Transsexualism in Spain: a Cultural and Legal Perspective

In this paper I will present an overview of the current legal, social and political situation of transsexual and transgendered people in Spain. The study is based on qualitative data gathered from in-depth interviews with transsexual people, transgendered activists and legal experts in Spain, including some aspects of a cross-cultural comparison between Spain and the UK. The empirical study accounts for the development of social policies related to sex-reassignment and their evolution in the last decade in Spain, as well as for transsexual associations and activism, issues of social exclusion and prostitution. The study on transsexuals consists of qualitative interviews with selected individuals of the transsexual community in Scotland and Catalonia about their life experiences. The analysis of the qualitative data explores the cultural assumptions underlying the legal aspects of sex-reassignment. Amongst other issues, the paper will deal with Spanish juridical procedures for documental reorientation and its potential role as incentive for undergoing sex-reassignment operation, and the performative character of transsexualism as a scientific category and folk gender myths in the shaping of gender. The cross-cultural comparison concerns scientific terminology, funding, cultural and legal aspects of sex-reassignment. The study reveals the performative character of scientific categories, the mobilisation of conflicting discourses in the negotiation of meaning, the circularity and self-referentiality of the terms used both in expert and folk discourse. Moreover, the cross-cultural comparison demonstrates the conventionality of transsexualism as a scientific category and some of the ways in which social institutions act to perpetuate the erasure of gender fluidity.Gender, Performativity, Sex-Reassignment, Social Policy, Transgenderism, Transsexuality, Spain

Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression

The ATR-Chk1 and ATM-Chk2 pathways are central in DNA damage repair (DDR) and their over-activation may confer aggressive molecular features, being an adaptive response to endogenous DNA damage and oncogene-induced replication stress. Herein we investigated the ATR-Chk1 and ATM-Chk2 signalings in male breast cancer (MBC). The expression of DDR kinases (pATR, pATM, pChk1, pChk2, and pWee1) and DNA damage markers (pRPA32 and γ-H2AX) was evaluated by immunohistochemistry in 289 MBC samples to assess their association. Survival analyses were carried out in 112 patients. Survival curves were estimated with the Kaplan-Meier method and compared by log-rank test. Cox proportional regression models were generated to identify variables impacting survival outcomes. The expression of pATR conferred poorer survival outcomes (log rank p = 0.013, p = 0.007 and p = 0.010 for overall, 15- and 10-year survival, respectively). Multivariate Cox models of 10-year survival and overall indicated that pATR expression, alone or combined with pChk2, was an independent predictor of adverse outcomes (10-year survival: pATR: HR 2.74, 95% CI: 1.23–6.10; pATR/pChk2: HR 2.92, 95% CI: 1.35–6.33; overall survival: pATR: HR 2.58, 95% CI: 1.20–5.53; pATR/pChk2: HR 2.89, 95% CI: 1.37–6.12). Overall, the ATR/ATM-initiated molecular cascade seems to be active in a fraction of MBC patients and may represent a negative prognostic factor

Gang Innovation, Patriarchy and Powerlessness : Expanding Theory To Relfect [Reflect] American Politics

When cities grew large enough to develop slums, gangs began to form. The heritage of gang behavior is poverty and its children: abuse, alcoholism, and drug addiction, to name a few. Today we are facing a problem of major proportions in our cities. Gang membership is seemingly growing with no end in sight, and a beleaguered nation, a struggling city, the mother of a gang member all ask: Why? There are probably several answers and more questions. This paper is an attempt to understand the problem of gang delinquency by utilizing already existing theory. Robert Merton\u27s Strain Theory lends itself to the discussion of gang delinquency; however, this paper will expand on the theory and link it to the powerlessness of young minority males and patriarchal ideology

Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition

The DNA Damage Response (DDR) pathway represents a signalling mechanism that is activated in eukaryotic cells following DNA damage and comprises of proteins involved in DNA damage detection, DNA repair, cell cycle arrest and apoptosis. This pathway consists of an intricate network of signalling interactions driving the cellular ability to recognise DNA damage and recruit specialised proteins to take decisions between DNA repair or apoptosis. ATM and ATR are central components of the DDR pathway. The activities of these kinases are vital in DNA damage induced phosphorylational induction of DDR substrates. Here, firstly we have experimentally determined DDR signalling network surrounding the ATM/ATR pathway induced following double stranded DNA damage by monitoring and quantifying time dependent inductions of their phosphorylated forms and their key substrates. We next involved an automated inference of unsupervised predictive models of time series data to generate in silico (molecular) interaction maps. We characterized the complex signalling network through system analysis and gradual utilisation of small time series measurements of key substrates through a novel network inference algorithm. Furthermore, we demonstrate an application of an assumption-free reverse engineering of the intricate signalling network of the activated ATM/ATR pathway. We next studied the consequences of such drug induced inductions as well as of time dependent ATM kinase inhibition on cell survival through further biological experiments. Intermediate and temporal modelling outcomes revealed the distinct signaling profile associated with ATM kinase activity and inhibition and explained the underlying signalling mechanism for dual ATM functionality in cytotoxic and cytoprotective pathways

A Tractable Extension of Linear Indexed Grammars

It has been shown that Linear Indexed Grammars can be processed in polynomial time by exploiting constraints which make possible the extensive use of structure-sharing. This paper describes a formalism that is more powerful than Linear Indexed Grammar, but which can also be processed in polynomial time using similar techniques. The formalism, which we refer to as Partially Linear PATR manipulates feature structures rather than stacks.Comment: 8 pages LaTeX, uses eaclap.sty, to appear in EACL-9

FEAT-PATR : eine Erweiterung des D-PATR zur Feature-Erkennung in CAD/CAM

In diesem Papier wird aufgezeigt, wie der im Bereich der natürlichsprachlichen Systeme bekannte unifikationsbasierte Grammatikformalismus D-PATR [Kartt86] erweitert werden kann, um im Bereich CAD/CAM zur geometrischen Interpretation von Werkstücken herangezogen werden zu können. Das resultierende System FEAT-PATR demonstriert zum einen die Nützlichkeit einer Analogie zwischen (formalen) Sprachen und der geometrischen Interpretation von Werkstücken und zum anderen die Schwächen bestehender Grammatikformalismen für String-Grammatiken zur geometrischen Interpretation von Werkstücken

A Structured PC-PATR Grammar Editor And Application To Bahasa Indonesia

This thesis describes the development of a structured editor for grammar files for the PC-PATR syntactic parsing program and an analysis tool for its output called PC-PATR-EDITOR. It describes the difficulties with authoring plain text grammar files and reading the parser\u27s output. The editor solves these problems by providing an editing environment where users do not have to remember the file\u27s syntax, where users can only input content valid at the point of editing, and by processing the parser\u27s output and displaying it in ways familiar to most linguists. The paper contains three case studies that illustrate PC-PATR-EDITOR\u27s usefulness by implementing a grammar fragment for Bahasa Indonesia. It offers critiques and suggestions for future improvements for the editor and analysis tool

On the asymmetric zero-range in the rarefaction fan

We consider the one-dimensional asymmetric zero-range process starting from a step decreasing profile. In the hydrodynamic limit this initial condition leads to the rarefaction fan of the associated hydrodynamic equation. Under this initial condition and for totally asymmetric jumps, we show that the weighted sum of joint probabilities for second class particles sharing the same site is convergent and we compute its limit. For partially asymmetric jumps we derive the Law of Large Numbers for the position of a second class particle under the initial configuration in which all the positive sites are empty, all the negative sites are occupied with infinitely many first class particles and with a single second class particle at the origin. Moreover, we prove that among the infinite characteristics emanating from the position of the second class particle, this particle chooses randomly one of them. The randomness is given in terms of the weak solution of the hydrodynamic equation through some sort of renormalization function. By coupling the zero-range with the exclusion process we derive some limiting laws for more general initial conditions.Comment: 22 pages, to appear in Journal of Statistical Physic