Motions with inertial and diurnal period in a numerical model of the navifacial boundary layer

A model that represents a complex local theory concerning the navifacial planetary boundary layer is presented. The model includes the effects of boundary-layer turbulence in stratified (humidity-dependent and salinity-dependent) flow, of mixing due to windgenerated waves at the naviface, and of cloud-dependent radiative heating throughout the layer...

Inertial oscillations in an Ekman layer containing a horizontal discontinuity surface

Solutions are obtained for systems of equations that determine the development of velocity profiles in an infinitely deep fluid system subjected to Coriolis accelerations and composed of two layers of viscous fluid differing in density, viscosity, and geostrophic velocity. The density, viscosity, and horizontal pressure gradient are assumed to remain constant in space and time within each layer and to differ discontinuously at the horizontal interface between the layers...

Villa Stein-De-Monzie by Le Corbusier (1926-1928). Conservation strategies between research and education

The paper focuses on the educational experience produced during the International Workshop, organized by the IUAV University of Venice and dedicated to both the understanding and conservation of the maison Stein-de-Monzie "Les Terrasses", an emblematic work of Le Corbusier's early career period. The villa, located in Garches (Vaucresson), was designed and built between 1926 and 1928, the exact same years when Le Corbusier was elaborating the "Five Points of Architecture" (1927): the building is the first complete application of these principles, while it represents an evolution of the maison Dom-Ino's structural scheme. Nowadays, both the interior spaces and the external surfaces of the maison Stein-de-Monzie show profound changes caused by problematic events leading to the present-day appearance of the building, in many cases misrepresenting the original design goals. The building's integrated instrumental survey (laser scanning, photogrammetry, topography) allowed to document and understand the history of the villa beyond the mere and well known project phase, contributing to the definition of the actual construction characteristics and to ascertain both the material consistency and the state of conservation. The knowledge acquisition process – supported by survey data – constitutes a prerequisite to outline the design of new solutions, which could effectively express the cultural choices connected to the conservation of the Twentieth-Century built heritage

Impact of climate change on climatic zoning of common bean in the South of Brazil.

Made available in DSpace on 2018-02-07T23:41:08Z (GMT). No. of bitstreams: 1 ID442932017v25n2p313Agrometeoros.pdf: 968008 bytes, checksum: 63e30154bc5c055b60315bd82beae840 (MD5) Previous issue date: 2018-02-07bitstream/item/172342/1/ID44293-2017v25n2p313Agrometeoros.pd

Urinary, bowel and sexual symptoms in a cohort of patients with Friedreich's ataxia

BACKGROUND: Pelvic symptoms are distressing symptoms experienced by patients with Friedreich’s Ataxia (FRDA). The aim of this study was to describe the prevalence of lower urinary tract symptoms (LUTS), bowel and sexual symptoms in FRDA. METHODS: Questionnaire scores measuring LUTS, bowel and sexual symptoms were analysed with descriptive statistics as a cohort and as subgroups (Early/Late-onset and Early/Late-stage FRDA) They were also correlated with validated measures of disease severity including those of ataxia severity, non-ataxic symptoms and activities of daily living. RESULTS: 80% (n = 46/56) of patients reported LUTS, 64% (n = 38/59) reported bowel symptoms and 83% (n = 30/36) reported sexual symptoms. Urinary and bowel or sexual symptoms were significantly likely to co-exist among patients. Late-onset FRDA patients were also more likely to report LUTS than early-onset ones. Patients with a longer disease duration reported higher LUTS scores and poorer quality of life scores related to urinary symptoms. CONCLUSIONS: A high proportion of FRDA have symptoms suggestive of LUTS, bowel and sexual dysfunction. This is more marked with greater disease duration and later disease onset. These symptoms need to be addressed by clinicians as they can have a detrimental effect on patients

Lenguajes específicos y herramientas de soporte al modelado de procesos del negocio en el contexto del desarrollo dirigido por modelos

En el desarrollo de software dirigido por modelos (MDD), los lenguajes de modelado juegan un rol central. Abarcan desde los más genéricos como UML hasta los llamados lenguajes específicos del dominio (DSL). En el dominio de los procesos de negocio, existen distintas notaciones y también lenguajes estándares para modelado (como BPMN) y tal como sucede en otras áreas, el diseño de un modelo BPMN necesita ser mejorado a través de técnicas de refactorización. En MDD, la refactorización de modelos es vista como una forma particular de transformaciones de modelos. Es deseable entonces contar con lenguajes de transformaciones específicos para soportar refactorización de modelos de proceso. En este proyecto proponemos brindar asistencia al desarrollador proveyendo construcciones específicas para refactorización de modelos de proceso. Específicamente se analizarán los distintos lenguajes existentes para modelado de procesos; se logrará llegar a un manejo adecuado de herramientas específicas para modelado de procesos; se compararán las distintas herramientas existentes actualmente en el mercado y se definirán herramientas específicas y maduras para Gestión de Procesos de Negocios (BPM), que incluirán refactorizaciones básicas y avanzadas de modelos de proceso del negocio a través de la técnica de transformaciones de modelos.Eje: Ingeniería de SoftwareRed de Universidades con Carreras en Informática (RedUNCI

Spinocerebellar ataxia types 1, 2, 3, and 6: disease severity and nonataxia symptoms.

OBJECTIVE: To identify factors that determine disease severity and clinical phenotype of the most common spinocerebellar ataxias (SCAs), we studied 526 patients with SCA1, SCA2, SCA3. or SCA6. METHODS: To measure the severity of ataxia we used the Scale for the Assessment and Rating of Ataxia (SARA). In addition, nonataxia symptoms were assessed with the Inventory of Non-Ataxia Symptoms (INAS). The INAS count denotes the number of nonataxia symptoms in each patient. RESULTS: An analysis of covariance with SARA score as dependent variable and repeat lengths of the expanded and normal allele, age at onset, and disease duration as independent variables led to multivariate models that explained 60.4% of the SARA score variance in SCA1, 45.4% in SCA2, 46.8% in SCA3, and 33.7% in SCA6. In SCA1, SCA2, and SCA3, SARA was mainly determined by repeat length of the expanded allele, age at onset, and disease duration. The only factors determining the SARA score in SCA6 were age at onset and disease duration. The INAS count was 5.0 +/- 2.3 in SCA1, 4.6 +/- 2.2 in SCA2, 5.2 +/- 2.5 in SCA3, and 2.0 +/- 1.7 in SCA6. In SCA1, SCA2, and SCA3, SARA score and disease duration were the strongest predictors of the INAS count. In SCA6, only age at onset and disease duration had an effect on the INAS count. CONCLUSIONS: Our study suggests that spinocerebellar ataxia (SCA) 1, SCA2, and SCA3 share a number of common biologic properties, whereas SCA6 is distinct in that its phenotype is more determined by age than by disease-related factors

Spontaneous self-assembly of an unsymmetric trinuclear triangular copper(II) pyrazolate complex, [Cu3(μ3-OH)(μ-pz) 3(MeCOO)2(Hpz)] (Hpz = pyrazole). Synthesis, experimental and theoretical characterization, reactivity, and catalytic activity

The almost quantitative formation of the triangular trinuclear copper derivative [Cu3(μ3-OH)(μ-pz)3(MeCOO) 2(Hpz)] (1) (Hpz = pyrazole), has been simply achieved by adding Hpz to an ethanol solution of Cu(MeCOO)2·H2O. An X-ray molecular structure determination shows that 1 is completely unsymmetric and that trinuclear units result assembled in an extended bidimensional network formed through acetate bridges and hydrogen bonds. EPR and magnetic measurements are consistent with the presence of a single unpaired electron. Theoretical density functional calculations carried out for S = 1/2 provide a thorough description of the electronic structure of 1, allowing a detailed assignment of its UV-vis absorption spectrum. Compound 1 reacts with MeONa, yielding [Cu 3(μ3-OH)(μ-pz)3(MeCOO)(MeO)(Hpz)] (2) and [Cu3(μ3-OH)(μ-pz)3(MeO) 2(Hpz)] (3) through the substitution of one and two acetate ions, respectively, with MeO- ion(sS). The spontaneous self-assembly of the triangular trinuclear Cu3 moiety seems to occur only with pyrazole as can be inferred by the results obtained in the reactions of copper(II) acetate with some substituted pyrazoles leading to the formation of mononuclear [Cu(MeCOO)2(L)2] (4-8) and dinuclear [Cu(MeCOO) 2(L)]2 (9-11) (L = substituted pyrazole) compounds. Also the presence of acetate ions seems to play a leading role in determining the formation of the trinuclear triangular arrangement, as indicated by the formation of a mononuclear derivative, [Cu(CF3COO) 2(Hpz)]2 (compound 12), in the reaction of copper(II) trifluoroacetate with pyrazole. Compounds 1-3, as well as some other mono- and dinuclear copper(II)-substituted pyrazole complexes, have been tested as catalyst precursors in cyclopropanation reaction, observing the formation of products in a syn:anti ratio opposite that normally reported

Noncoding RNAs as novel biomarkers in pancreatic cancer: what do we know?

Pancreatic cancer is an aggressive cancer of the digestive system, which is becoming a serious health problem worldwide. Overall survival for patients with pancreatic cancer is poor, mainly due to a lack of biomarkers to enable early diagnosis and a lack of prognostic markers that can inform decision-making, facilitating personalized treatment and an optimal clinical outcome. ncRNAs play an important role in pancreatic carcinogenesis. Here we review the literature on the role of ncRNAs as biomarkers in pancreatic cancer. We focus on the significance of ncRNAs as markers for early diagnosis, as prognostic biomarkers able to inform clinical management and as targets for novel therapeutics for patients with pancreatic cancer