyl 4-(3H)-quinazolinone. (2) The amino group of synthesized quinazolinone with substituted acid chloride which gives 3-Chloroacetyl amino-2-methyl-4-quinazolinone (3) which on condensation with various primary amines gives 2-(2-methyl-4-oxo-4H-quinazoline-3yl-amino)-N-substituted acetamide (4a-4j). Which were characterized by IR and 1HNMR spectral data. Conclusion: All the synthesized compounds were screened for antimicrobial activity by Broth dilution method. Most of the derivatives showed good antimicrobial activity against Gram-Positive and Gram-negative bacteria

Risk perception and decision making in the supply chain: theory and practice

For over sixty years, academics and practitioners from different backgrounds, including psychology, sociology, and management, have studied the perception of risk and how different decision making affects daily life and business activities. Although it is almost six hundred years since Machiavelli stressed the importance of calculation of risk and effective response to it, approaches to risk measurement and assessment, and to decision making in risky situations, continue to develop and evolve. In the business world, managers strive to find ways to understand how different internal and external factors influence risk, how to judge and interpret the available evidence on the possibility of loss, and how to take individual actions to manage the risk (Slovic 2000). In this decade, a number of risk management frameworks (e.g. IS031000) have been proposed and employed in different areas. These frameworks provide foundations and building blocks for managers to collect available data to analyse risk. Most importantly, such frameworks allow managers to gather knowledge intellectually, to properly judge their experience and to assess the current situation, so as to enter into the most appropriate decision

Comparative Study about organizational Ergonomics between IT Sector and Banking Sector

In today’s competitive world employer is more focus on employee welfare and benefits. Employee is important resource for any organization. Companies are focusing on the employee health and wealth. Healthy workforce is result more productivity and more output. Ergonomics is work law related sitting jobs. The purpose of this paper is to Comparison between organizational Ergonomics awareness and practices in IT & Banking Sector. This study examines the following factors: Work Environment, Work Posture, Office design, Ergonomics Furniture. There is no one permanent practices which show the significance of the influence of all these above broad points because different organizations place different emphasis on these pointers depending upon their correctness impacting organizational Ergonomics. Based on understanding of the primary data collected by the researcher, suggestions are drawn which give a complete view on the various practices that both sector companies or Banks  should adopt to keep the Organizational Ergonomics