Conducting rapid qualitative research amongst people with experience of rough sleeping in London during the COVID-19 pandemic

In March 2020, the ‘Everyone In’ initiative was introduced by the UK government as a public health response to COVID-19. This initiative sought to temporarily accommodate people experiencing rough sleeping in hotels in all local authority areas throughout England. In London, ‘Everyone In’ involved the procurement of vacant accommodation in over 100 hotels and temporarily re-housed approximately 2000 individuals. A rapid qualitative study was undertaken within two hotels to explore experiences of the initiative from the perspective of people accommodated in the hotels. This article describes how standard qualitative methods were adapted and implemented to complete the study whilst meeting COVID-19 social distancing guidelines. The research involved a longitudinal design of a two-stage qualitative interview that sought to capture residents’ experience of ‘Everyone In’ at two points in time (while in the hotel and when residents had left the hotel). Adapted qualitative methods were employed by a team of 13 researchers. These adaptations included socially distanced leaflet dropping, telephone-based participant recruitment, a remote, multistage, longitudinal qualitative telephone interviewing and rapid framework analysis. 35 hotel residents were recruited into the study (two subsequently withdrew participation). A total of 299 (of a possible 330) short interviews were completed by 33 participants (26 male and 7 female) as part of the multi-stage, longitudinal design of the study. This study indicates that adapted qualitative research methods employed during a pandemic can be successfully applied to obtain insights and experiences (of individuals and groups) otherwise difficult to reach and/or complex to understand

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

The <i>Ansa</i> Effect in Permethylmolybdenocene Chemistry: A [Me₂Si] <i>Ansa</i> Bridge Promotes Intermolecular C−H and C−C Bond Activation

Access to the [Me2Si] ansa-bridged permethylmolybdenocene system is provided by the synthesis of [Me2Si(C5Me4)2]MoCl2 from the reaction of MoCl5 with a mixture of [Me2Si(C5Me4)2]Li2 and NaBH4, followed by treatment with CHCl3. Comparison with the chemistry of the non-ansa Cp*2MoX2 system indicates that incorporation of the [Me2Si] ansa bridge promotes intermolecular C−H and C−C bond activation reactions

The <i>Ansa</i> Effect in Permethylmolybdenocene Chemistry: A [Me₂Si] <i>Ansa</i> Bridge Promotes Intermolecular C−H and C−C Bond Activation

Access to the [Me2Si] ansa-bridged permethylmolybdenocene system is provided by the synthesis of [Me2Si(C5Me4)2]MoCl2 from the reaction of MoCl5 with a mixture of [Me2Si(C5Me4)2]Li2 and NaBH4, followed by treatment with CHCl3. Comparison with the chemistry of the non-ansa Cp*2MoX2 system indicates that incorporation of the [Me2Si] ansa bridge promotes intermolecular C−H and C−C bond activation reactions

The <i>Ansa</i> Effect in Permethylmolybdenocene Chemistry: A [Me₂Si] <i>Ansa</i> Bridge Promotes Intermolecular C−H and C−C Bond Activation

Access to the [Me2Si] ansa-bridged permethylmolybdenocene system is provided by the synthesis of [Me2Si(C5Me4)2]MoCl2 from the reaction of MoCl5 with a mixture of [Me2Si(C5Me4)2]Li2 and NaBH4, followed by treatment with CHCl3. Comparison with the chemistry of the non-ansa Cp*2MoX2 system indicates that incorporation of the [Me2Si] ansa bridge promotes intermolecular C−H and C−C bond activation reactions