On The Stabilization of the Linear Kawahara Equation with Periodic Boundary Conditions

We study the stabilization of global solutions of the linear Kawahara equation (K) with periodic boundary conditions under the effect of a localized damping mechanism. The Kawahara equation is a model for small amplitude long waves. Using separation of variables, the Ingham inequality, multiplier techniques and compactness arguments we prove the exponential decay of the solutions of the (K) model

Assessing the association between hypoxia during craniofacial development and oral clefts

Objectives: To evaluate the association between hypoxia during embryo development and oral clefts in an animal model, and to evaluate the association between polymorphisms in the HIF-1A gene with oral clefts in human families. Material and Methods: The study with the animal model used zebrafish embryos at 8 hours post-fertilization submitted to 30% and 50% hypoxia for 24 hours. At 5 days post-fertilization, the larvae were fixed. The cartilage structures were stained to evaluate craniofacial phenotypes. The family-based association study included 148 Brazilian nuclear families with oral clefts. The association between the genetic polymorphisms rs2301113 and rs2057482 in HIF-1A with oral clefts was tested. We used real time PCR genotyping approach. ANOVA with Tukey's post-test was used to compare means. The transmission/disequilibrium test was used to analyze the distortion of the inheritance of alleles from parents to their affected offspring. Results: For the hypoxic animal model, the anterior portion of the ethmoid plate presented a gap in the anterior edge, forming a cleft. The hypoxia level was associated with the severity of the phenotype (p<0.0001). For the families, there was no under-transmitted allele among the affected progeny (p>0.05). Conclusion: Hypoxia is involved in the oral cleft etiology, however, polymorphisms in HIF-1A are not associated with oral clefts in humans

ASSISTÊNCIA DE ENFERMAGEM DURANTE O PROCESSO GRAVÍDICO GEMELAR

A gestao gemelar caracterizada pela presena de dois conceptos presentes simultaneamente no tero ou fora dele e que chamamos de gmeos. Na espcie humana mais freqente em mulheres com idade acima de 27 anos, raa negra, multparas, historia familiar pelo lado materno, maior assiduidade de atividades sexuais. A incidncia de gravidez mltipla tem aumentado expressivamente nas ltimas dcadas, em conseqncia do avano tecnocientfico que proporciona tcnicas de reproduo assistida. Existem dois tipos de gravidez gemelar a monozigtica que descreve a fecundao de um vulo por um nico espermatozide que se dividi, sendo denominado univitelinos ou uniovulares, e a dizigtica que decorre da fecundao de dois vulos por dois espermatozides, designados fraternos, biovulares ou bivitelinos. Com o objetivo de identificar a assistncia de enfermagem durante o processo gravdico gemelar. Trata-se de uma pesquisa de reviso de literatura de carter descritivo exploratrio, com enfoque no processo gravdico gemelar e assistncia de enfermagem. Foram utilizadas literaturas do acervo da Biblioteca Martin Luther-Ji-Paran do Ceuji-Ulbra, artigos e dados da Bireme, Scielo (Scientific Electronic Library Online) e Google Acadmico no qual foi selecionado um total de 14 publicaes e 3 livros entre os anos de 2001 a 2010, a busca se deu entre os meses de agosto e setembro do ano de 2010. Como critrios de excluso artigos que no abordaram diretamente a temtica gestao gemelar e assuntos publicados em ingls e incluso de publicaes que falassem especificamente sobre a atuao da enfermagem e gestao gemelar. Todos foram lidos e analisados rigorosamente o qual foram encontrados apenas 1 artigo que descreveu a atuao de enfermagem nas complicaes materno-fetais relacionadas gestao gemelar, 7 publicaes sobre os riscos materno-fetais associados a gemelaridade, 3 artigos falam sobre as implicaes do processo gemelar imperfeito e 2 sobre a importncia do aleitamento materno exclusivo e seu poder energtico. As publicaes contextualizam concordncia entre todos os agravos maternos e fetais, embora um contradiga a idia da incidncia de gemelaridade inerente raa negra, multiparidade, gentica ou hereditariedade, 2 livros abordam o desenvolvimento gemelar e 1 assistncia de enfermagem. Diante do estudo percebe-se uma ausncia de informaes sobre a assistncia de enfermagem, embora os estudos enfatizem que o pr-natal de qualidade ainda o melhor momento de deteco das possveis eventualidades e achados no ultra-som, minimizando os riscos do processo gravdico gemelar.Palavras chaves: Gemelaridade, gravidez mltipla, enfermagem

In vitro characterization, modelling, and antioxidant properties of Polyphenon-60 from green tea in Eudragit S100-2 chitosan microspheres

Eudragit S100-coated chitosan microspheres (S100Ch) are proposed as a new oral delivery system for green tea polyphenon-60 (PP60). PP60 is a mixture of polyphenolic compounds, known for its active role in decreasing oxidative stress and metabolic risk factors involved in diabetes and in other chronic diseases. Chitosan-PP60 microspheres prepared by an emulsion cross-linking method were coated with Eudragit S100 to ensure the release of PP60 in the terminal ileum. Different corecoat ratios of Eudragit and chitosan were tested. Optimized chitosan microspheres were obtained with a chitosan:PP60 ratio of 8:1 (Ch-PP608:1), rotation speed of 1500 rpm, and surfactant concentration of 1.0% (m/v) achieving a mean size of 7.16 µm. Their coating with the enteric polymer (S100Ch-PP60) increased the mean size significantly (51.4 µm). The in vitro modified-release of PP60 from S100Ch-PP60 was confirmed in simulated gastrointestinal conditions. Mathematical fitting models were used to characterize the release mechanism showing that both Ch-PP608:1 and S100Ch-PP60 fitted the KorsmeyersPeppas model. The antioxidant activity of PP60 was kept in glutaraldehyde-crosslinked chitosan microspheres before and after their coating, showing an IC50 of 212.3 µg/mL and 154.4 µg/mL, respectively. The potential of chitosan microspheres for the delivery of catechins was illustrated, with limited risk of cytotoxicity as shown in Caco-2 cell lines using the 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The beneficial effects of green tea and its derivatives in the management of metabolic disorders can be exploited using mucoadhesive chitosan microspheres coated with enteric polymers for colonic delivery.This research was supported by the Coordenação Aperfeiçoamento de Pessoal de Nivel Superior (CAPES), Fundação de Amparo à Pesquisa do Estado de Sergipe (FAPITEC) CHAMADA MS/CNPq/FAPITEC/SE/SES N◦ 06/2018 – PROGRAMA DE PESQUISA PARA O SUS: GESTÃO COMPARTILHADA EM SAÚDE – PPSUS SERGIPE 2017/2018, and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). This work was also financed through the projects M-ERA-NET/0004/2015-PAIRED, UIDB/04469/2020 (strategic fund) and PEst-OE/UID/AGR/04033/2019 (CITAB strategic fund), receiving support from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020. The authors acknowledge the support of the research project: Nutraceutica come supporto nutrizionale nel paziente oncologico, CUP: B83D18000140007.info:eu-repo/semantics/publishedVersio

Major clinical evidence of cervicofacial liposculpture: a concise systematic review

Introduction: Liposculpture (LS) can complement cervicofacial aging surgery. Modern trends in face sculpting are expanding and adipose tissue transfer can result in optimal esthetic effects with minimally invasive techniques. Facial LS focuses on repositioning adipose tissue and increasing facial transition zones. This is accomplished using internal suspension sutures as well as with autologous fat grafting. Objective: To carry out a concise systematic review of the main clinical considerations and advances in facial and cervical liposculpture as an important aesthetic tool for dental surgeons. Methods: The rules of the Systematic Review-PRISMA Platform were followed. The search was carried out from November 2021 to February 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results: Fifty articles were found involving facial liposculpture. A total of 30 articles were fully evaluated and 16 were included and developed in the present study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 10 studies at high risk of bias and 4 studies that did not meet the GRADE. Most patients who were involved in the studies showed improvements in facial augmentation and contouring. In patients with loss of facial volume, high-density fat transfer with SVF-gel facial injection resulted in significantly higher improvement scores and better patient satisfaction, with an improved/much improved esthetic appearance being observed. As a follow-up analysis of the studies, at an average of six months after completion, most patients were satisfied with the results. All procedures were well tolerated. Conclusion: According to the main clinical studies selected in the present study, cervicofacial liposculpture proved to be advantageous, with safety and efficacy

Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America

Background Mutations associated with resistance to rifampin or streptomycin have been reported for W/Beijing and Latin American Mediterranean (LAM) strain families of Mycobacterium tuberculosis. A few studies with limited sample sizes have separately evaluated mutations in katG, ahpC and inhA genes that are associated with isoniazid (INH) resistance. Increasing prevalence of INH resistance, especially in high tuberculosis (TB) prevalent countries is worsening the burden of TB control programs, since similar transmission rates are noted for INH susceptible and resistant M. tuberculosis strains. Results We, therefore, conducted a comprehensive evaluation of INH resistant M. tuberculosis strains (n = 224) from three South American countries with high burden of drug resistant TB to characterize mutations in katG, ahpC and inhA gene loci and correlate with minimal inhibitory concentrations (MIC) levels and spoligotype strain family. Mutations in katG were observed in 181 (80.8%) of the isolates of which 178 (98.3%) was contributed by the katG S315T mutation. Additional mutations seen included oxyR-ahpC; inhA regulatory region and inhA structural gene. The S315T katG mutation was significantly more likely to be associated with MIC for INH ≥2 μg/mL. The S315T katG mutation was also more frequent in Haarlem family strains than LAM (n = 81) and T strain families. Conclusion Our data suggests that genetic screening for the S315T katG mutation may provide rapid information for anti-TB regimen selection, epidemiological monitoring of INH resistance and, possibly, to track transmission of INH resistant strains.Fil: Dalla Costa, Elis R. State Foundation for Production and Research in Health (FEPPS); Brasil.Fil: Ribeiro, Marta O. State Foundation for Production and Research in Health (FEPPS); Brasil.Fil: Silva, Márcia S. N. State Foundation for Production and Research in Health (FEPPS); Brasil.Fil: Arnold, Liane S. State Foundation for Production and Research in Health (FEPPS); Brasil.Fil: Rostirolla, Diana C. State Foundation for Production and Research in Health (FEPPS); Brasil.Fil: Cafrune, Patricia I. State Foundation for Production and Research in Health (FEPPS); Brasil.Fil: Espinoza, Roger C. Blufstein Clinic Laboratory; Perú.Fil: Palaci, Moises. Federal University of Espírito Santo; Brasil.Fil: Telles, Maria A. Adolfo Lutz Institute; Brasil.Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Micobacterias; Argentina.Fil: Suffys, Philip N. Oswaldo Cruz Institute; Brasil.Fil: Lopes, Maria L. Evandro Chagas Institute; Brasil.Fil: Campelo, Creuza L. LACEN Ceará; BrasilFil: Miranda, Silvana S. Federal University of Minas Gerais; Brasil.Fil: Kremer, Kristin. National Institute for Public Healthand the Environment (RIVM). Mycobacteria Reference Unit (CIb-LIS); Países Bajos.Fil: Almeida da Silva, Pedro E. Federal Foundation of Rio Grande; Brasil.Fil: de Souza Fonseca, Leila. Federal University of Rio de Janeiro. Tuberculosis Academic Program; Brasil.Fil: Ho, John L. Cornell University; Estados Unidos.Fil: Kritski, Afrânio L. Federal University of Rio de Janeiro. Tuberculosis Academic Program; Brasil.Fil: Rossetti, María L. R. State Foundation for Production and Research in Health (FEPPS); Brasil

Characterization of Smoke/Dust Episode over West Africa: Comparison of MERRA-2 Modeling with Multiwavelength Mie-Raman Lidar Observations

Observations of multiwavelength Mie-Raman lidar taken during the SHADOW field campaign are used to analyze a smoke/dust episode over West Africa on 24-27 December 2015. For the case considered, the dust layer extended from the ground up to approximately 2000 m while the elevated smoke layer occurred in the 2500 m - 4000 m range. The profiles of lidar measured backscattering, extinction coefficients and depolarization ratios are compared with the vertical distribution of aerosol parameters provided by the Modern-Era Retrospective analysis for Research and Applications, Version 2 (MERRA-2). The MERRA-2 model simulated the correct location of the near-surface dust and elevated smoke layers. The value of modeled and observed aerosol extinction coefficients at both 355 nm and 532 nm are also rather close. In particular, for the episode reported, the mean value of difference between the measured and modeled extinction coefficients at 355 nm is 0.01 km(exp -1) with standard deviation of 0.042 km(exp -1). The model predicts significant concentration of dust particles inside the elevated smoke layer, which is supported by an increased depolarization ratio of 15% observed in the center of this layer. The modeled at 355 nm the lidar ratio of 65 sr in the near-surface dust layer is close to the observed value (70+/-10) sr. At 532 nm however, the simulated lidar ratio (about 40 sr) is lower than measurements (55+/-8 sr). The results presented demonstrate that the lidar and model data are complimentary and the synergy of observations and models is a key to improve the aerosols characterization