A multilabel fuzzy relevance clustering system for malware attack attribution in the edge layer of cyber-physical networks

The rapid increase in the number of malicious programs has made malware forensics a daunting task and caused users’ systems to become in danger. Timely identification of malware characteristics including its origin and the malware sample family would significantly limit the potential damage of malware. This is a more profound risk in Cyber-Physical Systems (CPSs), where a malware attack may cause significant physical damage to the infrastructure. Due to limited on-device available memory and processing power in CPS devices, most of the efforts for protecting CPS networks are focused on the edge layer, where the majority of security mechanisms are deployed. Since the majority of advanced and sophisticated malware programs are combining features from different families, these malicious programs are not similar enough to any existing malware family and easily evade binary classifier detection. Therefore, in this article, we propose a novel multilabel fuzzy clustering system for malware attack attribution. Our system is deployed on the edge layer to provide insight into applicable malware threats to the CPS network. We leverage static analysis by utilizing Opcode frequencies as the feature space to classify malware families. We observed that a multilabel classifier does not classify a part of samples. We named this problem the instance coverage problem. To overcome this problem, we developed an ensemble-based multilabel fuzzy classification method to suggest the relevance of a malware instance to the stricken families. This classifier identified samples of VirusShare, RansomwareTracker, and BIG2015 with an accuracy of 94.66%, 94.26%, and 97.56%, respectively

The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers.

G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factor-seven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on the surface of leukocytes. The EGF domains on the N-terminus add significant size to these receptors and they are considered to be among the largest members of the TM7 family. Although not all of their ligands or downstream targets have been identified, there is evidence implicating the EGF-TM7 family diverse processes such as cell adhesion, migration, inflammation, and autoimmune disease. Recent studies have identified expression of EGF-TM7 family members on human neoplasms including those of the thyroid, stomach, colon, and brain. Their presence on these tissues is not surprising given the ubiquity of GPCRs, but because their functional significance and pathways are not completely understood, they are of tremendous clinical and scientific interest. Current evidence suggests that expression of certain EGF-TM7 receptors is correlated with tumor grade, confers a more invasive phenotype, and increases the likelihood of metastatic disease. In this review, we will discuss the structure, function, and regulation of these receptors. We also describe the expression of these receptors in human cancers and explore their potential mechanistic significance

Corporate social responsibility reporting in China: political, social and corporate influences

This paper explores the main drivers of CSR and its reporting for large Chinese listed companies, and identifies the key institutional pressures and stakeholder influences that shape CSR and its reporting. The data were collected through interviews with managers from large listed Chinese companies. Our findings reveal how the Chinese government uses social organisations and social intermediaries to facilitate and mediate CSR and its reporting to meet changing societal expectations across regions, while ensuring that companies remain responsive to the expectations of international stakeholders. We find that CSR and its reporting help companies gain political legitimacy domestically, while retaining their legitimacy in global markets. Companies co-operate with social organisations and social intermediaries actively and continuously. This helped companies secure political legitimacy with the government, while helping officials maintain their social legitimacy. Our findings on regional differences support the idea that relations between Chinese business and society have a fundamental effect on CSR and its reporting

Immunocompetent murine models for the study of glioblastoma immunotherapy.

Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in clinical outcomes are modest, in no small part due to tumor-induced immunosuppressive mechanisms that promote immune escape and immuno-resistance. Immunotherapeutic strategies aimed at bolstering the immune response while neutralizing immunosuppression will play a critical role in improving treatment outcomes for glioblastoma patients. In vivo murine models of glioma provide an invaluable resource to achieving that end, and their use is an essential part of the preclinical workup for novel therapeutics that need to be tested in animal models prior to testing experimental therapies in patients. In this article, we review five contemporary immunocompetent mouse models, GL261 (C57BL/6), GL26 (C57BL/6) CT-2A (C57BL/6), SMA-560 (VM/Dk), and 4C8 (B6D2F1), each of which offer a suitable platform for testing novel immunotherapeutic approaches

Short communication: Identification of by-catch species of tuna purse seiners in Iranian waters of Oman Sea

One of the most visible direct impacts of fishing is the capture of non-target species, known collectively as by-catch. By-catch includes species that are unwanted and discarded (discards) and species that are retained and sold (byproduct) (Stobutzki et al., 2003). Although tuna purse seine fisheries have been shown to be selective, leading to lower levels of by-catch than other fisheries (Alverson et al., 1994; Kelleher, 2005), several species can be incidentally caught and, in some cases, discarded at sea. These include vulnerable and sensitive species such as turtles, mammals, and sharks (Minami et al. 2007; Romanov, 2008b). Tuna purse seine fisheries probably apply the most intensive direct human impact on the tropical epipelagic ecosystems in all oceans. Because of the worldwide scale of purse seine fisheries, an assessment of their impact on associated and dependent species is essential (Romanov, 2002a)

Giant thoracic schwannoma presenting with abrupt onset of abdominal pain: a case report

<p>Abstract</p> <p>Introduction</p> <p>Giant intradural extramedullary schwannomas of the thoracic spine are not common. Schwannomas, that is, tumors derived from neoplastic Schwann cells, and neurofibromas represent the most common intradural extramedullary spinal lesions. We report the case of a patient with a giant thoracic schwannoma presenting unusually with acute abdominal pain and with delayed neurological impairment.</p> <p>Case presentation</p> <p>A 26-year-old Hispanic man with no previous medical problems presented with acute periumbilical pain. After extensive work-up including an exploratory laparotomy for appendectomy, magnetic resonance imaging scans of the lumbar and thoracic spine revealed a giant intradural extramedullary thoracic schwannoma within the spinal canal posterior to the T9, T10, and T11 vertebral bodies. Magnetic resonance imaging signal prolongation was noted in the spinal cord both rostral and caudal to the schwannoma. The patient underwent an urgent laminectomy from T8 to L1. After sacrificing the T10 root, the tumor was removed en bloc. Postoperatively, the patient improved significantly gaining antigravity strength in both lower extremities.</p> <p>Conclusion</p> <p>The T10 dermatome is represented by the umbilical region. This referred pain may represent a mechanism by which a giant thoracic schwannoma may present as acute abdominal pain. Acute, intense abdominal pain with delayed neurologic deficit is a rare presentation of a thoracic schwannoma but should be considered as a possible cause of abdominal pain presenting without clear etiology. Although these lesions may be delayed in their diagnosis, early diagnosis and treatment may lead to an improved clinical outcome.</p

Global vaccine equity demands reparative justice-not charity

By late April, more than 80% of the world’s COVID-19 vaccines had gone to people in wealthy countries, with just 0.3% to people in low-income countries.1 This reprehensible imbalance is no accident. High-income countries have used neocolonial negotiating power, global policy leverage and capital to procure enough doses to cover 245% of their citizens while leaving few doses for poorer countries.2 As a result, lower-income countries may not be able to vaccinate their populations until 2023.3 Such inequity is yet another example of how the interests of racial capitalism run roughshod over the golden rule of global solidarity—attend to the highest risk first.4 Currently, older and medically vulnerable individuals are dying from COVID-19 disproportionately in poor countries, while young, healthy individuals are getting vaccinated in wealthy ones.5 Vaccine apartheid is a not novel phenomenon. The notion that only certain corners of the world get to benefit from life-saving treatments is an everyday reality of a global health system driven by a capitalist, philanthropic model.6 7 But in times of crises—and as new variants threaten the vaccination plans of wealthy countries—these inequities and their solutions come to the forefront of global debate.8 Policy-makers in rich nations are aware of these issues. But the solutions they have proposed so far do nothing to address the underlying structural problems. They offer charitable donations and partial, temporary fixes that are designed to deflect the substantive demands for reform that global South countries are fighting for, including challenges to unethical intellectual property (IP) regimes.9 This approach will not work, because it is not designed to ‘work.’ If we want to end vaccine apartheid, we need to target the root causes of global health inequities. We need reparative justice. There are currently three approaches to reduce inequity in

A single-coil-based method for electromagnetic interference reduction in point-of-care low field MRI systems

One of the main challenges for point-of-care (POC) MRI systems is electromagnetic interference (EMI), since such systems are intended for use outside conventional Faraday-shielded rooms. Many methods have been proposed based on EMI detection via sensors external to the MRI system, followed by different types of signal processing to reduce artifacts in the image. Although these methods can be very effective, they do increase the complexity of the overall system, and introduce more potential failure points for sys-tems designed for challenging environments. In this work we introduce a new method that does not require external sensors, but rather uses the "MR-silent" mode of an RF coil to detect the EMI, followed by simple subtraction from the signal from the "MR-active" mode. This method can be performed post-acquisition if there are two receive channels available, or as demonstrated here can operate with a single -channel receive detection system with the addition of a simple passive 180 degrees power splitter/combiner into the receive chain. Proof-of-concept in vivo results show that a reduction in the standard deviation of the EMI up to -97 % is possible, with average values -90 %.(c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).Radiolog

Very low field F-19 MRI of perfluoro-octylbromide: minimizing chemical shift effects and signal loss due to scalar coupling

F-19 images have been obtained from perflurooctylbromide (PFOB) at very low magnetic field (50 mT). The small spectral dispersion (in Hz) means that all fluorine nuclei contribute to the signal without chemical shift artifacts or the need for specialized imaging sequences. Turbo spin echo trains with short interpulse intervals and full 180 degrees refocussing pulses suppress scalar coupling, leading to long apparent T-2 values and highly efficient data collection. Overall, the detection efficiency of PFOB is very similar that of water in tissue. (C) 2021 The Author(s). Published by Elsevier Inc.Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas