Risk-aware linear bandits with convex loss

In decision-making problems such as the multi-armed bandit, an agent learns sequentially by optimizing a certain feedback. While the mean reward criterion has been extensively studied, other measures that reflect an aversion to adverse outcomes, such as mean-variance or conditional value-at-risk (CVaR), can be of interest for critical applications (healthcare, agriculture). Algorithms have been proposed for such risk-aware measures under bandit feedback without contextual information. In this work, we study contextual bandits where such risk measures can be elicited as linear functions of the contexts through the minimization of a convex loss. A typical example that fits within this framework is the expectile measure, which is obtained as the solution of an asymmetric least-square problem. Using the method of mixtures for supermartingales, we derive confidence sequences for the estimation of such risk measures. We then propose an optimistic UCB algorithm to learn optimal risk-aware actions, with regret guarantees similar to those of generalized linear bandits. This approach requires solving a convex problem at each round of the algorithm, which we can relax by allowing only approximated solution obtained by online gradient descent, at the cost of slightly higher regret. We conclude by evaluating the resulting algorithms on numerical experiments

Energies and widths of atomic core-levels in liquid mercury

High-resolution measurements of the photoinduced X-ray emission of liquid mercury were performed, using a transmission DuMond-type crystal spectrometer for transitions above 11 keV and a reflection von Hamos-type crystal spectrometer for transitions below 11 keV. The target X-ray fluorescence was produced by irradiating the sample with the Bremsstrahlung from X-ray tubes. The energies and natural linewidths of 6 K-shell, 26 L-shell and 2 M-shell X-ray transitions were determined. Using a least-squares-fit method to solve the two sets of equations derived from the observed transition energies and transition widths the binding energies of the subshells K to M₅ and O₁ and the level widths of the subshells K to N₅ and O₁ could also be determined

Efficient numerical computations of yield stress fluid flows using second-order cone programming

International audienceThis work addresses the numerical computation of the two-dimensional flow of yield stress fluids (with Bingham and Herschel-Bulkley models) based on a variational approach and a finite element discretization. The main goal of this paper is to propose an alternative op-timization method to existing procedures such as penalization and augmented Lagrangian techniques. It is shown that the minimum principle for Bingham and Herschel-Bulkley yield stress fluid steady flows can, indeed, be formulated as a second-order cone programming (SOCP) problem, for which very efficient primal-dual interior point solvers are available. In particular, the formulation does not require any regularization of the visco-plastic model as is usually the case for existing techniques, avoiding therefore the difficult choice of the regularization parameter. Besides, it is also unnecessary to adopt a mixed stress-velocity approach or discretize explicitly auxiliary variables as frequently proposed in existing meth-ods. Finally, the performance of dedicated SOCP solvers, like the Mosek software package, enables to solve large-scale problems on a personal computer within seconds only. The pro-posed method will be validated on classical benchmark examples and used to simulate the flow generated around a plate during its withdrawal from a bath of yield stress fluid

Les « niveaux de formation » à l’heure européenne. Un examen à partir de l’homologation des titres

Cet article s’inscrit dans le cadre d’une réflexion autour de la nomenclature des « niveaux de formation », interrogée par la logique de la certification et les politiques d’harmonisation européenne. Il propose un retour sur les pratiques de classement de la Commission technique d’homologation (CTH), chargée, pendant près de trente ans, d’attribuer un niveau à des titres initialement prévus dans le cadre de la formation continue. Il montre que le caractère consensuel des opérations d’attribution de niveau a été rendu possible grâce à une naturalisation des principes et de la logique classificatoire contenus dans cet outil, y compris après le choix de la CTH, en 1993, de privilégier d’autres registres et critères d’examen.This study is part of an attempt to review the nomenclature of "vocational training levels”, in the framework of the European approach to qualifications and the policies designed to harmonise qualifications between member countries. The authors suggest the need to revise the classification practices of the Technical Homologation Commission (THC), which has been responsible for almost thirty years for attributing levels to diplomas initially designed in the framework of continuing vocational training. They suggest that the consensus about the levels attributed may be due to the fact that the underlying principles and classification logics have never been challenged, even when it was decided in 1993 by the THC to change the criteria on which these assessments are based.Este artículo se inscribe en el marco de una reflexión sobre la nomenclatura de los « niveles de formación », cuestionada por la lógica de la certificación y las políticas de armonización europea. Propone un retorno a las prácticas de clasificación de la Comisión técnica de homologación (CTH), encargada durante casi treinta años de atribuir un nivel a títulos inicialmente previstos en el marco de la formación continua. Muestra que el carácter consensuado de las operaciones de atribución de nivel fue posible gracias a una naturalización de los principios y la lógica clasificatoria contenidos en este instrumento, inclusive luego de la decisión de la CTH en 1993 de privilegiar otros criterios de examen.Dieser Beitrag ist im Rahmen der Arbeiten zum Verzeichnis der „Ausbildungsniveaus“ zu sehen, die hier unter dem Gesichtspunkt der Zertifizierung und Harmonisierung von Abschlüssen auf europäischer Ebene untersucht werden. Die Autoren schlagen vor, die Klassifizierungspraktiken der Commission technique d’homologation (CTH - technischer Ausschuss für die Anerkennung von Titeln und Abschlüssen) neu zu hinterfragen. Dieser Fachausschuss war dreißig Jahre lang für die Anerkennung der ursprünglich für die berufliche Weiterbildung vergebenen Abschlüsse und Titel zuständig. Die Autoren zeigen, dass der bestehende Konsens hinsichtlich der Einstufung der Abschlüsse auf den diesem Instrument zugrunde liegenden Prinzipien sowie auf der Logik der Klassifizierung basieren, die sich auch nach 1993 nicht verändert haben, obwohl der CTH ab diesem Zeitpunkt den Akzent auf andere Anerkennungskriterien legte

The biotope of branchial ectoparasites of fishes : factors of variations in the pattern sea bass - monogeneans

International audienceFor the analysis of functional structure of communities, the ecologists are obliged to extend their investigations to the heterogeneity of their environment and colonized biotopes. The gills of sea bass Dicentrarchus labrax serve as a biotope for several ectoparasites ; some aspects of the heterogeneity of this biotope were studied quantitatively. The models expressing the variations of number of branchial filaments, and branchial area that can be colonized by monogeneans, were established in function of the lenght of fishes. Such biotopes being subjected to significant physical modifications, the effects of the latter over the organization of parasitic settlements are then discussed

Identification of a Functional, CRM-1-Dependent Nuclear Export Signal in Hepatitis C Virus Core Protein

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. HCV core protein is involved in nucleocapsid formation, but it also interacts with multiple cytoplasmic and nuclear molecules and plays a crucial role in the development of liver disease and hepatocarcinogenesis. The core protein is found mostly in the cytoplasm during HCV infection, but also in the nucleus in patients with hepatocarcinoma and in core-transgenic mice. HCV core contains nuclear localization signals (NLS), but no nuclear export signal (NES) has yet been identified

Diagnostic performance of the WHO definition of probable dengue within the first 5 days of symptoms on Reunion Island.

The relevance of the World Health Organization (WHO) criteria for defining probable dengue had not yet been evaluated in the context of dengue endemicity on Reunion Island. The objective of this retrospective diagnostic study was to evaluate the diagnostic performance of the 2009 WHO definition of probable dengue and to propose an improvement thereof. From the medical database, we retrieved the data of subjects admitted to the emergency department of the University Hospital of Reunion Island in 2019 with suspected dengue fever (DF) within a maximum of 5 days post symptom onset, and whose diagnosis was confirmed by a Reverse Transcriptase Polymerase Chain Reaction (RT-PCR). The intrinsic characteristics of probable dengue definitions were reported in terms of sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR-), using RT-PCR as the gold standard. Of the 1,181 subjects who exhibited a positive RT-PCR, 652 (55%) were classified as probable dengue. The WHO definition of probable dengue yielded a sensitivity of 64% (95%CI 60-67%), a specificity of 57% (95%CI 52-61%), a LR+ of 1.49 (95%CI 1.33-1.67), and a LR- of 0.63 (95%CI 0.56-0.72). The sensitivity and LR- for diagnosing and ruling out probable dengue could be improved by the addition of lymphopenia on admission (74% [95%CI: 71-78%] and 0.54 [95%CI: 0.46-0.63] respectively), at the cost of slight reductions of specificity and LR+ (48% [95%CI: 44-53%] and 1.42 [95%CI: 1.29-1.57], respectively). In the absence of, or when rapid diagnostic testing is unreliable, the use of the improved 2009 WHO definition of probable dengue could facilitate the identification of subjects who require further RT-PCR testing, which should encourage the development of patient management, while also optimizing the count and quarantine of cases, and guiding disease control

KILT: a Benchmark for Knowledge Intensive Language Tasks

Challenging problems such as open-domain question answering, fact checking, slot filling and entity linking require access to large, external knowledge sources. While some models do well on individual tasks, developing general models is difficult as each task might require computationally expensive indexing of custom knowledge sources, in addition to dedicated infrastructure. To catalyze research on models that condition on specific information in large textual resources, we present a benchmark for knowledge-intensive language tasks (KILT). All tasks in KILT are grounded in the same snapshot of Wikipedia, reducing engineering turnaround through the re-use of components, as well as accelerating research into task-agnostic memory architectures. We test both task-specific and general baselines, evaluating downstream performance in addition to the ability of the models to provide provenance. We find that a shared dense vector index coupled with a seq2seq model is a strong baseline, outperforming more tailor-made approaches for fact checking, open-domain question answering and dialogue, and yielding competitive results on entity linking and slot filling, by generating disambiguated text. KILT data and code are available at https://github.com/facebookresearch/KILT.Comment: accepted at NAACL 202

Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection.

International audienceHepatitis C virus (HCV) establishes infection using host lipid metabolism pathways that are thus considered potential targets for indirect anti-HCV strategies. HCV enters the cell via clathrin-dependent endocytosis, interacting with several receptors, and virus-cell fusion, which depends on acidic pH and the integrity of cholesterol-rich domains of the hepatocyte membrane. The ATP-binding Cassette Transporter A1 (ABCA1) mediates cholesterol efflux from hepatocytes to extracellular Apolipoprotein A1 and moves cholesterol within cell membranes. Furthermore, it generates high-density lipoprotein (HDL) particles. HDL protects against arteriosclerosis and cardiovascular disease. We show that the up-regulation of ABCA1 gene expression and its cholesterol efflux function in Huh7.5 hepatoma cells, using the liver X receptor (LXR) agonist GW3965, impairs HCV infection and decreases levels of virus produced. ABCA1-stimulation inhibited HCV cell entry, acting on virus-host cell fusion, but had no impact on virus attachment, replication, or assembly/secretion. It did not affect infectivity or properties of virus particles produced. Silencing of the ABCA1 gene and reduction of the specific cholesterol efflux function counteracted the inhibitory effect of the GW3965 on HCV infection, providing evidence for a key role of ABCA1 in this process. Impaired virus-cell entry correlated with the reorganisation of cholesterol-rich membrane microdomains (lipid rafts). The inhibitory effect could be reversed by an exogenous cholesterol supply, indicating that restriction of HCV infection was induced by changes of cholesterol content/distribution in membrane regions essential for virus-cell fusion. Stimulation of ABCA1 expression by GW3965 inhibited HCV infection of both human primary hepatocytes and isolated human liver slices. This study reveals that pharmacological stimulation of the ABCA1-dependent cholesterol efflux pathway disrupts membrane cholesterol homeostasis, leading to the inhibition of virus-cell fusion and thus HCV cell entry. Therefore besides other beneficial roles, ABCA1 might represent a potential target for HCV therapy