Enhanced Room Temperature Coefficient of Resistance and Magneto-resistance of Ag-added La0.7Ca0.3-xBaxMnO3 Composites

In this paper we report an enhanced temperature coefficient of resistance (TCR) close to room temperature in La0.7Ca0.3-xBaxMnO3 + Agy (x = 0.10, 0.15 and y = 0.0 to 0.40) (LCBMO+Ag) composite manganites. The observed enhancement of TCR is attributed to the grain growth and opening of new conducting channels in the composites. Ag addition has also been found to enhance intra-granular magneto-resistance. Inter-granular MR, however, is seen to decrease with Ag addition. The enhanced TCR and MR at / near room temperature open up the possibility of the use of such materials as infrared bolometric and magnetic field sensors respectively.Comment: 22 pages of Text + Figs:comments/suggestions([email protected]

Lead optimisation of dehydroemetine for repositioned use in malaria

Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the multi-drug resistant strain K1 of Plasmodium falciparum (IC50: 47 nM ± 2.1 nM). Dehydroemetine, a synthetic analogue of emetine dihydrochloride has been reported to have less cardiotoxic effects than emetine. The structures of two diastereomers of dehydroemetine were modelled on the published emetine binding site on cryo-EM structure 3J7A (Pf 80S ribosome in complex with emetine) and it was found that (-)-R,S-dehydroemetine mimicked the bound pose of emetine more closely than (-)-S,S-dehydroisoemetine. (-)-R,S-dehydroemetine (IC50 71.03 ± 6.1 nM) was also found to be highly potent against the multi-drug resistant K1 strain of P. falciparum in comparison with (-)-S,S-dehydroisoemetine (IC50 2.07 ± 0.26 μM), which loses its potency due to the change of configuration at C-1′. In addition to its effect on the asexual erythrocytic stages of P. falciparum, the compounds exhibited gametocidal properties with no cross-resistance against any of the multi-drug resistant strains tested. Drug interaction studies showed (-)-R,S-dehydroemetine to have synergistic antimalarial activity with atovaquone and proguanil. Emetine dihydrochloride, and (-)-R,S-dehydroemetine failed to show any inhibition of the hERG potassium channel and displayed activity on the mitochondrial membrane potential indicating a possible multi-modal mechanism of action. [Abstract copyright: Copyright © 2020 Panwar et al.

Characteristics of gravity waves generated in a convective and a non-convective environment revealed from hourly radiosonde observation under CPEA-II campaign

Analyses of hourly radiosonde data of temperature, wind, and relative humidity during four days (two with convection and two with no convection) as a part of an intensive observation period in CPEA-2 campaign over Koto Tabang (100.32° E, 0.20° S), Indonesia, are presented. Characteristics of gravity waves in terms of dominant wave frequencies at different heights and their vertical wavelengths are shown in the lower stratosphere during a convective and non-convective period. Gravity waves with periods ~10 h and ~4–5 h were found dominant near tropopause (a region of high stability) on all days of observation. Vertical propagation of gravity waves were seen modified near heights of the three identified strong wind shears (at ~16, 20, and 25 km heights) due to wave-mean flow interaction. Between 17 and 21 km heights, meridional wind fluctuations dominated over zonal wind, whereas from 22 to 30 km heights, wave fluctuations with periods ~3–5 h and ~8–10 h in zonal wind and temperature were highly associated, suggesting zonal orientation of wave propagation. Gravity waves from tropopause region to 30 km heights were analyzed. In general, vertical wavelength of 2–5 km dominated in all the mean-removed (~ weekly mean) wind and temperature hourly profiles. Computed vertical wavelength spectra are similar, in most of the cases, to the source spectra (1–16 km height) except that of zonal wind spectra, which is broad during active convection. Interestingly, during and after convection, gravity waves with short vertical wavelength (~2 km) and short period (~2–3 h) emerged, which were confined in the close vicinity of tropopause, and were not identified on non-convective days, suggesting convection to be the source for them. Some wave features near strong wind shear (at 25 km height) were also observed with short vertical wavelengths in both convective and non-convective days, suggesting wind shear to be the sole cause of generation and seemingly not associated with deep convection below. A drop in the temperature up to ~4–5 K (after removal of diurnal component) was observed at ~16 km height near a strong wind shear (~45–55 m s⁻¹ km⁻¹) during active period of convection

Diagnostic accuracy of neutrophil to lymphocyte ratio in comparison with liver function tests for the diagnosis of intrahepatic cholestasis of pregnancy

Background: In this study, we aimed to find diagnostic accuracy of neutrophil to lymphocyte ratio in comparison with liver function tests for the diagnosis of intrahepatic cholestasis of pregnancy and adverse fetal-maternal outcomes.Methods: NLR and aminotransferase (AST/ALT) levels in the blood samples of pregnant women with complaint of pruritus. 90 women with elevated transaminase were taken as cases and same number of women with normal aminotransferase levels taken as control. All were examined in this prospective case-control study.Results: Not only was the mean NLR elevated in the pregnant women with cholestasis when compared to the controls, but it also predicted the severity of the cholestasis. The correlation between transaminase levels and NLR was significant.Conclusions: Although TBA is still the diagnostic standard, NLR can be used as an initial screening tool due to its high specificity

Low-mass young stellar population and star formation history of the cluster IC 1805 in the W4 H{\sc ii} region

W4 is a giant H{\sc ii} region ionized by the OB stars of the cluster IC~1805. The H{\sc ii} region/cluster complex has been a subject of numerous investigations as it is an excellent laboratory for studying the feedback effect of massive stars on the surrounding region. However, the low-mass stellar content of the cluster IC~1805 remains poorly studied till now. With the aim to unravel the low-mass stellar population of the cluster, we present the results of a multiwavelength study based on deep optical data obtained with the Canada-France-Hawaii Telescope, infrared data from 2MASS, $Spitzer$ Space Telescope and X-ray data from $Chandra$ Space Telescope. The present optical dataset is complete enough to detect stars down to 0.2~M$_\odot$, which is the deepest optical observations so far for the cluster. We identified 384 candidate young stellar objects (YSOs; 101 Class I/II and 283 Class III) within the cluster using various colour-colour and colour-magnitude diagrams. We inferred the mean age of the identified YSOs to be $\sim$ 2.5 Myr and mass in the range 0.3 - 2.5 M$_\odot$. The mass function of our YSO sample has a power law index of -1.23 $\pm$ 0.23, close to the Salpeter value (-1.35), and consistent with those of other star-forming complexes. We explored the disk evolution of the cluster members and found that the diskless sources are relatively older compared to the disk bearing YSO candidates. We examined the effect of high-mass stars on the circumstellar disks and found that within uncertainties, the influence of massive stars on the disk fraction seems to be insignificant. We also studied the spatial correlation of the YSOs with the distribution of gas and dust of the complex to conclude that IC 1805 would have formed in a large filamentary cloud.Comment: Accepted for publication in MNRAS; 34 pages, 10 figure

Hierarchical Control of Grid-Connected Hydrogen Electrolyzer Providing Grid Services

This paper presents the operation modes and control architecture of the grid-connected hydrogen electrolyzer systems for the provision of frequency and voltage supports. The analysis is focused on the primary and secondary loops in the hierarchical control scheme. At the power converter inner control loop, the voltage- and current-control modes are analyzed. At the primary level, the droop and opposite droop control strategies to provide voltage and frequency support are described. Coordination between primary control and secondary, tertiary reserves is discussed. The case studies and real-time simulation results are provided using Typhoon HIL to back the theoretical investigation

Variability of young stellar objects in the star-forming region Pelican Nebula

We observed a field of $16'\times 16'$ in the star-forming region Pelican Nebula (IC 5070) at $BVRI$ wavelengths for 90 nights spread over one year in 2012-2013. More than 250 epochs in $VRI$-bands are used to identify and classify variables up to $V\sim 21$~mag. We present a catalogue of optical time-series photometry with periods, mean-magnitudes and classifications for 95 variable stars including 67 pre-main-sequence variables towards star-forming region IC 5070. The pre-main-sequence variables are further classified as candidate classical T Tauri and weak-line T Tauri stars based on their light curve variations and the locations on the color-color and color-magnitude diagrams using optical and infrared data together with Gaia DR2 astrometry. Classical T Tauri stars display variability amplitudes up to three times the maximum fluctuation in disk-free weak-line T Tauri stars, which show strong periodic variations. Short-term variability is missed in our photometry within single nights. Several classical T Tauri stars display long-lasting ($\geq 10$ days) single or multiple fading and brightening events up to a couple of magnitudes at optical wavelengths. The typical mass and age of the pre-main-sequence variables from the isochrone-fitting and spectral energy distributions are estimated to be $\le 1~M_\odot$ and $\sim 2$ Myr, respectively. We do not find any correlation between the optical amplitudes or periods with the physical parameters (mass and age) of pre-main-sequence stars.Comment: 17 pages, 14 figures, accepted for publication in Astronomy and Astrophysic