21 research outputs found

    Control mechanisms and perceived organizational support: exploring the relationship between new and traditional forms of control

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    Purpose: Taking into account the need to make a clearer distinction between traditional and new organizational controls, this paper aims to investigate similarities and differences between those two forms and explore the extent to which new forms of control can be operationalized from a quantitative point of view. Design/methodology/approach: Suggesting that new organizational controls can be understood also in light of quantitative paradigms, we develop and test a scale to measure the existence of these types of controls, examine its construct validity and evaluate its convergent validity. Findings: The theoretical dimensions of new controls have empirical correspondence. Input and behaviour controls are strongly associated with the promotion of values and beliefs in organizations. New controls become responsible for employees’ acceptance of companies’ management, an aspect measured by Perceived-Organizational-Support (POS)

    Intimate partner violence: a study in men and women from six European countries

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    OBJECTIVES: We aimed to assess intimate partner violence (IPV) among men and women from six cities in six European countries. METHODS: Four IPV types were measured in a population-based multicentre study of adults (18-64 years; n = 3,496). Sex- and city-differences in past year prevalence were examined considering victims, perpetrators or both and considering violent acts' severity and repetition. RESULTS: Male victimization of psychological aggression ranged from 48.8 % (Porto) to 71.8 % (Athens) and female victimization from 46.4 % (Budapest) to 70.5 % (Athens). Male and female victimization of sexual coercion ranged from 5.4 and 8.9 %, respectively, in Budapest to 27.1 and 25.3 % in Stuttgart. Male and female victims of physical assault ranged from 9.7 and 8.5 %, respectively, in Porto, to 31.2 and 23.1 % in Athens. Male victims of injury were 2.7 % in Östersund and 6.3 % in London and female victims were 1.4 % in Östersund and 8.5 % in Stuttgart. IPV differed significantly across cities (p < 0.05). Men and women predominantly experienced IPV as both victims and perpetrators with few significant sex-differences within cities. CONCLUSIONS: Results support the need to consider men and women as both potential victims and perpetrators when approaching IPV

    Inhibition of Nipah Virus Infection In Vivo: Targeting an Early Stage of Paramyxovirus Fusion Activation during Viral Entry

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    In the paramyxovirus cell entry process, receptor binding triggers conformational changes in the fusion protein (F) leading to viral and cellular membrane fusion. Peptides derived from C-terminal heptad repeat (HRC) regions in F have been shown to inhibit fusion by preventing formation of the fusogenic six-helix bundle. We recently showed that the addition of a cholesterol group to HRC peptides active against Nipah virus targets these peptides to the membrane where fusion occurs, dramatically increasing their antiviral effect. In this work, we report that unlike the untagged HRC peptides, which bind to the postulated extended intermediate state bridging the viral and cell membranes, the cholesterol tagged HRC-derived peptides interact with F before the fusion peptide inserts into the target cell membrane, thus capturing an earlier stage in the F-activation process. Furthermore, we show that cholesterol tagging renders these peptides active in vivo: the cholesterol-tagged peptides cross the blood brain barrier, and effectively prevent and treat in an established animal model what would otherwise be fatal Nipah virus encephalitis. The in vivo efficacy of cholesterol-tagged peptides, and in particular their ability to penetrate the CNS, suggests that they are promising candidates for the prevention or therapy of infection by Nipah and other lethal paramyxoviruses

    Toward precision medicine of breast cancer

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    Nonlinear truss models for strain‐based seismic evaluation of planar RC walls

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    This paper introduces a new approach for the seismic performance evaluation of planar RC walls. Compared to existing assessment guidelines, such as those in ASCE/SEI 41-17, where performance limits are described by plastic rotation or lateral drift, the proposed method uses local (strain) quantities, obtained from computational models. The analyses rely on a user-friendly implementation of the nonlinear truss model for RC structures, which eliminates the need to manually create a line-element representation of a wall and includes a material law for steel accounting for buckling and rupture of reinforcement. The capability of the models to capture common failure patterns for planar walls is validated for a set of six previously tested wall components which experienced a variety of damage modes (bar rupture, boundary element failure, diagonal compression and tension failures). The analytical models accurately predict the lateral strength, deformation capacity and failure modes observed in the tests. A set of acceptance criteria, based on the analytically obtained concrete and steel strains, is then established for the immediate occupancy, life safety and collapse prevention levels, consistent with different levels and types of damage. An initial calibration of the limit values associated with these criteria is proposed and verified using the analytical results for the six walls considered. The results of the proposed assessment methodology applied to the six walls are compared to those obtained using the nonlinear procedures in ASCE/SEI 41-17. The results indicate that ASCE/SEI 41-17 may not accurately describe the deformability of walls exhibiting mixed flexure-shear inelastic deformations.The research presented in this paper is supported by the National Institute of Standards and Technology (NIST) under award No. 70NANB19H060. Any opinions and findings presented in this paper are those of the authors alone, and do not necessarily reflect the opinions of the sponsor.Peer ReviewedPostprint (published version
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