12 research outputs found
A Tribute to Lara D. Gass
- Author
- Publication venue
- Washington & Lee University School of Law Scholarly Commons
- Publication date
- 01/03/2014
- Field of study
Mutation of HIV-1 Genomes in a Clinical Population Treated with the Mutagenic Nucleoside KP1461
- Author
- A Airaksinen
- AG Rodrigo
- Alexis Hansen
- AM Tsibris
- AR Sedaghat
- AS Kamath-Loeb
- AS Lauring
- C Perales
- CK Biebricher
- D Shriner
- Deyu Li
- DH Chung
- E Domingo
- E Domingo
- E Murakami
- H Hatano
- J Coffin
- J Felsenstein
- James I. Mullins
- James P. Hughes
- JD Graci
- Jean-Pierre Laurent
- Jeffrey H. Simpson
- Jeffrey Parkins
- Jessica Kicha
- JI Mullins
- JJ Holland
- John M. Essigmann
- JP Anderson
- Kevin S. Harris
- Kim G. Wong
- KS Harris
- LA Loeb
- Laura Heath
- Lawrence A. Loeb
- LK Schrager
- LM Frenkel
- M Eigen
- M Eigen
- M Piatak Jr
- M Vignuzzi
- M Vignuzzi
- MJ Dapp
- N Galtier
- NH Tobin
- P Pitisuttithum
- PB Gilbert
- PJ Gerrish
- R Shankarappa
- RA Smith
- RC Edgar
- RE Lanford
- Reuben S. Harris
- S Crotty
- S Zhou
- S-L Liu
- Sheila Styrchak
- T Rhodes
- T Schacker
- T Wrin
- T Zhu
- T Zhu
- Ushnal Rao
- W Deng
- W Deng
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/08/2010
- Field of study
The deoxycytidine analog KP1212, and its prodrug KP1461, are prototypes of a new class of antiretroviral drugs designed to increase viral mutation rates, with the goal of eventually causing the collapse of the viral population. Here we present an extensive analysis of viral sequences from HIV-1 infected volunteers from the first “mechanism validation” phase II clinical trial of a mutagenic base analog in which individuals previously treated with antiviral drugs received 1600 mg of KP1461 twice per day for 124 days. Plasma viral loads were not reduced, and overall levels of viral mutation were not increased during this short-term study, however, the mutation spectrum of HIV was altered. A large number (N = 105 per sample) of sequences were analyzed, each derived from individual HIV-1 RNA templates, after 0, 56 and 124 days of therapy from 10 treated and 10 untreated control individuals (>7.1 million base pairs of unique viral templates were sequenced). We found that private mutations, those not found in more than one viral sequence and likely to have occurred in the most recent rounds of replication, increased in treated individuals relative to controls after 56 (p = 0.038) and 124 (p = 0.002) days of drug treatment. The spectrum of mutations observed in the treated group showed an excess of A to G and G to A mutations (p = 0.01), and to a lesser extent T to C and C to T mutations (p = 0.09), as predicted by the mechanism of action of the drug. These results validate the proposed mechanism of action in humans and should spur development of this novel antiretroviral approach.Koronis Pharmaceutical
Registered Ship Notes
- Author
- Abbot William
- Adams Thomas
- Atkins John
- Atwood Henry
- Avery J.
- Avery Thatcher
- Babblidge Levi
- Bains Jonathan
- Bakeman John
- Barlett Sam
- Bishop Jasper
- Boyd Jasper
- Bradley Bryant
- Bradley Bryant
- Bray Caleb
- Bray Simeon
- Bray Simon
- Bray Simon
- Brown James
- Brown Moses
- Bryant Joseph
- Buck Moses G.
- Caswell Richard
- Caswell Richard
- Chamberlain Mellen
- Choate Ivan
- Clay Benjamin
- Clough Asa
- Clough Moses F.
- Coan Elisha
- Coffin Issac
- Crawford James
- Crawford Jasper
- Crosby John
- Crosby John
- Curtiss Alfred
- Cushing John
- Darling Henry
- Darling Henry
- Darling Henry
- Davidson Edward
- Dodge R.
- Dudley William
- Dunbar David
- Dyer Elisha
- Eaton Theophilus
- Ellis John
- Emerson Bushby
- Emerson Edward
- Folsom Joseph R.
- Freethy William
- French Josiah
- French Josiah
- Ginn James
- Ginn James
- Godfrey Thomas
- Gordon Amos
- Hall Caleb B.
- Harmon Nathanial
- Harmon Nathaniel
- Haskell Mark
- Hatch Jona
- Hatch Mark
- Hatch Mark
- Hatch Mark
- Hatch Mark, Jr
- Hatch Mark, Jr.
- Herrick Benjamin
- Hinckley Jabez
- Hinckley Nehemiah
- Hinckley Obed
- Holbrook Jesse
- Holbrook John
- Holbrook John
- Holbrook Samuel
- Holt J. J.
- Holt Jonah
- Holt Jonah J.
- Holt Stephen
- Horton Sparrow
- Hunnewell Richard
- Hunnewell. T.
- Jameson Samuel
- Jarvis John
- Jarvis John H.
- Jenkins David
- Johnson Daniel
- Johnson John P.
- Johnston Daniel
- Johnston Daniel
- Keyes Samuel
- Lake Sewall
- Lee Joseph
- Leman Charles
- Leman William
- Littlefield Otis
- Low David
- Lunt Horace B.
- Lymeburner John
- Martin Silas
- Mc. Farlane Ephriam
- Mc. Kenzie Roderick
- Mc. Kenzie William
- Miller James
- Miller Robert
- Mudge Thomas
- Norton Stephen
- Ooggins Thomas
- Parker Issac
- Parker Robert
- Parker Samuel
- Parkins John
- Parkins Joseph
- Patterson Nathaniel
- Patterson Nehemiah
- Patterson Starret
- Patterson William
- Patterson William, 3rd
- Peabody Asa
- Pendleton Jasper
- Pendleton Job
- Pendleton John
- Pendleton Thomas
- Pendleton William
- Perkins Eben
- Perkins John, Jr.
- Perkins Joseph
- Perkins Storer
- Peters John
- Peters John, Jr.
- Phillips Thomas
- Pickering Sam
- Powers B. M.
- Pressey Jeremiah
- Pressy Jonathan
- Pressy Joshua
- Prince Joseph
- Ray Mathew
- Rich Sylvanus
- Rogers Abel
- Rogers Samuel
- Rogers Samuel
- Schute Benjamin
- Sherburns Jacob
- Sinclair Eben
- Small M.
- Smith Heman
- Smith Heman
- Smith Hiram
- Spofford Dan
- Spofford Parker
- Staples John
- Staples William
- Stetson Martin
- Stevens John
- Storer Benjamin
- Storer George
- Storer Varmin
- Swazey John W.
- Swazey Thomas
- Tayler William
- Thurlo David
- Thurlo Jerrimiah
- Tilden Charles K.
- Towns Samuel G.
- Treat Robert
- Treat Robert
- Trent Robert
- Tyler William
- Wescott Joseph
- Wescott Joseph, Jr.
- Whitney Henry
- Whitney Samuel A.
- Whitney William
- Williams Hezekiel
- Willis Benjamin, Sr.
- Witherle William
- Wood Johnson
- Wood Johnson
- Woodman Joshua
- Publication venue
- Digital Maine
- Publication date
- 20/07/2022
- Field of study
https://digitalmaine.com/blue_hill_documents/1179/thumbnail.jp
Registered Ship Notes
- Author
- Abbot William
- Adams Thomas
- Atkins John
- Atwood Henry
- Avery J.
- Avery Thatcher
- Babblidge Levi
- Bains Jonathan
- Bakeman John
- Barlett Sam
- Bishop Jasper
- Boyd Jasper
- Bradley Bryant
- Bradley Bryant
- Bray Caleb
- Bray Simeon
- Bray Simon
- Bray Simon
- Brown James
- Brown Moses
- Bryant Joseph
- Buck Moses G.
- Caswell Richard
- Caswell Richard
- Chamberlain Mellen
- Choate Ivan
- Clay Benjamin
- Clough Asa
- Clough Moses F.
- Coan Elisha
- Coffin Issac
- Crawford James
- Crawford Jasper
- Crosby John
- Crosby John
- Curtiss Alfred
- Cushing John
- Darling Henry
- Darling Henry
- Darling Henry
- Davidson Edward
- Dodge R.
- Dudley William
- Dunbar David
- Dyer Elisha
- Eaton Theophilus
- Ellis John
- Emerson Bushby
- Emerson Edward
- Folsom Joseph R.
- Freethy William
- French Josiah
- French Josiah
- Ginn James
- Ginn James
- Godfrey Thomas
- Gordon Amos
- Hall Caleb B.
- Harmon Nathanial
- Harmon Nathaniel
- Haskell Mark
- Hatch Jona
- Hatch Mark
- Hatch Mark
- Hatch Mark
- Hatch Mark, Jr
- Hatch Mark, Jr.
- Herrick Benjamin
- Hinckley Jabez
- Hinckley Nehemiah
- Hinckley Obed
- Holbrook Jesse
- Holbrook John
- Holbrook John
- Holbrook Samuel
- Holt J. J.
- Holt Jonah
- Holt Jonah J.
- Holt Stephen
- Horton Sparrow
- Hunnewell Richard
- Hunnewell. T.
- Jameson Samuel
- Jarvis John
- Jarvis John H.
- Jenkins David
- Johnson Daniel
- Johnson John P.
- Johnston Daniel
- Johnston Daniel
- Keyes Samuel
- Lake Sewall
- Lee Joseph
- Leman Charles
- Leman William
- Littlefield Otis
- Low David
- Lunt Horace B.
- Lymeburner John
- Martin Silas
- Mc. Farlane Ephriam
- Mc. Kenzie Roderick
- Mc. Kenzie William
- Miller James
- Miller Robert
- Mudge Thomas
- Norton Stephen
- Ooggins Thomas
- Parker Issac
- Parker Robert
- Parker Samuel
- Parkins John
- Parkins Joseph
- Patterson Nathaniel
- Patterson Nehemiah
- Patterson Starret
- Patterson William
- Patterson William, 3rd
- Peabody Asa
- Pendleton Jasper
- Pendleton Job
- Pendleton John
- Pendleton Thomas
- Pendleton William
- Perkins Eben
- Perkins John, Jr.
- Perkins Joseph
- Perkins Storer
- Peters John
- Peters John, Jr.
- Phillips Thomas
- Pickering Sam
- Powers B. M.
- Pressey Jeremiah
- Pressy Jonathan
- Pressy Joshua
- Prince Joseph
- Ray Mathew
- Rich Sylvanus
- Rogers Abel
- Rogers Samuel
- Rogers Samuel
- Schute Benjamin
- Sherburns Jacob
- Sinclair Eben
- Small M.
- Smith Heman
- Smith Heman
- Smith Hiram
- Spofford Dan
- Spofford Parker
- Staples John
- Staples William
- Stetson Martin
- Stevens John
- Storer Benjamin
- Storer George
- Storer Varmin
- Swazey John W.
- Swazey Thomas
- Tayler William
- Thurlo David
- Thurlo Jerrimiah
- Tilden Charles K.
- Towns Samuel G.
- Treat Robert
- Treat Robert
- Trent Robert
- Tyler William
- Wescott Joseph
- Wescott Joseph, Jr.
- Whitney Henry
- Whitney Samuel A.
- Whitney William
- Williams Hezekiel
- Willis Benjamin, Sr.
- Witherle William
- Wood Johnson
- Wood Johnson
- Woodman Joshua
- Publication venue
- Digital Maine
- Publication date
- 20/07/2022
- Field of study
https://digitalmaine.com/blue_hill_documents/1179/thumbnail.jp
Phenotypic Heterogeneity of Pseudomonas aeruginosa Populations in a Cystic Fibrosis Patient
- Author
- A Mena
- AR Hauser
- B Lee
- BA Glezerson
- Bryan Glezerson
- CD Sibley
- CD Sibley
- CD Sibley
- CD Sibley
- CD Sibley
- Christopher D. Sibley
- CJ Davidson
- CN Wilder
- DA D'Argenio
- E Amiel
- E Drenkard
- E Kerem
- E Mahenthiralingam
- EE Smith
- F Götz von
- FA Stressmann
- GB Rogers
- H Matsui
- Harvey R. Rabin
- HL Smith
- I Leone
- J Emerson
- J Zhao
- JB Lyczak
- JE Foweraker
- JE Foweraker
- Jens C. Norgaard-Gron
- JJ Lipuma
- JL Fothergill
- John R. Battista
- JR Govan
- K Duan
- K Duan
- KL Palmer
- M Kahm
- M Starkey
- Matthew L. Workentine
- MD Parkins
- MH Rashid
- Michael D. Parkins
- Michael G. Surette
- MR Kosorok
- O Ciofu
- PA Sokol
- PA Sokol
- PB Davis
- PB Rainey
- PJ Baynham
- R Kassen
- R Kassen
- RL Henry
- S Häussler
- SM Lee
- Swathi Purighalla
- T Wagner
- Z Li
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Exploring the Gastrointestinal “Nemabiome”: Deep Amplicon Sequencing to Quantify the Species Composition of Parasitic Nematode Communities
- Author
- A Valentini
- BE Stromberg
- BJ Darby
- C Camacho
- CK Lee
- E Serrano
- Elizabeth M. Redman
- Emmanuel Serrano Ferron
- F Roeber
- F Roeber
- F Roeber
- FHS Roberts
- G von Samson-Himmelstjerna
- GB Gloor
- GB Rogers
- HM Bik
- IA Sutherland
- J Agneessens
- J Höglund
- J Lello
- JA van Wyk
- JA Van Wyk
- James D. Wasmuth
- JJ Parkins
- John S. Gilleard
- JP Brooks
- JR Lichtenfels
- LC Gasbarre
- MC Durette-Desset
- NB Chilton
- ND Sargison
- P Hotez
- R Mochizuki
- RB Gasser
- RB Gasser
- RC Edgar
- RJ Dobson
- Roy Lewis
- Russell W. Avramenko
- S Ito
- T Magoč
- T Supali
- TG Mamedov
- Thomas A. Yazwinski
- TO Powers
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- Author
- A'Court J
- Aawsaj Y
- Abbadessa F
- Abbas A
- Abbott S
- Abdalaziz H
- Abdalla M
- Abdeh L
- Abdelsaid K
- Abdou H
- Abdul-Jabar H
- Abood A
- Abou-Foul AK
- Abrate A
- Abu-Nayla I
- Abual-Rub Z
- Abuown A
- Adamec A
- Adegbola S
- Ademuyiwa AO
- Advani R
- Aftab R
- Agarwal A
- Agarwal K
- Aggarwal A
- Aghababyan K
- Agilinko J
- Agrawal S
- Ahad S
- Ahmad Y
- Ahmed Elamin H
- Ahmed I
- Ahmeidat A
- Akhtar MA
- Al Ameer E
- Al-mukhtar A
- Al-omishy H
- Al-Samaraee A
- Al-Sukaini A
- Al-Yaseen M
- Aladeojebi A
- Alanbuki A
- Alderson D
- Aldridge K
- Alexander ME
- Alga A
- Ali M
- Ali Mahmoud F
- Ali S
- Allana A
- Allen M
- Almeida AC
- Almond M
- Alotaibi M
- Alqallaf A
- Alsakkaf M
- Alser O
- Alser O
- Altomare DF
- Alves R
- Alwadiya A
- Alzetani A
- Amaral MJ
- Ambler GK
- Ameerally P
- Anania G
- Anazor F
- Anderson C
- Andrade R
- Andreani SM
- Andronic A
- Aneke IA
- Angamuthu N
- Anjarwalla N
- Antar M
- Anthoney J
- Anton-Eguia BT
- Antunes J
- Apampa AA
- Aragon Achig EJ
- Archer JE
- Arigoni M
- Arkani S
- Armao T
- Arminio A
- Arnaud AP
- Arrieta M
- Asaad P
- Ascensao J
- Ashcroft J
- Asher S
- Askari A
- Athayde Nemesio R
- Augestad KM
- Aujayeb A
- Aujayeb A
- Awadallah M
- Ayeni F
- Ayorinde J
- Azevedo P
- Baban C
- Babawale O
- Babu BHB
- Bacarese-Hamilton J
- Bacarese-Hamilton T
- Badran A
- Bagouri E
- Baig M
- Baig MMAS
- Baker M
- Baker OJ
- Balaguer-Castro M
- Balakrishnan A
- Balasubramaniam D
- Balasubramanian SP
- Balau P
- Baldwin AJ
- Ballabio M
- Ballantyne K
- Baltazar G
- Bandyopadhyay S
- Bankhad-Kendall B
- Bankhead-Kendall B
- Bankhead-Kendall B
- Baquedano M
- Barbe Y
- Barbier L
- Barmayehvar B
- Barmpagianni C
- Barret E
- Barry C
- Bartsch A
- Basgaran A
- Basha A
- Bashkirova V
- Baskaran D
- Bateman A
- Bath MF
- Baumber R
- Baxter Z
- Bayer J
- Beak P
- Beamish AJ
- Begona E
- Bekheit M
- Belcher E
- Bellis C
- Beltran-Miranda P
- Ben-Sassi A
- Bence M
- Benitez-Linero I
- Benjamin MW
- Benson RA
- Bernal-Sprekelsen JC
- Bernasconi M
- Bevan K
- Bhalla A
- Bhangu A
- Bhangu A
- Bhangu A
- Bhasin S
- Bhaskar Pala RR
- Bhatia K
- Bhattacharya S
- Bhojwani D
- Bhutiani N
- Bierman W
- Bisagni P
- Blair J
- Blake I
- Blanco J
- Blanco-Colino R
- Blas Laina JL
- Blasco-Moreu J
- Blasco-Torres L
- Bleibleh S
- Blencowe NS
- Bloom O
- Blundell C
- Boal M
- Board T
- Bobak P
- Bodla AS
- Boeckxstaens A
- Boeker C
- Bond-Smith G
- Booth K
- Bordenave M
- Borghi F
- Borgstein ABJ
- Bosanquet D
- Bosch KD
- Bouche PA
- Bourke G
- Bowen D
- Branco C
- Brar A
- Brathwaite CEM
- Bravo A Minaya
- Breda D
- Breen K
- Breen KA
- Breik O
- Brennan C
- Brennan P
- Bretherton C
- Bretherton C
- Brian E
- Britton E
- Brown A
- Brown BC
- Brown O
- Brown O
- Brown S
- Brown SR
- Brown V
- Brunelli A
- Brunt A
- Buarque I Lima
- Burahee A
- Burke JR
- Byrne J
- Byrne MHV
- Cabeleira A
- Cadersa A
- Cagigal Ortega EP
- Caja Vivancos P
- Callahan MP
- Callan R
- Calvo Rey A
- Camacho C
- Camacho-Carrasco P
- Campain N
- Campbell R
- Campuzano-Bitterling B
- Canhoto C
- Cao H
- Capitan-Morales L
- Capitelli-McMahon H
- Caputo M
- Carcoforo P
- Cardoso N
- Cardoso N
- Cardoso P
- Cardoso P
- Carlos W
- Carmichael H
- Carreras-Castaner A
- Carrillo-Rivas M
- Carter J
- Caruana E
- Carvalho L
- Castano-Leon AM
- Castellanos J
- Catala Bauset JC
- Cathala N
- Cathelineau X
- Cato LD
- Catton A
- Cernei C
- Cervera I
- Chakrabortee S
- Chan CD
- Chan CH
- Chan M
- Chase T
- Chatterji S
- Chaudhry D
- Chaudhry D
- Chauhan G
- Chebaro A
- Chek Syed Nong SAH
- Chelva R
- Chen F
- Cheng D
- Chetty G
- Cheung J
- Chia Z
- Chiarpenello R
- Chidambaram S
- Chiozza M
- Choron R
- Choudhry A
- Chowdhury M
- Chowdhury S
- Chrastek D
- Christensen MA
- Christoforidis D
- Chu H
- Chui K
- Chung C
- Chung E
- Cianflocca D
- Cioci A
- Ciriello V
- Cirocchi N
- Clancy H
- Clark J
- Clifford R
- Clough E
- Clynch AL
- Cohnert TU
- Coleman NL
- Colino M
- Collaborative COVIDSurg
- Collera P
- Collier T
- Collis J
- Colombo F
- Colquhoun A
- Colvin HV
- Combellack T
- Connolly H
- Conso C
- Constable J
- Cooper Z
- Cordonnier A
- Cornish J
- Correia S
- Costa M
- Costeira B
- Cotoia A
- Cotsoglou C
- Coughlin P
- Crego-Vita D
- Cresner R
- Crichton A
- Crichton R
- Cros B
- Cross GWV
- Cuming T
- Cumpstey A
- Cunha C
- Cunha MF
- Cunningham Y
- Cuschieri J
- Cuthbert R
- Cymes W
- D'Agruma M
- Daadipour A
- Dalgleish S
- Daliya P
- Dalmasso E
- Daniele A
- Daniels IR
- Das R
- Dasa M
- Dass D
- Dauer MDE
- Davenport D
- Davidson B
- Davidson GH
- Davidson GH
- Davies E
- Davies RJ
- Davies-Jones G
- Davis NF
- Davison S
- Dawe N
- Dawson AC
- Dawson BE
- De Barros J
- de Castro Rubio Garcia E
- De Coster J
- De Gheldere C
- de la Manzanara Cano Lopez CA
- De la Rosa-Estadella M
- de Lacy FB
- De Marchi J
- De Oliveira Lopez AL
- De Vries JPPM
- Dean B
- Dean H
- Deglurkar I
- Dehal A
- del Toro Lopez MD
- Delgado Fernandez J
- Dellonder Frigole J
- Demetriou C
- Denning A
- Denning M
- Desai A
- Desai A
- Dewan V
- Dhaif F
- Di Chiara F
- Di Giuseppe M
- Di Saverio S
- Di Taranto G
- Diaz Del Gobbo R
- Diaz Pena P
- Diaz J
- Diaz J
- Dickson K
- Divecha H
- Dixon J
- Doe M
- Domenech J
- Domingues JC
- Domingues JC
- Doorgakant A
- Dos Santos Carregal L
- Dott C
- Doulias T
- Dovell G
- Drake T
- Drane A
- Duchateau N
- Duck E
- Dudek J
- Duff S
- Duggleby L
- Dunn J
- Dunne N
- Dunning J
- Dunstan M
- Duque M
- Duran-Munoz-Cruzado VM
- Durrani A
- Durst AZED
- Dvorkin LS
- Eardley N
- Eberbach H
- Ebrahim A
- Edmondson R
- Edwards J
- Edwards J
- Egan RJ
- Egglestone A
- Eibinger N
- Eiriz Fernandez C
- El Amrani M
- El Drubi Vega S
- El Hechi M
- El Kafsi J
- El Moheb M
- El-Hasani S
- Elhadi M
- Elhusseini M
- Elkadi H
- Elliott L
- Elmaleh N
- Emerson H
- Emmerson O
- Emslie K
- Enemosah I
- Engel J
- English C
- Enjuto D
- Erdle B
- Eriberto F
- Erridge S
- Escartin J
- Escobar D
- Espino Segura-Illa M
- Estaire Gomez M
- Esteban Sinovas O
- Evans J
- Evans J
- Evans JP
- Evans R
- Exley R
- Farik S
- Farre Font R
- Farrell T
- Fathelbab MSAT
- Faulkner G
- Fawi H
- Fayad A
- Fediuk M
- Fell A
- Ferguson D
- Ferguson H
- Fernandez Bernabe P
- Fernandez Camunas A
- Fernandez-Colorado A
- Fernandez-Marin MR
- Ferrero Herrero E
- Finch JG
- Fine N
- Fiore M
- Fisher A
- Fitzgerald JE
- Flannery O
- Flatman M
- Flindall I
- Flores Clotet R
- Folorunso A
- Ford D
- Ford S
- Ford S
- Forlani S
- Foster L
- Fountain DM
- Fowler GE
- Freedman J
- Freijeiro M
- Freystaetter K
- Fu H
- Fudulu DP
- Fuks D
- Fusai G
- Gabr A
- Gagliano A
- Gainza A
- Gaitanidis A
- Galhoum M
- Galipienso Eri M
- Gallagher B
- Gallagher P
- Gallo G
- Gammeri E
- Ganau M
- Garces Garcia R
- Garcia de Cortazar U
- Garcia Egea J
- Garcia Gutierrez JJ
- Garcia Montesino JD
- Garcia Opere G
- Garcia Perez D
- Garcia Santos EP
- Garcia Villar O
- Garcia-Borda J
- Gardner A
- Garner M
- Garnero A
- Garrido R
- Garrido S
- Garrido-Ondono S
- Gasset-Teixidor A
- Gasulla-Rodriguez A
- Gaujoux S
- Gaunt A
- Gelarda E
- George K
- Georgiades F
- Georgopoulou N
- Gerogiannis I
- Ghanbari A
- Ghattaura H
- Ghobrial M
- Ghosh D
- Ghosh K
- Giblin A
- Gil-Albarova O
- Gilabert Estelles J
- Gill C
- Gill DF
- Gilliland J
- Giraudo G
- Gisbertz SS
- Giuffrida MC
- Glasbey JC
- Gnanachandran C
- Godbole C
- Godinho M
- Gohil K
- Gokcen E
- Gomes GMA
- Gomes H
- Gomez Cruzado Fernandez L
- Gomez Diaz CJ
- Gomez Suarez J
- Gomez P
- Gomez-Rosado J
- Gonzalez De Miguel M
- Gonzalez J
- Gossot D
- Goubran A
- Gowda M
- Goyal A
- Gracia I
- Gradinariu G
- Grainger T
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- Publication venue
- 'BMJ'
- Publication date
- 01/01/2021
- Field of study
Objectives Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis. Setting Prospective, international, multicentre, observational cohort study. Participants Patients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative). Primary outcome 30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality. Results This study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787). Conclusions Patients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups. Trial registration number NCT0432364
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Aawsaj Y
- Abadia M
- Abad‐Gurumeta A
- Abad‐Motos A
- Abassy J
- Abate E
- Abbasov A
- Abbott D
- Abbott Tom EF
- Abdalla M
- Abdeldayem H
- Abdelkabir M
- Abdelkader Salama I
- Abdelkarim M
- Abdelsamed A
- Abdulfattah F
- Abdulwahed E
- Abdur‐Rahman LO
- Abel MK
- Abelevich A
- Abiyere H
- Aboelkassem Ibrahim A
- Aboharp Hasan Z
- Abou Chaar MK
- Abreu da Silva A
- Abubakar A
- Abukhalaf SA
- Abukhalaf Sadi
- Acebes García F
- Achalandabaso Boira M
- Acher A
- Acosta Mérida MA
- Acrich E
- Adam Essa Adam ME
- Adamina M
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adeyeye A
- Adi H
- Adiamah A
- Adisa Adewale
- Afzal MF
- Agapov M
- Agarwal Arnav
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- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agrawal A
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- Agresta F
- Aguado López H
- Aguiar Júnior S
- Aguilar Gonzalez M
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- Aiken T
- Aimé A
- Akalin M
- Akaydin E
- Akbas A
- Akhtar MA
- Akhtar N
- Akhter Rahman MM
- Akin E
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al ahmad F
- Al Asadi T
- Al Awwad S
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- Karandikar S
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- Karimuddin A
- Karlović D
- Kashif M
- Kasivisvanathan Veeru
- Kassir R
- Katory M
- Kattakayam A
- Katusic Z
- Kaul S
- Kauppila JH
- Kauppila JH
- Kaushal M
- Kavanagh D
- Kaya T
- Kayyal MY
- Kazachenko E
- Keatley James M
- Kebabçı E
- Kecmanović D
- Keeler BD
- Keller Debby
- Keller Debby
- Kembuan G
- Kenic M
- Kennelly R
- Kent A
- Kerawala AA
- Khajuria A
- Khan A
- Khan AH
- Khan F
- Khan J
- Khan K
- Khan S
- Khan Tabassum
- Khatri Chetan
- Khaw Rachel A
- Khokhar MI
- Kiconco H
- Kilani AI
- Kilinc Tuncer G
- Killeen S
- Kim NJ
- Kirmizi Y
- Kjaer DW
- Klaristenfeld D
- Klatte Tobias
- Kleeff J
- Kler A
- Klimopoulos S
- Kloppers C
- Kmezić S
- Knezevic D
- Knight Andrew
- Knights E
- Knowles C
- Knowles J
- Kocatas A
- Koh A
- Kokkinos G
- Kokobelyan AK
- Kokoropoulos P
- Koleva Radica M
- Kolias Angelos
- Kolias Angelos
- Kolla C
- Kollengode VV
- Kolli VS
- Konney Thomas
- Konstadoulakis M
- Konstantinou C
- Konsten J
- Kontovounisios C
- Kornblith LZ
- Kottayasamy Seenivasagam R
- Koukoulis G
- Kourdouli A
- Kovacevic B
- Kowalewski P
- Krarup P
- Krdzic I
- Kredan A
- Kretzmer L
- Krishnan E
- Kristensen HØ
- Krivokapic Z
- Kroon HM
- Kruijff Schelto
- Kršul D
- Kubiliute E
- Kubyshkin V
- Kucuk GO
- Kudchadkar S
- Kuiper S
- Kulkarni N
- Kulkarni R
- Kulle CB
- Kumar A
- Kumar L
- Kumar S
- Kumar V
- Kutkevičius J
- Kuttanchettiyar KG
- Kwan‐Feinberg R
- Kwiatkowski A
- Kyriacou H
- Kälviäinen H
- Königsrainer A
- Küçük IF
- La Regina D
- La Torre F
- Labib PL
- Lacy AM
- Ladd MR
- Laface L
- Laforest A
- Laharwal A
- Lakkis Z
- Lala AK
- Lalou L
- Lamb Benjamin
- Landaluce‐olavarria A
- Lapolla P
- Laporte G
- Larentzakis A
- Larkin J
- Laskar N
- Lasses Martínez B
- Latinčić S
- Lauretta A
- Lauscher J
- Lavy R
- Law J
- Lawani Ismail
- Lawday S
- Lawday Samuel
- Lawday Samuel
- Layton Georgia R
- Le Roy B
- Lecolle K
- Lederhuber Hans
- Lederhuber Hans
- Ledesma FS
- Lee M
- Lee N
- Leede E
- Lenzi E
- Leon R
- Leung Elaine YL
- Leventoglu Sezai
- Leventoglu Sezai
- Lewis‐Lloyd C
- Li Elizabeth
- Li Elizabeth
- Li M
- Li Z
- Liakakos T
- Liao CCL
- Lieske B
- Lim M
- Lim RZM
- Lima Buarque I
- Lima da Cruz L
- Lima da Silva C
- Lima MJ
- Linari C
- Lippa Laura
- Lira dos Santos Leite A
- Litta F
- Litvin A
- Litvin Andrey
- Litvina Y
- Liu J
- Liu T
- Lizzi V
- Locatelli A
- Loch FN
- Loehrer A
- Loehrer Andrew
- Loncar Z
- Long C
- Longhi M
- Longhini A
- Longstaff L
- Lopes L
- Lopez Abad A
- Lora‐Cumplido P
- Lorena Maria Aguilera
- Lorenzon L
- Losada M
- Lott N
- Loubani M
- Loutzidou L
- Lowery A
- Lozano Lominchar P
- Lucchini SM
- Luglio G
- Lule H
- Lun EWY
- Lunevicius R
- Lunghi EG
- Lynch N
- Lyons A
- Lázaro A
- López Antoñanzas L
- Löffler Markus W
- Löffler MW
- Löfgren N
- M. elghazaly S
- Maa Albared S
- Maccabe TA
- MacDonald L
- Machado D
- Machado N
- Macina S
- Madani Kia T
- Madani R
- Madonini M
- Maffioli A
- Magee C
- Maghrebi H
- Magowan D
- Mahajan A
- Mahendran V
- Mahmood M
- Mahmoud Ali F
- Mahvi D
- Maida P
- Maiga A
- Maimbo Mayaba
- Majbar AM
- Majkowska A
- Major P
- Major Piotr
- Majrashi S
- Majumdar KS
- Mak TWC
- Malapati H
- Malcolm FL
- Malgras B
- Malibary N
- Mall JW
- Maltinti G
- Manatakis DK
- Manfredelli S
- Manku B
- Mann Harvinder S
- Manrique E
- Manso I
- Manson J
- Mantoglu B
- Manu N
- Maqueda González R
- Marafante C
- Marano A
- Marchbank Adrian
- Marcos‐Santos P
- Marcus Hani J
- Mardare M
- Margalit A
- Mari G
- Marialva J
- Mariani NM
- Marie‐Macron L
- Marinello P
- Marino Cosentino L
- Marino M
- Marino MV
- Markaryan D
- Markovic I
- Markovic V
- Marques R
- Marques T
- Marqueta De Salas M
- Marra AA
- Marra E
- Marreiro A
- Marson Ella J
- Marte G
- Martel A
- Martin E
- Martin E
- Martin Janet
- Martin ST
- Martinek L
- Martinez German A
- Martins dos Santos G
- Martins Jordão D
- Martins A
- Martins D
- Martins R
- Martin‐Perez B
- Martin‐Perez E
- Martín Anoro LF
- Martín L
- Martínez Chicote C
- Martínez‐Hurtado E
- Martínez‐Pinedo C
- Martínez‐Pérez P
- Martín‐Arévalo J
- Marx W
- Marzi F
- Marçal A
- Marín H
- Masciandaro A
- Mashat A
- Mashbari Hassan N
- Massey LH
- Massie E
- Massobrio A
- Mastoridis S
- Math S
- Mathew S
- Matić S
- Matos Costa P
- Matute M
- Maté Mate P
- Matías‐García B
- Maw A
- Mazingi Dennis
- Mazzotta E
- Mazzotti F
- McAleer J
- McAree B
- McCanny A
- Mccluney S
- Mccormick P
- McDermott FD
- McElhinney K
- McEwen R
- McGivern K
- McGrath John S
- McIlmunn C
- McIntosh S
- McIntyre J
- McKay Siobhan
- Mckay Siobhan C
- McKevitt K
- McLean Kenneth A
- McNaught C
- McNeill Alan
- McNicol F
- MdRazali. I null
- Mehigan BJ
- Mehraj A
- Meima‐van Praag EM
- Mekhael M
- Melchor‐Ruan J
- Melenhorst J
- Melhem S
- Memon AS
- Memos N
- Mendes F
- Mendes JR
- Mendoza‐Moreno F
- Meneghini S
- Mercado MÁ
- Merdrignac A
- Merh R
- Meriç S
- Messner F
- Metallidis Symeon
- Metwalli M
- Metzger J
- Michalopoulos N
- Michalski C
- Michel M
- Micic D
- Migliore M
- Mignot G
- Miguel T
- Mihanovic J
- Mihmanli M
- Miladinov M
- Milanović M
- Milic LJ
- Mills Emily C
- Mills SJ
- Milne K
- Minaya Bravo AM
- Minaya‐Bravo Ana
- Minaya‐Bravo Ana
- Minaya‐Bravo Ana
- Mingoli A
- Minicozzi A
- Minto G
- Mir I
- Mirabella A
- Miranda P
- Mirica RM
- Mirnezami R
- Mishra N
- Mishra S
- Mishra T
- Misra S
- Mitchell D
- Mitchell S
- Mithany R
- Mitra JK
- Mitrofan C
- Mittal R
- Mittal Rohin
- Miu V
- Mochet S
- Modolo Maria Marta
- Modolo Maria Marta
- Moftah M
- Moggia E
- Mohamed Sidek AS
- Mohammad Z
- Mohammed MM
- MohammedJibreel M
- Mohan H
- Mohan Helen M
- Mohan Helen M
- Mohd Azman ZA
- Mohd Yunus MF
- Mohsine R
- Mongelli F
- Montauban P
- Montelatici M
- Monteleone M
- Montella MT
- Montori G
- Montuori M
- Moore Rachel
- Moorthy M
- Morais H
- Moras L
- Mora‐Guzmán I
- Morelli L
- Moretto G
- Morgan R
- Moritani K
- Moro‐Valdezate D
- Morris A
- Morsi A
- Mosley F
- Moss J
- Moszkowicz David
- Moug S
- Moug Susan
- Moug Susan
- Moura F
- Mourad M
- Mshelbwala P
- Msherghi A
- Mudawi I
- Muduly D
- Muguerza JM
- Muiesan P
- Mukherjee S
- Muller B
- Mulligan CS
- Mungo S
- Muratore A
- Murawa D
- Murgese A
- Murphy C
- Musetti S
- Mustafa A
- Mutter D
- Muzamil J
- Muñoz Camarena JM
- Muñoz‐Atienza V
- Muñoz‐Bellvis L
- Naar L
- Nacif L
- Nafees Ahmed R
- Nageh MA
- Nahm C
- Najarian M
- Nally D
- Namazov İ
- Nankivell Paul
- Narahari Krishna
- Nassa H
- Nassif M
- Natale J
- Naumann D
- Navaratne L
- Nazir S
- Neary P
- Neary PM
- Neely D
- Negoi I
- Negoi Ionut
- Negoita VM
- Nel D
- Nelli T
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Neri J
- Nespoli LC
- Nessim C
- Neville Iuri
- Newman S
- Newman T
- Newton C
- Newton K
- Ng HJ
- Ng Joe
- Ng S
- Ng V
- Ng V
- Ngo CW
- Ng‐Kamstra Joshua S
- Nicolás‐López T
- Nikaj H
- Nikolaou S
- Nikolic S
- Niquen Milagros
- Nisar P
- Nitschke C
- Nogueira O
- Nogueiro J
- Nogués A
- Noiret B
- Nolan GJ
- Norcini C
- Nordberg M
- Notte F
- Nouh T
- Novello S
- Novikova A
- Nowak K
- Ntirenganya Faustin
- Nugent E
- Nunes Coelho M
- Nunes R
- Nunez‐Garcia B
- Nunoo‐Mensah JW
- Nuñez Del Barrio H
- Nwabuoku SE
- Núñez J
- Obeidat K
- Ocaña J
- Ochagavía S
- Oguttu B
- Okafor B
- Okunlola A
- Olaogun J
- Olasehinde O
- Oldfield F
- Oliva Mompean F
- Oliveira A
- Olivier J
- Olivieri M
- Olivos Maricarmen
- Olori S
- Olson KA
- Olute A
- Omar W
- Omeroglu S
- Ong SL
- Onos L
- Oosterlinck W
- Oosterling S
- Opocher E
- Ortega Vázquez I
- Ortiz de Solórzano Aurusa FJ
- Ortiz López D
- Osagie O
- Oseira A
- Osman N
- Osorio Ramos A
- Otero A
- Otoniel LR
- Oussama Kacimi
- Outani Oumaima
- Ovejero Merino E
- Owen H
- Owens P
- Oyende O
- Ozben V
- Ozcelık MF
- Ozgediz D
- Ozmen BB
- O’Brien H
- O’Brien S
- O’Donnell S
- O’Malley S
- O’Riordan J
- O’Shea M
- P Delrio
- Pacheco Sánchez D
- Padilla‐Valverde D
- Padmore G
- Pagano G
- Pajan H
- Palagi S
- Palma P
- Palmeri M
- Panahi P
- Pandey D
- Paniagua García Señorans M
- Papaconstantinou I
- Papadopoulos V
- Papagni V
- Papatheodorou P
- Paquette N
- Parasyris S
- Pareek P
- Pareja Rene
- Parello A
- Parente A
- Parini S
- Parise P
- Park J
- Parkin E
- Parkins K
- Parlanti D
- Parmar C
- Parra Baños PA
- Parray FQ
- Parreira R
- Parreño‐Sacdalan Marie Dione
- Parreño‐Sacdalan Marie Dione
- Parseliunas A
- Parwaiz I
- Pasini F
- Paspaliari D
- Pata Francesco
- Pata Francesco
- Pata Francesco
- Patel Akshay
- Patel K
- Patel M
- Patel P
- Patil S
- Patrone R
- Patrício B
- Pattyn P
- Pattyn P
- Pavlov M
- Pedrazzani C
- Pedro J
- Pedro V
- Peirce C
- Pejnovic L
- Pejovic I
- Pellegrino L
- Pellino G
- Pellino Gianluca
- Peluso C
- Penumadu P
- Pera R
- Peralta Ferreira M
- Pereca J
- Pereira Rodrigues A
- Pereira A
- Pereira C
- Pereira I
- Pereira R
- Perez Gonzalez M
- Perez D
- Pergolini I
- Perivoliotis K
- Peros G
- Perotto LO
- Perra T
- Perrone G
- Persad A
- Persiani R
- Pertile D
- Peteja M
- Petrillo A
- Peyroteo M
- Pezzuto AP
- Peña Ros E
- Peña Soria MJ
- Pham H
- Phan D
- Phang PT
- Phillips E
- Picardo AL
- Picciariello A
- Picciochi Maria
- Pickett L
- Picón Rodríguez R
- Pieniowski E
- Piessen G
- Pina S
- Pinilla Morales RE
- Pinkney Thomas D
- Pinotti E
- Pinto J
- Pipara A
- Piper Rory J
- Pipitone Federico NS
- Pirozzolo G
- Pirzada A
- Pisani Ceretti A
- Pisanu A
- Pius Ogolekwu I
- Pla‐Marti V
- Pockney P
- Pockney Peter
- Pockney Peter
- Pockney Peter
- Podda M
- Poeze M
- Poggioli G
- Police A
- Polydorou A
- Pol‐Fachin L
- Ponchietti L
- Popoola AA
- Porcu A
- Portinari M
- Posadas‐Trujillo OE
- Posma‐Bouman L
- Potter R
- Pourcher G
- Powell S
- Pozotou I
- Praetorius C
- Pramesh CS
- Prando D
- Presl J
- Price C
- Price Stephen J
- Prieto Calvo M
- Prieto Nieto MI
- Pronk AJM
- Prosperi P
- Provozina A
- Pruvot FR
- Pujari R
- Pujol Cano N
- Pérez Sánchez MA
- Pérez‐Saborido B
- Qadan M
- Qasem A
- Qatora MS
- Quante M
- Quintana Martinic M
- Quiroga‐Valcárcel A
- Qureshi Ahmad
- Qureshi AU
- Raby‐Smith W
- Radenkovic Dejan
- Raggio E
- Rai L
- Rajan S
- Rajaretnam N
- Rakvin I
- Ramachandran A
- Ramalho de Almeida F
- Ramamoorthy R
- Ramasamy S
- Ramcharan S
- Ramesh P
- Ramirez Faraco M
- Ramirez Romero P
- Ramos Bonilla A
- Ramos D
- Ramos‐De la Medina Antonio
- Ramos‐Martín P
- Ramwell A
- Rao S
- Rapaport S
- Rashid A
- Rashid MM
- Rasoaherinomenjanahary F
- Rattizzato S
- Ratto C
- Raval M
- Ravindrakumar S
- Ravindran S
- Rayamajhi S
- Raymond T
- Razafindrahita JB
- Recordare A
- Reddy P
- Redfern J
- Refky B
- Rega D
- Rega D
- Regina de Sampaio L
- Reilly J
- Reim D
- Reinhard T
- Revez T
- Rey Ferro M
- Rey Valcarcel C
- Reynolds IS
- Ribeiro A
- Ribeiro CG
- Ribeiro R
- Ribolla M
- Rice D
- Richards S
- Richards T
- Richards Toby
- Riddell A
- Ridgway PF
- Righini E
- Riley C
- Rimonda R
- Ringressi MN
- Ripollés‐Melchor J
- Riquoir Altamirano C
- Risaliti M
- Riva C
- Rivas R
- Rivera Carlos Jose Perez
- Rivera‐Alonso D
- Rizk M
- Rizzi A
- Roberts Keith
- Roberts Keith
- Robertson Faith
- Robinson A
- Roca Calvo MJ
- Rodrigo VSD
- Rodrigues K
- Rodriguez Artigas JM
- Rodriguez JL
- Rodríguez Gómez L
- Rodwell H
- Rogers LJ
- Rogers M
- Rojo López JA
- Roldón Golet M
- Romano M
- Romero Bañuelos E
- Romero de Diego A
- Ronellenfitsch U
- Rooney SM
- Rosa F
- Rose J
- Roslani AC
- Roslani April C
- Rosseau Gail
- Rossi S
- Roszkowski R
- Rottoli M
- Roux A
- Roxo V
- Roy Mahapatra S
- Royle T
- Rubio‐Perez I
- Ruivo A
- Ruiz Esquide M
- Ruiz Manzanera JJ
- Ruiz Soriano M
- Ruiz‐Escobar A
- Ruiz‐Marín M
- Russ J
- Russo IS
- Rutegård M
- Rutegård Martin
- Rutegård Martin
- Rutherford D
- Ruzgar NM
- Ruzzenente A
- Ryan M
- Ryan ÉJ
- Ryska O
- Río Lafuente FD
- S RRR
- Saad MM
- Saafan T
- Saavedra J
- Sabry A
- Saeed S
- Saez Carlin P
- Sagar J
- Sagnotta A
- Sahid Nik Amin
- Sahin I
- Sahnan K
- Saklani A
- Sakr A
- Saksena AR
- Salazar A
- Saleem A
- Saleem A
- Saleh M
- Salem H
- Salem H
- Salem M
- Salerno G
- Sales Mallafré R
- Salgado‐Nesme N
- Salim A
- Salimoğlu S
- Salindera S
- Sallam I
- Samadov E
- Samih A
- Samir Abdelaal A
- Samison LH
- Samkari A
- Sammarco G
- Sammour T
- Sampaio da Nóvoa Gomes Miguel II
- Sampaio Soares A
- Sampietro GM
- San Miguel C
- Sanchez Cabezudo Noguera F
- Sanchez Gonzalez J
- Sanchez Jimenez R
- Sanchez‐Casado AB
- Sanchez‐Pelaez D
- Sanchon L
- Sancho‐Muriel J
- Sanli AN
- Santanach C
- Santarrufina Martinez S
- Santero‐Ramirez MS
- Santos Bezerra T
- Santos Irène
- Santos PMDD
- Santos R
- Santos‐Sousa H
- Sanz Larrainzar A
- Sanz Ortega G
- Sanz‐López R
- Sapienza P
- Sapre D
- Saraiva P
- Sarantitis I
- Sarigul M
- Sarin A
- Sarjanoja E
- Sarma DR
- Sarpel U
- Sarre C
- Sartarelli L
- Sarveswaran J
- Sasapu K
- Sasia D
- Satoi Sohei
- Satoi Sohei
- Saudí S
- Sauvain M
- Sauvat F
- Saverio Salomone Di
- Saverio Salomone Di
- Savković N
- Sayyed R
- Sayyed Raza
- Scabini S
- Scalabre A
- Scanu AM
- Schache Andrew
- Schache Andrew G
- Schaller Karl
- Scheiwiller A
- Schiavo M
- Schiergens T
- Schineis C
- Schizas D
- Schlesinger N
- Schnitzbauer Andreas A
- Schwartz PB
- Scott L
- Scotton G
- Scrima O
- Sebai A
- Seebah K
- Seeliger B
- Seenivasagam Rajkumar Kottayasamy
- Seguin‐givelet A
- Segura‐Sampedro JJ
- Segura‐Sampedro Juan José
- Sehgal T
- Sehouli Jalid
- Seleim A
- Selmani J
- Semina E
- Sena G
- Senossi O
- Serevina OL
- Serralta de Colsa D
- Serrano González J
- Serrano‐Navidad M
- Sert İ
- Servadei Franco
- Seyi‐Olajide Justina O.
- Seymour Z
- Sganga G
- Sgrò A
- Shah J
- Shah S
- Shah ZA
- Shaikh I
- Shaikh S
- Shakoor Z
- Shanthakunalan K
- Sharabiany S
- Sharma Neil
- Sharma P
- Shaw Catherine A
- Shaw Richard
- Shaw Richard
- Sheel A
- Shehata S
- Shenit K
- Sheridan K
- Sherief M
- Sherif A
- Sherif Ahmed Elshawadfy
- Sherif G
- Shokuhi P
- Sholadoye TT
- Shortland T
- Shream S
- Shrestha A
- Shu Sebastian
- Shylasree TS
- Sian T
- Siaw‐Acheampong Kwabena
- Sibilla MG
- Siddiqui MT
- Sidiropoulos T
- Silva A
- Silva M
- Silva N
- Silva R
- Silveira Nunes I
- Silvestre D
- Simões JFF
- Singh AA
- Singh Jagdeep K
- Singh MP
- Singh R
- Singh S
- Singh S
- Sion M
- Skrovina M
- Smart Neil
- Smart Neil J
- Smith C
- Smith H
- Smith J
- Smith L
- Soh JY
- Sohrabi C
- Sokolov M
- Solari F
- Soldevila Verdeguer C
- Soliman H
- Soltan H
- Soreide Kjetil
- Soriano AI
- Soriero D
- Sorrentino L
- Sorribas Grifell M
- Sosa Duran EE
- Sosa‐Rodríguez MV
- Soto Montesinos C
- Souadka A
- Soulé Martínez CE
- Sousa Fernandes M
- Sousa R
- Sousa S
- Spagni G
- Spampinato MG
- Spanu A
- Spartalis E
- Spencer N
- Spiezio G
- Spinelli A
- Spinelli Antonino
- Spolini A
- Sreedharan L
- Srikumar B
- Sriram RK
- Srishankar S
- Sroczyński P
- St John S
- Stafford J
- Stavrinidou O
- Stebbing J
- Steele C
- Steidle C
- Steinke J
- Stevens K
- Stevenson J
- Stevic D
- Stewart Grant D
- Stewart Grant D
- Stewart KE
- Stockdale T
- Stoica B
- Strate T
- Stylianides N
- Stylianidis G
- Subhi MT
- Subocius A
- Subramaniam S
- Sud A
- Sund Malin
- Sundar Sudha
- Sundar Sudha
- Sundaram Venkatesan G
- Sundhu M
- Suszták N
- Sutherland A
- Swinson B
- Syed WAS
- Syllaios A
- Szatmary P
- Szubota I
- Sánchez del Pueblo C
- Sánchez Fuentes N
- Sánchez Tocino JM
- Sánchez‐García S
- Sánchez‐Guillén L
- Tabiri Stephen
- Tactuk N
- Taddei A
- Tadic B
- Taibi A
- Talaat M
- Talal El‐Abur I
- Talukder S
- Talwar R
- Tamini N
- Tammaro P
- Tan JA
- Tan KHM
- Tan XS
- Tanal M
- Tang AM
- Tanzanu M
- Tartaglia D
- Tasis N
- Tatar OC
- Tavares F
- Tawheed A
- Tayeh S
- Taylor Elliott H
- Tebala GD
- Teh C
- Teixeira J
- Teixeira M
- Tejero‐Pintor FJ
- Telma K
- Testa V
- Tewari N
- Tezas S
- Thaha MA
- Thalgaspitiya SPB
- Thanapal MR
- Thekinkattil Dinesh
- Theodosopoulos T
- Theophilidou E
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- Žatecký J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P ConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.
- Author
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- Abad Gurumeta A
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- Zouzoulas D
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- Zullo A
- Publication venue
- Br J Surg
- Publication date
- 11/11/2020
- Field of study
BACKGROUND: Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. METHODS: This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. RESULTS: Of 8784 patients (432 hospitals, 53 countries), 2303 patients (26.2 per cent) underwent preoperative testing: 1458 (16.6 per cent) had a swab test, 521 (5.9 per cent) CT only, and 324 (3.7 per cent) swab and CT. Pulmonary complications occurred in 3.9 per cent, whereas SARS-CoV-2 infection was confirmed in 2.6 per cent. After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; P = 0.040) was associated with a lower rate of pulmonary complications. Swab testing was beneficial before major surgery and in areas with a high 14-day SARS-CoV-2 case notification rate, but not before minor surgery or in low-risk areas. To prevent one pulmonary complication, the number needed to swab test before major or minor surgery was 18 and 48 respectively in high-risk areas, and 73 and 387 in low-risk areas. CONCLUSION: Preoperative nasopharyngeal swab testing was beneficial before major surgery and in high SARS-CoV-2 risk areas. There was no proven benefit of swab testing before minor surgery in low-risk areas
Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study
- Author
- Aawsaj Y
- Abad Gurumeta A
- Abad-Motos A
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- on behalf of the COVIDSurg Collaborative
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- Spinelli A
- Spinelli Antonino
- Spriano G
- Spurnic I
- Sravanam S
- Srbinovic L
- Sreedharan L
- Srikanth P
- Srinathan S
- Sriram RK
- Srishankar S
- Ssentongo A
- Ssentongo P
- St. John S
- Stafford J
- Stanimirovic A
- Stavrinidou O
- Stavroglou A
- Stavroulias D
- Stebbing J
- Steel B
- Steele C
- Stefanovic A
- Steidle C
- Steiner MA
- Steinke J
- Stepanyan A
- Stevens K
- Stevenson J
- Stevic D
- Stewart GD
- Stewart Grant D
- Stewart Grant D.
- Stewart KE
- Stojiljkovic D
- Stranz C
- Stroman L
- Stylianides N
- Stylianidis G
- Subhi MT
- Subocius A
- Subramaniam S
- Sultana A
- Sumrak S
- Sund M
- Sund Malin
- Sundar MRCOG, Sudha
- Sundar S
- Sundar Sudha
- Sundaram Venkatesan G
- Sureshkumar Shah N
- Suszták N
- Sutherland A
- Swinson B
- Syed WAS
- Syllaios A
- Symeonidis D
- Szatmary P
- Szpytma M
- Szubota I
- Sánchez Aniceto G
- Sánchez del Pueblo C
- Sánchez Fuentes N
- Sánchez-García S
- Sánchez-Pernaute A
- Sánchez-Rubio M
- Tabiri Stephen
- Taddei A
- Tadic B
- Taffurelli M
- Taflin H
- Taggarsi M
- Tagliabue M
- Tahhan G
- Taibi A
- Tailor A
- Takeda F
- Talal El-Abur I
- Talukder S
- Talwar R
- Tamini N
- Tammaro T
- Tan JA
- Tan JR
- Tan KL
- Tan XS
- Tanabalan C
- Tanal M
- Tanase Y
- Tang A
- Tang CY
- Tanzanu M
- Tartaglia D
- Tasis N
- Taskiran C
- Tatar OC
- Tatsis D
- Tavares F
- Tayeh S
- Taylor Elliott H
- Tebala GD
- Tedde A
- Tedde M
- Teh C
- Teh E
- Teixeira J
- Teixeira M
- Tejero-Pintor FJ
- Tenreiro N
- Teoh LY
- Tepetes K
- Tercero-Uribe AI
- Terra RM
- Tesei M
- Testa V
- Testelin S
- Teves M
- Tewari N
- Tezas S
- Thaha M
- Thakur B
- Tham D
- Thanapal MR
- Thekinkattil Dinesh
- Thekkinkattil D
- Theodosopoulos T
- Theophilidou E
- Theophilou G
- Thiruchelvam J
- Thole S
- Thomas A
- Thomas E
- Thomas M
- Thomas R
- Thompson A
- Thompson D
- Thornhill M
- Thrumurthy S
- Thulasiraman SV
- Tilaveridis I
- Timbrell S
- Timon C
- Tingle S
- Tirloni L
- Tirotta F
- Tirotta Fabio
- Titu S
- Tiwari Abhinav
- Todorovic M
- Toia F
- Tojal A
- Tolani MA
- Tonini V
- Toogood G
- Tooulias A
- Topczewski TE
- Torales J
- Tormey S
- Torne A
- Tornese S
- Torné R
- Torres Arcos C
- Torres A
- Torretta S
- Townend D
- Townend P
- Townend Philip
- Townson A
- Trabulsi N
- Travaglio E
- Tribillon E
- Trivic A
- Troncoso Pereira P
- Tropeano FP
- Trout Isobel M
- Truant S
- Trujillo Díaz J
- Tsai L
- Tsaousis V
- Tsarkov P
- Tsiamalou I
- Tsiaoussis J
- Tsibulak I
- Tsirlis T
- Tsolakidis D
- Tsoulfas G
- Tsoulfas Georgios
- Tucci R
- Tudela M
- Tudisco R
- Tufo A
- Tugmen C
- Tulina I
- Tuncer K
- Turkington R
- Turnage K
- Turnbull A
- Turrado-Rodriguez V
- Turri G
- Tustin H
- Tutoveanu G
- Tuveri M
- Tweedle E
- Tzedakis S
- Tzerbinis H
- Tzovaras G
- Ugarte-Sierra B
- Uludağ SS
- Umair M
- Umar M
- Underwood C
- Uno M
- Uras C
- Urbani A
- Urbieta A
- Usai A
- Usandivaras M
- Uslu G
- Uson-Bouthelier T
- Usseglio J
- Utkan NZ
- Uyanik MS
- Uzunoglu FG
- Vaccarella G
- Vahtsevanos K
- Valbuena Jabares V
- Valdes-Hernandez J
- Valente da Costa A
- Valero Soriano M
- Valero R
- Vallance A
- Vallance Abigail
- Valle Rubio A
- Valtzoglou V
- Valverde S
- Van den Eynde J
- Van den Eynde R
- van der Plas Willemijn
- Van Duijvendijk P
- Van Heinsbergen M
- Van Houdt W
- van Ramshorst Gabrielle H
- Van Wyngaard T
- Vanounou T
- Varazzani A
- Vargas L
- Varley I
- Varma M
- Vasljević J
- Vassiliu P
- Vatansever D
- Vatish J
- Vatish M
- Vaz Pereira R
- Vaz OP
- Vaz S
- Vazquez fernandez A
- Veiga D
- Velagapudi S
- Velchuru V
- Velickovic D
- Velidedeoglu M
- Venetis G
- Venn M
- Venn Mary L
- Venn Mary L.
- Venskutonis D
- Vera Mansilla C
- Verberne C
- Vergari R
- Vernon L
- Vervoort D
- Vescio G
- Vezakis A
- Vidakovic S
- Videira JF
- Videria Jose Flavio
- Vidya R
- Vidya Raghavan
- Vieira Caroço T
- Vieira Paiva Lopes AC
- Vieira A
- Vieira B
- Vieira P
- Vignali A
- Vigorita V
- Vijayan D
- Vilatoba M
- Vilendecic Z
- Villalabeitia Ateca I
- Vimalachandran D
- Vimalachandran Dale
- Vimalchandran Dale
- Vinayagam R
- Violante T
- Visgauss J
- Viswambaram P
- Viswanath Y
- Vitali A
- Vitone L
- Vives RV
- Vo UG
- Vogel J
- Vollkommer T
- Von Papen M
- Vovola F
- Vucic N
- Vujanac V
- Wade R
- Wadham B
- Waheed S
- Wai K
- Wali A
- Walker C
- Walker D
- Walkes K
- Wallwork K
- Walton G
- Walton T
- Waqar SH
- Warburton H
- Ward D
- Ward S
- Waris Farooka M
- Warren O
- Warren Oliver J
- Waseem S
- Wasim T
- Watson D
- Watson LJ
- Watson N
- Weaver H
- Webber L
- Wedderburn Duane
- Weitz J
- Welsch T
- Wensley F
- Werner J
- West C
- West D
- Westwood E
- Whelan M
- Whelan P
- Whisker L
- Whitehall E
- Whitmore H
- Wilkin R
- Wilkin Richard JW
- Wilkins A
- Wilkins Alex
- Williams G
- Williams J
- Williams K
- Williams MA
- Williams T
- Williamson K
- Wilson M
- Wimberger P
- Wimmer A
- Winnand P
- Winter D
- Winter S
- Winter Stuart C
- Wolfer S
- Wong MPK
- Wong S
- Wong WJ
- Woodham A
- Woodun H
- Worku D
- Wright G
- Wright Naomi
- Wullschleger M
- Wustrack R
- Xenaki S
- Xu MJ
- Xyda SE
- Xynos E
- Yahaya AS
- Yang W
- Yassin N
- Ye G
- Yesantharao P
- Yetkin G
- Yeşilyurt D
- Yiallourou A
- Yıldırım A
- Yildiz A
- Ying Y
- Yip V
- Yordanov S
- Young R
- Yousof EA
- Youssef A
- Youssef M
- Yurttas C
- Yánez C
- Yüksel E
- Zacharoulis D
- Zafar SN
- Zakai D
- Zakaria AD
- Zakaria R
- Zakaria Z
- Zambelli MF
- Zambon M
- Zamora L
- Zamvar V
- Zani S
- Zanotti S
- Zanus G
- Zapardiel I
- Zarabini AG
- Zegarac M
- Zelić M
- Zeller N
- Zengin AK
- Zerbib P
- Zervas K
- Zese M
- Zhang H
- Zivanovic M
- Zivkovic M
- Zizzo M
- Zografos C
- Zonta S
- Zorrilla Ortúzar J
- Zourntou S
- Zouzoulas D
- Zubaidi A
- Zullo A
- Ângelo M
- Älgå A
- Çapoğlu R
- Çelebi F
- Çolak E
- Öfner D
- Öhlberger L
- Öğücü H
- Überrück L
- Ćoza I
- Šimko K
- Šćepanović V
- Žatecký J
- Камалов А
- Publication venue
- American Society of Clinical Oncology
- Publication date
- 01/01/2021
- Field of study