4,802 research outputs found
SB 301 - Wills, Trusts, and Administration of Estates
The Act creates the “Revised Uniform Fiduciary Access to Digital Assets Act,” extends fiduciaries’ powers to include managing tangible property and digital assets, and provides conforming cross-references for a conservator
Increased GABA Contributes to Enhanced Control over Motor Excitability in Tourette Syndrome
Tourette syndrome (TS) is a developmental neurological disorder characterized by vocal and motor tics [1] and associated with cortical-striatal-thalamic-cortical circuit dysfunction [2, 3], hyperexcitability within cortical motor areas [4], and altered intracortical inhibition [4, 5, 6, 7]. TS often follows a developmental time course in which tics become increasingly more controlled during adolescence in many individuals [1], who exhibit enhanced control over their volitional movements [8, 9, 10, 11]. Importantly, control over motor outputs appears to be brought about by a reduction in the gain of motor excitability [6, 7, 12, 13]. Here we present a neurochemical basis for a localized gain control mechanism. We used ultra-high-field (7 T) magnetic resonance spectroscopy to investigate in vivo concentrations of γ-aminobutyric acid (GABA) within primary and secondary motor areas of individuals with TS. We demonstrate that GABA concentrations within the supplementary motor area (SMA)—a region strongly associated with the genesis of motor tics in TS [14]—are paradoxically elevated in individuals with TS and inversely related to fMRI blood oxygen level-dependent activation. By contrast, GABA concentrations in control sites do not differ from those of a matched control group. Importantly, we also show that GABA concentrations within the SMA are inversely correlated with cortical excitability in primary motor cortex and are predicted by motor tic severity and white-matter microstructure (FA) within a region of the corpus callosum that projects to the SMA within each hemisphere. Based upon these findings, we propose that extrasynaptic GABA contributes to a form of control, based upon localized tonic inhibition within the SMA, that may lead to the suppression of tics
The Gravitational Lens Candidate FBQ 1633+3134
We present our ground-based optical imaging, spectral analysis, and high
resolution radio mapping of the gravitational lens candidate FBQ 1633+3134.
This z=1.52, B=17.7 quasar appears double on CCD images with an image
separation of 0.66 arcseconds and a flux ratio of ~3:1 across BVRI filters. A
single 0.27 mJy radio source is detected at 8.46 GHz, coincident to within an
arcsecond of both optical components, but no companion at radio wavelengths is
detected down to a flux level of 0.1 mJy (3 sigma). Spectral observations
reveal a rich metal-line absorption system consisting of a strong Mg II doublet
and associated Fe I and Fe II absorption features, all at an intervening
redshift of z=0.684, suggestive of a lensing galaxy. Point spread function
subtraction however shows no obvious signs of a third object between the two
quasar images, and places a detection limit of I > 23.0 if such an object
exists. Although the possibility that FBQ 1633+3134 is a binary quasar cannot
be ruled out, the evidence is consistent with it being a single quasar lensed
by a faint, metal-rich galaxy.Comment: 24 pages, 5 figures. Accepted by AJ. A calibration error affecting B
and V band apparent magnitudes has been corrected. The conclusions of the
paper are not change
CTQ 414: A New Gravitational Lens
We report the discovery and ground based observations of the new
gravitational lens CTQ 414. The source quasar lies at a redshift of z = 1.29
with a B magnitude of 17.6. Ground based optical imaging reveals two point
sources separated by 1.2 arcsec with a magnitude difference of roughly 1 mag.
Subtraction of two stellar point spread functions from images obtained in
subarcsecond seeing consistently leaves behind a faint, residual object. Fits
for two point sources plus an extended object places the fainter object
collinear with the two brighter components. Subsequent HST/NICMOS observations
have confirmed the identification of the fainter object as the lensing galaxy.
VLA observations at 8.46 GHz reveal that all components of the lensing system
are radio quiet down to the 0.2 mJy flux level.Comment: Latex, 18 pages including 2 ps figures; accepted for publication in
A
CTQ 839: Candidate for the Smallest Projected Separation Binary Quasar
We report the discovery of the new double quasar CTQ 839. This B = 18.3,
radio quiet quasar pair is separated by 2.1" in BRIH filters with magnitude
differences of delta m_B = 2.5, delta m_R = delta m_I = 1.9, and delta m_H =
2.3. Spectral observations reveal both components to be z = 2.24 quasars, with
relative redshifts that agree at the 100 km/s level, but exhibit pronounced
differences in the equivalent widths of related emission features, as well as
an enhancement of blue continuum flux in the brighter component longward of the
Ly alpha emission feature. In general, similar redshift double quasars can be
the result of a physical binary pair, or a single quasar multiply imaged by
gravitational lensing. Empirical PSF subtraction of R and H band images of CTQ
839 reveal no indication of a lensing galaxy, and place a detection limit of R
= 22.5 and H = 17.4 for a third component in the system. For an Einstein-de
Sitter cosmology and SIS model, the R band detection limit constrains the
characteristics of any lensing galaxy to z_lens >= 1 with a corresponding
luminosity of L >~ 5 L_*, while an analysis based on the redshift probability
distribution for the lensing galaxy argues against the existence of a z_lens >~
1 lens at the 2 sigma level. A similar analysis for a Lambda dominated
cosmology, however, does not significantly constrain the existence of any
lensing galaxy. The broadband flux differences, spectral dissimilarities, and
failure to detect a lensing galaxy make the lensing hypothesis for CTQ 839
unlikely. The similar redshifts of the two components would then argue for a
physical quasar binary. At a projected separation of 8.3/h kpc (Omega_matter =
1), CTQ 839 would be the smallest projected separation binary quasar currently
known.Comment: Latex, 23 pages including 5 ps figures; accepted for publication in
A
Dual EGFR inhibition in combination with anti-VEGF treatment: a phase I clinical trial in non-small cell lung cancer.
BackgroundPreclinical data indicate EGFR signals through both kinase-dependent and independent pathways and that combining a small-molecule EGFR inhibitor, EGFR antibody, and/or anti-angiogenic agent is synergistic in animal models.MethodsWe conducted a dose-escalation, phase I study combining erlotinib, cetuximab, and bevacizumab. The subset of patients with non-small cell lung cancer (NSCLC) was analyzed for safety and response.ResultsThirty-four patients with NSCLC (median four prior therapies) received treatment on a range of dose levels. The most common treatment-related grade ≥2 adverse events were rash (n=14, 41%), hypomagnesemia (n=9, 27%), and fatigue (n=5, 15%). Seven patients (21%) achieved stable disease (SD) ≥6 months, two achieved a partial response (PR) (6%), and two achieved an unconfirmed partial response (uPR) (6%) (total=32%). We observed SD≥6 months/PR/uPR in patients who had received prior erlotinib and/or bevacizumab, those with brain metastases, smokers, and patients treated at lower dose levels. Five of 16 patients (31%) with wild-type EGFR experienced SD≥6 months or uPR. Correlation between grade of rash and rate of SD≥6 months/PR was observed (p less than 0.01).ConclusionThe combination of erlotinib, cetuximab, and bevacizumab was well-tolerated and demonstrated antitumor activity in heavily pretreated patients with NSCLC
RETROCAM: A Versatile Optical Imager for Synoptic Studies
We present RETROCAM, an auxiliary CCD camera that can be rapidly inserted
into the optical beam of the MDM 2.4m telescope. The speed and ease of
reconfiguring the telescope to use the imager and a straightforward user
interface permit the camera to be used during the course of other observing
programs. This in turn encourages RETROCAM's use for a variety of monitoring
projects.Comment: 6 pages, 6 figures, Accepted by A
PMN J1632-0033: A new gravitationally lensed quasar
We report the discovery of a gravitationally lensed quasar resulting from our
survey for lenses in the southern sky. Radio images of PMN J1632-0033 with the
VLA and ATCA exhibit two compact, flat-spectrum components with separation
1.47" and flux density ratio 13.2. Images with the HST reveal the optical
counterparts to the radio components and also the lens galaxy. An optical
spectrum of the bright component, obtained with the first Magellan telescope,
reveals quasar emission lines at redshift 3.42. Deeper radio images with MERLIN
and the VLBA reveal a faint third radio component located near the center of
the lens galaxy, which is either a third image of the background quasar or
faint emission from the lens galaxy.Comment: 21 pp., including 4 figures; thoroughly revised in light of new
MERLIN/HST data; accepted for publication in A
The long-term evolution of the spin, pulse shape, and orbit of the accretion-powered millisecond pulsar SAX J1808.4-3658
We present a 7 yr timing study of the 2.5 ms X-ray pulsar SAX J1808.4-3658,
an X-ray transient with a recurrence time of ~2 yr, using data from the Rossi
X-ray Timing Explorer covering 4 transient outbursts (1998-2005). We verify
that the 401 Hz pulsation traces the spin frequency fundamental and not a
harmonic. Substantial pulse shape variability, both stochastic and systematic,
was observed during each outburst. Analysis of the systematic pulse shape
changes suggests that, as an outburst dims, the X-ray "hot spot" on the pulsar
surface drifts longitudinally and a second hot spot may appear. The overall
pulse shape variability limits the ability to measure spin frequency evolution
within a given X-ray outburst (and calls previous nudot measurements of this
source into question), with typical upper limits of |nudot| < 2.5x10^{-14} Hz/s
(2 sigma). However, combining data from all the outbursts shows with high (6
sigma) significance that the pulsar is undergoing long-term spin down at a rate
nudot = (-5.6+/-2.0)x10^{-16} Hz/s, with most of the spin evolution occurring
during X-ray quiescence. We discuss the possible contributions of magnetic
propeller torques, magnetic dipole radiation, and gravitational radiation to
the measured spin down, setting an upper limit of B < 1.5x10^8 G for the
pulsar's surface dipole magnetic field and and Q/I < 5x10^{-9} for the
fractional mass quadrupole moment. We also measured an orbital period
derivative of Pdot = (3.5+/-0.2)x10^{-12} s/s. This surprising large Pdot is
reminiscent of the large and quasi-cyclic orbital period variation observed in
the so-called "black widow" millisecond radio pulsars, supporting speculation
that SAX J1808.4-3658 may turn on as a radio pulsar during quiescence. In an
appendix we derive an improved (0.15 arcsec) source position from optical data.Comment: 22 pages, 10 figures; accepted for publication in Ap
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