Individualità collettiva

L’anello circolare rappresenta senza dubbio l’affermazione architettonica di un obiettivo: l’incontro fra collettività e individualità, ma in questo caso riflette anche un’idea di sviluppo urbano e sociale molto chiaro. La forma sembra rifarsi alle antiche abitazioni collettive della Cina meridionale, i Tulou, dove gli spazi si aprivano, per ragioni difensive, soprattutto verso il cortile interno

Design[ing]

Il rapporto fra Michele De Lucchi e la progettazione credo sia espresso chiaramente dall’esistenza di quel luogo, quasi fantastico, che è il Chioso. Il suo ‘rifugio’ sul Lago Maggiore, ma anche il suo laboratorio, atelier, officina, archivio: il Chioso, come la progettazione, non è un’entità univoca, ma un insieme di suggestioni, immagini, sensibilità, tecnologie, che attingono in maniera continua al mondo reale

Pill’ ’e Mata

Il rapporto di un territorio e di un popolo con la propria storia è senza dubbio uno dei legami più forti. Leggendo la storia di questo progetto sembra di leggere uno dei racconti de Le città invisibili di Calvino, e precisamente il terzo, quello su Zaira

Cardiac Regeneration: the Heart of the Issue

Purpose of Review The regenerative capacity of the heart is insufficient to compensate for the pathological loss of cardiomyocytes during a large injury, such as a myocardial infarction. Therapeutic options for patients after cardiac infarction are limited: treatment with drugs that only treat the symptoms or extraordinary measures, such as heart transplantation. Cell therapies offer a promising strategy for cardiac regeneration. In this brief review, the major issues in these areas are discussed, and possible directions for future research are indicated. Recent Findings Cardiac regeneration can be obtained by at least two strategies: the first is direct to generate an ex vivo functional myocardial tissue that replaces damaged tissue; the second approach aims to stimulate endogenous mechanisms of cardiac repair. However, current cell therapies are still hampered by poor translation into actual clinical applications. In this scenario, recent advancements in cell biology and biomaterial-based technologies can play a key role to design effective therapeutic approaches

Scientific evidence for the treatment of children with irritable bowel syndrome

Irritable bowel syndrome (IBS) is the commonest cause of recurrent abdominal pain in children in both more developed and developing parts of the world. It is characterized by abdominal pain that is improved by defecation and whose onset is associated with a change in stool form and/or frequency and is not explained by structural or biochemical abnormalities. A number of potential patho-physiological mechanisms have been described, but so far the exact underlying etiology of IBS is unclear. Likewise, no optimal treatment has ever been found neither for adult nor for pediatric patients. Current therapeutic options include drugs, dietary interventions and biopsychosocial therapies. The present review aims at evaluating the scientific evidence supporting the efficacy of these treatments for children with IBS

Smart Grid in China, EU, and the US: State of Implementation

Depletion of fossil fuel deposits is the main current issue related to the world's power generation. Renewable energy sources integrated with energy efficiency represent an effective solution. The electrification of end-use coupled with renewable power generation integration is considered as an important tool to achieve these tasks. However, the current electric power system does not currently have the suitable features to allow this change. Therefore, in the future, it has to allow two-way direction power flows, communication, and automated controls to fully manage the system and customers. The resulting system is defined as the smart grid. This article analyses the smart grid state of play within China, the US, and the EU, assessing the completion state of each smart grid technology and integrated asset. The analysis related to these countries presented here shows that the smart grid overall state of play in China, the US, and the EU are equal to 18%, 15%, and 13%, respectively, unveiling the need related to further efforts and investments in these countries for the full smart grid development

Insulin deficiency and reduced expression of lipogenic enzymes in cardiomyopathic hamster.

Evidence is given that the heart of the cardiomyopathic UM-X7.1 hamster has a lipid composition different from that of the same tissue isolated from animals of the Syrian hamster parent strain. Also, noncardiac tissues from cardiomyopathic and healthy hamsters exhibit significant compositional differences. On the basis of these preliminary observations, a comparative study of the hepatic biosynthesis of lipids in cardiomyopathic and healthy Syrian hamsters was undertaken. The results obtained indicate that the cardiomyopathic hamster is characterized by a generalized disturbance of lipid metabolism. In particular, the fatty acid synthase and stearoyl-CoA desaturase activities were significantly lower in the liver of UM-X7.1 hamsters than in age-matched healthy controls fed the same diet. Northern blot analysis of the mRNAs encoding the two enzymatic proteins and the "lipogenic" S14 nuclear protein indicated that the transcription of the respective genes was impaired in UM-X7.1.Short-term dietary manipulations modulated the expression of the above-mentioned genes both in cardiomyopathic and healthy animals. However, dietary carbohydrates were less effective in inducing the expression of lipogenic enzymes in UM-X7.1 liver than healthy controls. The main determinant of the metabolic defect pointed out in the present work appears to be represented by the low insulin level detectable in the plasma of the cardiomyopathic hamster.-Vecchini, A., L. Binaglia, M. Bibeau, M. Minieri, F. Carotenuto, and P. Di Nardo. Insulin deficiency and reduced expression of lipogenic enzymes in cardiomyopathic hamster. J. Lipid Res. 2001. 42: 96;-105

Acute appendicitis in infants

Acute appendicitis is very uncommon in the first year of life and often its presentation is atypical with high risk of complications. Hereby, we present 4 clinical cases of infants, who were diag- nosed with acute appendicitis in our hospital over the last year. The reported clinical cases high- light the several drawbacks clinicians face when managing infants with symptoms suggestive for acute appendicitis. After specific diagnostic work-up, even if not conclusive, patients were intra- operatively diagnosed with acute appendicitis and underwent appendicectomy. Maintaining a high index of suspicion for acute appendicitis in infants presenting with intra-abdominal sepsis of unclear etiology is, in our opinion, the most crucial factor to avoid complications and longer hospitalization

Investigation of pepsin in tears of children with laryngopharyngeal reflux disease

Objectives: Numerous investigations postulated that Laryngopharyngeal reflux (LPR) is implicated in the pathogenesis of various upper airway inflammatory diseases as sinusitis or dacryostenosis. The presence of pepsin in tears might be confirmed the presuntive hypothesis of the arrival in the nasolacrimal ducts and precorneal tears film through the laryngopharyngeal reflux of either gastric acid or stomach secretions (pepsin) with inflammatory potentialities. The aim of this preliminary study was to identify the presence or absence of pepsin in the tears collected from children with a high suspicion of LPR who underwent 24-h pH (MII-pH) monitoring to confirm the disease. Methods: This study enrolled twenty patients suffering from symptoms of laryngopharyngeal reflux that underwent 24-h multichannel intraluminal impedance (MII)-pH monitoring to confirm the disease. The findings of the study group were compared with those of a control group of patients with negative pH monitoring. The quantitative analysis of human pepsin concentration in the tear samples was performed by ELISA method in both groups. Results: Four children (20%) of the study group showed pepsin in the tears. All of the subjects belonging to the control group were negative for its presence. No difference differences in the total number of reflux episodes and the number of weakly basic reflux in the pepsin positive patients vs pepsin negative children were present. Conclusions: 20% of the children with diagnosed LPR showed pepsin in the tears. Our specific investigation might provide information regarding sinusitis or dacryostenosis