Blowup Phenomena for a Modified Dullin-Gottwald-Holm Shallow Water System

We discuss blowup phenomena for a modified two-component Dullin-Gottwald-Holm shallow water system. In this paper, some new blowup criteria of strong solutions involving the density and suitable integral form of the momentum are established

View of Pakistani residents toward coronavirus disease (COVID-19) during a rapid outbreak: A rapid online survey

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Background: Coronavirus disease (COVID-19) is a deadly disease that is affecting most of the countries worldwide. Public understanding, including knowledge about signs and symptoms, mode of transmission, and hygiene of COVID-19, is vital for designing effective control strategies during a public health crisis. The current study is aimed at investigating the public’s perspective about COVID-19, including their knowledge, attitude, and practices. Methods: A rapid online survey comprising 22 items was administered during the rapid outbreak of COVID-19 in Pakistan. Questions were focused on the prevention, transmission, clinical features, and control of COVID-19. In addition, the attitudes and practices of the participants were explored. Descriptive statistics, Mann–Whitney tests, Kruskal–Wallis tests, and regression analysis were carried out during data analysis. Results: A total of 1257 respondents participated in this study. Most of the respondents had good knowledge (good = 64.8%, average = 30.5%, poor = 4.7%) of COVID-19. Gender, marital status, education, and residence were observed to have a significant association with the knowledge score. A vast majority of the survey respondents (77.0%) believed that COVID-19 would be controlled successfully in Pakistan. The practices of wearing a mask (85.8%) and handwashing (88.1%) were common among the participants. Conclusion: The participants demonstrated good knowledge and reasonable attitudes and practices toward most aspects of the COVID-19 outbreak. Improvements in certain areas could be made by mass-level education

Perspective of Pakistani physicians towards hospital antimicrobial stewardship programs: A multisite exploratory qualitative study

© 2019 Raha Orfali et al. Plicosepalus is an important genus of the Loranthaceae family, and it is a semiparasitic plant grown in Saudi Arabia, traditionally used as a cure for diabetes and cancer in human and for increasing lactation in cattle. A flavonoid quercetin (P1), (-)-catechin (P2), and a flavane gallate 2S,3R-3,3′,4′,5,7-pentahydroxyflavane-5-O-gallate (P3) were isolated from the methanol extract of the aerial parts of P. curviflorus (PCME). The PCME and the isolated compounds were subjected to pharmacological assays to estimate peroxisome proliferator-activated receptors PPARα and PPARγ agonistic, anti-inflammatory, cytotoxic, and antimicrobial activities. Results proved for the first time the dual PPAR activation effect of the PCME and catechin (P2), in addition to the promising anti-inflammatory activity of the flavonoid quercetin (P1). Interestingly, both PCME and isolated compounds showed potent antioxidant activities while no antimicrobial effect against certain microbial strains had been reported from the extract and the isolated compounds. Based on the pharmacological importance of these compounds, an HPTLC validated method was developed for the simultaneous estimation of these compounds in PCME. It was found to furnish a compact and sharp band of compounds P1, P2, and P3 at Rf = 0.34, 0.47, and 0.65, respectively, using dichloromethane, methanol, and formic acid (90: 9.5: 0.5, (v/v/v)) as the mobile phase. Compounds P1, P2, and P3 were found to be 11.06, 10.9, 6.96 μg/mg, respectively, in PCME. The proposed HPTLC method offers a sensitive, precise, and specific analytical tool for the quantification of quercetin, catechin, and flavane gallates in P. curviflorus

Clinical and Prognostic Value of PET/CT Imaging with Combination of 68

Background. To evaluate the clinical and prognostic value of PET/CT with combination of 68Ga-DOTATATE and 18F-FDG in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). Method. 83 patients of GEP-NENs who underwent 68Ga-DOTATATE and 18F-FDG PET/CT were enrolled between June 2013 and December 2016. Well-differentiated (WD) NETs are divided into group A (Ki-67 < 10%) and group B (Ki-67 ≥ 10%), and poorly differentiated (PD) NECs are defined as group C. The relationship between PET/CT results and clinicopathological characteristics was retrospectively investigated. Result. For groups A/B/C, the sensitivities of 68Ga-DOTATATE and 18F-FDG were 78.8%/83.3%/37.5% and 52.0%/72.2%/100.0%. A negative correlation between Ki-67 and SUVmax of 68Ga-DOTATATE (R = −0.415; P ≤ 0.001) was observed, while a positive correlation was noted between Ki-67 and SUVmax of 18F-FDG (R = 0.683; P ≤ 0.001). 62.5% (5/8) of patients showed significantly more lesions in the bone if 68Ga-DOTATATE was used, and 22.7% (5/22) of patients showed more lymph node metastases if 18F-FDG was used. Conclusions. The sensitivity of dual tracers was correlated with cell differentiation, and a correlation between Ki-67 and both SUVmax of PET-CTs could be observed. 68Ga-DOTATATE is suggested for WD-NET and 18F-FDG is probably suitable for patients with Ki-67 ≥ 10%

Study on evolution law of mechanical properties of coal samples subjected to freezing and freeze-thaw cycles of liquid nitrogen

The permeability of coal reservoir is generally low in China, how to effectively improve the permeability of coal reservoir is a key and difficult point of coalbed methane exploitation, Liquid nitrogen fracturing technology as a kind waterless fracturing technology has received extensive attention in recent years. In order to reveal the influence of liquid nitrogen freezing and freeze-thaw on the mechanical properties of coal, the temperature distribution of coal samples was monitored by infrared thermal imaging technology, and uniaxial compression and acoustic emission tests were performed on the coal samples after the liquid nitrogen freezing and freezethaw, the P-wave velocity, porosity, acoustic emission and energy evolution characteristics of coal samples before and after the freezing and freeze thaw were analyzed. The research result showed that: ①After 360 min freezing and 12 freeze-thaw cycles, the P-wave velocity of coal samples decreased by 58.2% and 64.7%, respectively. The P-wave velocity does not decrease significantly during the initial freezing and freeze-thaw cycle stages, the velocity gradually decreases with the increase of freezing time and freeze-thaw cycles. ②The temperature of the coal sample gradually decreases with increase of freezing times. The surface temperature of the coal sample drops below -60°C after the liquid nitrogen frozen for 180s, the temperature distribution fluctuations at the center of the coal sample occurs due to the different thermal conduction coefficient of the coal particles. ③After liquid nitrogen freezing and freezethaw, the elastic modulus of coal sample decreases exponentially, while the porosity gradually increases. The increase in porosity of the coal sample after liquid nitrogen freeze-thaw is greater than that after liquid nitrogen freezing. ④The acoustic emission activity of coal samples during uniaxial loading is divided into development phase, active phase and severe phase, the maximum acoustic emission ringing count and cumulative acoustic emission ringing count of coal samples increase with the increase of freezing time and freeze-thaw cycles. ⑤Liquid nitrogen freezing and freeze-thaw will weaken the energy storage limit of coal sample, resulting in the reduction of the total energy, elastic energy and dissipated energy at the peak point during the uniaxial loading process

Urinary dysfunction in patients with vascular cognitive impairment

Vascular cognitive impairment (VCI) is caused by vascular pathologies, with the spectrum of cognitive disorders ranging from subjective cognitive dysfunction to dementia. Particularly among older adults, cognitive impairment is often complicated with urinary dysfunction (UD); some patients may present with UD before cognitive impairment owing to stroke or even when there are white matter hyperintensities on imaging studies. Patients with cognitive impairment often have both language and movement dysfunction, and thus, UD in patients with VCI can often be underdiagnosed and remain untreated. UD has an impact on the quality of life of patients and caregivers, often leading to poor outcomes. Medical history is an important aspect and should be taken from both patients and their caregivers. Clinical assessment including urinalysis, voiding diary, scales on UD and cognitive impairment, post-void residual volume measurement, uroflowmetry, and (video-) urodynamics should be performed according to indication. Although studies on UD with VCI are few, most of them show that an overactive bladder (OAB) is the most common UD type, and urinary incontinence is the most common symptom. Normal urine storage and micturition in a specific environment are complex processes that require a sophisticated neural network. Although there are many studies on the brain–urinary circuit, the specific circuit involving VCI and UD remains unclear. Currently, there is no disease-modifying pharmacological treatment for cognitive impairment, and anti-acetylcholine drugs, which are commonly used to treat OAB, may cause cognitive impairment, leading to a vicious circle. Therefore, it is important to understand the complex interaction between UD and VCI and formulate individualized treatment plans. This review provides an overview of research advances in clinical features, imaging and pathological characteristics, and treatment options of UD in patients with VCI to increase subject awareness, facilitate research, and improve diagnosis and treatment rates

Corrigendum to: The TianQin project: current progress on science and technology

In the originally published version, this manuscript included an error related to indicating the corresponding author within the author list. This has now been corrected online to reflect the fact that author Jun Luo is the corresponding author of the article

Blowup Phenomena for a Modified Dullin-Gottwald-Holm Shallow Water System

We discuss blowup phenomena for a modified two-component Dullin-Gottwald-Holm shallow water system. In this paper, some new blowup criteria of strong solutions involving the density and suitable integral form of the momentum are established

Blow-up Phenomena and Persistence Properties of Solutions to the Two-Component DGH Equation

This paper is concerned with blow-up phenomena and persistence properties for an integrable two-component Dullin-Gottwald-Holm shallow water system. We give sufficient conditions on the initial data which guarantee blow-up phenomena of solutions in finite time for both periodic and nonperiodic cases, respectively. Furthermore, the persistence properties of solutions to the system are investigated