Yearly licensing studies from 1997 to 2007 of the inactivated whole virus seasonal influenza vaccine fluval--a useful approach to pandemic vaccine development even in less well developed countries?

OBJECTIVE: Seasonal vaccination has been consistently shown to significantly reduce morbidity and mortality because of influenza epidemics, even in healthy, working adults. Here we report the results of the yearly licensing studies of the past 11 influenza seasons (1997-2007) with a trivalent, inactivated whole virus vaccine with an aluminum phosphate adjuvant system. METHODS: Sixty healthy volunteers per age group (18-60 years and 60 years and older) were enrolled to receive vaccination each year, thus, a total of 1080 subjects were studied. Serum antibody titers were measured by hemagglutination inhibition (HI). RESULTS: The vaccine met the criteria for licensing each year, meaning seroprotection (achievement of an HI titer of >1:40 in >70% of subjects); seroconversion, i.e. a >4-fold increase in HI antibody titer, or reaching a titer of >1:40, in >40% of subjects; and an increase in geometric mean titers by >2.5-fold. Side effects were rare and mild. The same method was used to produce a pre-pandemic vaccine against influenza A (H5N1), which has been shown to be safe and immunogenic in humans. CONCLUSIONS: We conclude that the method presented is safe, effective and may serve as a useful approach to seasonal and pandemic vaccine production even in less well-developed countries by means of technological transfer

VLBI imaging of extremely high redshift quasars at 5 GHz

We present very long baseline interferometry (VLBI) images of ten very high redshift (z>3) quasars at 5 GHz. The sources 0004+139, 0830+101, 0906+041, 0938+119 and 1500+045 were observed in September 1992 using a global VLBI array, while 0046+063, 0243+181, 1338+381, 1428+423 and 1557+032 were observed in October 1996 with the European VLBI Network and Hartebeesthoek, South Africa. Most of the sources are resolved and show asymmetric structure. The sample includes 1428+423, the most distant radio loud quasar known to date (z=4.72). It is barely resolved with an angular resolution of about 2.0*1.4 mas.Comment: Astronomy and Astrophysics, in press, Latex2e, 10 pages, 3 figures (and lots of sub-figures

VSOP observation of the quasar PKS 2215+020: a new laboratory for core-jet physics at z=3.572

We report results of a VSOP (VLBI Space Observatory Programme) observation of a high redshift quasar PKS 2215+020 (z=3.572). The ~1 milliarcsecond resolution image of the quasar reveals a prominent `core-jet' structure on linear scales from 5/h to 300/h pc ($H_0=100*h km/(s*Mpc). The brightness temperatures and sizes of bright features identified in the jet are consistent with emission from relativistic shocks dominated by adiabatic energy losses. The jet is powered by the central black hole with estimated mass of ~4*10^9 solar masses. Comparisons with VLA and ROSAT observations indicate a possible presence of an extended radio/X-ray halo surrounding 2215+020.Comment: 15 pages, 6 figures, aastex macros; accepted for publication in The Astrophysical Journal, V.546, N.2 *(January 10 2001

A kinematic study of the compact jet in quasar B3 1633+382

We present a study of the motion of compact jet components in quasar B3 1633+382. Through analyzing 14 epochs of VLBI observations of three components (B1, B2, and B3) at 22 GHz, we find two different possibilities of component classification. Thus two corresponding kinematical models can be adopted to explain the evolutionary track of components. One is a linear motion, while another is a helical model. Future observations are needed to provide new kinematical constraints for the motion of these components in this source.Comment: 7 pages, 3 figures; Accepted for publication in A&

A Possible Periodicity in the Radio Lightcurves of 3C454.3

During the period 1966.5 - 2006.2 the 15GHz and 8GHz lightcurves of 3C454.3 (z=0.859) show a qsasi-periodicity of ~12.8 yr (~6.9 yr in the rest frame of the source) with a double-bump structure. This periodic behaviour is interpreted in terms of a rotating double-jet model in which the two jets are created from the black holes in a binary system and rotate with the period of the orbital motion. The periodic variations in the radio fluxes of 3C454.3 are suggested to be mainly due to the lighthouse effects (or the variation in Doppler boosting) of the precessing jets which are caused by the orbital motion. In addition, variations in the mass-flow rates accreting onto the black holes may be also involved.Comment: 15 pages, 11 figure

Radio Frequency Spectra of 388 Bright 74 MHz Sources

As a service to the community, we have compiled radio frequency spectra from the literature for all sources within the VLA Low Frequency Sky Survey (VLSS) that are brighter than 15 Jy at 74 MHz. Over 160 references were used to maximize the amount of spectral data used in the compilation of the spectra, while also taking care to determine the corrections needed to put the flux densities from all reference on the same absolute flux density scale. With the new VLSS data, we are able to vastly improve upon previous efforts to compile spectra of bright radio sources to frequencies below 100 MHz because (1) the VLSS flux densities are more reliable than those from some previous low frequency surveys and (2) the VLSS covers a much larger area of the sky (declination >-30 deg.) than many other low frequency surveys (e.g., the 8C survey). In this paper, we discuss how the spectra were constructed and how parameters quantifying the shapes of the spectra were derived. Both the spectra and the shape parameters are made available here to assist in the calibration of observations made with current and future low frequency radio facilities.Comment: Accepted to ApJ

Early-life telomere dynamics differ between the sexes and predict growth in the barn swallow (Hirundo rustica)

Telomeres are conserved DNA-protein structures at the termini of eukaryotic chromosomes which contribute to maintenance of genome integrity, and their shortening leads to cell senescence, with negative consequences for organismal functions. Because telomere erosion is influenced by extrinsic and endogenous factors, telomere dynamics may provide a mechanistic basis for evolutionary and physiological trade-offs. Yet, knowledge of fundamental aspects of telomere biology under natural selection regimes, including sex- and context-dependent variation in early-life, and the covariation between telomere dynamics and growth, is scant. In this study of barn swallows (Hirundo rustica) we investigated the sex-dependent telomere erosion during nestling period, and the covariation between relative telomere length and body and plumage growth. Finally, we tested whether any covariation between growth traits and relative telomere length depends on the social environment, as influenced by sibling sex ratio. Relative telomere length declined on average over the period of nestling maximal growth rate (between 7 and 16 days of age) and differently covaried with initial relative telomere length in either sex. The frequency distribution of changes in relative telomere length was bimodal, with most nestlings decreasing and some increasing relative telomere length, but none of the offspring traits predicted the a posteriori identified group to which individual nestlings belonged. Tail and wing length increased with relative telomere length, but more steeply in males than females, and this relationship held both at the within- and among-broods levels. Moreover, the increase in plumage phenotypic values was steeper when the sex ratio of an individual's siblings was female-biased. Our study provides evidence for telomere shortening during early life according to subtly different dynamics in either sex. Furthermore, it shows that the positive covariation between growth and relative telomere length depends on sex as well as social environment, in terms of sibling sex ratio