Representative DaTSCAN images.

<p>3a. DaTscan from 50 year old man with <i>GBA</i> mutation, note predominantly right sided tracer loss. 3b. DaTscan from 67 year old woman with PINK1 mutation associated Parkinson's disease, note symmetrical loss of tracer uptake in caudate heads. 3c. DaTscan from 45 year old man with Parkin mutation associated Parkinson's disease and symmetrical loss of tracer uptake. 3d. DaTscan from 32 year old man with LRRK2 mutation, note asymmetrical loss of tracer uptake in caudate heads.</p

Striatal asymmetry index by genotype.

<p>The striatal asymmetry index was significantly higher for the GBA and LRRK2 genotypes (p<0.001). Graph shows mean SASI +/−1 standard error.</p

Asymmetry indices for each subtype of genetic Parkinson's disease.

<p>Key: CASI, PASI = right/left asymmetry index quoted as median and interquartile range for caudate and putamen, SASI = striatal asymmetry index quoted as mean and standard error.</p>*<p> = significantly different than ASI from control (Mann-Whitney u-test).</p

Clinical, genetic and demographic characteristics of patient cohort.

<p>Clinical, genetic and demographic characteristics of patient cohort.</p

Caudate and putament asymmetry index for subtypes of genetic Parkinson's disease.

<p>1a. Boxplot of caudate asymmetry index for each genotype. Median caudate asymmetry is signficantly different for GBA compared to control. 1b. Boxplot of putamen asymmetry index for each genotype. Median putamen asymmetry is significantly different for GBA and LRRK2 groups compared to control.</p