El problema del aislamiento de los bienes inmuebles arqueológicos: la búsqueda del significado

Romula nº 7 (2008), p. 331-353El incremento de actividades arqueológicas en los últimos años, sigue suscitando intensos debates entorno a la protección y gestión de los elementos patrimoniales inmuebles en las ciudades históricas. Siendo la sociedad la principal receptora, todavía hay un vacío significativo sobre cómo debemos afrontar su presentación pública para que la comunicación sirva como base para crear claves que nos acerquen a la salvaguarda del patrimonio desde el prisma de la educación ciudadana. En este artículo analizo el problema del aislamiento de los bienes arqueológicos inmuebles conservados en la ciudad histórica, proponiendo una serie de ideas para su presentación pública dentro de una planifi cación conjunta e integral.The increase of archaeological activities in the last years is arousing intense arguments around the protection and management of the heritage in the historical cities. The society is the first beneficiary but there is a significant emptiness about how we should face the public exhibition to create keys that bring us over to the safeguard of the heritage from the prism of the civil education. I analyze in this article the threat in the archaeological sites in the historical cities, proposing a series of ideas for the public exhibition inside a comprehensive planning.Versión del edito

El problema del aislamiento de los bienes inmuebles arqueológicos. La búsqueda del significado

El incremento de actividades arqueológicas en los últimos años, sigue suscitando intensos debates entorno a la protección y gestión de los elementos patrimoniales inmuebles en las ciudades históricas. Siendo la sociedad la principal receptora, todavía hay un vacío significativo sobre cómo debemos afrontar su presentación pública para que la comunicación sirva como base para crear claves que nos acerquen a la salvaguarda del patrimonio desde el prisma de la educación ciudadana. En este artículo analizo el problema del aislamiento de los bienes arqueológicos inmuebles conservados en la ciudad histórica, proponiendo una serie de ideas para su presentación pública dentro de una planifi cación conjunta e integral.---------------------------------------------------------------------The increase of archaeological activities in the last years is arousing intense arguments around the protection and management of the heritage in the historical cities. The society is the first beneficiary but there is a significant emptiness about how we should face the public exhibition to create keys that bring us over to the safeguard of the heritage from the prism of the civil education. I analyze in this article the threat in the archaeological sites in the historical cities, proposing a series of ideas for the public exhibition inside a comprehensive planning

Museo Arqueológico de Sevilla. Origen, evolución, cambio y continuidad

El origen del Museo Arqueológico de Sevilla debemos buscarlo como resultado de esa segunda generación de museos que nacieron vinculados a la aparición del Real Decreto 20 de marzo de 1867, por el que se creaba el Museo Arqueológico Nacional y que contemplaba la posibilidad de creación de los museos arqueológicos provinciales. En este artículo pretendemos hacer un recorrido por su rica historia, desde sus inicios compartidos como “Sección de Antigüedades” del Museo Provincial de Sevilla hasta las últimas transformaciones en los años 80, dando una visión general de dos aspectos fundamentales: En primer lugar, la exposición, gracias a la documentación fotográfica y a las memorias conservadas en el archivo del centro y, en segundo lugar, los visitantes, siguiendo las estadísticas que nos ofrece la documentación de la institución desde 1880.-----------------------------------------------------------------The origin of Archaeological Museum of Seville should be found as a result of a second generation of museums related with the enactment a new law (Real Decreto) on 20th March 1867. This article shows all over its history from the beggining as a part of the Provincial Museum of Seville to the changings on the eighties. We have tryed to give a new general point of view from two aspects: First, the exposition, thanks to the photographic documents and information kept at its archive, and the second point, the visitors, according to the statistics documentation from 1880

Museo Arqueológico de Sevilla: origen, evolución, cambio y continuidad

Romula nº 8 (2009), p. 257-316El origen del Museo Arqueológico de Sevilla debemos buscarlo como resultado de esa segunda generación de museos que nacieron vinculados a la aparición del Real Decreto 20 de marzo de 1867, por el que se creaba el Museo Arqueológico Nacional y que contemplaba la posibilidad de creación de los museos arqueológicos provinciales. En este artículo pretendemos hacer un recorrido por su rica historia, desde sus inicios compartidos como ¿Sección de Antigüedades¿ del Museo Provincial de Sevilla hasta las últimas transformaciones en los años 80, dando una visión general de dos aspectos fundamentales: En primer lugar, la exposición, gracias a la documentación fotográfica y a las memorias conservadas en el archivo del centro y, en segundo lugar, los visitantes, siguiendo las estadísticas que nos ofrece la documentación de la institución desde 1880.The origin of Archaeological Museum of Seville should be found as a result of a second generation of museums related with the enactment a new law (Real Decreto) on 20th March 1867. This article shows all over its history from the beggining as a part of the Provincial Museum of Seville to the changings on the eighties. We have tryed to give a new general point of view from two aspects: First, the exposition, thanks to the photographic documents and information kept at its archive, and the second point, the visitors, according to the statistics documentation from 1880.Versión del edito

First measurements of a monitoring project on a BTES system

Performance of Borehole Thermal Energy Storage (BTES) systems depends on the temperature of the secondary fluid, circulating through the ground-loop heat exchangers. Borehole systems are therefore designed in order to ensure that inlet and outlet temperatures of the secondary fluid are within given operational limits during the whole life-time of the system. Monitoring the operation of the bore fields is crucial for the validation of existing models utilized for their design. Measured data provides valuable information for researchers and practitioners working in the field. A first data-set from an ongoing monitoring project is presented in this article. The monitoring system comprises temperature sensors and power meters placed at strategic locations within the bore field. A distributed temperature sensing rig that employs fiber optic cables as linear sensors is utilized to measure temperature every meter along the depth of nine monitored boreholes, yielding data regarding both temporal and spatial variation of the temperature in the ground. The heat exchanged with the ground is also measured via power meters in all nine monitored boreholes as well as at the manifold level. The BTES system is located at the Stockholm University Campus, Sweden, and consists of 130 boreholes, 230 meters deep. After more than a year of planning and installation work, some selected measurements recorded in the BTES during the first months of operation are reported in this article

Design of a laboratory borehole storage model

This paper presents the design process of a 4x4 Laboratory Borehole Storage (LABS) model through analytical and numerical analyses. This LABS is intended to generate reference Thermal Response Functions (TRFs) as well as to be a validation tool for borehole heat transfer models. The objective of this design process is to determine suitable geometrical and physical parameters for the LABS. An analytical scaling analysis is first performed and important scaling constraints are derived. In particular, it is shown that the downscaling process leads to significantly higher values for Neumann and convective boundary conditions whereas the Fourier number is invariant. A numerical model is then used to verify the scaling laws, determine the size of the LABS, as well as to evaluate the influence of top surface convection and borehole radius on generated TRFs. An adequate shape for the LABS is found to be a quarter cylinder of radius and height 1.0 m, weighing around 1.2 tonnes. Natural convection on the top boundary proves to have a significant effect on the generated TRF with deviations of at least 15%. This convection effect is proposed as an explanation for the difference observed between experimental and analytical results in Cimmino and Bernier (2015). A numerical reproduction of their test leads to a relative difference of 1.1% at the last reported time. As small borehole radii are challenging to reproduce in a LABS, the effect of the borehole radius on TRFs is investigated. It is found that Eskilson's radius correction (1987) is not fully satisfactory and a new correction method must be undertaken

Validation of a Novel, Sensitive, and Specific Urine-Based Test for Recurrence Surveillance of Patients With Non-Muscle-Invasive Bladder Cancer in a Comprehensive Multicenter Study

Bladder cancer (BC), the most frequent malignancy of the urinary system, is ranked the sixth most prevalent cancer worldwide. Of all newly diagnosed patients with BC, 70-75% will present disease confined to the mucosa or submucosa, the non-muscle-invasive BC (NMIBC) subtype. Of those, approximately 70% will recur after transurethral resection (TUR). Due to high rate of recurrence, patients are submitted to an intensive follow-up program maintained throughout many years, or even throughout life, resulting in an expensive follow-up, with cystoscopy being the most cost-effective procedure for NMIBC screening. Currently, the gold standard procedure for detection and follow-up of NMIBC is based on the association of cystoscopy and urine cytology. As cystoscopy is a very invasive approach, over the years, many different noninvasive assays (both based in serum and urine samples) have been developed in order to search genetic and protein alterations related to the development, progression, and recurrence of BC. TERT promoter mutations and FGFR3 hotspot mutations are the most frequent somatic alterations in BC and constitute the most reliable biomarkers for BC. Based on these, we developed an ultra-sensitive, urine-based assay called Uromonitor®, capable of detecting trace amounts of TERT promoter (c.1-124C > T and c.1-146C > T) and FGFR3 (p.R248C and p.S249C) hotspot mutations, in tumor cells exfoliated to urine samples. Cells present in urine were concentrated by the filtration of urine through filters where tumor cells are trapped and stored until analysis, presenting long-term stability. Detection of the alterations was achieved through a custom-made, robust, and highly sensitive multiplex competitive allele-specific discrimination PCR allowing clear interpretation of results. In this study, we validate a test for NMIBC recurrence detection, using for technical validation a total of 331 urine samples and 41 formalin-fixed paraffin-embedded tissues of the primary tumor and recurrence lesions from a large cluster of urology centers. In the clinical validation, we used 185 samples to assess sensitivity/specificity in the detection of NMIBC recurrence vs. cystoscopy/cytology and in a smaller cohort its potential as a primary diagnostic tool for NMIBC. Our results show this test to be highly sensitive (73.5%) and specific (93.2%) in detecting recurrence of BC in patients under surveillance of NMIBC.info:eu-repo/semantics/publishedVersio

Proyecto de rehabilitación integral del Museo Arqueológico de Sevilla

Proyecto Fin de Máster de Museología. III edición 2005-06. Univ. Granada. Facultad de Bellas Arte

High Rate of Inappropriate Antibiotics in Patients with Hematologic Malignancies and Pseudomonas aeruginosa Bacteremia following International Guideline Recommendations

ABSTRACT Optimal coverage of Pseudomonas aeruginosa is challenging in febrile neutropenic patients due to a progressive increase in antibiotic resistance worldwide. We aimed to detail current rates of resistance to antibiotics recommended by international guidelines for P. aeruginosa isolated from bloodstream infections (BSI) in patients with hematologic malignancies. Secondarily, we aimed to describe how many patients received inappropriate empirical antibiotic treatment (IEAT) and its impact on mortality. We conducted a retrospective, multicenter cohort study of the last 20 BSI episodes caused by P. aeruginosa in patients with hematologic malignancies from across 14 university hospitals in Spain. Of the 280 patients with hematologic malignancies and BSI caused by P. aeruginosa, 101 (36%) had strains resistant to at least one of the β-lactam antibiotics recommended in international guidelines, namely, cefepime, piperacillin-tazobactam, and meropenem. Additionally, 21.1% and 11.4% of the strains met criteria for MDR and XDR P. aeruginosa, respectively. Even if international guidelines were followed in most cases, 47 (16.8%) patients received IEAT and 66 (23.6%) received inappropriate β-lactam empirical antibiotic treatment. Thirty-day mortality was 27.1%. In the multivariate analysis, pulmonary source (OR 2.22, 95% CI 1.14 to 4.34) and IEAT (OR 2.67, 95% CI 1.37 to 5.23) were factors independently associated with increased mortality. We concluded that P. aeruginosa-causing BSI in patients with hematologic malignancies is commonly resistant to antibiotics recommended in international guidelines, which is associated with frequent IEAT and higher mortality. New therapeutic strategies are needed. IMPORTANCE Bloodstream infection (BSI) caused by P. aeruginosa is related with an elevated morbidity and mortality in neutropenic patients. For this reason, optimal antipseudomonal coverage has been the basis of all historical recommendations in the empirical treatment of febrile neutropenia. However, in recent years the emergence of multiple types of antibiotic resistances has posed a challenge in treating infections caused by this microorganism. In our study we postulated that P. aeruginosa-causing BSI in patients with hematologic malignancies is commonly resistant to antibiotics recommended in international guidelines. This observation is associated with frequent IEAT and increased mortality. Consequently, there is a need for a new therapeutic strategy