Dynamic and Transparent Analysis of Commodity Production Systems

We propose a framework that provides a programming interface to perform complex dynamic system-level analyses of deployed production systems. By leveraging hardware support for virtualization available nowadays on all commodity machines, our framework is completely transparent to the system under analysis and it guarantees isolation of the analysis tools running on its top. Thus, the internals of the kernel of the running system needs not to be modified and the whole platform runs unaware of the framework. Moreover, errors in the analysis tools do not affect the running system and the framework. This is accomplished by installing a minimalistic virtual machine monitor and migrating the system, as it runs, into a virtual machine. In order to demonstrate the potentials of our framework we developed an interactive kernel debugger, nicknamed HyperDbg. HyperDbg can be used to debug any critical kernel component, and even to single step the execution of exception and interrupt handlers.Comment: 10 pages, To appear in the 25th IEEE/ACM International Conference on Automated Software Engineering, Antwerp, Belgium, 20-24 September 201

Plastics waste trade and the environment

Europe is at crossroads regarding its management of plastic, plastic waste and the plastic waste trade. Rapidly growing amounts of plastic have negative environmental and climate impacts. Plastic and plastic waste are traded worldwide. Exporting plastic waste from the EU to Asia is a means of dealing with insufficient recycling capacities in the EU. Waste import restrictions in China have shifted exports to other countries. Because some types of plastic waste have been added to the United Nations Basel Convention, the option of exporting plastic waste is becoming increasingly difficult. This requires policymakers, business and other actors to build a more robust and circular economy for plastic in Europe. Annual global plastic production has increased from 2 to 380 million tonnes since 1950 and is projected to double by 2035 and almost quadruple by 2050. European countries lack the capacity to manage growing amounts of plastic waste in circular and sustainable ways. In early 2019, the EU exported around 150 000 tonnes of plastic waste per month. This figure was about twice as high in 2015 and 2016 - up to 300.000 tons monthly - when exports went to China and Hong Kong primarily. Import restrictions are the reason for the decrease and shift in exports of plastic waste to other countries in Asia. Poor management of plastic waste has negative environmental and climate effects, such as deposits of plastic and microplastics appearing on land and in rivers and oceans worldwide. Plastic contributes to climate change through greenhouse gas emissions from production and from waste management, and to harmful effects from chemicals and water use. There is little knowledge or transparency about how plastic waste imported from the EU is managed in other countries.Recent restrictions on imports of plastic waste in China, combined with some types of plastic being added to the Basel Convention, is likely to further decrease EU exports. This poses the risk of increased incineration and landfilling of plastic waste in Europe. The EU must find circular and climate-friendly ways of managing its plastic waste e.g. by increasing reuse and recycling

Kaposi's Sarcoma and HIV-Tat: Challenges to Antiangiogenesis Research

Kaposi's sarcoma (KS) is characterized by an abnormal growth of blood vessels. KS was found mainly in older men of Mediterranean or African origin (classic KS) or in patients after organ transplantation (iatrogenic KS). However, in the early 1980s, an aggressive epidemic form, linked to AIDS, was noticed and was one of the first clues to the existence of HIV-1 pandemy. The link between KS occurrence and HIV has raised multiple hypotheses. The drastic reduction of KS after the introduction of HAART, suggests HIV as a powerful co-factor for KS progression. We and others have contributed to the elucidation of KS cell nature and the possible involvement of extracellular HIV Tat. Tat is proangiogenic and is a true promoter of KS lesions acting as a VEGFR2 ligand both on KS and endothelial cells, in addition Tat is able to bind and activate chemokine receptors on monocytes and granulocytes causing a pro-inflammatory status. Evaluation of the effects of extracellular Tat on KS cells by microarray analysis after 24 h of incubation shows an interesting clustering of gene products involved in signal transduction, especially GTP-ase, Kinase and cAMP activity, confirming that Tat acts extracellularly by ways that are probably unrelated to its nuclear activity. KS occurrence is reduced by HAART but still present and in Africa is one of the most frequent oncologic disease. To find suitable drugs with low toxic impact on KS patients, we have tested several drugs and gene therapy approaches in in vivo models. from 2005 International Meeting of The Institute of Human Virology Baltimore, USA, 29 August – 2 September 200

Fully inorganic oxide-in-oxide ultraviolet nanocrystal light emitting devices

The development of integrated photonics and lab-on-a-chip platforms for environmental and biomedical diagnostics demands ultraviolet electroluminescent materials with high mechanical, chemical and environmental stability and almost complete compatibility with existing silicon technology. Here we report the realization of fully inorganic ultraviolet light-emitting diodes emitting at 390 nm with a maximum external quantum efficiency of ~0.3%, based on SnO(2) nanoparticles embedded in SiO(2) thin films obtained from a solution-processed method. The fabrication involves a single deposition step onto a silicon wafer followed by a thermal treatment in a controlled atmosphere. The fully inorganic architecture ensures superior mechanical robustness and optimal chemical stability in organic solvents and aqueous solutions. The versatility of the fabrication process broadens the possibility of optimizing this strategy and extending it to other nanostructured systems for designed applications, such as active components of wearable health monitors or biomedical devices

Advances in the investigation of shock-induced reflectivity of porous carbon

AbstractWe studied the behavior of porous carbon compressed by laser-generated shock waves. In particular, we developed a new design for targets, optimized for the investigation of carbon reflectivity at hundred-GPa pressures and eV/k temperatures. Specially designed "two-layer-two materials" targets, comprising porous carbon on transparent substrates, allowed the probing of carbon reflectivity and a quite accurate determination of the position in the P, T plane. This was achieved by the simultaneous measurement of shock breakout times, sample temperature (by optical pyrometry) and uid velocity. The experiments proved the new scheme is reliable and appropriate for reflectivity measurements of thermodynamical states lying out of the standard graphite or diamond hugoniot. An increase of reflectivity in carbon has been observed at 260 GPa and 14,000 K while no increase in reflectivity is found at 200 GPa and 20,000 K. We also discuss the role of numerical simulations in the optimization of target parameters and in clarifying shock dynamics